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Contrasting effects of 17 beta-estradiol on the growth of human ovarian carcinoma cells in vitro and in vivo.

Abstract：

:A human ovarian adenocarcinoma cell line (PE04) has been established as a xenograft in nude mice. In vitro, this cell line is estrogen receptor (ER)-positive and its growth is stimulated by 17 beta-estradiol at concentrations between 10(-12) and 10(-6) M. When xenografted, PE04 cells remain ER-positive and also possess progesterone receptors (PR); treatment with 17 beta-estradiol reduces the concentration of ER and increases levels of PR. Growth of the xenograft is reduced in ovariectomized animals while implantation of estrogen pellets also results in growth inhibition. Similar treatment with estrogen does not inhibit the ER-negative HOX 60 ovarian xenograft, and stimulates growth of the ER-positive ZR-75-I breast carcinoma xenograft. Serum measurements of 17 beta-estradiol confirm that ovariectomy reduces the level of 17 beta-estradiol while implantation of estrogen pellets results in raised levels of the hormone. Tamoxifen inhibits growth of the PE04 xenograft but not that of the HOX 60 xenograft, consistent with ER status. These results indicate that ER-positive PE04 ovarian cancer cells are sensitive to 17 beta-estradiol in vivo but that the response may be of a different type from the in vitro response. This lends further support to the concept that ovarian cancer may be hormone-sensitive and potentially responsive to endocrine therapy.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Langdon SP,Ritchie A,Young K,Crew AJ,Sweeting V,Bramley T,Hillier S,Hawkins RA,Tesdale AL,Smyth JF

doi

10.1002/ijc.2910550323

subject

Has Abstract,Author List Incomplete

pub_date

1993-09-30 00:00:00

pages

459-64

issue

3

eissn

0020-7136

issn

1097-0215

journal_volume

55

pub_type

杂志文章

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