Impact of technology on cytology outcome in cervical cancer screening of young and older women.

Abstract:

:Little is known about age-dependent variation in outcomes of cervical cytology with modern technologies. This population-based study evaluated age-dependent changes after routine implementation of ThinPrep and SurePath technology in two independent laboratories, and controlled for time trends in a third laboratory using manually read conventional cytology continually. Data were collected from the Danish National Health Care Registers. For each laboratory, we compared proportions of abnormal cytology defined as atypical squamous cells of undetermined significance or worse (ASCUS+) by age and technology phase. The study included 489,960 cytological samples with no recent abnormality from women aged 23-59 years, routinely screened between 1998 and 2007. Implementation of SurePath liquid-based cytology (LBC) was followed by an increase in abnormal cytology in women aged 23-29 years from 4.6 to 6.1%, relative proportion (RP): 1.31 [95% confidence interval (CI): 1.08-1.61], and a decrease in women aged 45-59 years from 2.9 to 2.0%, RP: 0.71 (95% CI: 0.60-0.83). Implementation of ThinPrep LBC was followed by a decrease in abnormal cytology both in women aged 23-29 years from 7.7 to 6.8%, RP: 0.89 (95% CI: 0.78-1.02) and in women aged 45-59 years from 3.4 to 1.0%, RP: 0.30 (95% CI: 0.24-0.37). With implementation of imaging-assisted reading, regardless of the brand of technology, the proportion of abnormality increased by around 30% in all age groups (range from 19 to 41%). In the laboratory with unchanged technology no trends in abnormality proportions were observed. The impact of LBC implementation on cytological abnormality proportions varied considerably across age groups.

journal_name

Int J Cancer

authors

Rask J,Lynge E,Franzmann M,Hansen B,Hjortebjerg A,Rygaard C,Schledermann D,Wåhlin A,Rebolj M

doi

10.1002/ijc.28532

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

2168-79

issue

9

eissn

0020-7136

issn

1097-0215

journal_volume

134

pub_type

杂志文章
  • Mothers' active and passive smoking during pregnancy and risk of brain tumours in children.

    abstract::As part of a collaborative study of risk factors for childhood brain tumours, the effects of the mother's smoking and her potential for passive smoking exposure during the pregnancy were assessed in a case-control study. Parents of 91 cases and 321 population controls from Northern Italy, matched for age, sex and resi...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ijc.2910570602

    authors: Filippini G,Farinotti M,Lovicu G,Maisonneuve P,Boyle P

    更新日期:1994-06-15 00:00:00

  • Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions: a longitudinal French cohort study.

    abstract::Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high-grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASC...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.11222

    authors: Dalstein V,Riethmuller D,Prétet JL,Le Bail Carval K,Sautière JL,Carbillet JP,Kantelip B,Schaal JP,Mougin C

    更新日期:2003-09-01 00:00:00

  • Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue.

    abstract::Use of herbal preparations containing Aristolochia species has led to progressive nephropathy and urothelial cancer in humans. Analysis of DNA adducts formed in human target tissues and studies in animal models have pointed out a major role of the secondary plant metabolites, aristolochic acids, in these effects. Only...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.21480

    authors: Meinl W,Pabel U,Osterloh-Quiroz M,Hengstler JG,Glatt H

    更新日期:2006-03-01 00:00:00

  • Characterization of clones of tumorigenic feline cells transformed by a chemical carcinogen.

    abstract::Tumorigenic clonal lines derived from soft agar colonies induced by DMBA-transformed feline embryo cells were isolated and characterized. The morphologically altered clonal cells formed large aggregates, growing in this aggregate form when suspended in liquid growth medium above an agar base and forming colonies in so...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910280110

    authors: Rhim JS,Koh KS,Chen A,Essex M

    更新日期:1981-07-15 00:00:00

  • Hot maté drinking and precancerous lesions of the oesophagus: an endoscopic survey in southern Brazil.

    abstract::Thermal injury resulting from drinking very hot beverages has been incriminated as a risk factor for oesophageal cancer, although no information is available on the lesions caused by this injury in human or experimental animals. The drinking of hot maté tea is very common in areas of moderately high incidence of oesop...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910390609

    authors: Muñoz N,Victora CG,Crespi M,Saul C,Braga NM,Correa P

    更新日期:1987-06-15 00:00:00

  • Effects of NQO1 deficiency on levels of cyclopurines and other oxidative DNA lesions in liver and kidney of young mice.

    abstract::I-compounds are bulky indigenous DNA adducts that can be detected by (32)P-postlabeling. A subgroup, termed type II I-compounds, represents DNA lesions induced by oxidative stress. Several major type II I-compounds have been identified as dinucleotides containing 3'-terminal 8,5'-cyclo-2'-deoxyadenosine (cA). Levels o...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.20375

    authors: Zhou GD,Randerath K,Donnelly KC,Jaiswal AK

    更新日期:2004-12-10 00:00:00

  • Authentication of M14 melanoma cell line proves misidentification of MDA-MB-435 breast cancer cell line.

    abstract::A variety of analytical approaches have indicated that melanoma cell line UCLA-SO-M14 (M14) and breast carcinoma cell line MDA-MB-435 originate from a common donor. This indicates that at some point in the past, one of these cell lines became misidentified, meaning that it ceased to correspond to the reported donor an...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.31067

    authors: Korch C,Hall EM,Dirks WG,Ewing M,Faries M,Varella-Garcia M,Robinson S,Storts D,Turner JA,Wang Y,Burnett EC,Healy L,Kniss D,Neve RM,Nims RW,Reid YA,Robinson WA,Capes-Davis A

    更新日期:2018-02-01 00:00:00

  • CXCL12-CXCR7 axis is important for tumor endothelial cell angiogenic property.

    abstract::We reported that tumor endothelial cells (TECs) differ from normal endothelial cells (NECs) in many aspects, such as gene expression profiles. Although CXCR7 is reportedly highly expressed in blood vessels of several tumors, its function in TECs is still unknown. To investigate this role, we isolated TECs from mouse t...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.29655

    authors: Yamada K,Maishi N,Akiyama K,Towfik Alam M,Ohga N,Kawamoto T,Shindoh M,Takahashi N,Kamiyama T,Hida Y,Taketomi A,Hida K

    更新日期:2015-12-15 00:00:00

  • Tumorigenicity of Epstein-Barr virus (EBV)-transformed lymphoid line cells in autologous squirrel monkeys.

    abstract::Eight squirrel monkeys (Saimiri sciureus) challenged with EBV or EBV-transformed SLCL were naturally or experimentally infected with Plasmodium knowlesi or Pl. brasilianum. Most of the animals had been splenectomized and unilaterally nephrectomized. Three of these monkeys received one dose of 6 to 12 X 10(8) autologou...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910170417

    authors: Leibold W,Huldt G,Flanagan TD,Andersson M,Dalens M,Wright DH,Voller A,Klein G

    更新日期:1976-04-15 00:00:00

  • Leukemic progenitor cells are susceptible to targeting by stimulated cytotoxic T cells against immunogenic leukemia-associated antigens.

    abstract::Leukemic stem cells (LSC) might be the source for leukemic disease self-renewal and account for disease relapse after treatment, which makes them a critical target for further therapeutic options. We investigated the role of cytotoxic T-lymphocytes (CTL) counteracting and recognizing LSC. Leukemia-associated antigens ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.29583

    authors: Schneider V,Zhang L,Rojewski M,Fekete N,Schrezenmeier H,Erle A,Bullinger L,Hofmann S,Götz M,Döhner K,Ihme S,Döhner H,Buske C,Feuring-Buske M,Greiner J

    更新日期:2015-11-01 00:00:00

  • DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant.

    abstract::We previously reported that DX-8951f, a novel water-soluble camptothecin analog, significantly inhibits the growth of various human and murine tumors in vitro and in vivo. The antitumor effects and topoisomerase I inhibitory activity of DX-8951f are stronger than those of other current camptothecin analogs. In this st...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19970807)72:4<680::aid-ijc

    authors: Joto N,Ishii M,Minami M,Kuga H,Mitsui I,Tohgo A

    更新日期:1997-08-07 00:00:00

  • Nutrients and gastric cancer risk. A population-based case-control study in Sweden.

    abstract::A population-based case-control study of gastric cancer was conducted in areas with contrasting incidence rates in Sweden. Face-to-face interviews were carried out with 338 (74.1%) of all eligible cases and 679 (77.3%) of the selected controls. Consumption of selected nutrients during adolescence and 20 years prior to...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910570505

    authors: Hansson LE,Nyrén O,Bergström R,Wolk A,Lindgren A,Baron J,Adami HO

    更新日期:1994-06-01 00:00:00

  • Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors.

    abstract::A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) nega...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.29188

    authors: Rudolph A,Milne RL,Truong T,Knight JA,Seibold P,Flesch-Janys D,Behrens S,Eilber U,Bolla MK,Wang Q,Dennis J,Dunning AM,Shah M,Munday HR,Darabi H,Eriksson M,Brand JS,Olson J,Vachon CM,Hallberg E,Castelao JE,Carrac

    更新日期:2015-03-15 00:00:00

  • Association study of genetic variation in the autophagy lysosome pathway genes and risk of eight kinds of cancers.

    abstract::The autophagy lysosome pathway is essential to maintain cell viability and homeostasis in response to many stressful environments, which is reported to play a vital role in cancer development and therapy. However, the association of genetic alterations of this pathway with risk of cancer remains unclear. Based on geno...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.31288

    authors: Tan J,Fu L,Chen H,Guan J,Chen Y,Fang J

    更新日期:2018-07-01 00:00:00

  • Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum.

    abstract::Ocimum sp. is a traditionally used medicinal herb, which shows anti-oxidant, anti-carcinogenic, radio-protective and free radical scavenging properties. So far no detailed studies have been reported on its effects on human cancers. Thus, we analyzed its effects on human breast cancer utilizing in vitro and in vivo met...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.22733

    authors: Nangia-Makker P,Tait L,Shekhar MP,Palomino E,Hogan V,Piechocki MP,Funasaka T,Raz A

    更新日期:2007-08-15 00:00:00

  • Ki-67 index enhances the prognostic accuracy of the urothelial superficial bladder carcinoma risk group classification.

    abstract::Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.11049

    authors: Santos L,Amaro T,Costa C,Pereira S,Bento MJ,Lopes P,Oliveira J,Criado B,Lopes C

    更新日期:2003-06-10 00:00:00

  • Geographic distribution of HTLV-I and identification of a new high-risk population.

    abstract::Epidemiologic studies indicate that human T-cell lymphotropic virus type I (HTLV-I), the causative agent of most cases of adult T-cell leukemia/lymphoma (ATLL) in Southeast Japan and the Caribbean islands and the probable cause of a progressive neurological disorder often referred to as tropical spastic paraparesis, o...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910420103

    authors: Levine PH,Blattner WA,Clark J,Tarone R,Maloney EM,Murphy EM,Gallo RC,Robert-Guroff M,Saxinger WC

    更新日期:1988-07-15 00:00:00

  • Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma.

    abstract::The genetic events underlying the development of prostate cancer are poorly defined. c-Myc is often activated in tumors that have progressed to metastatic status, so events that promote this process may be important. Bin1 is a nucleocytoplasmic adaptor protein with features of a tumor suppressor that was identified th...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(20000415)86:2<155::aid-ijc

    authors: Ge K,Minhas F,Duhadaway J,Mao NC,Wilson D,Buccafusca R,Sakamuro D,Nelson P,Malkowicz SB,Tomaszewski J,Prendergast GC

    更新日期:2000-04-15 00:00:00

  • Oncogenesis by interspecific interaction of malignant murine and non-malignant hamster cells in vitro.

    abstract::A clone of Cloudman S91 murine melanoma was fused in vitro with non-malignant hamster cheek pouch cells by means of lysolecithin, and the putative hybrid progeny cells, HCP-MM, were found to be highly malignant in hamster, but not in appropriate mice. A malignant clone of HCP-MM cells was shown to have hamster species...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910150214

    authors: Goldenberg DM,Pavia RA

    更新日期:1975-02-15 00:00:00

  • Comparison of mammographic densities and their determinants in women from Japan and Hawaii.

    abstract::Breast cancer incidence increases considerably in women who migrate from Japan to the United States. Based on the hypothesis that mammographic density in healthy mammograms reflects differences in breast cancer risk, we compared mammographic density in 3 groups of women at different levels of risk: Caucasian and Japan...

    journal_title:International journal of cancer

    pub_type: 历史文章,杂志文章

    doi:10.1002/ijc.10673

    authors: Maskarinec G,Nagata C,Shimizu H,Kashiki Y

    更新日期:2002-11-01 00:00:00

  • Modulation of T leukaemic cell phenotype with phorbol ester.

    abstract::A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TP...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910290106

    authors: Delia D,Greaves MF,Newman RA,Sutherland DR,Minowada J,Kung P,Goldstein G

    更新日期:1982-01-15 00:00:00

  • Cytosine deaminase/5-fluorocytosine gene therapy can induce efficient anti-tumor effects and protective immunity in immunocompetent mice but not in athymic nude mice.

    abstract::Murine hepatocellular carcinoma cells were retrovirally transduced with the bacterial cytosine deaminase (CD) gene. CD-transduced cells exhibited more than 120-fold higher sensitivity to 5-fluorocytosine (5-FC) compared with parental cells. When syngeneic immunocompetent mice were inoculated s.c. with parental hepatoc...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19990517)81:4<592::aid-ijc

    authors: Kuriyama S,Kikukawa M,Masui K,Okuda H,Nakatani T,Sakamoto T,Yoshiji H,Fukui H,Ikenaka K,Mullen CA,Tsujii T

    更新日期:1999-05-17 00:00:00

  • Loss of heterozygosity on chromosome 13 and its association with delayed growth of retinoblastoma.

    abstract::Loss of heterozygosity (LOH) on chromosome 13 and the age of patients at operation were studied in 46 cases of retinoblastoma (RB) tumors, of which 25 were hereditary and 21 were non-hereditary. The frequency of LOH was 70% for all informative tumors, but significantly higher in non-hereditary tumors (90%) than in her...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910540609

    authors: Kato MV,Ishizaki K,Ejima Y,Kaneko A,Tanooka H,Sasaki MS

    更新日期:1993-07-30 00:00:00

  • Establishment of primary cultures from human colonic tissue during tumor progression: vitamin-D responses and vitamin-D-receptor expression.

    abstract::Primary cultures derived from pre-cancerous and cancerous human colon tissue are essential for understanding normal and abnormal growth function in the large intestine. Here presented are (i) the methodology for routine establishment of primary cultures of normal, adenoma- and carcinoma-derived cells, and (ii) data fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19980130)75:3<467::aid-ijc

    authors: Tong WM,Bises G,Sheinin Y,Ellinger A,Genser D,Pötzi R,Wrba F,Wenzl E,Roka R,Neuhold N,Peterlik M,Cross HS

    更新日期:1998-01-30 00:00:00

  • Serum and salivary IgA antibodies against a defined epitope of the Epstein-Barr virus nuclear antigen (EBNA) are elevated in nasopharyngeal carcinoma.

    abstract::The Epstein-Barr virus nuclear antigen I (EBNA I) is the only latent EBV antigen consistently expressed in malignant tissues of the nasopharynx. A 20-amino-acid synthetic peptide, p107 contains a major epitope of EBNA I. We tested sera from 210 patients with nasopharyngeal carcinoma (NPC) and from 128 normal individua...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910450614

    authors: Foong YT,Cheng HM,Sam CK,Dillner J,Hinderer W,Prasad U

    更新日期:1990-06-15 00:00:00

  • Tumour growth fraction measured by immunohistochemical staining of Ki67 is an independent prognostic factor in preoperative prostate biopsies with small-volume or low-grade prostate cancer.

    abstract::Accurate prognostic parameters in prostate biopsies are needed to better counsel individual patients with prostate cancer. We evaluated the prognostic impact of morphologic and immunohistochemical parameters in preoperative prostate cancer biopsies. A consecutive series of prostate biopsies of 279 men (72% with clinic...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.24174

    authors: Zellweger T,Günther S,Zlobec I,Savic S,Sauter G,Moch H,Mattarelli G,Eichenberger T,Curschellas E,Rüfenacht H,Bachmann A,Gasser TC,Mihatsch MJ,Bubendorf L

    更新日期:2009-05-01 00:00:00

  • Clinical and biological significance of HSP89 alpha in human breast cancer.

    abstract::In order to isolate and characterize genes whose expression may be altered in breast malignancy, we screened a cDNA library with a polyclonal anti-serum against breast-cancer-metastasis membranes and isolated several immunopositive clones. One of these, AJ1, was analyzed in detail and found to be expressed at varying ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910500315

    authors: Jameel A,Skilton RA,Campbell TA,Chander SK,Coombes RC,Luqmani YA

    更新日期:1992-02-01 00:00:00

  • Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation.

    abstract::We have examined several types of tumor cell lines and shown that they invariably expressed little or no Egr-1, in contrast to their normal counterparts. We have previously shown that the expression of exogenous Egr-1 in human breast and other tumor cells markedly reduces transformed growth and tumorigenicity. We ther...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19970703)72:1<102::aid-ijc

    authors: Huang RP,Fan Y,de Belle I,Niemeyer C,Gottardis MM,Mercola D,Adamson ED

    更新日期:1997-07-03 00:00:00

  • Cervical nitric oxide release and persistence of high-risk human papillomavirus in women.

    abstract::Nitric oxide may serve as one cofactor for human papillomavirus (HPV)-induced development of cervical cancer. Therefore, we first assessed the levels of cervical fluid nitric oxide metabolite (NOx) in 283 women with and without high-risk (hr) HPV. The NOx level in women with hr HPV (48.4 μmol/L [95% CI: 39.4-56.6], n ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.25637

    authors: Rahkola P,Väisänen-Tommiska M,Tuomikoski P,Ylikorkala O,Mikkola TS

    更新日期:2011-06-15 00:00:00

  • Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study.

    abstract::While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.33008

    authors: Jochems SHJ,Reulen RC,van Osch FHM,Witlox WJA,Goossens ME,Brinkman M,Giles GG,Milne RL,van den Brandt PA,White E,Weiderpass E,Huybrechts I,Hémon B,Agudo A,Bueno-de-Mesquita B,Cheng KK,van Schooten FJ,Bryan RT,Wesseliu

    更新日期:2020-10-15 00:00:00