Abstract:
:While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by pooling individual data from 13 cohort studies. Cox regression models with attained age as time scale were used to estimate hazard ratios (HRs) for intakes of total fruit and citrus fruits, soft fruits, stone fruits, tropical fruits, pome fruits and fruit products. Analyses were stratified by sex, smoking status and bladder cancer subtype. During on average 11.2 years of follow-up, 2836 individuals developed incident bladder cancer. Increasing fruit consumption (by 100 g/day) was inversely associated with the risk of bladder cancer in women (HR = 0.92; 95% CI 0.85-0.99). Although in women the association with fruit consumption was most evident for higher-risk nonmuscle invasive bladder cancer (NMIBC; HR = 0.72; 95% CI 0.56-0.92), the test for heterogeneity by bladder cancer subtype was nonsignificant (P-heterogeneity = .14). Increasing fruit consumption (by 100 g/day) was not associated with bladder cancer risk in men (HR = 0.99; 95% CI 0.94-1.03), never smokers (HR = 0.96; 95% CI 0.88-1.05), former smokers (HR = 0.98; 95% CI 0.92-1.05) or current smokers (HR = 0.95; 95% CI 0.89-1.01). The consumption of any type of fruit was not found to be associated with bladder cancer risk (P values > .05). Our study supports no evidence that the consumption of specific types of fruit reduces the risk of bladder cancer. However, increasing total fruit consumption may reduce bladder cancer risk in women.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Jochems SHJ,Reulen RC,van Osch FHM,Witlox WJA,Goossens ME,Brinkman M,Giles GG,Milne RL,van den Brandt PA,White E,Weiderpass E,Huybrechts I,Hémon B,Agudo A,Bueno-de-Mesquita B,Cheng KK,van Schooten FJ,Bryan RT,Wesseliudoi
10.1002/ijc.33008subject
Has Abstractpub_date
2020-10-15 00:00:00pages
2091-2100issue
8eissn
0020-7136issn
1097-0215journal_volume
147pub_type
杂志文章abstract::The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.32820
更新日期:2020-06-15 00:00:00
abstract::The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31740
更新日期:2018-12-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit proliferation and angiogenesis in colorectal cancer. We examined a possible involvement of store-operated calcium (SOC) entry in human colon carcinoma cells (HRT-18), which require calcium for proliferation. Acetyl-salicylic-acid (ASA), mefenamic acid (MEF) and su...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1280
更新日期:2001-06-15 00:00:00
abstract::Metastasis to the liver often occurs in patients during the natural course of pancreatic cancer. Using carcinoma cell lines established from 9 such patients, we examined phenotypes of cell lines to search for correlations with their potential to metastasize to the liver. Anti-asialo GMI-treated nude mice were used. PC...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960822)69:4<290::AID-IJC
更新日期:1996-08-22 00:00:00
abstract::We aimed to determine the prognostic values of 39 circulating cytokines in Chinese patients with metastatic colorectal cancer (CRC) and to develop a novel cytokine-based prognostic classifier (CBPC) for prognostic prediction. A total of 176 patients were divided into two cohorts based on the date of first-line chemoth...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29017
更新日期:2015-02-01 00:00:00
abstract::Variability in the expression of enzymes metabolizing carcinogens derived from cigarette smoke may contribute to individual susceptibility to pulmonary carcinogenesis. This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000601)86:5<610::aid-ijc
更新日期:2000-06-01 00:00:00
abstract::As part of a collaborative study of risk factors for childhood brain tumours, the effects of the mother's smoking and her potential for passive smoking exposure during the pregnancy were assessed in a case-control study. Parents of 91 cases and 321 population controls from Northern Italy, matched for age, sex and resi...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910570602
更新日期:1994-06-15 00:00:00
abstract::Normal thyroid epithelial cells lack major histocompatibility complex (MHC) Class II antigen. Oncogenic kinases involved in papillary thyroid carcinoma (PTC) trigger the expression of Class II transactivator and MHC Class II complex. However, the relationship between MHC Class II antigen expression and clinical outcom...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23167
更新日期:2008-02-15 00:00:00
abstract::Telomerase activity is involved in the maintenance of telomere length and is thought to be required for cellular immortality and oncogenesis. Three major subunits composing telomerase, human telomerase RNA (hTR), telomerase-associated protein (TPI) and human telomerase catalytic subunit (hTERT), have been identified. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990315)80:6<804::aid-ijc
更新日期:1999-03-15 00:00:00
abstract::A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TP...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290106
更新日期:1982-01-15 00:00:00
abstract::Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26229
更新日期:2012-05-01 00:00:00
abstract::The expression of the nuclear SV40-induced T antigen was measured by microfluorimetry on individual, asynchronously growing SV40-transformed cells which had been stained with hamster T-antiserum by the indirect immunofluorescence method. The same individual cells were first measured for T antigen and then for DNA by F...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150403
更新日期:1975-04-15 00:00:00
abstract::Our previous studies demonstrate that introduction of a approximately 70 cM region (now estimated at 63.75 Mb by the Human Genome Project) of human chromosome 12 into the highly metastatic Dunning rat prostate cancer cell line AT6.1 results in >30-fold (>/=90%) reduction in the number of overt metastases in spontaneou...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11483
更新日期:2004-01-01 00:00:00
abstract::Previously, we studied the surface expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in a panel of 16 human T-cell lines and found that those carrying HTLV-1 pro-viruses expressed high levels of ICAM-1. Enhanced expression of ICAM-1 was also seen in fresh leukemic cells from ATL patients. In the present study, we sys...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550520
更新日期:1993-11-11 00:00:00
abstract::Breast cancer incidence increases considerably in women who migrate from Japan to the United States. Based on the hypothesis that mammographic density in healthy mammograms reflects differences in breast cancer risk, we compared mammographic density in 3 groups of women at different levels of risk: Caucasian and Japan...
journal_title:International journal of cancer
pub_type: 历史文章,杂志文章
doi:10.1002/ijc.10673
更新日期:2002-11-01 00:00:00
abstract::Increased secretion of matrix metalloproteinases and serine proteinases is well known to be associated with cancer invasion and metastasis. We aimed to elucidate the implication of trypsin, a serine proteinase and a representative digestive enzyme in invasion and metastasis of human carcinomas. Northern blot, RT-PCR a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630205
更新日期:1995-10-09 00:00:00
abstract::A Kunitz-type protease inhibitor, bikunin, downregulates expression of uPA and its receptor uPAR at the mRNA and protein levels in several types of tumor cells. Our recent work showed that, using a cDNA microarray analysis, pregnancy-associated plasma protein-A (PAPP-A) is a candidate bikunin target gene. To clarify h...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11700
更新日期:2004-04-10 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with a very high mortality. Because the success of the conventional therapies is limited, gene therapy may represent an alternative for HCC management. Our earlier study has shown that Bid plays a role in the development of HCC. The aim of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22040
更新日期:2006-10-15 00:00:00
abstract::Children are especially sensitive to ionizing radiation and chemical carcinogens, and limiting their cancer risk is of great public concern. Calorie restriction (CR) is a potent intervention for suppressing cancer. However, CR is generally not appropriate for children. This study, therefore, examined to see if adult-o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28751
更新日期:2014-09-01 00:00:00
abstract::Hyaluronan (HA) has been shown to play important roles in the growth, invasion and metastasis of malignant tumors. Our previous study showing that high HA expression in malignant peripheral nerve sheath tumors (MPNST) is predictive of poor patient prognosis, prompted us to speculate that inhibition of HA synthesis in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30460
更新日期:2017-01-15 00:00:00
abstract::In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32361
更新日期:2019-11-15 00:00:00
abstract::There is increasing use of multiple molecular markers to predict prognosis in human cancer. Our aim was to examine the prognostic significance of cyclin D1 and retinoblastoma (pRb) expression in association with human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma. Clinical records and specimens ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25479
更新日期:2011-04-01 00:00:00
abstract::The prognostic significance of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in patients with gastric cancer (GC) is controversial. The aims of our meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in GC. PubMed, Embase, the Cochrane d...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.28954
更新日期:2015-01-01 00:00:00
abstract::The myxobacterial agent archazolid inhibits the vacuolar proton pump V-ATPase. V-ATPases are ubiquitously expressed ATP-dependent proton pumps, which are known to regulate the pH in endomembrane systems and thus play a crucial role in endo- and exocytotic processes of the cell. As cancer cells depend on a highly activ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28562
更新日期:2014-05-15 00:00:00
abstract::Lung cancer is one of the greatest threats to human health, and is initially detected and attacked by the immune system through tumor-reactive T cells. The aim of this study was to determine the basic characteristics and clinical significance of the peripheral blood T-cell receptor (TCR) repertoire in patients with ad...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32145
更新日期:2019-09-01 00:00:00
abstract::CD16 surface antigens represent activatory molecules in CD3-16+ NK cells. In order to target NK cells against relatively NK-resistant ovarian carcinomas, we used an anti-CD16 monoclonal antibody (MAb) (VD4), together with an anti-ovarian carcinoma-associated antigen (MOV19), to construct biMAbs. To this end, hybrid hy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480213
更新日期:1991-05-10 00:00:00
abstract::Murine monoclonal antibody HRS-4 (Ab1), which defines the cell-bound and soluble CD30 antigen associated with Hodgkin's lymphoma, was used to generate monoclonal anti-idiotypic antibodies (Ab2) in syngeneic BALB/c mice. Murine monoclonal Ab2 14G9 and Ab2 9G10 directed against HRS-4 were shown to be anti-idiotypic Ab2 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500623
更新日期:1992-04-01 00:00:00
abstract::Bone-marrow (BM) hematopoietic precursors are recruited into proliferative activity when colony-stimulating factors (CSF) are sequenced with chemotherapy (CT). Previous studies suggested that further CT can be safely administered only when the increased proliferative activity of these cells has subsided, because most ...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/ijc.2910630508
更新日期:1995-11-27 00:00:00
abstract::With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor be...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33394
更新日期:2020-11-13 00:00:00
abstract::In biliary tract cancer (BTC), tissue biopsies to guide treatment are rarely feasible, thus implementing liquid biopsy approaches to improve patient management represents a priority. So far, studies on circulating tumor cells (CTCs) in BTC are insufficient to promote their use in patient clinical management and are li...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32822
更新日期:2020-06-15 00:00:00