Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells.

abstract：:Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...

journal_title：International journal of cancer

authors： Santos L,Amaro T,Costa C,Pereira S,Bento MJ,Lopes P,Oliveira J,Criado B,Lopes C

更新日期：2003-06-10 00:00:00

abstract：:We describe an innovative strategy to quantify risk of cancer associated with varying levels of exposure to chronic parasitic infection through the identification of asymptomatic cases of cholangiocarcinoma within a population-based survey of Opisthorchis viverrini infection. Stool samples from 12,311 adults over age ...

journal_title：International journal of cancer

authors： Haswell-Elkins MR,Mairiang E,Mairiang P,Chaiyakum J,Chamadol N,Loapaiboon V,Sithithaworn P,Elkins DB

更新日期：1994-11-15 00:00:00

abstract：:Evidence from randomized controlled trials suggests that calcium may protect against recurrence of colorectal adenomas, which could lead to the subsequent prevention of cancer. Yet the trials used only a large single dose and were of small sizes, and thus, knowledge of the dose-response relationship and influence on h...

journal_title：International journal of cancer

authors： Keum N,Lee DH,Greenwood DC,Zhang X,Giovannucci EL

更新日期：2015-04-01 00:00:00

abstract：:The Japanese have a much lower incidence of nonmelanoma skin cancers (NMSCs) than Caucasians, presumably due in part to their skin type conferring relative protection from ultraviolet light radiation (UVR). To examine the contribution of environmental or endogenous mutagens other than UVR, which are expected to be rel...

journal_title：International journal of cancer

authors： Takata M,Rehman I,Rees JL

更新日期：1997-05-02 00:00:00

abstract：:Hypoxia is known to play important roles in the development and progression of tumors. We previously demonstrated that S100A4, a critical molecule for metastasis, was upregulated in ovarian cancer cells. Therefore, we examined the mechanisms of the upregulation of S100A4 expression in ovarian carcinoma cells, with par...

journal_title：International journal of cancer

authors： Horiuchi A,Hayashi T,Kikuchi N,Hayashi A,Fuseya C,Shiozawa T,Konishi I

更新日期：2012-10-15 00:00:00

abstract：:The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt...

journal_title：International journal of cancer

authors： Monsonego J,Hudgens MG,Zerat L,Zerat JC,Syrjänen K,Halfon P,Ruiz F,Smith JS

更新日期：2011-08-01 00:00:00

abstract：:Epidemiological studies of in situ breast cancer are sparse, and the role of reproductive history, an established risk modifier for invasive breast cancer, remains incompletely investigated. To examine possible associations with parity and age at first birth, we undertook a case-control study nested in a nationwide co...

journal_title：International journal of cancer

authors： Lambe M,Hsieh CC,Tsaih SW,Ekbom A,Trichopoulos D,Adami HO

更新日期：1998-07-29 00:00:00

abstract：:Two genome-wide association studies (GWAS) have identified 5p15.33 (TERT-CLPTM1L) as one of the susceptible regions for glioma in European background. A replication research of our group highlighted the association signals in the TERT gene of this region in a Chinese Han population. To comprehensively explore the regi...

journal_title：International journal of cancer

authors： Zhao Y,Chen G,Zhao Y,Song X,Chen H,Mao Y,Lu D

更新日期：2012-10-01 00:00:00

abstract：:Dietary intake of many fruits and vegetables has been shown to be associated with reduced risk of cancer. We investigated the in vivo efficacy of grape seed extract (GSE, patented as Traconol) against prostate cancer (PCA) and associated molecular events. Athymic nude mice were implanted with hormone-refractory human ...

journal_title：International journal of cancer

authors： Singh RP,Tyagi AK,Dhanalakshmi S,Agarwal R,Agarwal C

更新日期：2004-02-20 00:00:00

abstract：:We have previously produced a monoclonal antibody (MAb) against TMK-1 cells, a poorly differentiated stomach-cancer cell line, and designated the antigen as 9A3. Immunohistochemical analysis of various tumor tissues revealed that the expression of 9A3 antigen is specific for human adenocarcinoma. In the present study,...

journal_title：International journal of cancer

authors： Fukuyama R,Minoshima S,Ochiai A,Tahara E,Shimizu N

更新日期：1991-04-22 00:00:00

abstract：:Familial risk of pancreatic cancer has been mainly assessed through case-control studies based on reported but not medically verified cancers in family members. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 21,000 pancreatic cancers to calculate standardized incidence ratios (SI...

journal_title：International journal of cancer

authors： Hemminki K,Li X

更新日期：2003-02-10 00:00:00

abstract：:Physiological concentrations of insulin support the in vitro growth of LB T-cell lymphoma. We could not detect similar insulin dependence in other tumor cell lines. This study reports that insulin also enhances the growth of LB cells in vivo. Mice treated with Streptozotocin (SZ) developed partial resistance to LB lym...

journal_title：International journal of cancer

authors： Sharon R,Pillemer G,Ish-Shalom D,Kalman R,Ziv E,Berry EM,Naor D

更新日期：1993-03-12 00:00:00

abstract：:The role of spontaneous and induced abortion on breast cancer risk is examined among 267,361 women recruited into the European Prospective Investigation into Cancer and nutrition between 1992 and 2000. The data were collected from 20 centers, across 9 countries, and included information on a total of 4,805 women with ...

journal_title：International journal of cancer

authors： Reeves GK,Kan SW,Key T,Tjønneland A,Olsen A,Overvad K,Peeters PH,Clavel-Chapelon F,Paoletti X,Berrino F,Krogh V,Palli D,Tumino R,Panico S,Vineis P,Gonzalez CA,Ardanaz E,Martinez C,Amiano P,Quiros JR,Tormo MR,Kha

更新日期：2006-10-01 00:00:00

abstract：:Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of polypeptide growth factors, which includes EGF, transforming growth factor alpha(TGF-alpha), amphiregulin (AR) and betacellulin (BTC). To assess the potential role of HB-EGF in human gastric carcinomas, the expre...

journal_title：International journal of cancer

authors： Naef M,Yokoyama M,Friess H,Büchler MW,Korc M

更新日期：1996-05-03 00:00:00

abstract：:Promoter hypermethylation of various tumor-related genes is extremely frequent in gastric carcinoma (GC) associated with Epstein-Barr virus (EBV). To investigate the significance of the promoter methylation in this type of GC, we examined the methylation densities of the promoter regions of p14ARF and p16INK4A in EBV-...

journal_title：International journal of cancer

authors： Sakuma K,Chong JM,Sudo M,Ushiku T,Inoue Y,Shibahara J,Uozaki H,Nagai H,Fukayama M

更新日期：2004-11-01 00:00:00

abstract：:Metastatic tumor formation via vessel route begins with cancer cell extravasation from vessel lumen, migration into the connective tissue surrounding vessels, and invasion into target organ parenchyma. Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) have been recognized to play an i...

journal_title：International journal of cancer

authors： Aokage K,Ishii G,Ohtaki Y,Yamaguchi Y,Hishida T,Yoshida J,Nishimura M,Nagai K,Ochiai A

更新日期：2011-04-01 00:00:00

abstract：:There is concern that hormone replacement therapy (HRT) increases the risk of breast cancer. We undertook a case-control study of this risk relationship within a cohort of 40- to 74-year-old women in Uppsala County, Sweden, who participated in mammography screening. Incident cases of breast cancer were ascertained dur...

journal_title：International journal of cancer

authors： Persson I,Thurfjell E,Bergstrom R,Holmberg L

更新日期：1997-09-04 00:00:00

abstract：:Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN) are well-characterised molecular features of sporadic colorectal cancers (CRCs). In addition to CpG island methylator phenotype (CIMP) associated with MSI, an intermediate methylation subgroup is also a feature of non-MSI canc...

journal_title：International journal of cancer

authors： Silver A,Sengupta N,Propper D,Wilson P,Hagemann T,Patel A,Parker A,Ghosh A,Feakins R,Dorudi S,Suraweera N

更新日期：2012-03-01 00:00:00

abstract：:Regulation of cell differentiation is most often impaired in malignant tumors and may represent a key mechanism for the progression of the disease. CCAAT-enhancer binding protein (C/EBP) is a family of transcription factors involved in the regulation of embryonic gut development in rodents, which has also been detecte...

journal_title：International journal of cancer

authors： Rask K,Thörn M,Pontén F,Kraaz W,Sundfeldt K,Hedin L,Enerbäck S

更新日期：2000-05-01 00:00:00

abstract：:The numbers of new cancer cases in 16 common sites occurring in 1980 have been estimated for 24 areas of the world for which the United Nations produces population estimates. For the world as a whole, the total number of new cases was 6.35 million, almost exactly evenly divided between the developed and developing cou...

journal_title：International journal of cancer

authors： Parkin DM,Läärä E,Muir CS

更新日期：1988-02-15 00:00:00

abstract：:The association between fish, ω-3 and ω-6 polyunsaturated fatty acid (PUFA) intake and risk of colorectal cancer (CRC) remains inconclusive. Recent prospective studies suggest that the relationship may vary by gender, subsite and duration of follow-up. We followed 123,529 US adults (76,386 women and 47,143 men) withou...

journal_title：International journal of cancer

authors： Song M,Chan AT,Fuchs CS,Ogino S,Hu FB,Mozaffarian D,Ma J,Willett WC,Giovannucci EL,Wu K

更新日期：2014-11-15 00:00:00

abstract：:A diet high in linoleic acid (an ω-6 PUFA) increased the formation of miscoding etheno (ε)--DNA adducts in WBC-DNA of women, but not in men (Nair et al., Cancer Epidemiol Biomark Prev 1997;6:597-601). This gender specificity could result from an interaction between ω-6 PUFA intake and estrogen catabolism, via redox-cy...

journal_title：International journal of cancer

authors： Sun X,Nair J,Linseisen J,Owen RW,Bartsch H

更新日期：2012-11-01 00:00:00

abstract：:alpha beta+ TCR T cells recognize peptide fragments displayed by MHC-class I or -class II molecules. Recently, additional mechanisms of antigen recognition by T cells have been identified, including CD1-mediated presentation of nonpeptide antigens. Only a limited number of CD1 antigens is retained in the mouse, i.e., ...

journal_title：International journal of cancer

authors： Fiedler T,Walter W,Reichert TE,Maeurer MJ

更新日期：2002-03-20 00:00:00

abstract：:The LIM 1863 colon carcinoma cell line grows in the form of morphologically and functionally organized organoids. Cells are arranged around a central lumen with a brush border and nuclei are polarized to the periphery. The organoids contain 3 morphological cell types (columnar, goblet and caveolated cells). By agar cl...

journal_title：International journal of cancer

authors： Hayward IP,Whitehead RH

更新日期：1992-03-12 00:00:00

abstract：:Mice transgenic for the carcinoembryonic (CEA) gene were used to study the biodistribution and tumor targeting of a radioiodinated monoclonal antibody (MAb), T84.66. The specificity of antibody uptake in tumors was assessed in mice bearing a CEA-transfected syngeneic tumor as well as the antigen-negative parental tumo...

journal_title：International journal of cancer

authors： Szalai G,Williams LE,Primus FJ

更新日期：2000-03-15 00:00:00

abstract：:Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was...

journal_title：International journal of cancer

authors： Lifsted T,Le Voyer T,Williams M,Muller W,Klein-Szanto A,Buetow KH,Hunter KW

更新日期：1998-08-12 00:00:00

abstract：:Human kallikrein 11 (hK11/trypsin-like serine protease/TLSP, encoded by the KLK11 gene) is a member of the kallikrein family of secreted serine proteases. Recently, we developed a highly sensitive and specific immunoassay for hK11 and found that this protease is expressed in the prostate, stomach and trachea as well a...

journal_title：International journal of cancer

authors： Borgoño CA,Fracchioli S,Yousef GM,Rigault de la Longrais IA,Luo LY,Soosaipillai A,Puopolo M,Grass L,Scorilas A,Diamandis EP,Katsaros D

更新日期：2003-09-10 00:00:00

abstract：:The activity of systemic and in situ natural killer (NK) cells was measured in 3- to 5-week-old CBA mice with progressively growing murine sarcoma virus (MSV)-induced tumors. Splenic NK activity was depressed in tumor-bearing mice. NK activity was quite low or not detectable in unfractionated cell suspensions from the...

journal_title：International journal of cancer

authors： Gerson J,Varesio L,Herberman RB

更新日期：1981-02-15 00:00:00

abstract：:The active form of vitamin D(3), 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), induces caspase-independent apoptosis in MCF-7 and T47D breast cancer cells. Before the appearance of apoptotic cells at Day 4 after the addition of 1,25(OH)(2)D(3), the MCF-7 cells are sensitized to the caspase-mediated apoptosis induced b...

journal_title：International journal of cancer

authors： Mathiasen IS,Hansen CM,Foghsgaard L,Jäättelä M

更新日期：2001-07-15 00:00:00

abstract：:Fecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all FOBT-positive persons have screen-detected adenomas. Despite removal of these, patients with large/multiple adenomas have increased risk of later developing new advanced adenomas and CRC....

journal_title：International journal of cancer

authors： Bjerrum A,Lindebjerg J,Andersen O,Fischer A,Lynge E

更新日期：2020-08-15 00:00:00