p53 mutation spectrum in Japanese Bowen's disease suggests a role for mutagens other than ultraviolet light.

abstract：:Renewed interest in the use of therapeutic enzymes combined with an improved knowledge of cancer cell metabolism, has led to the translation of several arginine depletion strategies into early phase clinical trials. Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginos...

journal_title：International journal of cancer

authors： Fultang L,Vardon A,De Santo C,Mussai F

更新日期：2016-08-01 00:00:00

abstract：:Telomerase appears to be an important factor for the control of cellular proliferation capacity and for tumorigenesis. Enzyme activity is highly increased in almost all human tumors and distinguishes them from benign lesions. Besides its diagnostic value, telomerase activity appears to be associated with tumor progres...

journal_title：International journal of cancer

authors： Hoos A,Hepp HH,Kaul S,Ahlert T,Bastert G,Wallwiener D

更新日期：1998-02-20 00:00:00

abstract：:Aberrant methylation of CpG islands (CGI) not only plays a role in gene silencing, but is also a potential cancer biomarker. To identify more CGI aberrantly methylated in human breast cancers, we carried out a genome-wide search for aberrant methylation, using methylation-sensitive-representational difference analysis...

journal_title：International journal of cancer

authors： Miyamoto K,Fukutomi T,Akashi-Tanaka S,Hasegawa T,Asahara T,Sugimura T,Ushijima T

更新日期：2005-09-01 00:00:00

abstract：:In our previous study on hepatocellular carcinoma (HCC) susceptibility genes in chronic hepatitis patients, we identified the MHC class I polypeptide-related sequence A (MICA). Natural killer cells eliminate various cancer cells, including HCC, by suppressing MICA shedding. Therefore, we investigated MICA sheddases an...

journal_title：International journal of cancer

authors： Arai J,Goto K,Tanoue Y,Ito S,Muroyama R,Matsubara Y,Nakagawa R,Kaise Y,Lim LA,Yoshida H,Kato N

更新日期：2018-11-15 00:00:00

abstract：:The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer ...

journal_title：International journal of cancer

authors： Raskov H,Orhan A,Salanti A,Gögenur I

更新日期：2020-06-15 00:00:00

abstract：:Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also modulates host immune responses. Emerging evidence from tumor biology studies indicates that LL-37 pla...

journal_title：International journal of cancer

authors： Wu WK,Wang G,Coffelt SB,Betancourt AM,Lee CW,Fan D,Wu K,Yu J,Sung JJ,Cho CH

更新日期：2010-10-15 00:00:00

abstract：:MEK1/2 inhibitors like U0126 can potentiate or antagonize the antitumor activity of cytotoxic agents such as cisplatin, paclitaxel or vinblastine, depending on the drug or the target cells. We now investigated whether U0126, differentially regulates melanoma signaling in response to UV radiation or betulinic acid, a d...

journal_title：International journal of cancer

authors： Rieber M,Rieber MS

更新日期：2006-03-01 00:00:00

abstract：:We have analyzed the BRAF locus on chromosome 7q34 with microsatellites for allelic changes and exons 11 and 15 of the BRAF with sequencing for mutations in 50 kidney cancers including 20 papillary, 15 conventional and 15 chromophobe renal cell carcinomas (RCC). Allelic changes at the BRAF locus were seen in 16 of the...

journal_title：International journal of cancer

authors： Nagy A,Balint I,Kovacs G

更新日期：2003-10-10 00:00:00

abstract：:Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...

journal_title：International journal of cancer

authors： Raguz S,Randle RA,Sharpe ER,Foekens JA,Sieuwerts AM,Meijer-van Gelder ME,Melo JV,Higgins CF,Yagüe E

更新日期：2008-03-01 00:00:00

abstract：:The combination of cis-diamminedichloroplatinum(II) (CDDP) and 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), a topoisomerase-I inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To elucidate the mechanism of...

journal_title：International journal of cancer

authors： Masumoto N,Nakano S,Esaki T,Fujishima H,Tatsumoto T,Niho Y

更新日期：1995-07-04 00:00:00

abstract：:The age-standardized mortality rates for malignant melanoma of the skin in immigrants to New Zealand were compared with those of New Zealand-born non-Maoris. Immigrants from European countries had mortality rates that were generally similar to those prevailing in their countries of origin, although, among immigrants f...

journal_title：International journal of cancer

authors： Cooke KR,Fraser J

更新日期：1985-08-15 00:00:00

abstract：:The mechanisms involved in mucosal immune control of cervical human papillomavirus (HPV) infection remain ill defined. Because toll-like receptors (TLRs) are key players in innate immune responses, we investigated the association between TLR expression and viral persistence or clearance in young women with incident in...

journal_title：International journal of cancer

authors： Daud II,Scott ME,Ma Y,Shiboski S,Farhat S,Moscicki AB

更新日期：2011-02-15 00:00:00

abstract：:No animal model exists for the in vivo growth of Hodgkin's-lymphoma-derived cells. Neither unmanipulated Hodgkin's-disease(HD)-derived cell lines nor primary biopsy tissue could be grown in nude mice. Since the severe combined immunodeficient (SCID) mouse has been reported to be a better recipient for transplanted hum...

journal_title：International journal of cancer

authors： von Kalle C,Wolf J,Becker A,Sckaer A,Munck M,Engert A,Kapp U,Fonatsch C,Komitowski D,Feaux de Lacroix W

更新日期：1992-12-02 00:00:00

abstract：:Colonic tumors of human origin produce abundant transforming growth factor (TGF)-beta suggesting that TGF-beta is critical to their growth. Dietary lipids regulate a number of growth factors including TGF-beta. Whether elevated TGF-beta levels are consistently expressed in colonic tumors irrespective of the environmen...

journal_title：International journal of cancer

authors： Raju J,McCarthy B,Bird RP

更新日期：2002-08-20 00:00:00

abstract：:The tumor microenvironment consists of an immunosuppressive niche created by the complex interactions between cancer cells and surrounding stromal cells. A critical component of this environment are myeloid-derived suppressor cells (MDSCs), a heterogeneous group of immature myeloid cells arrested at different stages o...

journal_title：International journal of cancer

authors： Pyzer AR,Cole L,Rosenblatt J,Avigan DE

更新日期：2016-11-01 00:00:00

abstract：:Src has been one of the most studied proto-oncogenes. The cellular Src (c-Src) holds a critical role in several human malignancies and has emerged as a key factor that promotes tumor progression during the multistep process of colorectal cancer (CRC) pathogenesis. The robust activation of Src in CRC of aggressive phen...

journal_title：International journal of cancer

authors： Gargalionis AN,Karamouzis MV,Papavassiliou AG

更新日期：2014-05-01 00:00:00

abstract：:Data are limited regarding cancer risk in human immunodeficiency virus (HIV)-infected persons with modest immunosuppression, before the onset of acquired immunodeficiency syndrome (AIDS). For some cancers, risk may be affected by highly active antiretroviral therapy (HAART) widely available since 1996. We linked HIV/A...

journal_title：International journal of cancer

authors： Engels EA,Biggar RJ,Hall HI,Cross H,Crutchfield A,Finch JL,Grigg R,Hylton T,Pawlish KS,McNeel TS,Goedert JJ

更新日期：2008-07-01 00:00:00

abstract：:NDRG3 belongs to the N-myc down-regulated gene (NDRG) family that contains 4 paralogs: NDRG1, -2, -3 and -4. The function of NDRG3 and its relationship to cancer has not been studied. We herein report our examination of the expression and biological roles of NDRG3 in prostate cancers. We showed that NDRG3 expression i...

journal_title：International journal of cancer

authors： Wang W,Li Y,Li Y,Hong A,Wang J,Lin B,Li R

更新日期：2009-02-01 00:00:00

abstract：:Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. The efficacy of its antitumor activity largely depends on the level of intracellular ASS, whi...

journal_title：International journal of cancer

authors： Yoon CY,Shim YJ,Kim EH,Lee JH,Won NH,Kim JH,Park IS,Yoon DK,Min BH

更新日期：2007-02-15 00:00:00

abstract：:EPLIN is frequently downregulated or lost in various cancers. The purpose of this study was to evaluate the importance of EPLIN in prostate cancer progression, with particular focus on the mechanistic implications to elucidate EPLIN's tumor suppressive function in cancer. EPLIN expression was evaluated in prostate can...

journal_title：International journal of cancer

authors： Collins RJ,Morgan LD,Owen S,Ruge F,Jiang WG,Sanders AJ

更新日期：2018-11-15 00:00:00

abstract：:The tumor site is a strong clinical factor in head and neck squamous cell carcinoma (HNSCC). To clarify the biologic and clinical role of p53 alterations in HNSCC, we have examined the prevalence and the nature of p53 alterations in a large cohort of tumors from the different sites. For immunohistochemical analysis of...

journal_title：International journal of cancer

authors： Bosch FX,Ritter D,Enders C,Flechtenmacher C,Abel U,Dietz A,Hergenhahn M,Weidauer H

更新日期：2004-09-10 00:00:00

abstract：:Tumour necrosis factor alpha (TNF) mRNA is detected in the macrophage infiltrate surrounding the tumour, but the cellular/molecular interactions leading to TNF gene expression in macrophages are unknown. The in vitro system in which human blood monocytes are stimulated with human cancer cells for TNF release was used ...

journal_title：International journal of cancer

authors： Zembala M,Siedlar M,Ruggiero I,Wieckiewicz J,Mytar B,Mattei M,Colizzi V

更新日期：1994-01-15 00:00:00

abstract：:The targeted radiotherapy of neuroblastoma with 131l-labelled metaiodobenzyl guanidine (mIBG) is now the subject of several clinical studies. The precise intracellular localization of mIBG, necessary for nuclear microdosimetry, has not previously been described. We report the use of electron-energy-loss spectroscopy a...

journal_title：International journal of cancer

authors： Gaze MN,Huxham IM,Mairs RJ,Barrett A

更新日期：1991-04-01 00:00:00

abstract：:Condylomata acuminata have been shown to increase the risk of anogenital cancers. However, previous studies have been of limited sample size and/or short follow-up duration, which prevent precise estimates of long-term excess risk, especially for specific cancer sites. We estimated the risk of specific cancers in a la...

journal_title：International journal of cancer

authors： Nordenvall C,Chang ET,Adami HO,Ye W

更新日期：2006-08-15 00:00:00

abstract：:Neoplastic transformation is characterised by an imbalance in favour of cell growth over programmed cell death (apoptosis). The tumour-suppressor gene p53, responsible for maintaining cell-cycle control, is mutated in the majority of human cancers. Loss of function of the target genes of p53 are therefore important in...

journal_title：International journal of cancer

authors： Hollowood AD,Lai T,Perks CM,Newcomb PV,Alderson D,Holly JM

更新日期：2000-11-01 00:00:00

abstract：:Nitric oxide may serve as one cofactor for human papillomavirus (HPV)-induced development of cervical cancer. Therefore, we first assessed the levels of cervical fluid nitric oxide metabolite (NOx) in 283 women with and without high-risk (hr) HPV. The NOx level in women with hr HPV (48.4 μmol/L [95% CI: 39.4-56.6], n ...

journal_title：International journal of cancer

authors： Rahkola P,Väisänen-Tommiska M,Tuomikoski P,Ylikorkala O,Mikkola TS

更新日期：2011-06-15 00:00:00

abstract：:A loss of chromosome-9 material is one of the most frequent genomic aberrations known in bladder cancer. In order to better understand the role of chromosome-9 losses in bladder cancer, 125 formalin-fixed and 37 unfixed bladder tumors were examined using fluorescence in situ hybridization (FISH). A repetitive probe fo...

journal_title：International journal of cancer

authors： Sauter G,Moch H,Carroll P,Kerschmann R,Mihatsch MJ,Waldman FM

更新日期：1995-04-21 00:00:00

abstract：:B-cell chronic lymphocytic leukaemia (B-CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus represents an attractive tool for...

journal_title：International journal of cancer

authors： Garofalo M,Romano G,Quintavalle C,Romano MF,Chiurazzi F,Zanca C,Condorelli G

更新日期：2007-03-15 00:00:00

abstract：:Phosphorylation/activation of c-jun NH2-terminal kinase (JNK) has an ambivalent role, pro-proliferation or antiproliferation, in human cancers, which is determined by different cell types and by its crosstalk with other kinases. So far, the role of phosphorylated JNK (p-JNK) in breast cancer is mostly undefined. In th...

journal_title：International journal of cancer

authors： Yeh YT,Hou MF,Chung YF,Chen YJ,Yang SF,Chen DC,Su JH,Yuan SS

更新日期：2006-06-01 00:00:00

abstract：:By transmission and scanning electron microscopic studies of MC-29 virus-infected CEC cultures, C-type virus particles were detected in the medium of infected cultures, in infected cells and in intracellular vacuoles. Virus budding was also observed. In the scanning electron microscope (SEM) so-called blebs appeared o...

journal_title：International journal of cancer

authors： Podmaniczky E,Szende B,Lapis K,Ferenc G

更新日期：1976-10-15 00:00:00