Enzymatic inhibition of MICA sheddase ADAM17 by lomofungin in hepatocellular carcinoma cells.

abstract：:For many years, clinicians and scientists attempt to develop methods to stimulate the immune system to target malignant cells. Recent data suggest that effective cancer vaccination requires combination immunotherapies to overcome tumor immune evasion. Through presentation of both MHC-I and II molecules, DCs-based vacc...

journal_title：International journal of cancer

authors： Sharbi-Yunger A,Grees M,Cafri G,Bassan D,Eichmüller SB,Tzehoval E,Utikal J,Umansky V,Eisenbach L

更新日期：2019-02-15 00:00:00

abstract：:Various angiogenesis-related self-molecules have been considered to be therapeutic targets. However, the direct use of self-molecules as vaccines is not recommended because of the inherent ability of the host to develop immune tolerance. Antigen 43 (Ag43) is a surface protein found in E. coli and contains an α and a β...

journal_title：International journal of cancer

authors： Huang FY,Li L,Liu Q,Li YN,Bai RZ,Huang YH,Zhao HG,Guo JL,Zhou SL,Wang H,Lin YY,Tan GH

更新日期：2014-04-15 00:00:00

abstract：:An increased risk of prostate cancer associated with a family history of prostate cancer has been documented in multiple published reports. Risk has been shown to vary by degree of relationship and age of onset of disease in the affected relative. Several studies, using various designs, have estimated the relative ris...

journal_title：International journal of cancer

authors： Bruner DW,Moore D,Parlanti A,Dorgan J,Engstrom P

更新日期：2003-12-10 00:00:00

abstract：:We have established human oral-squamous-cancer cell lines, BHY and HN, derived from non-metastatic cancer and metastatic cancer respectively. We examined the expression of matrix-degrading enzymes and their inhibitors in these cell lines. Both cell lines expressed pro-matrix metalloproteinase (MMP)1, proMMP2, proMMP9,...

journal_title：International journal of cancer

authors： Kawamata H,Nakashiro K,Uchida D,Harada K,Yoshida H,Sato M

更新日期：1997-01-06 00:00:00

abstract：:Recent genome-wide scans identified several novel breast cancer risk alleles, including variants of the FGFR2, MAP3K1 and LSP1 genes, and a study of associations between these alleles and characteristics of breast cancer patients reported a borderline significant correlation between the number of FGFR2 minor alleles a...

journal_title：International journal of cancer

authors： Gates MA,Tworoger SS,Terry KL,De Vivo I,Hunter DJ,Hankinson SE,Cramer DW

更新日期：2009-02-01 00:00:00

abstract：:Tyrosine kinase inhibitors are effective treatments for cancers. Knowing the specific kinase mutants that drive the underlying cancers predict therapeutic response to these inhibitors. Thus, the current protocol for personalized cancer therapy involves genotyping tumors in search of various driver mutations and subseq...

journal_title：International journal of cancer

authors： Klinghammer K,Keller J,George J,Hoffmann J,Chan EL,Hayman MJ

更新日期：2018-01-01 00:00:00

abstract：:Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identif...

journal_title：International journal of cancer

authors： Jones RJ,Seaman WT,Feng WH,Barlow E,Dickerson S,Delecluse HJ,Kenney SC

更新日期：2007-09-15 00:00:00

abstract：:The clinical diagnosis of cervical neoplasia by spectroscopic methods is potentially a reliable, fast and cost-effective alternative to the conventional smear test. However, it is currently limited by significant inter-patient variation in the spectroscopic properties of the cervix. Characterisation of suitable in vit...

journal_title：International journal of cancer

authors： Martin SF,Wood AD,McRobbie MM,Mazilu M,McDonald MP,Samuel ID,Herrington CS

更新日期：2007-05-01 00:00:00

abstract：:Although 45% of men and 39% of women will be diagnosed with cancer in their lifetime, it is difficult to predict which individuals will be affected. For some cancers, substantial progress in individual risk estimation has already been made. However, relatively few models have been developed to predict lung cancer risk...

journal_title：International journal of cancer

authors： Cassidy A,Duffy SW,Myles JP,Liloglou T,Field JK

更新日期：2007-01-01 00:00:00

abstract：:Aberrant cyclin expression has been implicated in oncogenesis in a number of human cancers. Since altered function of regulators of cyclin-dependent kinase (CDK) activity other than cyclins, in particular CDK inhibitors, might play a similar role in oncogenesis, we examined the expression and regulation of the CDK inh...

journal_title：International journal of cancer

authors： Musgrove EA,Lilischkis R,Cornish AL,Lee CS,Setlur V,Seshadri R,Sutherland RL

更新日期：1995-11-15 00:00:00

abstract：:Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC functions. Here, we show that human NK cells promote cross-presentation of tumor cell-derived Ag...

journal_title：International journal of cancer

authors： Deauvieau F,Ollion V,Doffin AC,Achard C,Fonteneau JF,Verronese E,Durand I,Ghittoni R,Marvel J,Dezutter-Dambuyant C,Walzer T,Vie H,Perrot I,Goutagny N,Caux C,Valladeau-Guilemond J

更新日期：2015-03-01 00:00:00

abstract：:Because renal-cell carcinoma (RCC) is considered relatively resistant to radio- and chemotherapy, RCC patients may benefit from new treatment modalities, e.g. immunotherapy. In vitro and in vivo studies suggest that combinations of cytokines such as interferon gamma or interferon alpha (IFN-gamma, IFN-alpha) and tumor...

journal_title：International journal of cancer

authors： van Dijk J,Uemura H,Beniers AJ,Peelen WP,Zegveld ST,Fleuren GJ,Warnaar SO,Oosterwijk E

更新日期：1994-01-15 00:00:00

abstract：:Although surgical resection is considered the adequate treatment in early stages of nonsmall cell lung cancer, long-term survival is not satisfactory and recurrence rate is high. We previously showed that postoperative chemotherapy at stage IB reduces recurrences and prolongs overall survival. We extended size and obs...

journal_title：International journal of cancer

authors： Roselli M,Mariotti S,Ferroni P,Laudisi A,Mineo D,Pompeo E,Ambrogi V,Mineo TC

更新日期：2006-08-15 00:00:00

abstract：:In a case-control study of gastric cancer (GC) in high-risk and low-risk areas of Italy, 923 GCs were systematically categorized by one pathologist according to the Lauren classification distinguishing 2 main histologic types, intestinal (55%) and diffuse (23%). Intestinal types outnumbered diffuse types by a 3 to 1 m...

journal_title：International journal of cancer

authors： Buiatti E,Palli D,Bianchi S,Decarli A,Amadori D,Avellini C,Cipriani F,Cocco P,Giacosa A,Lorenzini L

更新日期：1991-05-30 00:00:00

abstract：:Phenotypic and functional characteristics of tumor-infiltrating lymphocytes (TIL) obtained from human primary and metastatic liver tumors were studied. Lymphocytes isolated from 18 tumors and autologous (A) peripheral blood (6 cases) were phenotyped by 2-color flow cytometry and cloned in a limiting dilution system, w...

journal_title：International journal of cancer

authors： Shimizu Y,Iwatsuki S,Herberman RB,Whiteside TL

更新日期：1990-11-15 00:00:00

abstract：:The application of dendritic cells (DC) to the active immunotherapy of cancer currently relies on the generation of potent DC capable of presenting tumor antigens such as carcinoembryonic antigen (CEA). It is unknown whether the T cells of patients with advanced malignancies can be reliably stimulated against tumor an...

journal_title：International journal of cancer

authors： Nair SK,Hull S,Coleman D,Gilboa E,Lyerly HK,Morse MA

更新日期：1999-07-02 00:00:00

abstract：:Previous work from this laboratory established a large bank of human colon carcinoma cell lines in culture and classified them with respect to growth regulatory phenotypes based on several biological and biochemical characteristics. In the present report, Northern analysis indicates that addition of the maturational a...

journal_title：International journal of cancer

authors： Mulder KM,Brattain MG

更新日期：1988-07-15 00:00:00

abstract：:The suppressive activity of regulatory T cells (Treg) has been implicated as an important factor limiting immune mediated destruction of tumor cells. However, not much is known about the presence and function of Treg within tumors. Here we show in a syngeneic murine glioma model a time-dependent accumulation of CD4+Fo...

journal_title：International journal of cancer

authors： Grauer OM,Nierkens S,Bennink E,Toonen LW,Boon L,Wesseling P,Sutmuller RP,Adema GJ

更新日期：2007-07-01 00:00:00

abstract：:Accurate prognostic parameters in prostate biopsies are needed to better counsel individual patients with prostate cancer. We evaluated the prognostic impact of morphologic and immunohistochemical parameters in preoperative prostate cancer biopsies. A consecutive series of prostate biopsies of 279 men (72% with clinic...

journal_title：International journal of cancer

authors： Zellweger T,Günther S,Zlobec I,Savic S,Sauter G,Moch H,Mattarelli G,Eichenberger T,Curschellas E,Rüfenacht H,Bachmann A,Gasser TC,Mihatsch MJ,Bubendorf L

更新日期：2009-05-01 00:00:00

abstract：:History of diabetes may be associated with decreased prostate cancer (PCa) risk. Published studies have not always accounted for time since diabetes diagnosis or confounding and effect modification by lifestyle factors. The authors investigated the relationship between diabetes and PCa risk in men in the Health Profes...

journal_title：International journal of cancer

authors： Kasper JS,Liu Y,Giovannucci E

更新日期：2009-03-15 00:00:00

abstract：:Cervical cancer is a public health concern as it represents the second cause of cancer death in women worldwide. High-risk human papillomaviruses (HPV) are the etiologic agents, and HPV E6 and/or E7 oncogene-specific therapeutic vaccines are under development to treat HPV-related lesions in women. Whether the use of m...

journal_title：International journal of cancer

authors： Decrausaz L,Domingos-Pereira S,Duc M,Bobst M,Romero P,Schiller JT,Jichlinski P,Nardelli-Haefliger D

更新日期：2011-08-01 00:00:00

abstract：:Cancer awareness public campaigns aim to shorten the interval between symptom onset and presentation to a doctor (the 'patient interval'). Appreciating variation in promptness of presentation can help to better target awareness campaigns. We explored variation in patient intervals recorded in consultations with genera...

journal_title：International journal of cancer

authors： Keeble S,Abel GA,Saunders CL,McPhail S,Walter FM,Neal RD,Rubin GP,Lyratzopoulos G

更新日期：2014-09-01 00:00:00

abstract：:HER3 (ERBB3) is a catalytically inactive pseudokinase of the HER receptor tyrosine kinase family, frequently overexpressed in prostate and other cancers. Aberrant expression and mutations of 2 other members of the family, EGFR and HER2, are key carcinogenic events in several types of tumors, and both are well- validat...

journal_title：International journal of cancer

authors： Soler M,Mancini F,Meca-Cortés O,Sánchez-Cid L,Rubio N,López-Fernández S,Lozano JJ,Blanco J,Fernández PL,Thomson TM

更新日期：2009-12-01 00:00:00

abstract：:It is unclear which chromosome arms frequently show loss of heterozygosity (LOH) in adenocarcinoma of the uterine cervix. To identify such chromosomal arms, LOH on 52 different chromosome loci was examined using laser capture microdissection and PCR-LOH analysis in 25 common-type adenocarcinomas, comprising 13 cases o...

journal_title：International journal of cancer

authors： Tsuda H,Takarabe T,Okada S,Uchida H,Kasamatsu T,Yamada T,Tsunematsu R,Ohmi K,Hirohashi S

更新日期：2002-04-10 00:00:00

abstract：:The therapeutic potential of the somatostatin analogue RC-160 radiolabeled with 188Re was evaluated in nude mice bearing xenografts of human prostate adenocarcinoma. 188Re-RC-160 was selectively retained in both DU-145 and PC-3 tumors following direct intra-tumor injection at all time points examined (2, 6 and 24 hr p...

journal_title：International journal of cancer

authors： Zamora PO,Gulhke S,Bender H,Diekmann D,Rhodes BA,Biersack HJ,Knapp FF Jr

更新日期：1996-01-17 00:00:00

abstract：:We have previously shown that anti-Ly-6C monoclonal antibody (MAb) 2B6-F2 identifies a subset of (CBA +/- C57BL/6)F1 splenic NK-1.1+ natural T (NT) cells which kill the NK-sensitive YAC-1 target in vitro. Furthermore, these Ly-6C+ cells are responsible for 40-50% of in vitro YAC-1 killing in all mouse strains tested. ...

journal_title：International journal of cancer

authors： Martiniello R,Burton RC,Smart YC

更新日期：1996-05-16 00:00:00

abstract：:The expression of two discrete cell properties related to the host natural effector mechanisms, i.e., resistance to damage by H2O2, a cytotoxic product of activated macrophages, and the ability to secrete PGE, which inhibits NK-cell cytotoxicity, has been examined in parental Syrian hamster embryo cells spontaneously ...

journal_title：International journal of cancer

authors： Deichman GI,Kluchareva TE,Matveeva VA,Kushlinsky NE,Bassalyk LS,Vendrov EL

更新日期：1989-11-15 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) has profound impacts on cancer progression and also on drug resistance, including epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Nowadays, there is still no predictive biomarker identified for the use of EGFR-TKIs in non-small cell lung cancer (NSCLC...

journal_title：International journal of cancer

authors： Ren S,Su C,Wang Z,Li J,Fan L,Li B,Li X,Zhao C,Wu C,Hou L,He Y,Gao G,Chen X,Ren J,Li A,Xu G,Zhou X,Zhou C,Schmid-Bindert G

更新日期：2014-12-15 00:00:00

abstract：:Conjugates (immunotoxins) comprising ricin A-chain and monoclonal antibody 96.5, which is specific for human melanoma-associated antigen p97, inhibited protein synthesis and colony formation of cultured human melanoma cells that expressed more than 80,000 molecules of p97 per cell. Cells expressing fewer than 5,000 mo...

journal_title：International journal of cancer

authors： Casellas P,Brown JP,Gros O,Gros P,Hellström I,Jansen FK,Poncelet P,Roncucci R,Vidal H,Hellström KE

更新日期：1982-10-15 00:00:00

abstract：:The antigen recognized by the MOv18 MAb (Ca-MOv18) was recently shown to be a glycosylphosphatidylinositol (GPI)-linked protein. In this report we show that GPI-anchorage is not limited to IGROVI cells nor to other ovary carcinoma cell lines, but Ca-MOv18 was also found to be sensitive to phosphatidylinositol-specific...

journal_title：International journal of cancer

authors： Miotti S,Alberti S,Facheris P,Mantovani L,Fornaro M,Stella M,Ménard S,Canevari S,Colnaghi MI

更新日期：1992-05-28 00:00:00