Alterations in c-myc expression in relation to maturational status of human colon carcinoma cells.


:Previous work from this laboratory established a large bank of human colon carcinoma cell lines in culture and classified them with respect to growth regulatory phenotypes based on several biological and biochemical characteristics. In the present report, Northern analysis indicates that addition of the maturational agent N,N-dimethylformamide (DMF) (1.0%) to proliferating HCT 116 and MOSER cells resulted in a repression of c-myc proto-oncogene expression; retinoic acid (1.0 microM) was less effective in this regard. Repression of c-myc expression by DMF was observed in MOSER and HCT 116 cells, whether it was added to proliferating or late log phase cultures, and was associated with a corresponding reduction in cellular proliferation. The reduction in c-myc expression by DMF did not require new protein synthesis and occurred within a few minutes after its addition, resulting in a 70% reduction within approximately 2 hr. Previous work from this laboratory indicated that transforming growth factor-beta (TGF-beta) elicited alterations in MOSER cells similar to those observed following DMF treatment. The present report demonstrates that proliferating, but not late log phase, MOSER cells responded to TGF-beta with a repression of c-myc expression. Similarly, an inhibition of cellular proliferation was only observed when TGF-beta (10 ng/ml) was added to proliferating cells. Collectively, these findings indicate that repression of c-myc expression is associated with diminished cellular proliferation and the induction of a more benign phenotype in human colon carcinoma cells. Furthermore, this report is the first demonstration of a c-myc response to TGF-beta in an epithelial cell line.


Int J Cancer


Mulder KM,Brattain MG




Has Abstract


1988-07-15 00:00:00












  • Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer.

    abstract::Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome-wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylated CpG island within the first in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Versmold B,Felsberg J,Mikeska T,Ehrentraut D,Köhler J,Hampl JA,Röhn G,Niederacher D,Betz B,Hellmich M,Pietsch T,Schmutzler RK,Waha A

    更新日期:2007-08-01 00:00:00

  • VEGFR-2 expression in human melanoma: revised assessment.

    abstract::Vascular endothelial growth factor (VEGF) is an angiogenic factor that also functions as an autocrine growth factor for VEGF receptor (VEGFR)-2(+) melanomas. In multiple studies, VEGFR-2 was detected by immunostaining in 78-89% of human melanoma cells, suggesting that most patients with melanoma would benefit from an...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Molhoek KR,Erdag G,Rasamny JK,Murphy C,Deacon D,Patterson JW,Slingluff CL Jr,Brautigan DL

    更新日期:2011-12-15 00:00:00

  • AFP-synthesis induction in mouse hepatomas.

    abstract::Highly differentiated, spontaneous hepatomas occurring in 13- to 15-month-old CBA mice were unable to produce embryo-specific serum protein alpha-fetoprotein (AFP). AFP synthesis, however, was induced in such tumors by minimal mechanical damage (small incisions of the tumors). On the 3rd day following surgery, AFP-pos...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shipova LY,Gleiberman AS

    更新日期:1985-01-15 00:00:00

  • Population differences in immune marker profiles associated with human T-lymphotropic virus type I infection in Japan and Jamaica.

    abstract::The natural history of human T-lymphotropic virus type I (HTLV-I) has been shown to differ markedly by geographic area. The differences include contrasting patterns of risk of adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which may be due in part to differences in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Birmann BM,Breen EC,Stuver S,Cranston B,Martínez-Maza O,Falk KI,Okayama A,Hanchard B,Mueller N,Hisada M

    更新日期:2009-02-01 00:00:00

  • The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells.

    abstract::Melanoma is the most lethal human skin cancer. If metastatic, it becomes very aggressive and resistant to standard modalities of anticancer treatment. During the last 10 years, several therapeutic strategies have been tested including the use of single and combined small drugs. Experimental results indicate that RAS a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: López-Fauqued M,Gil R,Grueso J,Hernandez-Losa J,Pujol A,Moliné T,Recio JA

    更新日期:2010-04-01 00:00:00

  • LAF-4 is aberrantly expressed in human breast cancer.

    abstract::LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: To MD,Faseruk SA,Gokgoz N,Pinnaduwage D,Done SJ,Andrulis IL

    更新日期:2005-07-01 00:00:00

  • In vitro and in vivo antitumor activity of liposomal Fenretinide targeted to human neuroblastoma.

    abstract::Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In advanced disease stages, prognosis is poor and treatments have limited efficacy, thus novel strategies are warranted. The synthetic retinoid Fenretinide (HPR) induces apoptosis in NB and melanoma cell lines. We reported an in vitro potenti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Raffaghello L,Pagnan G,Pastorino F,Cosimo E,Brignole C,Marimpietri D,Montaldo PG,Gambini C,Allen TM,Bogenmann E,Ponzoni M

    更新日期:2003-05-01 00:00:00

  • Elevated expression of ICAM1 (CD54) and minimal expression of LFA3 (CD58) in Epstein-Barr-virus-positive nasopharyngeal carcinoma cells.

    abstract::Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Busson P,Zhang Q,Guillon JM,Gregory CD,Young LS,Clausse B,Lipinski M,Rickinson AB,Tursz T

    更新日期:1992-04-01 00:00:00

  • Clonal analysis of tumor-infiltrating lymphocytes from human primary and metastatic liver tumors.

    abstract::Phenotypic and functional characteristics of tumor-infiltrating lymphocytes (TIL) obtained from human primary and metastatic liver tumors were studied. Lymphocytes isolated from 18 tumors and autologous (A) peripheral blood (6 cases) were phenotyped by 2-color flow cytometry and cloned in a limiting dilution system, w...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shimizu Y,Iwatsuki S,Herberman RB,Whiteside TL

    更新日期:1990-11-15 00:00:00

  • Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein.

    abstract::Activity of Janus kinase 2 (JAK2) in the JAK2/STAT5 signaling pathway is critically controlled by suppressor of cytokine signaling-1 (SOCS-1). We have previously shown that SOCS-1 is biallelically mutated in the primary mediastinal B-cell lymphoma (PMBL) cell line MedB-1, resulting in impaired JAK2 degradation and sus...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Melzner I,Weniger MA,Bucur AJ,Brüderlein S,Dorsch K,Hasel C,Leithäuser F,Ritz O,Dyer MJ,Barth TF,Möller P

    更新日期:2006-04-15 00:00:00

  • Tumoricidal activity and cytokine secretion by tumor-infiltrating macrophages.

    abstract::Murine macrophages from different anatomical sites were compared for their ability to become tumoricidal and to secrete interleukin-1 (IL-1) and tumor necrosis factor (TNF) following stimulation in vitro by several biological response modifiers (BRM). Peritoneal macrophages (PM), alveolar macrophages (AM), and tumor-i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Brunda MJ,Sulich V,Wright RB,Palleroni AV

    更新日期:1991-07-09 00:00:00

  • Prognosis of early breast cancer by immunohistochemistry defined intrinsic sub-types in patients treated with adjuvant chemotherapy in the NEAT/BR9601 trial.

    abstract::Breast cancer can be classified into molecular sub-types that have distinct survival patterns. We evaluated the prognostic significance of breast cancer sub-types in a cohort of women taking part in the NEAT and BR9601 clinical trials comparing cyclophosphamide, methotrexate and fluorouracil (CMF) with ECMF (epirubici...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ali AM,Provenzano E,Bartlett JM,Abraham J,Driver K,Munro AF,Twelves C,Poole CJ,Hiller L,Dunn JA,Earl HM,Caldas C,Pharoah PD

    更新日期:2013-09-15 00:00:00

  • Biological response of multicellular EMT6 spheroids to exogenous lactate.

    abstract::The influence of elevated lactate concentrations, as found in tumor microregions, on cellular growth, viability, and metabolic state was studied employing the multicellular spheroid model. Spheroids of EMT6/Ro cells were cultured at 37 degrees C in 5% or 20% (v/v) oxygen, using stirred media with various concentration...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bourrat-Floeck B,Groebe K,Mueller-Klieser W

    更新日期:1991-03-12 00:00:00

  • Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.

    abstract::Polyamines are essential for cell growth and differentiation. Their specific uptake contributes to the regulation of intracellular polyamine levels. In this study, we describe the modulation of this transport mechanism in a rat tumoral pancreatic acinar cell line (AR4-2J) and analyze the transport system characteristi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nicolet T,Scemama JL,Pradayrol L,Berthélémy P,Seva C,Vaysse N

    更新日期:1991-10-21 00:00:00

  • Betel quid not containing tobacco and oral leukoplakia: a report on a cross-sectional study in Papua New Guinea and a meta-analysis of current evidence.

    abstract::Leukoplakia is an asymptomatic, potentially malignant change in the oral mucosa. Previous studies have reported that smoking and betel quid chewing are associated with increased risk of leukoplakia; few studies have reported on these associations in populations where betel quid does not contain tobacco. We conducted a...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Thomas SJ,Harris R,Ness AR,Taulo J,Maclennan R,Howes N,Bain CJ

    更新日期:2008-10-15 00:00:00

  • pp60c-src protein kinase activity in human gastric carcinomas.

    abstract::We examined pp60c-src protein kinase activity in human gastric carcinoma cell lines and gastric carcinoma tissues as well as normal mucosa. pp60c-src kinase activity was detected in all 5 carcinoma cell lines at various levels. Of 16 gastric carcinoma tissues, 8 showed higher pp60c-src kinase activity in tumor tissues...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Takekura N,Yasui W,Yoshida K,Tsujino T,Nakayama H,Kameda T,Yokozaki H,Nishimura Y,Ito H,Tahara E

    更新日期:1990-05-15 00:00:00

  • Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate.

    abstract::Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Karlsson M,Jensen PR,in 't Zandt R,Gisselsson A,Hansson G,Duus JØ,Meier S,Lerche MH

    更新日期:2010-08-01 00:00:00

  • Shut-down of virus synthesis during progression of erythroleukemia induced by Friend virus in mice.

    abstract::Infection of (C57BL/6 X DBA/2)F1 (BDF1) mice with 2,500 FFU of Friend virus complex (FV) resulted in erythroleukemia followed by recovery, at which time virus could not be detected in the spleens of mice, and with splenomegaly (progressor mice) or without splenomegaly (regressor mice). Progressor and regressor mice de...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yoosook C

    更新日期:1982-06-15 00:00:00

  • Differential effects of polyunsaturated fatty acids on chemosensitivity of NIH3T3 cells and its transformants.

    abstract::Polyunsaturated fatty acids (PUFAs) have been suggested, on the basis of animal-model studies, to be related not only to cancer development but also to chemotherapeutic effects. Controversy persists, however, as to which types of PUFAs are beneficial in terms of chemosensitivity. In this study, we used the NIH3T3 cell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tsai WS,Nagawa H,Muto T

    更新日期:1997-01-27 00:00:00

  • Induction of 2.5 OAS gene expression and activity is not sufficient for IFN-gamma-induced neuroblastoma cell differentiation.

    abstract::We showed earlier that interferon-gamma is a powerful inducer of differentiation of human neuroblastoma (NB) cells. Although 2',5' oligo-adenylate synthetase (2,5 OAS) may play a role in mediating the anti-proliferative and/or differentiative effects of interferons (IFNs), direct evidence is lacking. We have investiga...

    journal_title:International journal of cancer

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    authors: Corrias MV,Gribaudo G,Guarnaccia F,Ponzoni M

    更新日期:1995-07-17 00:00:00

  • Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus.

    abstract::Insulin-like growth factor-1 receptor (IGF-1R) and human epidermal growth factor receptor-2 (HER2) receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF-1R in esophageal cancer and to determine the effect of IGF-1R and HE...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kalinina T,Bockhorn M,Kaifi JT,Thieltges S,Güngör C,Effenberger KE,Strelow A,Reichelt U,Sauter G,Pantel K,Izbicki JR,Yekebas EF

    更新日期:2010-10-15 00:00:00

  • Protein content and functional characteristics of serum-purified exosomes from patients with colorectal cancer revealed by quantitative proteomics.

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    journal_title:International journal of cancer

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    authors: Chen Y,Xie Y,Xu L,Zhan S,Xiao Y,Gao Y,Wu B,Ge W

    更新日期:2017-02-15 00:00:00

  • Testicular cancer in nine northern European countries.

    abstract::The incidence of testicular cancer was examined in the Nordic and Baltic countries, Poland and Germany by collaboration among 10 cancer registries. Population-based registers were used to analyze a total of 34,309 cases, diagnosed from the start of registration (varying from 1943 in Denmark to 1980 in Latvia and Lithu...

    journal_title:International journal of cancer

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    authors: Adami HO,Bergström R,Möhner M,Zatoński W,Storm H,Ekbom A,Tretli S,Teppo L,Ziegler H,Rahu M

    更新日期:1994-10-01 00:00:00

  • Lectin-resistant variants of mouse melanoma cells. I. Altered metastasizing capacity and tumorigenicity.

    abstract::From C57BL mouse melanoma B-16 cells, variant clones were selected in vitro which were resistant to the lectins wheat-germ agglutinin and ricin. Cells were also selected which survived toxic concentrations of concanavalin A. Four different in vivo assays using intradermal, intravenous, intraperitoneal and intramuscula...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tao TW,Burger MM

    更新日期:1982-04-15 00:00:00

  • Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients.

    abstract::There is a well-established link between inflammation and cancer of various organs, but little data are available on inflammation-associated markers of diagnostic and prognostic clinical utility in pulmonary malignancy. Blood samples were prospectively collected from 75 resectable lung cancer patients before surgery a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Infante M,Allavena P,Garlanda C,Nebuloni M,Morenghi E,Rahal D,Roncalli M,Cavuto S,Pesce S,Monari M,Valaperta S,Montanelli A,Solomon D,Bottoni E,Errico V,Voulaz E,Bossi M,Chiesa G,Passera E,Mantovani A,Alloisio M

    更新日期:2016-02-15 00:00:00

  • Establishment and characterization of a human null-cell lymphoblastic lymphoma cell line (K-LL-3).

    abstract::A new cell line (K-LL-3) with exceptional characteristics was derived from a bone-marrow aspirate from a patient with poorly differentiated lymphoblastic lymphoma. The cell line was established and the cells maintained on agar feeders for over 1 year. The morphology and cytochemical staining of the primary tumor and t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Smith SD,Rosen D

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  • HER3 is required for the maintenance of neuregulin-dependent and -independent attributes of malignant progression in prostate cancer cells.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Soler M,Mancini F,Meca-Cortés O,Sánchez-Cid L,Rubio N,López-Fernández S,Lozano JJ,Blanco J,Fernández PL,Thomson TM

    更新日期:2009-12-01 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bruner DW,Moore D,Parlanti A,Dorgan J,Engstrom P

    更新日期:2003-12-10 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Moss DJ,Burrows SR,Castelino DJ,Kane RG,Pope JH,Rickinson AB,Alpers MP,Heywood PF

    更新日期:1983-06-15 00:00:00

  • Risk of somatic diseases in offspring of survivors with childhood or adolescent central nervous system tumor in Sweden.

    abstract::With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor be...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Huang W,Sundquist K,Sundquist J,Ji J

    更新日期:2020-11-13 00:00:00