Abstract:
:Effects of pretreatment with BCG, strain Japan, on tumor growth were studied using a transplatable methylcholanthrene (MCA)-induced fibrosarcoma in C3H/He mice. Injection of BCG7 weeks before tumor inoculation at a site distant from the tumor caused a slight inhibition of tumor growth. A low dose of tumor cells did not grow at the BCG-primed site when BCG was injected 7 and 11 weeks before the tumor. When a high dose was inoculated into the BCG-primed site, inhibition of the primary tumor occurred in mice which had received BCG 7 weeks previously, but the number of distant metastases in the popliteal lymph node and the lungs was increased in mice pretreated with BCG at any time. Furthermore, post treatment with BCG at a site distant from the tumor caused promotion of tumor growth. Enhanced antibody formation and suppression of delayed type hypersensitivity (DTH) occurred in tumor-bearing mice. BCG treatment of such mice caused a vigorously enhanced antibody formation and a marked suppression of DTH. The sera from tumor-bearing mice enhanced tumor growth. Tumor growth was suppressed in splenectomized mice. These findings suggested that antibodies against tumor-specific antigens enhanced tumor growth in this system and that BCG treatment of tumor-bearing mice stimulated formation of antibodies probably acting as blocking factors.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ishibashi T,Yamada H,Harada S,Harada Y,Takamoto M,Sugiyama Kdoi
10.1002/ijc.2910210112subject
Has Abstractpub_date
1978-01-15 00:00:00pages
67-71issue
1eissn
0020-7136issn
1097-0215journal_volume
21pub_type
杂志文章abstract::The prognostic impact of distinct KRAS mutations in colorectal carcinomas is not fully characterized. We hypothesized that the prognostic impact of KRAS mutations is modulated by KRAS mutant allele-specific imbalance (MASI). KRAS MASI was assessed by sequencing electropherograms in KRAS-mutated colorectal carcinomas (...
journal_title:International journal of cancer
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更新日期:2012-10-15 00:00:00
abstract::In order to target NK cells against the Hodgkin's-derived cell line L540, we developed bispecific monoclonal antibodies (Bi-MAbs) by somatic hybridization of the 2 mouse hybridoma cell line HRS-3 and A9 which produce monoclonal antibodies (MAbs) with reactivity against the Hodgkin and Reed-Sternberg cell-associated CD...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910550523
更新日期:1993-11-11 00:00:00
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journal_title:International journal of cancer
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更新日期:2017-02-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11700
更新日期:2004-04-10 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500408
更新日期:1992-02-20 00:00:00
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journal_title:International journal of cancer
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更新日期:1997-01-06 00:00:00
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journal_title:International journal of cancer
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更新日期:2008-03-15 00:00:00
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journal_title:International journal of cancer
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更新日期:1995-05-16 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560113
更新日期:1994-01-02 00:00:00
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journal_title:International journal of cancer
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更新日期:2000-04-01 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.2910590502
更新日期:1994-12-01 00:00:00
abstract::In a case-control study on lung cancer, risk was analysed in relation to smoking habits and frequency of vegetable and fruit consumption. Lung cancer cases in West Sweden and population controls were interviewed using a questionnaire where the frequency of consumption of dietary items and smoking habits were assessed....
journal_title:International journal of cancer
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doi:10.1002/ijc.21384
更新日期:2006-02-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490317
更新日期:1991-09-30 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/(SICI)1097-0215(19960126)65:3<372::AID-IJC
更新日期:1996-01-26 00:00:00
abstract::Modulation of cytoplasmic Ca++ concentration is a mechanism common to signal transduction pathways regulating many cellular phenomena, including the interactions of tumors with the hemostatic system. We have investigated the pro-aggregating and pro-coagulant activities of human tumor cell lines cultured in vitro and t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620310
更新日期:1995-07-28 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.10212
更新日期:2002-03-20 00:00:00
abstract::The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...
journal_title:International journal of cancer
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更新日期:1981-06-15 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1998-06-19 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1996-11-04 00:00:00
abstract::The major goal in cancer immunotherapy is the induction of tumor-specific T lymphocytes capable of killing tumor cells. As both dendritic cells (DCs) and interleukin-12 (IL-12) can play immunostimulatory roles in vivo, the use of a combination of these has become a promising approach. In the present study, we used a m...
journal_title:International journal of cancer
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doi:
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abstract::Results of epidemiologic studies of physical activity and ovarian cancer risk are inconsistent. Few have attempted to measure physical activity over the lifetime or in specific age windows, which may better capture etiologically relevant exposures. We examined participation in moderate-to-vigorous recreational physica...
journal_title:International journal of cancer
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更新日期:2020-04-01 00:00:00
abstract::Cutaneous T-Cell lymphoma (CTCL) is a non-Hodgkin's lymphoma of unknown pathogenesis. Mycosis fungoides (MF) is a clinically determined subset of CTCL with intensive infiltration of lymphoma cells into the epidermis. To determine whether Epstein-Barr virus (EBV) is associated with these lymphoma cells, we performed mR...
journal_title:International journal of cancer
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更新日期:2001-04-15 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1992-10-21 00:00:00
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journal_title:International journal of cancer
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更新日期:2017-09-01 00:00:00