Increased ether lipid cytotoxicity by reducing membrane cholesterol content.


:Ether-linked glycerophospholipids (ether lipids, EL) are selectively toxic and anti-proliferative agents against cancer cells in vitro. The reason for such selectivity is not completely clear. Their mechanism of action is mediated through an interaction with the plasma membrane and the membrane lipid composition may modulate it. As a continuation of previous reports, we now present data showing that cholesterol concentration modulates EL toxicity in the K562, U937 and MOLT4 leukemic cell lines in vitro. Cells become sensitive to otherwise ineffective doses of EL when their cholesterol content is lowered. Cell cholesterol levels were reduced by exposure to an egg lipid mixture (neutral glycerides, phosphatidylcholine and phosphatidylethanolamine, AL721). The data contribute to an understanding of the EL mechanism of action on membranes and suggest that the cellular cholesterol concentration must be considered a major factor in modulating the cytotoxic effects of EL.


Int J Cancer


Diomede L,Piovani B,Modest EJ,Noseda A,Salmona M




Has Abstract


1991-09-30 00:00:00












  • Lung cancer mortality associated with protracted low-dose occupational radiation exposures and smoking behaviors in U.S. radiologic technologists, 1983-2012.

    abstract::In the Japanese atomic bomb survivors, risk of lung cancer has been shown to increase with greater acute exposure to ionizing radiation. Although similar findings have been observed in populations exposed to low-dose, protracted radiation, such studies lack information on cigarette smoking history, a potential confoun...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Velazquez-Kronen R,Gilbert ES,Linet MS,Moysich KB,Freudenheim JL,Wactawski-Wende J,Simon SL,Cahoon EK,Alexander BH,Doody MM,Kitahara CM

    更新日期:2020-12-01 00:00:00

  • Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase.

    abstract::During malignant progression cancer cells undergo a series of changes, which promote their survival, invasiveness and metastatic process. One of them is a change in glucose metabolism. Unlike normal cells, which mostly rely on the tricarboxylic acid cycle (TCA), many cancer types rely on glycolysis. Pyruvate dehydroge...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Golias T,Kery M,Radenkovic S,Papandreou I

    更新日期:2019-02-15 00:00:00

  • Nuclear receptors and the Warburg effect in cancer.

    abstract::In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermenta...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Thorne JL,Campbell MJ

    更新日期:2015-10-01 00:00:00

  • Two distinct regions of deletion on chromosome 13q in primary nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC) is rare in most parts of the world, but prevalent in Southern China. Although this disease poses a serious health problem in our population, the genetic alterations that lead to the development of NPC have yet to be defined. In a comparative genomic hybridization (CGH) study on NPC by ou...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tsang YS,Lo KW,Leung SF,Choi PH,Fong Y,Lee JC,Huang DP

    更新日期:1999-10-29 00:00:00

  • Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

    abstract::Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone EO9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of EO9 and mitomycin C in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Plumb JA,Workman P

    更新日期:1994-01-02 00:00:00

  • Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X.

    abstract::Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To explore whether phenotypic differences among PPGLs reflect a MAX-mediated mechanism and opposing influence...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Qin N,de Cubas AA,Garcia-Martin R,Richter S,Peitzsch M,Menschikowski M,Lenders JW,Timmers HJ,Mannelli M,Opocher G,Economopoulou M,Siegert G,Chavakis T,Pacak K,Robledo M,Eisenhofer G

    更新日期:2014-11-01 00:00:00

  • High expression of bfl-1 contributes to the apoptosis resistant phenotype in B-cell chronic lymphocytic leukemia.

    abstract::In order to identify regulatory genes involved in the development of an apoptosis-resistant phenotype in patients with chemotherapy refractory B-cell chronic lymphocytic leukemia (B-CLL) expression of apoptosis-regulating genes in B-CLL cells was quantified using cDNA arrays and RT-PCR. Data were obtained from and com...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Morales AA,Olsson A,Celsing F,Osterborg A,Jondal M,Osorio LM

    更新日期:2005-02-20 00:00:00

  • Prevalence and clinical impact of TP53 germline mutations in Chinese women with breast cancer.

    abstract::The prevalence and clinical relevance of TP53 germline mutations in a large unselected breast cancer series are largely unknown. Here, we determined TP53 germline mutations in a large cohort of 10,053 unselected breast cancer patients through multigene panel-based next-generation and/or Sanger sequencing assays. We fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sheng S,Xu Y,Guo Y,Yao L,Hu L,Ouyang T,Li J,Wang T,Fan Z,Fan T,Lin B,Xie Y

    更新日期:2020-01-15 00:00:00

  • Effect of DNA repair gene polymorphisms on BPDE-DNA adducts in human lymphocytes.

    abstract::To determine whether variations in DNA repair genes are related to host DNA damage, we investigated the association between polymorphism in the XPD gene (codon 199, 312, 751) and the XRCC1 gene (codon 194, 399) and the presence of benzo(a)pyrene diolepoxide adducts to lymphocyte DNA (BPDE-DNA) in a group of male patie...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pastorelli R,Cerri A,Mezzetti M,Consonni E,Airoldi L

    更新日期:2002-07-01 00:00:00

  • Antiproliferative activity of interferon alpha and retinoic acid in SiHa carcinoma cells: the role of cell adhesion.

    abstract::Several lines of evidence have demonstrated that IFNs could be relevant in the treatment of certain neoplastic diseases such as carcinomas. In particular, IFN-alpha, in addition to the anti-proliferative and cytostatic effects, was demonstrated to be capable of inducing cell death by apoptosis both in vivo and in vitr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Matarrese P,Giandomenico V,Fiorucci G,Rivabene R,Straface E,Romeo G,Affabris E,Malorni W

    更新日期:1998-05-18 00:00:00

  • Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer.

    abstract::We used oligonucleotide microarrays to investigate gene expression changes associated with multi-step human papillomavirus type 16 (HPV16)-mediated carcinogenesis in vitro. Gene expression profiles in 4 early passage HPV16-immortalized human keratinocyte (HKc) lines derived from different donors were compared with the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wan F,Miao X,Quraishi I,Kennedy V,Creek KE,Pirisi L

    更新日期:2008-07-01 00:00:00

  • TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor.

    abstract::Maspin is a Class II tumor suppressor protein and plays a role in tumor growth by inhibiting cellular invasion and motility. It is a member of the serpin family of protease inhibitors and has been shown to reduce angiogenesis. Maspin gene expression can be upregulated by the tumor suppressor p53. We tested 7 p53-relat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Spiesbach K,Tannapfel A,Mössner J,Engeland K

    更新日期:2005-04-20 00:00:00

  • Human papillomavirus--the most significant risk determinant of cervical intraepithelial neoplasia.

    abstract::Sexual behavior has been consistently identified as a major risk factor for cervical cancer. Population-based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (HPV) infection. We conducted a case-control study of 199 cases with low-grade squamous intraepithelial lesion...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kjaer SK,van den Brule AJ,Bock JE,Poll PA,Engholm G,Sherman ME,Walboomers JM,Meijer CJ

    更新日期:1996-03-01 00:00:00

  • HLA-B35-restricted immune responses against survivin in cancer patients.

    abstract::Two HLA-A2 restricted epitopes have recently been identified from the broadly expressed tumor antigen survivin, and several vaccination trials in cancer patients based on these survivin-derived peptides have been initiated. Consequently, there is a crucial need for the identification of survivin epitopes restricted to...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Reker S,Becker JC,Svane IM,Ralfkiaer E,Straten PT,Andersen MH

    更新日期:2004-03-01 00:00:00

  • Two distinct human myeloma cell lines originating from one patient with myeloma.

    abstract::Two distinct cell lines (OPM-1 and OPM-2) were established from the peripheral blood of a 56-year-old female myeloma patient at the stage of terminal leukemic evolution associated with loss of cytoplasmic immunoglobulin heavy chain (G lambda----lambda). The lines grew in suspension with a doubling time of 36-42 hr and...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Katagiri S,Yonezawa T,Kuyama J,Kanayama Y,Nishida K,Abe T,Tamaki T,Ohnishi M,Tarui S

    更新日期:1985-08-15 00:00:00

  • Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3.

    abstract::Dietary intake of many fruits and vegetables has been shown to be associated with reduced risk of cancer. We investigated the in vivo efficacy of grape seed extract (GSE, patented as Traconol) against prostate cancer (PCA) and associated molecular events. Athymic nude mice were implanted with hormone-refractory human ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Singh RP,Tyagi AK,Dhanalakshmi S,Agarwal R,Agarwal C

    更新日期:2004-02-20 00:00:00

  • Nerve invasion distance is dependent on laminin gamma2 in tumors of pancreatic cancer.

    abstract::The distance of nerve invasion is an important prognostic factor in pancreatic cancer. The extracellular matrix (ECM) of nerve, mainly composed of laminin, collagen IV and anchoring fibrils, might affect nerve invasion. However, this relationship has not been demonstrated. Our study aimed at discovering the promoting ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mitsunaga S,Fujii S,Ishii G,Kinoshita T,Hasebe T,Aoyagi K,Sasaki H,Ochiai A

    更新日期:2010-08-15 00:00:00

  • Presence of EBV-DNA sequences in nasopharyngeal cells of individuals without IgA-VCA antibodies.

    abstract::Exfoliated nasopharyngeal (NP) cells from 62 normal Cantonese Chinese having IgA/VCA antibodies for more than a year and from 39 similar persons without IgA/VCA antibodies, were tested for the presence of EBV/DNA sequences by spot followed by blot hybridization tests, using the cloned internal repeat of B95-8 viral DN...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Desgranges C,Pi GH,Bornkamm GW,Legrand C,Zeng Y,de-Thé G

    更新日期:1983-11-15 00:00:00

  • Comorbidities, age and period of diagnosis influence treatment and outcomes in early breast cancer.

    abstract::Survival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7581 s...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Minicozzi P,Van Eycken L,Molinie F,Innos K,Guevara M,Marcos-Gragera R,Castro C,Rapiti E,Katalinic A,Torrella A,Žagar T,Bielska-Lasota M,Giorgi Rossi P,Larrañaga N,Bastos J,Sánchez MJ,Sant M,European HR Working Group on

    更新日期:2019-05-01 00:00:00

  • The roles of PAD2- and PAD4-mediated protein citrullination catalysis in cancers.

    abstract::Peptidylarginine deiminases (PADs) catalyze the conversion of arginine residues to citrulline residues on target proteins in the presence of calcium ions. This elaborate type of posttranslational modification is termed citrullination. PADs may regulate gene transcriptional activity via histone citrullination. There ha...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Wang Y,Chen R,Gan Y,Ying S

    更新日期:2021-01-15 00:00:00

  • An in vitro model of intra-epithelial expansion of transformed urothelial cells.

    abstract::Replacement of normal urothelium by pre-cancerous epithelium may explain the high recurrence rate of human bladder cancer. An in vitro model was designed in order to study the mechanisms of expansion of transformed urothelial cells at the expense of normal urothelium. For this purpose, mouse bladder explants were allo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rebel JM,de Boer WI,Thijssen CD,Vermey M,Zwarthoff EC,van der Kwast TH

    更新日期:1993-07-09 00:00:00

  • EGF modulation of the ras-related rhoB gene expression in human breast-cancer cell lines.

    abstract::The mRNA levels of the ras-related human rhoA, rhoB and rhoC genes were studied in human breast-cancer cell lines (HBCal), and in normal and immortalized mammary epithelial cells (HMEC) by Northern blot analysis and in situ hybridization. In contrast to the ubiquitous rhoA and rhoC gene expression, dramatic variations...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: de Cremoux P,Gauville C,Closson V,Linares G,Calvo F,Tavitian A,Olofsson B

    更新日期:1994-11-01 00:00:00

  • Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer.

    abstract::The aim of this study was to test the utility of AIMP3, an upstream regulator of DNA damage response following genotoxic stress, as a clinical biomarker in muscle-invasive bladder cancer (MIBC). AIMP3 was identified from a meta-analysis of a global gene-expression dataset. AIMP3 protein expression was determined by im...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Gurung PM,Veerakumarasivam A,Williamson M,Counsell N,Douglas J,Tan WS,Feber A,Crabb SJ,Short SC,Freeman A,Powles T,Hoskin PJ,West CM,Kelly JD

    更新日期:2015-02-01 00:00:00

  • Cigarette smoking and subsequent risk of lung cancer by histologic type in middle-aged Japanese men and women: the JPHC study.

    abstract::In order to update the findings of relative risk associated with cigarette smoking for lung cancer by histologic type in Japan, the data from a population-based cohort study of 91,738 men and women were analyzed. During 1990-1999, 422 lung cancer incident cases were identified. The relative risk for all incident cases...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sobue T,Yamamoto S,Hara M,Sasazuki S,Sasaki S,Tsugane S,JPHC Study Group. Japanese Public Health Center.

    更新日期:2002-05-10 00:00:00

  • Presence on a human melanoma of multiple antigens recognized by autologous CTL.

    abstract::We derived from blood lymphocytes of a melanoma patient a large number of cytolytic T-cell clones directed against a cell line of the autologous tumor. Three distinct groups of antigens were recognized by these CTL on the autologous melanoma cells: group A consisted of stable antigens present on all sublines, whereas ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Van den Eynde B,Hainaut P,Hérin M,Knuth A,Lemoine C,Weynants P,van der Bruggen P,Fauchet R,Boon T

    更新日期:1989-10-15 00:00:00

  • The MHC class-II and CD44 molecules are involved in the induction of tumour necrosis factor (TNF) gene expression by human monocytes stimulated with tumour cells.

    abstract::Tumour necrosis factor alpha (TNF) mRNA is detected in the macrophage infiltrate surrounding the tumour, but the cellular/molecular interactions leading to TNF gene expression in macrophages are unknown. The in vitro system in which human blood monocytes are stimulated with human cancer cells for TNF release was used ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zembala M,Siedlar M,Ruggiero I,Wieckiewicz J,Mytar B,Mattei M,Colizzi V

    更新日期:1994-01-15 00:00:00

  • Analysis of the polymorphic CAG repeat length in the androgen receptor gene in patients with testicular germ cell cancer.

    abstract::Changes in the length of a polymorphic trinucleotide (CAG) repeat in the androgen receptor (AR) gene, which may lead to altered transactivation of the AR gene, have been implicated to play a role in the pathogenesis of several forms of endocrine cancer and certain reproductive disorders. Subjects with reproductive dis...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rajpert-De Meyts E,Leffers H,Daugaard G,Andersen CB,Petersen PM,Hinrichsen J,Pedersen LG,Skakkebaek NE

    更新日期:2002-11-10 00:00:00

  • Suppressor cell activity in melanoma patients. II. Concanavalin A-induced suppressor cells in relation to tumor growth and suppressor T-cell subsets.

    abstract::The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean perce...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Werkmeister J,Phillips G,McCarthy W,Hersey P

    更新日期:1981-07-15 00:00:00

  • Expression of MaTu-MN protein in human tumor cultures and in clinical specimens.

    abstract::MaTu is a novel agent which may be of relevance in human oncogenesis, and has 2 components. One of them, the exogenous MX (coding for protein p58X), is transmissible to human fibroblasts, to HeLa and to HeLa x fibroblast (H/F) hybrids. The other component, MN, is a cellular gene. Its product, the protein p54/58N, is i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Závada J,Závadová Z,Pastoreková S,Ciampor F,Pastorek J,Zelník V

    更新日期:1993-05-08 00:00:00

  • Modulation of viability and maturation of human monocyte-derived dendritic cells by oncolytic adenoviruses.

    abstract::Adenoviral oncolysis is a promising new modality for treatment of cancer based on selective viral replication in tumor cells. However, tumor cell killing by adenoviral oncolysis needs to be improved to achieve therapeutic benefit in the clinic. Towards this end, the activation of anti-tumor immunity by adenoviral onco...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schierer S,Hesse A,Müller I,Kämpgen E,Curiel DT,Schuler G,Steinkasserer A,Nettelbeck DM

    更新日期:2008-01-01 00:00:00