Abstract:
:The peripheral blood monocyte is the reactive cell in the tube LAI assay. The monocyte loses its properties of adherence to glass upon exposure to specific antigen. Two different experiments to determine if lymphocytes, when they reacted with tumour, released mediators that were responsible for inhibiting monocyte glass adherence, gave negative results. The mechanism wherby the specific tumour antigen appeared to be recognized was the binding of cytophilic IgG antitumour antibody to receptors on the cell surface of the monocyte. The results of the experiments indicate that normal peripheral blood monocytes could be made specifically reactive ("armed") to the tumour extract by incubating normal peripheral blood leukocytes with serum from a reactive cancer patient. IgG isolated from "arming" sera was shown to have the capacity to sensitize normal leukocytes. Patients with breast cancer or malignant melanoma with limited tumour burdens had free cytophilic anti-tumour antibody in their serum, whereas the serum of patients with large tumour burdens (metastatic cancer), whose leukocytes did not react in the tube LAI assay, did not "arm".
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Marti JH,Grosser N,Thomson DMdoi
10.1002/ijc.2910180108subject
Has Abstractpub_date
1976-07-15 00:00:00pages
48-57issue
1eissn
0020-7136issn
1097-0215journal_volume
18pub_type
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1999-08-12 00:00:00
abstract::There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer...
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更新日期:2000-03-15 00:00:00
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更新日期:2002-12-01 00:00:00
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更新日期:2004-11-10 00:00:00
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更新日期:2002-10-20 00:00:00
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journal_title:International journal of cancer
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更新日期:1999-12-10 00:00:00
abstract::Fibrin deposition in the microenvironment of tumor cells may be critical to tumor growth and metastasis formation. Procoagulant activities of tumor cells themselves, or of infiltrating macrophages, activated by the host's immune system to the tumor, may both contribute to coagulopathies associated with metastases. Lym...
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doi:10.1002/ijc.2910370506
更新日期:1986-05-15 00:00:00
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pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960208)65:4<473::AID-IJC
更新日期:1996-02-08 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1989-12-15 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2012-07-01 00:00:00
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更新日期:2012-06-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章,评审
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更新日期:2021-01-04 00:00:00
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更新日期:2007-12-15 00:00:00
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更新日期:2004-12-20 00:00:00
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更新日期:2013-11-01 00:00:00
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journal_title:International journal of cancer
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更新日期:1995-09-04 00:00:00
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更新日期:1995-10-09 00:00:00