Tumor-platelet interaction in solid tumors.

abstract：:To identify characteristics of gastric cancer associated with hereditary non-polyposis colorectal cancer (HNPCC), we gathered clinical data and tumor samples relating to patients recorded in the Finnish HNPCC registry. Our series included 51 families with a characterized mutation and/or that met the Amsterdam criteria...

journal_title：International journal of cancer

authors： Aarnio M,Salovaara R,Aaltonen LA,Mecklin JP,Järvinen HJ

更新日期：1997-10-21 00:00:00

abstract：:Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimi...

journal_title：International journal of cancer

authors： Herbst A,Vdovin N,Gacesa S,Ofner A,Philipp A,Nagel D,Holdt LM,Op den Winkel M,Heinemann V,Stieber P,Graeven U,Reinacher-Schick A,Arnold D,Ricard I,Mansmann U,Hegewisch-Becker S,Kolligs FT

更新日期：2017-05-01 00:00:00

abstract：:The Raf murine sarcoma viral oncogene homolog B (BRAFV600E ) mutation (MT) in metastatic colorectal cancer (CRC) is a well-known prognostic indicator and a negative predictive biomarker for antiepidermal growth factor receptor (EGFR) treatment. However, the clinical characteristics and significance of BRAFnon-V600E MT...

journal_title：International journal of cancer

authors： Osumi H,Shinozaki E,Wakatsuki T,Suenaga M,Ichimura T,Ogura M,Takahari D,Ooki A,Suzuki T,Ota Y,Nakayama I,Chin K,Miki Y,Yamaguchi K

更新日期：2019-11-01 00:00:00

abstract：:Human lung tumors express different types of growth-factor receptors and corresponding ligands that might modulate several biological functions such as proliferation, differentiation, adhesion, and chemotaxis. In the present study, we have investigated the expression of different growth-factor receptors and their liga...

journal_title：International journal of cancer

authors： Bredin CG,Liu Z,Hauzenberger D,Klominek J

更新日期：1999-07-30 00:00:00

abstract：:Therapies targeted to human epidermal growth factor receptor 2 (HER2) have proven effective against tumors positive for HER2 amplification, but there is an unmet clinical need for the treatment of tumors that express HER2 protein in the absence of HER2 amplification. [fam-] trastuzumab deruxtecan (DS-8201a) is a novel...

journal_title：International journal of cancer

authors： Takegawa N,Tsurutani J,Kawakami H,Yonesaka K,Kato R,Haratani K,Hayashi H,Takeda M,Nonagase Y,Maenishi O,Nakagawa K

更新日期：2019-12-15 00:00:00

abstract：:The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cas...

journal_title：International journal of cancer

authors： Olsen AO,Gjøen K,Sauer T,Orstavik I,Naess O,Kierulf K,Sponland G,Magnus P

更新日期：1995-05-04 00:00:00

abstract：:Although the existence of a humoral response against tumor-associated antigens is well appreciated, a systematic analysis of its possible induction by the tumor remains missing. We compared the specific IgG response of Stage IV melanoma patients during vaccination. Patients had been treated within 2 clinical trials wi...

journal_title：International journal of cancer

authors： Ehlken H,Schadendorf D,Eichmüller S

更新日期：2004-01-10 00:00:00

abstract：:The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that ex...

journal_title：International journal of cancer

authors： Weedon SJ,Green NK,McNeish IA,Gilligan MG,Mautner V,Wrighton CJ,Mountain A,Young LS,Kerr DJ,Searle PF

更新日期：2000-06-15 00:00:00

abstract：:Malignant tumors are generally characterized by extensive local tissue invasion and destruction of ECM which may be due to increased constitutive expression and activity of secreted proteases. Moreover, a large number of diverse protease activities may be constitutively over-expressed in a simultaneous or co-ordinated...

journal_title：International journal of cancer

authors： Korczak B,Kerbel RS,Dennis J

更新日期：1991-06-19 00:00:00

abstract：:Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution multimodal imaging approach assessing in vivo the metabolism of i...

journal_title：International journal of cancer

authors： Lai M,Vassallo I,Lanz B,Poitry-Yamate C,Hamou MF,Cudalbu C,Gruetter R,Hegi ME

更新日期：2018-07-01 00:00:00

abstract：:More than 90% of oral cancers are histopathologically squamous cell carcinomas (SCCs). According to clinical behavior and histopathological features, we hypothesize that oral SCC can originate from either oral squamous epithelium or minor salivary glands. Here, we examined whether some oral SCCs originate from minor s...

journal_title：International journal of cancer

authors： Kinouchi M,Izumi S,Nakashiro KI,Haruyama Y,Kobashi G,Uchida D,Hasegawa T,Kawamata H

更新日期：2018-11-15 00:00:00

abstract：:Metastasis to the liver often occurs in patients during the natural course of pancreatic cancer. Using carcinoma cell lines established from 9 such patients, we examined phenotypes of cell lines to search for correlations with their potential to metastasize to the liver. Anti-asialo GMI-treated nude mice were used. PC...

journal_title：International journal of cancer

authors： Kishimoto T,Ishikura H,Kimura C,Takahashi T,Kato H,Yoshiki T

更新日期：1996-08-22 00:00:00

abstract：:Alterations of gene expression in squamous cell carcinoma (SCC) cell lines derived from the larynx and keratinocytes derived from adjacent normal mucosa of the larynx have been studied using the mRNA differential display technique. Lane-to-lane comparison of reverse transcribed mRNA showed a strong repression of a 148...

journal_title：International journal of cancer

authors： Görögh T,Rudert H,Lippert BM,Gottschlich S,Maune S,Heidorn K,Maass J,Hoffmann M,Meyer JE,Rathcke IO,Folz BJ,Hortobagyi T,Werner JA

更新日期：1999-12-10 00:00:00

abstract：:To identify genes associated with radioresistant oral squamous cell carcinoma (OSCC), we compared gene expression signatures between OSCC cell lines exhibiting radioresistance and cells with radiosensitivity after X-ray irradiation in a dose-dependent manner using Affymetrix GeneChip analysis with Human Genome-U133 pl...

journal_title：International journal of cancer

authors： Ishigami T,Uzawa K,Higo M,Nomura H,Saito K,Kato Y,Nakashima D,Shiiba M,Bukawa H,Yokoe H,Kawata T,Ito H,Tanzawa H

更新日期：2007-05-15 00:00:00

abstract：:The effects of combined administration of bombesin (40 micrograms/kg body weight) and the ornithine decarboxylase (ODC) inhibitor, 1,3-diaminopropane (DAP), on the development of large and small intestinal tumors and the incidence of their metastasis to the peritoneum induced by azoxymethane (AOM, 7.4 mg/kg body weigh...

journal_title：International journal of cancer

authors： Iishi H,Tatsuta M,Baba M,Uehara H,Nakaizumi A

更新日期：1994-08-15 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins, many of which play critical roles in tumor cell growth and survival. The ansamycin-based Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in Phase III clinical tes...

journal_title：International journal of cancer

authors： Yin X,Zhang H,Lundgren K,Wilson L,Burrows F,Shores CG

更新日期：2010-03-01 00:00:00

abstract：:Renal-cell carcinomas (RCC) are clinically, histologically and cytogenetically very heterogeneous. The present histological WHO classification shows no clear correlation between histologic subtypes and specific chromosomal abnormalities. In 1986, a new classification was proposed by Thoenes and Störkel based on the ce...

journal_title：International journal of cancer

authors： van den Berg E,van der Hout AH,Oosterhuis JW,Störkel S,Dijkhuizen T,Dam A,Zweers HM,Mensink HJ,Buys CH,de Jong B

更新日期：1993-09-09 00:00:00

abstract：:HPV35 has been found in only ∼2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub-Saharan Africa, warranting further investigation and consideration of impact on preventive strategies. We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using multiple large epide...

journal_title：International journal of cancer

authors： Pinheiro M,Gage JC,Clifford GM,Demarco M,Cheung LC,Chen Z,Yeager M,Cullen M,Boland JF,Chen X,Raine-Bennett T,Steinberg M,Bass S,Befano B,Xiao Y,Tenet V,Walker J,Zuna R,Poitras NE,Gold MA,Dunn T,Yu K,Zhu B,Bu

更新日期：2020-11-15 00:00:00

abstract：:Nitric oxide (NO) and its metabolites are implicated in carcinogenesis and metastasis. Both stimulatory and inhibitory effects of NO have been reported in relation to breast cancer and its role in the development of malignancies and metastasis remains uncertain. We have used the polyomavirus middle T antigen (PyV-mT) ...

journal_title：International journal of cancer

authors： Ellies LG,Fishman M,Hardison J,Kleeman J,Maglione JE,Manner CK,Cardiff RD,MacLeod CL

更新日期：2003-08-10 00:00:00

abstract：:Previously, we studied the surface expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in a panel of 16 human T-cell lines and found that those carrying HTLV-1 pro-viruses expressed high levels of ICAM-1. Enhanced expression of ICAM-1 was also seen in fresh leukemic cells from ATL patients. In the present study, we sys...

journal_title：International journal of cancer

authors： Imai T,Tanaka Y,Fukudome K,Takagi S,Araki K,Yoshie O

更新日期：1993-11-11 00:00:00

abstract：:The p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result of infection by human papillomavirus (HPV). The HPV E6 oncoprotein forms complexes with p53 and promotes its degradation via ubiquitin-dependent mechanism. In our study, we attempted to improve t...

journal_title：International journal of cancer

authors： Wang H,Song X,Zhang H,Zhang J,Shen X,Zhou Y,Fan X,Dai L,Qian G,Hoffman AR,Hu JF,Ge S

更新日期：2012-01-15 00:00:00

abstract：:Renewed interest in the use of therapeutic enzymes combined with an improved knowledge of cancer cell metabolism, has led to the translation of several arginine depletion strategies into early phase clinical trials. Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginos...

journal_title：International journal of cancer

authors： Fultang L,Vardon A,De Santo C,Mussai F

更新日期：2016-08-01 00:00:00

abstract：:A number of cancer genes have been identified by the study of hereditary human cancers and shown to be involved in sporadic genesis of the same tumors. We have identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2) predisposing gene in the Eker rat model. In this study, we searched ...

journal_title：International journal of cancer

authors： Satake N,Urakami S,Hirayama Y,Izumi K,Hino O

更新日期：1998-09-11 00:00:00

abstract：:We show that siRNA-mediated suppression of protein tyrosine phosphatase alpha (PTP alpha) reduces Src activity 2 to 4-fold in breast, colon and other human cancer cell lines. Src and PTP alpha RNAi induced apoptosis in estrogen receptor (ER)-negative breast cancer and colon cancer cells, but not in immortalized noncan...

journal_title：International journal of cancer

authors： Zheng X,Resnick RJ,Shalloway D

更新日期：2008-05-01 00:00:00

abstract：:The possibility that women, who receive breast implants for cosmetic purposes, have increased long-term risks of developing cancer continues to be debated. The objective of our study was to prospectively examine cancer incidence among women who received breast implants. A cohort was assembled of 24,558 women, 18 years...

journal_title：International journal of cancer

authors： Brisson J,Holowaty EJ,Villeneuve PJ,Xie L,Ugnat AM,Latulippe L,Mao Y

更新日期：2006-06-01 00:00:00

abstract：:Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...

journal_title：International journal of cancer

authors： Tomala J,Chmelova H,Strohalm J,Ulbrich K,Sirova M,Rihova B,Kovar M

更新日期：2011-10-15 00:00:00

abstract：:A variety of analytical approaches have indicated that melanoma cell line UCLA-SO-M14 (M14) and breast carcinoma cell line MDA-MB-435 originate from a common donor. This indicates that at some point in the past, one of these cell lines became misidentified, meaning that it ceased to correspond to the reported donor an...

journal_title：International journal of cancer

authors： Korch C,Hall EM,Dirks WG,Ewing M,Faries M,Varella-Garcia M,Robinson S,Storts D,Turner JA,Wang Y,Burnett EC,Healy L,Kniss D,Neve RM,Nims RW,Reid YA,Robinson WA,Capes-Davis A

更新日期：2018-02-01 00:00:00

abstract：:Resistance to cisplatin-based chemotherapy is a major cause of treatment failure in human ovarian cancer. Wild-type TP53 status is often, but not always, associated with cisplatin sensitivity, suggesting that additional factors may be involved. Overexpression/activation of the phosphatidylinositol-3-kinase/Akt pathway...

journal_title：International journal of cancer

authors： Fraser M,Bai T,Tsang BK

更新日期：2008-02-01 00:00:00

abstract：:The melanosomal protein TRP2 expressed by melanocytes and most melanoma cells is an attractive, clinically relevant model antigen for the experimental development of melanoma immunotherapy in mice. A peptide shared by murine and human TRP2 can be recognized by melanoma-reactive CTL in C57BL/6 mice, as well as in human...

journal_title：International journal of cancer

authors： Steitz J,Brück J,Steinbrink K,Enk A,Knop J,Tüting T

更新日期：2000-04-01 00:00:00

abstract：:The population of Leningrad suffered from severe starvation, cold and psychological stress during the siege in World War II in 1941-1944. We investigated the long-term effects of the siege on cancer mortality in 3,901 men and 1,429 women, born between 1910 and 1940. All study subjects were residents of St. Petersburg,...

journal_title：International journal of cancer

authors： Koupil I,Plavinskaja S,Parfenova N,Shestov DB,Danziger PD,Vågerö D

更新日期：2009-03-15 00:00:00