[fam-] trastuzumab deruxtecan, antitumor activity is dependent on HER2 expression level rather than on HER2 amplification.

abstract：:More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...

journal_title：International journal of cancer

authors： Jung AY,Hüsing A,Behrens S,Krzykalla J,Obi N,Becher H,Chang-Claude J

更新日期：2021-01-01 00:00:00

abstract：:A new antigan has been revealed by means of antisera against Rauscher virus in mice with Rauscher virus-induced leukemia. This antigen appears to be different from both Rauscher type-specific antigen and MULV-gs-1 (p-30), as shown by studies of electrophoretic mobility and immunochemical specificity. Except in leukemi...

journal_title：International journal of cancer

authors： Ievleva ES,Engelhardt NV,Abelev GI

更新日期：1976-06-15 00:00:00

abstract：:Limited penetration of anticancer drugs through tumour tissue is an important factor that may limit therapeutic effects against solid tumours. Here we report studies of the penetration of radiolabelled methotrexate through multicellular layers (MCL) of murine EMT-6 and human MCF-7 cells grown on semiporous teflon memb...

journal_title：International journal of cancer

authors： Cowan DS,Tannock IF

更新日期：2001-01-01 00:00:00

abstract：:Stem cell-like cells have recently been identified in melanoma cell lines, but their relevance for melanoma pathogenesis is controversial. To characterize the stem cell signature of melanoma, expression of stem cell markers BMI-1 and nestin was studied in 64 cutaneous melanomas, 165 melanoma metastases as well as 53 m...

journal_title：International journal of cancer

authors： Mihic-Probst D,Kuster A,Kilgus S,Bode-Lesniewska B,Ingold-Heppner B,Leung C,Storz M,Seifert B,Marino S,Schraml P,Dummer R,Moch H

更新日期：2007-10-15 00:00:00

abstract：:Anticancer drugs docetaxel and vinorelbine suppress cell growth by altering microtubule assembly and activating the proapoptotic signal pathway. Vinorelbine and docetaxel have been approved for treating several advanced cancers. However, their efficacy in the management of advanced hormone-refractory prostate cancer r...

journal_title：International journal of cancer

authors： Zelivianski S,Spellman M,Kellerman M,Kakitelashvilli V,Zhou XW,Lugo E,Lee MS,Taylor R,Davis TL,Hauke R,Lin MF

更新日期：2003-11-10 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated lymphoepithelioma. The aim of this study was to characterize the homogeneity and distinctness of the T-cell repertoires within and between primary and metastatic NPCs. We used ultra-deep sequencing of the hypervariably rearranged antigen-binding ...

journal_title：International journal of cancer

authors： Chung YL,Wu ML

更新日期：2018-08-01 00:00:00

abstract：:Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12ql3-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathol...

journal_title：International journal of cancer

authors： Mandahl N,Akerman M,Aman P,Dal Cin P,De Wever I,Fletcher CD,Mertens F,Mitelman F,Rosai J,Rydholm A,Sciot R,Tallini G,Van den Berghe H,Van de Ven W,Vanni R,Willén H

更新日期：1996-09-04 00:00:00

abstract：:Human oocytes in different stages of maturation were obtained by follicular aspiration from women given Clomovid and Gonadex. Particles similar to type-C virus were observed in three out of 16 oocytes. The particles were irregularly distributed along the oocyte membrane. They were seen both in a state of budding and l...

journal_title：International journal of cancer

authors： Larsson E,Nilsson BO,Sundström P,Widéhn S

更新日期：1981-11-15 00:00:00

abstract：:Previous studies have reported an association between hot tea drinking and risk of esophageal cancer, but no study has examined this association using prospectively and objectively measured tea drinking temperature. We examined the association of tea drinking temperature, measured both objectively and subjectively at ...

journal_title：International journal of cancer

authors： Islami F,Poustchi H,Pourshams A,Khoshnia M,Gharavi A,Kamangar F,Dawsey SM,Abnet CC,Brennan P,Sheikh M,Sotoudeh M,Nikmanesh A,Merat S,Etemadi A,Nasseri Moghaddam S,Pharoah PD,Ponder BA,Day NE,Jemal A,Boffetta P,Mal

更新日期：2020-01-01 00:00:00

abstract：:Heat shock protein (HSP) gp96/grp94 contains a signal peptide at the amino terminus and a -KDEL sequence at the carboxy terminus and is a major component of the lumen of the mammalian endoplasmic reticulum (ER). We show, by a number of immunolocalization methods using light and electron microscopy, that a significant ...

journal_title：International journal of cancer

authors： Altmeyer A,Maki RG,Feldweg AM,Heike M,Protopopov VP,Masur SK,Srivastava PK

更新日期：1996-08-22 00:00:00

abstract：:T24 human bladder carcinoma cells reveal a high locomotor activity (70% locomoting cells) within a 3-dimensional collagen matrix. This high migratory activity is induced by an autocrine engagement of the interleukin-8 receptor A, as was shown by antibodies neutralizing the secreted interleukin-8. Treatment of the cell...

journal_title：International journal of cancer

authors： Lang K,Niggemann B,Zanker KS,Entschladen F

更新日期：2002-06-10 00:00:00

abstract：:Previously, we have identified aloe-emodin (AE) as a new type of anticancer agent, with activity that is based on apoptotic cell death promoted by a neuroectodermal tumor-specific drug uptake. We attempt to clarify the intracellular target of AE and the apoptosis-signaling pathway activated by AE in neuroblastoma cell...

journal_title：International journal of cancer

authors： Pecere T,Sarinella F,Salata C,Gatto B,Bet A,Dalla Vecchia F,Diaspro A,Carli M,Palumbo M,Palù G

更新日期：2003-10-10 00:00:00

abstract：:The effects on breast cancer mortality seen after 16 years of biennial screening of younger women are assessed in this prospective cohort study. Since 1975 some 13,500 women, aged 35-49 in 1975, were invited to participate in the Nijmegen screening programme comprising a mammographic examination every 2 years. By the ...

journal_title：International journal of cancer

authors： Peer PG,Werre JM,Mravunac M,Hendriks JH,Holland R,Verbeek AL

更新日期：1995-03-16 00:00:00

abstract：:In a series of 135 patients with renal-cell carcinomas (followed up for a mean of 9.5 years), a variety of clinical and histological factors were analyzed in relation to morphometric measurements of the nuclear parameters in the primary tumours to establish their value as prognostic factors. Clinical, histological and...

journal_title：International journal of cancer

authors： Eskelinen M,Lipponen P,Aitto-Oja L,Hall O,Syrjänen K

更新日期：1993-10-21 00:00:00

abstract：:The underlying molecular mechanisms involved in the pathogenesis of endometrial cancer (EC) are still not well understood. Our goal was to investigate the composition of the endometrial microbiota and the association with inflammatory cytokines in EC. Endometrial microbiota profiles of women with EC (n = 25) and benig...

journal_title：International journal of cancer

authors： Lu W,He F,Lin Z,Liu S,Tang L,Huang Y,Hu Z

更新日期：2020-12-07 00:00:00

abstract：:Although aneuploidy is commonly observed in human cancers, the molecular mechanism underlying aneuploidization remains unclear. We used multiploid cancer model that had diploid and aneuploid cancer cells within the same cancerous tissue and attempted to detect specific epigenetic alterations associated with tumor cell...

journal_title：International journal of cancer

authors： Habano W,Sugai T,Jiao YF,Nakamura S

更新日期：2007-10-01 00:00:00

abstract：:Two groups of rabbits were inoculated on the day of birth or at 4 weeks of age with a human T-cell leukemia virus type-I (HTLV-I)-infected and transformed rabbit cell line (Ra-I). Rabbits seroconverted to HTLV-I, as determined by indirect immunofluorescence, by 3 weeks after inoculation and remained persistently serop...

journal_title：International journal of cancer

authors： Cockerell GL,Lairmore M,De B,Rovnak J,Hartley TM,Miyoshi I

更新日期：1990-01-15 00:00:00

abstract：:Microtubule-targeted drugs are now indispensable for the therapy of various cancer types worldwide. In this article, we report MT119 [6-[2-(4-methoxyphenyl) -ethyl]-9-[(pyridine-3-ylmethyl)amino]pyrido[2',1':2,3]imida-zo[4,5-c]isoquinolin-5(6H)-one] as a new microtubule-targeted agent. MT119 inhibited tubulin polymeri...

journal_title：International journal of cancer

authors： Zhang Z,Meng T,Yang N,Wang W,Xiong B,Chen Y,Ma L,Shen J,Miao ZH,Ding J

更新日期：2011-07-01 00:00:00

abstract：:Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glio...

journal_title：International journal of cancer

authors： Tsen AR,Long PM,Driscoll HE,Davies MT,Teasdale BA,Penar PL,Pendlebury WW,Spees JL,Lawler SE,Viapiano MS,Jaworski DM

更新日期：2014-03-15 00:00:00

abstract：:Human B- or T-cell lymphoma lines and primary murine lymphomas were treated with DNA oligonucleotides homologous to the telomere (TTAGGG repeat; "T-oligo"), either alone or in combination with standard, widely-used anticancer chemotherapeutic agents. T-oligo induces cell cycle arrest and apoptosis in cultured human or...

journal_title：International journal of cancer

authors： Longe HO,Romesser PB,Rankin AM,Faller DV,Eller MS,Gilchrest BA,Denis GV

更新日期：2009-01-15 00:00:00

abstract：:Murine mammary aplastic carcinoma, when it is passed from one alloxan-diabetic animal to another, after several passages becomes conditioned to hypoinsulinemia by secreting its own substance(s) immunologically cross-reactive with insulin (SICRI). Although not cytotoxic, the total daily dose of 2.5 mg of synthetic line...

journal_title：International journal of cancer

authors： Vuk-Pavlović S,Bozikov V,Pavelić K

更新日期：1982-06-15 00:00:00

abstract：:Actin, a highly conserved protein comprising cell stress fibers and other cellular structures, is found in both the cytoplasm and nucleus of cells and responds to both epigenetic signals and altered gene expression occurring during tumorigenesis. We have previously shown that changes in the cytoplasmic F- and G-actin ...

journal_title：International journal of cancer

authors： Rao JY,Bonner RB,Hurst RE,Liang YY,Reznikoff CA,Hemstreet GP 3rd

更新日期：1997-02-07 00:00:00

abstract：:A challenging task of the immune system is to fight cancer cells. However, a variety of human cancers educate immune cells to become tumor supportive. This is exemplified for tumor-associated macrophages (TAMs), which are polarized towards an anti-inflammatory and cancer promoting phenotype. Mechanistic explanations, ...

journal_title：International journal of cancer

authors： Weigert A,Schiffmann S,Sekar D,Ley S,Menrad H,Werno C,Grosch S,Geisslinger G,Brüne B

更新日期：2009-11-01 00:00:00

abstract：:The objective of this study was to assess the utility of a second generation human papillomavirus (HPV) virus-like particle (VLP)-based ELISA as an adjunct to HPV DNA testing to identify women at risk for high-grade cervical intraepithelial neoplasia (CIN). Participants provided blood, cervical samples and interviewer...

journal_title：International journal of cancer

authors： Einstein MH,Studentsov YY,Ho GY,Fazzari M,Marks M,Kadish AS,Goldberg GL,Runowicz CD,Burk RD

更新日期：2007-01-01 00:00:00

abstract：:The distribution of oestradiol in plasma from postmenopausal women with or without breast cancer has been measured and related to the metabolic clearance rates of oestradiol (MCR-E2). All measurements were carried out preoperatively. No difference in the free fraction of oestradiol was found between women with breast ...

journal_title：International journal of cancer

authors： Reed MJ,Beranek PA,Cheng RW,Ghilchik MW,James VH

更新日期：1985-04-15 00:00:00

abstract：:The c-KIT protooncogene encodes a tyrosine kinase receptor, KIT, that is expressed in many normal and cancerous tissues. In this study, we have examined the expression of c-KIT and its ligand, stem cell factor (SCF), in human epithelial ovarian tumors, in normal ovaries and in cultured ovarian surface epithelium (OSE)...

journal_title：International journal of cancer

authors： Tonary AM,Macdonald EA,Faught W,Senterman MK,Vanderhyden BC

更新日期：2000-05-20 00:00:00

abstract：:A panel of monoclonal antibodies (MAbs) has been obtained, directed against determinants of normal human colorectal epithelium. BALB/c mice were immunized and boosted with mucosal scrapings and cell membrane preparations from normal large intestine. In one case boosting was also performed with HT29 colon carcinoma cel...

journal_title：International journal of cancer

authors： Richman PI,Bodmer WF

更新日期：1987-03-15 00:00:00

abstract：:Benzene is considered a carcinogen, mostly based on evidence of causality for myeloid leukemia from high levels of exposure in occupational studies. We used United States Environmental Protection Agency National Ambient Toxics Assessment (NATA) estimates of low-level ambient benzene to examine potential associations f...

journal_title：International journal of cancer

authors： Teras LR,Diver WR,Deubler EL,Krewski D,Flowers CR,Switchenko JM,Gapstur SM

更新日期：2019-11-15 00:00:00

abstract：:FTY720, a derivative of fungus, has demonstrated dramatic anticancer effect in several malignancies recently. Our study evaluates the therapeutic potential of FTY720 in the treatment of androgen-independent prostate cancer using a human prostate cancer xenograft in nude mice. CWR22R, an androgen-independent human pros...

journal_title：International journal of cancer

authors： Chua CW,Lee DT,Ling MT,Zhou C,Man K,Ho J,Chan FL,Wang X,Wong YC

更新日期：2005-12-20 00:00:00

abstract：:Seventy to 40% of K-RAS wild type colorectal tumors does not seem to benefit from treatment with antiepidermal growth factor receptor (anti-EGFR) monoclonal antibodies. Recent data suggested that in presence of IGF-1 system, altered activation colorectal cancer cells may escape anti-EGFR mediated cell death. The inter...

journal_title：International journal of cancer

authors： Scartozzi M,Mandolesi A,Giampieri R,Pierantoni C,Loupakis F,Zaniboni A,Galizia E,Giustini L,Silva RR,Bisonni R,Berardi R,Biagetti S,Menzo S,Falcone A,Bearzi I,Cascinu S

更新日期：2010-10-15 00:00:00