Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase.


:Nitric oxide (NO) and its metabolites are implicated in carcinogenesis and metastasis. Both stimulatory and inhibitory effects of NO have been reported in relation to breast cancer and its role in the development of malignancies and metastasis remains uncertain. We have used the polyomavirus middle T antigen (PyV-mT) targeted to the mouse mammary gland and bred into an inducible NO synthase (iNOS)-deficient C57Bl/6 strain to examine a role for nitric oxide in modulating tumors that develop in the complex environment of the whole animal. The development of hyperplasias was delayed to the extent that the earliest palpable tumors arose 2-4 weeks later in PyV-mT/iNOS(-/-) mice compared with PyV-mT/iNOS(+/+) mice, identifying a role for iNOS in early events in mammary tumor formation. Tumors that did develop in PyV-mT/iNOS(-/-) mice were characteristically well differentiated and had a cribriform pattern. Other tumors were myoepithelial adenocarcinomas with uniform nuclear size. In contrast, mice capable of iNOS activity typically developed solid nodular adenocarcinomas with a high mitotic index and pleomorphic nuclei. No significant effect of iNOS deficiency was found on vascular density in hyperplasias or tumors by examining CD31-positive vessels. The infiltration of lesions by macrophages, cells capable of significant NO production, remained unchanged in PyV-mT/iNOS(-/-) mice. Metastatic potential was retained by PyV-mT-transformed epithelium in the absence of iNOS, indicating that NO production by iNOS is not essential for this process. These results indicate a role for iNOS in tumorigenesis, particularly in the regulation of early events.


Int J Cancer


Ellies LG,Fishman M,Hardison J,Kleeman J,Maglione JE,Manner CK,Cardiff RD,MacLeod CL





Has Abstract


2003-08-10 00:00:00












  • RACK1 regulates Ki-Ras-mediated signaling and morphological transformation of NIH 3T3 cells.

    abstract::Activating Ras mutations are involved in a significant fraction of human tumors. A suppressor screen using a retroviral mouse fibroblast cDNA library was performed to identify novel factors in Ras-mediated transformation. We identified a novel potent inhibitor of Ras-mediated morphological transformation encoded by a ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bjørndal B,Myklebust LM,Rosendal KR,Myromslien FD,Lorens JB,Nolan G,Bruland O,Lillehaug JR

    更新日期:2007-03-01 00:00:00

  • Cigarette smoking, alcohol consumption and primary liver cancer: a case-control study in the USA.

    abstract::Cigarette smoking and alcohol consumption were examined as potential risk factors in a case-control study of primary liver cancer (PLC). A total of 165 PLC cases and 465 matched controls from several US hospitals were studied. A weak but statistically significant (p less than 0.05) dose-response relationship was obser...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yu H,Harris RE,Kabat GC,Wynder EL

    更新日期:1988-09-15 00:00:00

  • Exclusion of BRAFV599E as a melanoma susceptibility mutation.

    abstract::Very recently, BRAF mutations were found in about 2/3 of malignant melanomas and at lower frequencies in other human cancers. The BRAF gene codes for a protein in the mitogen-activated protein kinase (MAPK) pathway. All mutations identified to date are within the kinase domain, with a single missense mutation (V599E) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Meyer P,Klaes R,Schmitt C,Boettger MB,Garbe C

    更新日期:2003-08-10 00:00:00

  • Drug-resistant human bladder-cancer cells are more sensitive to adenovirus-mediated wild-type p53 gene therapy compared to drug-sensitive cells.

    abstract::We investigated the therapeutic potential and molecular mechanism of adenovirus-mediated wt p53 gene therapy for drug-resistant human bladder cancers. KK47, a human bladder-cancer cell line, along with the drug-resistant sublines KK47/DDP10, KK47/DDP20 (cisplatin-resistant) and KK47/ADM (doxorubicin-resistant) were us...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shirakawa T,Sasaki R,Gardner TA,Kao C,Zhang ZJ,Sugimura K,Matsuo M,Kamidono S,Gotoh A

    更新日期:2001-10-15 00:00:00

  • Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC).

    abstract::The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Linseisen J,Rohrmann S,Miller AB,Bueno-de-Mesquita HB,Büchner FL,Vineis P,Agudo A,Gram IT,Janson L,Krogh V,Overvad K,Rasmuson T,Schulz M,Pischon T,Kaaks R,Nieters A,Allen NE,Key TJ,Bingham S,Khaw KT,Amiano P,Bar

    更新日期:2007-09-01 00:00:00

  • Racial/ethnic differences in colorectal cancer risk: the multiethnic cohort study.

    abstract::Incidence rates in the United States show clear racial/ethnic disparities for colorectal cancer. We examined the extent to which ethnic differences in risk factors could explain the age-adjusted variation in the risk of colorectal cancer, overall and by stage at diagnosis, among 165,711 African Americans, Japanese Ame...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ollberding NJ,Nomura AM,Wilkens LR,Henderson BE,Kolonel LN

    更新日期:2011-10-15 00:00:00

  • TPA induction of Epstein-Barr virus early antigens in Raji cells is blocked by selective protein kinase-C inhibitors.

    abstract::We have shown that modulation of intracellular calcium in EBV latently infected cells could induce the expression of viral antigens, and suggested that a protein kinase-C (PKC) may play a major role in the EBV genome activation. We now report further investigations on the role of PKC using 2 selective enzymatic inhibi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lazdins J,Zompetta C,Grimaldi S,Barile G,Venanzoni M,Frati L,Faggioni A

    更新日期:1987-12-15 00:00:00

  • Quality diet indexes and risk of hepatocellular carcinoma: Findings from the Singapore Chinese Health Study.

    abstract::There is limited research on the effect of dietary quality on hepatocellular carcinoma (HCC) risk in populations with relatively high risk of HCC. Using data from Singapore Chinese Health Study, a prospective cohort study, of 63 257 Chinese aged 45 to 74, we assessed four diet-quality index (DQI) scores: the Alternati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Luu HN,Neelakantan N,Geng TT,Wang R,Goh GB,Clemente JC,Jin A,van Dam RM,Jia W,Behari J,Koh WP,Yuan JM

    更新日期:2020-10-31 00:00:00

  • Tissue and serum metabolomic phenotyping for diagnosis and prognosis of hepatocellular carcinoma.

    abstract::More than two-thirds of patients with hepatocellular carcinoma (HCC) cannot receive curative therapy and have poor survival due to late diagnosis and few prognostic directions. In our study, nontargeted and targeted metabolomics analyses were conducted by liquid chromatography-mass spectrometry to characterize metabol...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Han J,Han ML,Xing H,Li ZL,Yuan DY,Wu H,Zhang H,Wang MD,Li C,Liang L,Song YY,Xu AJ,Wu MC,Shen F,Xie Y,Yang T

    更新日期:2020-03-15 00:00:00

  • Growth-inhibitory activity of interferon-beta against human colorectal carcinoma cell lines.

    abstract::Recombinant human interferon beta (rIFN-beta) inhibited in a time- and dose-dependent manner the proliferation of 18/18 human colon carcinoma cell lines in monolayer culture and 8/9 lines in a soft agar assay but had no effect on 4 human fibroblast cell lines. Maximal inhibition of cell proliferation by rIFN-beta requ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wong VL,Rieman DJ,Aronson L,Dalton BJ,Greig R,Anzano MA

    更新日期:1989-03-15 00:00:00

  • In vitro cell-mediated immune reactions of melanoma and colorectal carcinoma patients demonstrated by long-term 51chromium assays.

    abstract::In a series of consecutive 51chromium (51Cr) assays, 21 melanoma and 14 colo-rectal carcinoma patients were tested for their in vitro cell-mediated immune reactions to melanoma, rectal adenocarcinoma, and normal fibroblast target cells. Blood lymphocytes (BL) from four individuals were included in each experiment. In ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Steele G Jr,Sjögren HO,Stadenberg I

    更新日期:1976-01-15 00:00:00

  • Distribution and characterization of alpha hCG in the serum and tumor cytosol of patients with breast cancer.

    abstract::Serum and tumor tissue from breast cancer patients were evaluated for the presence of alpha subunit of hCG, by means of the specific radioimmunoassay. Elevated serum levels occurred in 0/50 (0%) of normal female controls, 1/17 (6%) of patients with benign breast disease, 3/53 (6%) of patients with primary breast cance...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shindelman JE,Ortmeyer AE,Wada HG,Stockdale F,Sussman HH

    更新日期:1980-05-15 00:00:00

  • MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma.

    abstract::Endometrial serous adenocarcinoma (ESC) is aggressive and carries a poor prognosis. p53 is frequently mutated in ESC. microRNAs (miRNAs) are a direct p53 target and have been implicated in cancer cell behavior. In this study, we compared miRNA expression levels in ESC with the levels in endometrial endometrioid adenoc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hiroki E,Suzuki F,Akahira J,Nagase S,Ito K,Sugawara J,Miki Y,Suzuki T,Sasano H,Yaegashi N

    更新日期:2012-08-15 00:00:00

  • Lifetime recreational moderate-to-vigorous physical activity and ovarian cancer risk: A case-control study.

    abstract::Results of epidemiologic studies of physical activity and ovarian cancer risk are inconsistent. Few have attempted to measure physical activity over the lifetime or in specific age windows, which may better capture etiologically relevant exposures. We examined participation in moderate-to-vigorous recreational physica...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Grundy A,Ho V,Abrahamowicz M,Parent MÉ,Siemiatycki J,Arseneau J,Gilbert L,Gotlieb WH,Provencher DM,Koushik A

    更新日期:2020-04-01 00:00:00

  • Proportion of lung cancers in males, due to occupation, in different areas of the USA.

    abstract::Occupational data from 5 case-control studies in the United States involving 2,973 male cases and 3,210 controls were analyzed to estimate the percentage of lung cancer attributable to well-known and suspected lung carcinogens. The studies were conducted in areas heterogeneous in terms of industrial activities. The pe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vineis P,Thomas T,Hayes RB,Blot WJ,Mason TJ,Pickle LW,Correa P,Fontham ET,Schoenberg J

    更新日期:1988-12-15 00:00:00

  • Expression of Epstein-Barr virus latent infection genes and oncogenes in lymphoma cell lines derived from pyothorax-associated lymphoma.

    abstract::Malignant lymphomas frequently develop in the pleural cavity of patients with long-standing pyothorax. The term pyothorax-associated lymphoma (PAL) has been proposed for this type of tumor. Most PALs are diffuse lymphomas of the B-cell type and contain Epstein-Barr virus (EBV) DNA. We have established 2 lymphoma cell ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kanno H,Yasunaga Y,Ohsawa M,Taniwaki M,Iuchi K,Naka N,Torikai K,Shimoyama M,Aozasa K

    更新日期:1996-07-03 00:00:00

  • A prospective, population-based study of 40,000 women regarding host factors, UV exposure and sunbed use in relation to risk and anatomic site of cutaneous melanoma.

    abstract::Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40,000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox reg...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nielsen K,Måsbäck A,Olsson H,Ingvar C

    更新日期:2012-08-01 00:00:00

  • Oncogenesis and classification of mixed-type liposarcoma: a radiological, histopathological and molecular biological analysis.

    abstract::Liposarcomas are separated into clinicopathological entities with a characteristic morphological spectrum and mutually exclusive genetic alterations. Therefore, the rare occurrence of cases with combined patterns of well-differentiated liposarcoma and myxoid liposarcoma designated as mixed-type liposarcoma pose a conc...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: de Vreeze RS,de Jong D,Koops W,Nederlof PM,Ariaens A,Haas RL,van Coevorden F

    更新日期:2011-02-15 00:00:00

  • Detergent extraction and characterization of tumor hemolytic factor from plasma membranes of oncogene transformed fibroblasts.

    abstract::Cancer cells have the capacity to lyse erythrocytes by a cell-contact-requiring phenomenon. Subcellular fractionation procedures have revealed that the hemolytic principle resides in the cancer cell plasma membrane. In this study we report the detergent extraction of a potent hemolytic factor from the plasma membranes...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zucker S,DiMassimo BI,Lysik RM,Vuaridel-Bonanomi E

    更新日期:1991-01-21 00:00:00

  • Laryngeal cancer mortality trends in European countries.

    abstract::After a steady increase between the 1950s and the 1970s, laryngeal cancer mortality has been levelling off since the early 1980s in men from most western and southern European countries and since the early 1990s in central and eastern Europe. To update trends in laryngeal cancer mortality, we analyzed data provided by...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chatenoud L,Garavello W,Pagan E,Bertuccio P,Gallus S,La Vecchia C,Negri E,Bosetti C

    更新日期:2016-02-15 00:00:00

  • Sister chromatid exchange and nasopharyngeal carcinoma.

    abstract::Sister chromatid exchange (SCE) is a genetic indicator of DNA damage in mammalian cells and may afford a sensitive monitor to follow genomic instability of some individuals with fragile chromosomal diseases or malignancies. In studies on the effect of dinitrosopiperazine (DNP), aflatoxin B1 (AFB1), methyl-nitro-nitros...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Li GY,Yao KT,Glaser R

    更新日期:1989-04-15 00:00:00

  • Fowlpox-based survivin vaccination for malignant mesothelioma therapy.

    abstract::Survivin protein is an attractive candidate for cancer immunotherapy since it is abundantly expressed in most common human cancers and mostly absent in normal adult tissues. Malignant mesothelioma (MM) is a deadly cancer associated with asbestos or erionite exposure for which no successful therapies are currently avai...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bertino P,Panigada M,Soprana E,Bianchi V,Bertilaccio S,Sanvito F,Rose AH,Yang H,Gaudino G,Hoffmann PR,Siccardi A,Carbone M

    更新日期:2013-08-01 00:00:00

  • In vivo growth inhibition of L1210 leukemia by 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), a new inhibitor of S-adenosylmethionine decarboxylase.

    abstract::We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A). L1210-bearing DBA-2 mice were treated with increasing CGP 48664A doses from 1 day after i.p. L1210 cell inoculation. Treatment was continued for 4 days, after w...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dorhout B,Te Velde RJ,Ferwerda H,Kingma AW,De Hoog E,Muskiet FA

    更新日期:1995-04-10 00:00:00

  • Prospective study on the role of glucose metabolism in breast cancer occurrence.

    abstract::High circulating glucose, insulin resistance and obesity appear to be associated with increased risk of breast cancer (BC). We sought further insight into the relation of these variables to BC. We assessed associations of BC risk with serum fasting glucose, insulin, homeostasis model assessment-insulin resistance (HOM...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sieri S,Muti P,Claudia A,Berrino F,Pala V,Grioni S,Abagnato CA,Blandino G,Contiero P,Schunemann HJ,Krogh V

    更新日期:2012-02-15 00:00:00

  • A population based cohort study of patients with multiple colon and endometrial cancer: correlation of microsatellite instability (MSI) status, age at diagnosis and cancer risk.

    abstract::Hereditary non-polyposis colorectal cancer, HNPCC, is an autosomal dominant condition predisposing to cancers of primarily the colorectum and the endometrium. The aim of our study was to identify persons at a high risk of hereditary colorectal cancer and to estimate their risk of colon and other HNPCC-associated tumou...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cederquist K,Golovleva I,Emanuelsson M,Stenling R,Grönberg H

    更新日期:2001-02-15 00:00:00

  • The growth inhibitory effect of actein on human breast cancer cells is associated with activation of stress response pathways.

    abstract::Previous studies indicate that the triterpene glycoside actein from the herb black cohosh inhibits growth of human breast cancer cells. This study seeks to identify genes altered in human breast cancer cells by treatment with actein, using gene expression analysis. We treated MDA-MB-453 human breast cancer cells with ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Einbond LS,Su T,Wu HA,Friedman R,Wang X,Ramirez A,Kronenberg F,Weinstein IB

    更新日期:2007-11-01 00:00:00

  • DNA methylation age as a biomarker for cancer.

    abstract::Cancer is well established as an age-associated disease, and there is substantial overlap in the molecular, cellular and physiological changes observed with both ageing and the progression of cancer. Age-specific declines in resilience mechanisms such as DNA repair or epigenetic maintenance may contribute to the devel...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Lau CE,Robinson O

    更新日期:2021-01-04 00:00:00

  • Characteristic patterns of HOX gene expression in different types of human leukemia.

    abstract::Homeobox-containing genes are a network of genes encoding DNA-binding proteins highly conserved throughout evolution. They are involved in the control of normal development as well as in the regulation of gene expression in adult differentiating systems, including hematopoiesis. Aberrant expression of homeobox-contain...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Celetti A,Barba P,Cillo C,Rotoli B,Boncinelli E,Magli MC

    更新日期:1993-01-21 00:00:00

  • Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase.

    abstract::Allelic loss at the short arm of chromosome 11 is one of the most common and potent events in the progression and metastasis of breast cancer. Here, we present evidence that the Integrin-Linked Kinase (ILK) gene maps to the commonly deleted chromosome 11p15.5 and suppresses malignant growth of human breast cancer cell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen P,Shen WZ,Karnik P

    更新日期:2004-10-10 00:00:00

  • Antitumor activity of IL-2/anti-IL-2 mAb immunocomplexes exerts synergism with that of N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugate due to its low immunosuppressive activity.

    abstract::Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tomala J,Chmelova H,Strohalm J,Ulbrich K,Sirova M,Rihova B,Kovar M

    更新日期:2011-10-15 00:00:00