Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase.

abstract：:An immunopotentiating factor associated with spleen cells of C57BL/6J mice bearing the 3LL tumor is described. Supernatants of cultured spleen cells from tumor-bearing mice (TBM) augmented the generation of both 19S and 7S antibody-producing cells, when injected with sheep erythrocytes into syngeneic C57BL/6J mice. Th...

journal_title：International journal of cancer

authors： Isakov N,Segal S,Hollander N,Feldman M

更新日期：1978-10-15 00:00:00

abstract：:Melanoma is the most lethal human skin cancer. If metastatic, it becomes very aggressive and resistant to standard modalities of anticancer treatment. During the last 10 years, several therapeutic strategies have been tested including the use of single and combined small drugs. Experimental results indicate that RAS a...

journal_title：International journal of cancer

authors： López-Fauqued M,Gil R,Grueso J,Hernandez-Losa J,Pujol A,Moliné T,Recio JA

更新日期：2010-04-01 00:00:00

abstract：:Using high-throughput analyses and the TRANSFAC database, we characterized TF signatures of head and neck squamous cell carcinoma (HNSCC) subgroups by inferential analysis of target gene expression, correcting for the effects of DNA methylation and copy number. Using this discovery pipeline, we determined that human p...

journal_title：International journal of cancer

authors： Gaykalova DA,Manola JB,Ozawa H,Zizkova V,Morton K,Bishop JA,Sharma R,Zhang C,Michailidi C,Considine M,Tan M,Fertig EJ,Hennessey PT,Ahn J,Koch WM,Westra WH,Khan Z,Chung CH,Ochs MF,Califano JA

更新日期：2015-10-15 00:00:00

abstract：:Experimental and epidemiological data support a role for sex steroid hormones in the pathogenesis of endometrial cancer. The associations of pre-diagnostic blood concentrations of estradiol, estrone, testosterone, androstenedione, DHEAS and SHBG with endometrial cancer risk were investigated. A case-control study was ...

journal_title：International journal of cancer

authors： Lukanova A,Lundin E,Micheli A,Arslan A,Ferrari P,Rinaldi S,Krogh V,Lenner P,Shore RE,Biessy C,Muti P,Riboli E,Koenig KL,Levitz M,Stattin P,Berrino F,Hallmans G,Kaaks R,Toniolo P,Zeleniuch-Jacquotte A

更新日期：2004-01-20 00:00:00

abstract：:Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...

journal_title：International journal of cancer

authors： Dai C,Zhang B,Liu X,Guo K,Ma S,Cai F,Yang Y,Yao Y,Feng M,Bao X,Deng K,Jiao Y,Wei Z,Junji W,Xing B,Lian W,Wang R

更新日期：2013-10-15 00:00:00

abstract：:A randomized clinical trial designed to compare the effectiveness of cytoxan (CTX) alone versus a combination consisting of CTX, vincristine (Oncovin) and methotrexate (COM) in the treatment of Burkitt's lymphoma (BL) was carried out. Nineteen patients were selected at random to receive CTX alone while 21 received COM...

journal_title：International journal of cancer

authors： Olweny CL,Katongole-Mbidde E,Kaddu-Mukasa A,Atine I,Owor R,Lwanga S,Carswell W,Magrath IT

更新日期：1976-04-15 00:00:00

abstract：:Risks of 2nd primary cancer were assessed in all patients with cutaneous melanoma (12,460) and all patients with ocular melanoma (2,018) incident in Denmark from 1943 to 1989 and followed for totals of 88,667 person-years and 16,045 person-years, respectively. After cutaneous melanoma, 972 2nd cancers occurred. The ri...

journal_title：International journal of cancer

authors： Swerdlow AJ,Storm HH,Sasieni PD

更新日期：1995-06-09 00:00:00

abstract：:Angiogenesis in pancreatic ductal adenocarcinomas depends on the presence of angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and is thought to be stimulated by hypoxia. We tested the angiogenic potential of 9 cell lines of pancreatic ductal carcinoma origi...

journal_title：International journal of cancer

authors： Sipos B,Weber D,Ungefroren H,Kalthoff H,Zühlsdorff A,Luther C,Török V,Klöppel G

更新日期：2002-12-20 00:00:00

abstract：:From an assessment of the presence of a junctional component in 8,380 pigmented naevi, and histological review of its extent and the presence of inflammation and regression in a sample of 216 junctional and compound naevi, it was determined that naevi excised in summer were more likely to have a junctional component a...

journal_title：International journal of cancer

authors： Holman CD,Heenan PJ,Caruso V,Glancy RJ,Armstrong BK

更新日期：1983-02-15 00:00:00

abstract：:Breast cancer is one of the most common and feared cancers faced by women. The prognosis of patients with advanced or recurrent breast cancer remains poor despite refinements in multimodality therapies involving chemotherapeutic and hormonal agents. Multimodal therapy with more specific and effective strategy is urgen...

journal_title：International journal of cancer

authors： Tan G,Kasuya H,Sahin TT,Yamamura K,Wu Z,Koide Y,Hotta Y,Shikano T,Yamada S,Kanzaki A,Fujii T,Sugimoto H,Nomoto S,Nishikawa Y,Tanaka M,Tsurumaru N,Kuwahara T,Fukuda S,Ichinose T,Kikumori T,Takeda S,Nakao A,Kode

更新日期：2015-04-01 00:00:00

abstract：:A panel of human breast cancer specimens was examined for single base change mutations by DNA sequencing and for larger deletions using a PCR-based assay. In the cancer specimens examined, no sequencing variants were detected other than a previously characterized polymorphism. Although most of the specimens contained ...

journal_title：International journal of cancer

authors： Anandappa SY,Sibson R,Platt-Higgins A,Winstanley JH,Rudland PS,Barraclough R

更新日期：2000-10-15 00:00:00

abstract：:A previously published case-control study of agricultural risk factors involved male cases of non-Hodgkin's lymphoma registered under code 202 of the International Classification of Diseases (ICD). This study has been expanded with the inclusion of cases registered under ICD code 200, and additional controls. The expa...

journal_title：International journal of cancer

authors： Pearce NE,Sheppard RA,Smith AH,Teague CA

更新日期：1987-02-15 00:00:00

abstract：:Expression of the MDR1 (P-glycoprotein) gene confers resistance to several classes of chemotherapeutic drugs (multi-drug resistance). Colon carcinomas frequently express high levels of MDR1 mRNA and P-glycoprotein, presumably reflecting the origin of these tumors from MDR1-expressing normal colonic cells. In 4 colon c...

journal_title：International journal of cancer

authors： Frommel TO,Coon JS,Tsuruo T,Roninson IB

更新日期：1993-09-09 00:00:00

abstract：:Four human colon cancer cell lines (SW620, LS 180, DLD-I, and HCT-15) and Adriamycin-resistant sub-lines with varying degrees of P-glycoprotein expression were studied to evaluate the reversibility of Adriamycin resistance in human colon cancer. Two groups of cell lines were studied. In the first, including a series o...

journal_title：International journal of cancer

authors： Lai GM,Chen YN,Mickley LA,Fojo AT,Bates SE

更新日期：1991-11-11 00:00:00

abstract：:DNA synthesis in heterokaryons of mouse peritoneal macrophages and various proliferating cultured cells was analyzed. Macrophages did not inhibit replication in the nuclei of non-immortalized and spontaneously immortalized cells (rat fibroblasts and macrophages, mouse pre-macrophages, NIH3T3 cells). On the contrary, t...

journal_title：International journal of cancer

authors： Prudovsky IA,Gumeniuk RR,Yegorov YE,Zelenin AV

更新日期：1989-12-15 00:00:00

abstract：:The relationship between breast cancer and radiation treatment for cervical cancer was evaluated in an international study of 953 women who subsequently developed breast cancer and 1,806 matched controls. Radiation doses to the breast (average 0.31 Gy) and ovaries (average 32 Gy) were reconstructed for exposed subject...

journal_title：International journal of cancer

authors： Boice JD Jr,Blettner M,Kleinerman RA,Engholm G,Stovall M,Lisco H,Austin DF,Bosch A,Harlan L,Krementz ET,Latouret HB,Merril JA,Petters LJ,Schulz MD,Wactawski J,Storm HH,Björkholm E,Pettersson F,Bell CM,Coleman MP,F

更新日期：1989-07-15 00:00:00

abstract：:MicroRNA-9-1(miR-9-1) plays an important role in the mechanism that regulates the lineage fate of differentiating hematopoietic cells. Recent studies have shown that miR-9-1 is downregulated in t (8; 21) AML. However, the pathogenic mechanisms underlying miR-9-1 downregulation and the RUNX1-RUNX1T1 fusion protein, gen...

journal_title：International journal of cancer

authors： Fu L,Shi J,Liu A,Zhou L,Jiang M,Fu H,Xu K,Li D,Deng A,Zhang Q,Pang Y,Guo Y,Hu K,Zhou J,Wang Y,Huang W,Jing Y,Dou L,Wang L,Xu K,Ke X,Nervi C,Li Y,Yu L

更新日期：2017-02-01 00:00:00

abstract：:Inbred rats were hyper-immunised against a syngeneic transplanted mammary carcinoma, Sp4, which originally arose spontaneously in a breeding female. Spleen cells from Sp4-immune rats were fused with P3-NSI-Ag4 mouse myeloma cells, and supernatants from the hybrid progeny were screened for antibody reacting with Sp4 ce...

journal_title：International journal of cancer

authors： Gunn B,Embleton MJ,Middle JG,Baldwin RW

更新日期：1980-09-15 00:00:00

abstract：:Serum samples from feral populations of African green monkeys (Cercopithecus aethiops) were screened for antibodies to the simian T-lymphotropic virus, type I (STLV-I). Blood samples had been collected from 336 monkeys in 4 regions of central and southern Kenya in 1978 and 1979, from 114 monkeys in central Ethiopia in...

journal_title：International journal of cancer

authors： Dracopoli NC,Turner TR,Else JG,Jolly CJ,Anthony R,Gallo RC,Saxinger WC

更新日期：1986-10-15 00:00:00

abstract：:Wilms' tumor development, like most tumors, involves multiple genetic alterations affecting diverse genes. Only one of these has thus far been identified, the Wilms' tumor 1 (WT1) gene on 11p13, which functions as a tumor suppressor gene. We assessed the involvement of the WT1 gene constitutionally and somatically in ...

journal_title：International journal of cancer

authors： Nordenskjöld A,Friedman E,Sandstedt B,Söderhäll S,Anvret M

更新日期：1995-11-15 00:00:00

abstract：:Malignant lymphomas frequently develop in the pleural cavity of patients with long-standing pyothorax. The term pyothorax-associated lymphoma (PAL) has been proposed for this type of tumor. Most PALs are diffuse lymphomas of the B-cell type and contain Epstein-Barr virus (EBV) DNA. We have established 2 lymphoma cell ...

journal_title：International journal of cancer

authors： Kanno H,Yasunaga Y,Ohsawa M,Taniwaki M,Iuchi K,Naka N,Torikai K,Shimoyama M,Aozasa K

更新日期：1996-07-03 00:00:00

abstract：:A case-control study involving interviews with 227 lung-cancer cases and 227 matched hospital controls was conducted in Heilongjiang Province in northeast China to examine the influence of dietary factors on the risk of developing lung cancer. Lung-cancer cases were all incident cases judged to be suitable candidates ...

journal_title：International journal of cancer

authors： Hu J,Johnson KC,Mao Y,Xu T,Lin Q,Wang C,Zhao F,Wang G,Chen Y,Yang Y

更新日期：1997-06-11 00:00:00

abstract：:Increasing use of heavy ions for cancer therapy and concerns from exposure to heavy charged particles in space necessitate the study of the basic biological mechanisms associated with exposure to heavy ions. As the most critical damage induced by ionizing radiation is DNA double strand break (DSB), this review focuses...

journal_title：International journal of cancer

authors： Okayasu R

更新日期：2012-03-01 00:00:00

abstract：:Very late antigen-4 (VLA-4) composed of alpha 4 and beta 1, a member of the beta 1-integrin subfamily, facilitates cell-to-cell interaction with vascular cell-adhesion molecule-1 (VCAM-1) on endothelial cells (EC). Attachment of blood-borne tumor cells to EC is a crucial step for hematogenous metastasis, and VLA-4-pos...

journal_title：International journal of cancer

authors： Tomita Y,Saito T,Saito K,Oite T,Shimizu F,Sato S

更新日期：1995-03-16 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) inhibits epithelial cell proliferation. Inactivation of the TGF-beta signaling pathway is thought to play a role in tumorigenesis. Our purpose was to clarify the correlation between TGF-beta receptors or TGF-beta 1 expression and the clinicopathologic characteristics of patie...

journal_title：International journal of cancer

authors： Fukai Y,Fukuchi M,Masuda N,Osawa H,Kato H,Nakajima T,Kuwano H

更新日期：2003-03-20 00:00:00

abstract：:By means of a chemical extraction procedure and confocal laser scanning microscopy, we investigated the kinetic patterns of uptake and biolocalization of 5-aminolevulinic acid (ALA)-induced porphyrins in s.c. transplanted tumors, adjacent normal skin and muscle, and liver of mice bearing mammary carcinoma, after i.p. ...

journal_title：International journal of cancer

authors： Peng Q,Moan J,Warloe T,Nesland JM,Rimington C

更新日期：1992-09-30 00:00:00

abstract：:To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Can...

journal_title：International journal of cancer

authors： Saberi Hosnijeh F,Casabonne D,Nieters A,Solans M,Naudin S,Ferrari P,Mckay JD,Benavente Y,Weiderpass E,Freisling H,Severi G,Boutron Ruault MC,Besson C,Agnoli C,Masala G,Sacerdote C,Tumino R,Huerta JM,Amiano P,Rodrigu

更新日期：2020-10-31 00:00:00

abstract：:The hepatitis B virus (HBV) is a major causative agent of chronic liver disease and subsequent liver cirrhosis worldwide. The reduced sensitivity of virus-infected liver cells to apoptosis may play a role in the failure to remove virus-infected cells and eventually promote viral chronicity. The purpose of our study wa...

journal_title：International journal of cancer

authors： Barreiros AP,Sprinzl M,Rosset S,Höhler T,Otto G,Theobald M,Galle PR,Strand D,Strand S

更新日期：2009-01-01 00:00:00

abstract：:Claudin7 (cld7) is a cancer-initiating cell (CIC) marker in gastrointestinal tumors, a cld7-knockdown (kd) being accompanied by loss of tumor progression. Tumor exosomes (TEX) restoring CIC activities, we explored the contribution of cld7. This became particularly interesting, as tight junction (TJ)- and glycolipid-en...

journal_title：International journal of cancer

authors： Kyuno D,Zhao K,Schnölzer M,Provaznik J,Hackert T,Zöller M

更新日期：2019-10-15 00:00:00

abstract：:A carcinogen-induced premalignant oral lesion model that progresses to oral cancer was used to examine the impact of blocking PD-1 on cytokine expression and on progression of lesions to cancer. The results of this study show increased production of IL-2 and the inflammatory cytokines IL-6, IL-17 and TNF-α by spleen c...

journal_title：International journal of cancer

authors： Levingston CA,Young MR

更新日期：2017-04-01 00:00:00