当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CANCER期刊下所有文献 > Radiation dose and breast cancer risk in patients treated for cancer of the cervix.

Radiation dose and breast cancer risk in patients treated for cancer of the cervix.

Abstract：

:The relationship between breast cancer and radiation treatment for cervical cancer was evaluated in an international study of 953 women who subsequently developed breast cancer and 1,806 matched controls. Radiation doses to the breast (average 0.31 Gy) and ovaries (average 32 Gy) were reconstructed for exposed subjects on the basis of their original radiotherapy records. Overall, 88% of the breast cancer cases and 89% of the controls received radiation treatment [relative risk (RR) = 0.88; 95% confidence interval (CI) = 0.7-1.2]. Among women with intact ovaries (561 cases, 1,037 controls), radiotherapy was linked to a significant 35% reduction in breast cancer risk, attributable in all likelihood to the cessation of ovarian function. Ovarian doses of 6 Gy were sufficient to reduce breast cancer risk but larger doses did not reduce risk further. This saturation-type response is probably due to the killing of a critical number of ovarian cells. Cervical cancer patients without ovaries (145 cases, 284 controls) were analyzed separately because such women are at especially low natural risk for breast cancer development. In theory, any effect of low-dose breast exposure, received incidentally during treatment for cervical cancer, should be more readily detectable. Among women without ovaries, there was a slight increase in breast cancer risk (RR = 1.07; 95% CI = 0.6-2.0), and a suggestion of a dose response with the RR being 1.0, 0.7, 1.5 and 3.1 for breast doses of 0, 0.01-0.24, 0.25-0.49 and 0.50+ Gy, respectively. However, this trend of increasing RR was not statistically significant. If low-dose radiation increases the risk of breast cancer among women over age 40 years, it appears that the risk is much lower than would be predicted from studies of younger women exposed to higher doses.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Boice JD Jr,Blettner M,Kleinerman RA,Engholm G,Stovall M,Lisco H,Austin DF,Bosch A,Harlan L,Krementz ET,Latouret HB,Merril JA,Petters LJ,Schulz MD,Wactawski J,Storm HH,Björkholm E,Pettersson F,Bell CM,Coleman MP,F

doi

10.1002/ijc.2910440103

subject

Has Abstract

pub_date

1989-07-15 00:00:00

pages

7-16

issue

eissn

0020-7136

issn

1097-0215

journal_volume

pub_type

杂志文章

在线工具

Radiation dose and breast cancer risk in patients treated for cancer of the cervix.