Dietary antioxidants and risk of Barrett's esophagus and adenocarcinoma of the esophagus in an Australian population.

abstract：:G-protein-coupled receptor (GPCR)-stimulated androgen-independent activation of androgen receptor (AR) contributes to acquisition of a hormone-refractory phenotype by prostate cancer. We previously reported that regulator of G-protein signaling (RGS) 2, an inhibitor of GPCRs, inhibits androgen-independent AR activatio...

journal_title：International journal of cancer

authors： Wolff DW,Xie Y,Deng C,Gatalica Z,Yang M,Wang B,Wang J,Lin MF,Abel PW,Tu Y

更新日期：2012-04-01 00:00:00

abstract：:Many tumors are impervious to anticancer agents. Resistance due to lack of cytotoxic penetration into the tumor is often overlooked but can play a significant role in undermining therapy. Insufficient and irregular vascularization of tumors is a possible barrier to drug delivery, but there are others, e.g., impaired v...

journal_title：International journal of cancer

authors： Wildiers H,Guetens G,de Boeck G,Landuyt W,Verbeken E,Highley M,de Bruijn EA,van Oosterom AT

更新日期：2002-06-01 00:00:00

abstract：:In a retrospective analysis of 203 patients with small cell lung cancer (SCLC), we examined the prognostic value of c-kit expression on survival. Expression of c-kit was examined immunohistochemically in formalin-fixed, paraffin-embedded tissue sections. c-kit was observed in 87.7% of SCLC tumors. Using the Kaplan-Mei...

journal_title：International journal of cancer

authors： Rohr UP,Rehfeld N,Pflugfelder L,Geddert H,Müller W,Steidl U,Fenk R,Gräf T,Schott M,Thiele KP,Gabbert HE,Germing U,Kronenwett R,Haas R

更新日期：2004-08-20 00:00:00

abstract：:Allelic losses on the chromosome arms 1p and 19q have been associated with favorable response to chemotherapy and good prognosis in anaplastic oligodendroglioma patients, but the molecular mechanisms responsible for this relationship are as yet unknown. The DNA repair enzyme O(6)-methylguanine DNA methyltransferase (M...

journal_title：International journal of cancer

authors： Möllemann M,Wolter M,Felsberg J,Collins VP,Reifenberger G

更新日期：2005-01-20 00:00:00

abstract：:A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells in normal epitheli...

journal_title：International journal of cancer

authors： Zhang Y,Hiraishi Y,Wang H,Sumi KS,Hayashido Y,Toratani S,Kan M,Sato JD,Okamoto T

更新日期：2005-10-20 00:00:00

abstract：:Studies of the MLTI were performed in a primary MSV-induced tumor system. Reactivity against mitomycin-C-treated RBL-5 cells could be detected during a limited period at about 14 days after virus injection. The degree of reactivity of MSV 14 spleen cells was quite variable; stimulation indices ranged from 2.2 to 9.4. ...

journal_title：International journal of cancer

authors： Kirchner H,Glaser M,Holden HT,Herberman RB

更新日期：1976-03-15 00:00:00

abstract：:A subgroup of head and neck squamous cell carcinomas (HNSCCs) contains high-risk human papillomavirus-type 16 (HPV16). The viral E6 and E7 oncoproteins inactivate the p53 and pRb proteins, respectively. We examined the causative effect of HPV16 E6 and E7 expression on the immortalization of normal oral keratinocytes (...

journal_title：International journal of cancer

authors： Smeets SJ,van der Plas M,Schaaij-Visser TB,van Veen EA,van Meerloo J,Braakhuis BJ,Steenbergen RD,Brakenhoff RH

更新日期：2011-04-01 00:00:00

abstract：:A new permanent cell line (GRU-1) derived from the lymph-node metastasis of a human epithelioid sarcoma was established in tissue culture. Immunohistochemically, the original tumor had exhibited an intriguing potential for multidirectional differentiation with features of mesenchymal, epithelial and neural differentia...

journal_title：International journal of cancer

authors： Gerharz CD,Moll R,Ramp U,Mellin W,Gabbert HE

更新日期：1990-01-15 00:00:00

abstract：:We performed post-mortem studies of oesophageal mucosa from 513 consecutive autopsies of cases who died from unnatural causes or from diseases not related to the oesophagus. Of these, 170 cases were rural blacks from endemic high-risk areas, 98 were urban blacks at high risk, 158 were coloureds at moderate risk and 87...

journal_title：International journal of cancer

authors： Jaskiewicz K,Banach L,Mafungo V,Knobel GJ

更新日期：1992-01-02 00:00:00

abstract：:Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. Although the results of case-control studies indicate that circulating 25-hydroxyvitamin D [25(OH)D] is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case-c...

journal_title：International journal of cancer

authors： Kühn T,Kaaks R,Becker S,Eomois PP,Clavel-Chapelon F,Kvaskoff M,Dossus L,Tjønneland A,Olsen A,Overvad K,Chang-Claude J,Lukanova A,Buijsse B,Boeing H,Trichopoulou A,Lagiou P,Bamia C,Masala G,Krogh V,Sacerdote C,Tumi

更新日期：2013-10-01 00:00:00

abstract：:Non-small-cell lung cancers (NSCLC) are often infiltrated by T lymphocytes. It is postulated that the presence of tumor-infiltrating lymphocytes (TIL) reflects a local host immune response against autologous tumors. To identify the nature of NSCLC TIL, we have characterized the molecular structure of the TCRbeta chain...

journal_title：International journal of cancer

authors： Echchakir H,Asselin-Paturel C,Dorothee G,Vergnon I,Grunenwald D,Chouaib S,Mami-Chouaib F

更新日期：1999-04-12 00:00:00

abstract：:Malignant mesothelioma of the pleura (MPM) is a highly aggressive neoplasm with a poor prognosis and limited treatment options. A better understanding of its pathogenesis is essential to developing alternative therapeutic strategies. We previously demonstrated that the Wnt signaling pathway is activated in MPM through...

journal_title：International journal of cancer

authors： Mazieres J,You L,He B,Xu Z,Twogood S,Lee AY,Reguart N,Batra S,Mikami I,Jablons DM

更新日期：2005-11-01 00:00:00

abstract：:High-grade serous epithelial ovarian cancer (HGS-EOC) is a systemic disease, with marked intra and interpatient tumor heterogeneity. The issue of spatial and temporal heterogeneity has long been overlooked, hampering the possibility to identify those genomic alterations that persist, before and after therapy, in the g...

journal_title：International journal of cancer

authors： Ballabio S,Craparotta I,Paracchini L,Mannarino L,Corso S,Pezzotta MG,Vescio M,Fruscio R,Romualdi C,Dainese E,Ceppi L,Calura E,Pileggi S,Siravegna G,Pattini L,Martini P,Delle Marchette M,Mangioni C,Ardizzoia A,Pelleg

更新日期：2019-11-15 00:00:00

abstract：:A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "s...

journal_title：International journal of cancer

authors： Yao QY,Rickinson AB,Epstein MA

更新日期：1985-01-15 00:00:00

abstract：:Oncogenic activation of MYC occurs often in breast carcinoma and is associated with poor prognosis. Loss or inactivation of mechanisms that restrain MYC may therefore be involved in tumor progression. In this study, we show that the MYC-interacting adaptor protein BIN1 is frequently missing in malignant breast cells a...

journal_title：International journal of cancer

authors： Ge K,Duhadaway J,Sakamuro D,Wechsler-Reya R,Reynolds C,Prendergast GC

更新日期：2000-02-01 00:00:00

abstract：:In vitro infection of EBV-negative lymphoma cell lines with immortalizing strains of Epstein-Barr virus induces the cell-surface expression of B-cell markers, such as the EBV receptor/CR2 (CD21) and the CD23 antigen. The non-immortalizing EBV variant, P3HRI, which carries a deletion encompassing the EBV nuclear antige...

journal_title：International journal of cancer

authors： Calender A,Cordier M,Billaud M,Lenoir GM

更新日期：1990-10-15 00:00:00

abstract：:Limited data are available on the carcinogenicity of smokeless tobacco products in organs other than the mouth. Snus is a smokeless tobacco product widely used in Norway. We studied 10,136 Norwegian men enrolled since 1966 in a prospective cohort study, 31.7% of whom were exposed to snus. The relative risk of pancreat...

journal_title：International journal of cancer

authors： Boffetta P,Aagnes B,Weiderpass E,Andersen A

更新日期：2005-05-10 00:00:00

abstract：:Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic association of PIK3CA mutation with KRAS mutation has been suggested to increase AKT signaling and resistance to antiepidermal growth factor receptor inhibitor ...

journal_title：International journal of cancer

authors： Whitehall VL,Rickman C,Bond CE,Ramsnes I,Greco SA,Umapathy A,McKeone D,Faleiro RJ,Buttenshaw RL,Worthley DL,Nayler S,Zhao ZZ,Montgomery GW,Mallitt KA,Jass JR,Matsubara N,Notohara K,Ishii T,Leggett BA

更新日期：2012-08-15 00:00:00

abstract：:Neuroblastoma (NBL), one of the most common childhood solid tumors, has a distinct nature in different prognostic subgroups. However, the precise mechanism underlying this phenomenon remains largely unknown. To understand the molecular and genetic bases of neuroblastoma, we have generated its cDNA libraries and identi...

journal_title：International journal of cancer

authors： Kato C,Miyazaki K,Nakagawa A,Ohira M,Nakamura Y,Ozaki T,Imai T,Nakagawara A

更新日期：2004-11-10 00:00:00

abstract：:The promoter variants of TNF-α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF-α promoter variants and risk of recurrence of squamous cell carcinoma of the oropharynx (SCCOP). We evaluated association...

journal_title：International journal of cancer

authors： Zhang C,Sturgis EM,Zheng H,Song X,Wei P,Jin L,Chao L,Wei Q,Li G

更新日期：2014-04-15 00:00:00

abstract：:Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence i...

journal_title：International journal of cancer

authors： Tsilidis KK,Allen NE,Key TJ,Sanjoaquin MA,Bakken K,Berrino F,Fournier A,Lund E,Overvad K,Olsen A,Tjønneland A,Byrnes G,Chajes V,Rinaldi S,Boutron-Ruault MC,Clavel-Chapelon F,Chang-Claude J,Kaaks R,Bergmann M,Boeing

更新日期：2011-04-15 00:00:00

abstract：:We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...

journal_title：International journal of cancer

authors： Merlo A,Jermann E,Hausmann O,Chiquet-Ehrismann R,Probst A,Landolt H,Maecke HR,Mueller-Brand J,Gratzl O

更新日期：1997-05-29 00:00:00

abstract：:Caveolae have been indicated as a center of cytoskeleton regulation for Src kinase/Rho GTPase signaling. In addition, Src recruitment on intact cortical actin cytoskeleton appears to be required for bFGF/FGFR signal activation. Recently, we established a relationship between caveolin-1 (Cav-1) expression and cell migr...

journal_title：International journal of cancer

authors： Fecchi K,Travaglione S,Spadaro F,Quattrini A,Parolini I,Piccaro G,Raggi C,Fabbri A,Felicetti F,Carè A,Fiorentini C,Sargiacomo M

更新日期：2012-03-15 00:00:00

abstract：:We recently reported that hormone therapy induces antigen-specific autoantibody responses in prostate cancer patients. However, the contribution of autoantibody responses to clinical outcomes is unknown. We used an animal model to test the hypothesis that hormone therapy-induced immune responses may be associated with...

journal_title：International journal of cancer

authors： Hahn S,Nesslinger NJ,Drapala RJ,Bowden M,Rennie PS,Pai HH,Ludgate C,Nelson BH

更新日期：2009-12-15 00:00:00

abstract：:The causative role of human papillomaviruses (HPV) and HPV16 variants has been extensively studied in uterine cervix dysplastic lesions and invasive carcinoma; few such studies, however, have been performed in penile tumors. We have investigated HPV genotype and HPV16 variant distribution on 41 penile cancer biopsies ...

journal_title：International journal of cancer

authors： Tornesello ML,Duraturo ML,Losito S,Botti G,Pilotti S,Stefanon B,De Palo G,Gallo A,Buonaguro L,Buonaguro FM

更新日期：2008-01-01 00:00:00

abstract：:The effects of long-term treatment with mouse interferon on the phenotype of untransformed C3H/10T1/2 cells and cloned derivatives transformed by methylcholanthrene (MCA) and Simian virus 40 (SV40) were investigated. Continuous presence of interferon induced morphologic reversion, with the development of thick, submem...

journal_title：International journal of cancer

authors： Brouty-Boyé D,Wybier-Franqui J,Calvo C,Feunteun J,Gresser I

更新日期：1984-07-15 00:00:00

abstract：:By transmission and scanning electron microscopic studies of MC-29 virus-infected CEC cultures, C-type virus particles were detected in the medium of infected cultures, in infected cells and in intracellular vacuoles. Virus budding was also observed. In the scanning electron microscope (SEM) so-called blebs appeared o...

journal_title：International journal of cancer

authors： Podmaniczky E,Szende B,Lapis K,Ferenc G

更新日期：1976-10-15 00:00:00

abstract：:The FUS-CHOP fusion protein has been found to be instrumental for specific oncogenic processes in liposarcoma, but its ability to induce metastasis and the underlying mechanisms by which this can be achieved remain unknown. To dissect its functional role in this context, we stably overexpressed this protein in SW872 l...

journal_title：International journal of cancer

authors： Patil N,Ahmed Kabeer Rasheed S,Abba M,Hendrik Leupold J,Schwarzbach M,Allgayer H

更新日期：2014-06-15 00:00:00

abstract：:Neoplastic transformation is characterised by an imbalance in favour of cell growth over programmed cell death (apoptosis). The tumour-suppressor gene p53, responsible for maintaining cell-cycle control, is mutated in the majority of human cancers. Loss of function of the target genes of p53 are therefore important in...

journal_title：International journal of cancer

authors： Hollowood AD,Lai T,Perks CM,Newcomb PV,Alderson D,Holly JM

更新日期：2000-11-01 00:00:00

abstract：:The therapeutic potential of the somatostatin analogue RC-160 radiolabeled with 188Re was evaluated in nude mice bearing xenografts of human prostate adenocarcinoma. 188Re-RC-160 was selectively retained in both DU-145 and PC-3 tumors following direct intra-tumor injection at all time points examined (2, 6 and 24 hr p...

journal_title：International journal of cancer

authors： Zamora PO,Gulhke S,Bender H,Diekmann D,Rhodes BA,Biersack HJ,Knapp FF Jr

更新日期：1996-01-17 00:00:00