Abstract:
:A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells in normal epithelia, and FGFR3b was localized in the cytoplasm and nucleus in non-FGFR3b mutant OSCC. Overexpressed FGFR3b protein on plasma membranes was noted in OSCC bearing the FGFR3b mutation. Enhanced tyrosine kinase activity of G697CFGFR3b was confirmed. Our results indicate that G697C is an activating mutation causing constitutive ligand-independent FGFR3b signaling. This mutation may be involved in the progression of OSCC and thus the FGFR3b coding sequence may have diagnostic or prognostic value for OSCC.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Zhang Y,Hiraishi Y,Wang H,Sumi KS,Hayashido Y,Toratani S,Kan M,Sato JD,Okamoto Tdoi
10.1002/ijc.21145keywords:
subject
Has Abstractpub_date
2005-10-20 00:00:00pages
166-8issue
1eissn
0020-7136issn
1097-0215journal_volume
117pub_type
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