Abstract：
:By radioimmunoassay (RIA) mammary tumour virus (MTV) antigens were detected in individual milk samples of C3Hf mice, (female BALB/c X male C3Hf)F1 mice and (female C3Hf X male BALB/c)F1 mice; milk samples of BALB/c mice were negative. In the segregating backcross I population, female BALB/c X male (female BALB/c X male C3Hf) viral antigens were found in the milk of 93 out of 169 mice (55%). In the Bc II population (daughters of Bc I mothers and BALB/c fathers) two groups were distinguished. In the first group, derived from positive Bc I mothers, 55 out of 110 mice (50%) had detectable levels of viral antigens in the milk. In the second group, progeny of negative Bc I mothers, 1 mouse out of 47 was positive. These data are consistent with the assumption that one dominant gene is responsible for the presence of viral antigens in the milk of C3Hf mice. This gene (Mtv-1) seems to be linked with the albino locus situated on chromosome 7; the recombination percentage was about 29. In the first experiment with Bc I mice a significant difference was found between the tumour ages of the mice with virus-positive milk and of the mice with virus-negative milk: all mice (18) with viral antigens in the milk developed mammary tumours at an age ranging from 7 to 18 months, whereas in only 7 out of 16 mice with virus-negative milk were mammary tumours found before the age of 21 months. Viral antigens were detectable (by RIA) in the tumours of mice of both subgroups; however, the amounts (mU/mg tumour) were significantly lower in the tumours derived from mice with virus-negative milk. Although MTV-L of C3Hf mothers could be transmitted to BALB/c mice by foster-nursing, viral antigens could not be detected in milk samples collected prior to the third lactation period; thus an influence on the data of extrachromosomally transmitted MTV-L is unlikely.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
van Nie R,Verstraeten AAdoi
10.1002/ijc.2910160606subject
Has Abstractpub_date
1975-12-15 00:00:00pages
922-31issue
6eissn
0020-7136issn
1097-0215journal_volume
16pub_type
杂志文章abstract：:By centrifuging total cellular DNA derived from human genital warts (condylomata acuminata) in CsCl-ethidium bromide gradients, supercoiled DNA was isolated. The molecular weight of this DNA was determined by agarose gel electrophoresis and amounted to 5.1 X 10(4). This DNA isolated from an individual genital wart was...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910250509
更新日期：1980-05-15 00:00:00
abstract：:Tenascin-C (TN-C) and matrix metalloproteinases (MMPs) are highly expressed in cancer tissues and probably promote cell migration during cancer progression. TN-C and MMPs are often co-localized in areas of active tissue remodeling in pathologic conditions, suggesting reciprocal regulation. To investigate whether TN-C ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11037
更新日期：2003-05-20 00:00:00
abstract：:Cryopreserved tumour cells obtained from the ascitic fluid of a patient with an ovarian carcinoma were employed to determine the effect on in vitro drug cytotoxicities of varying both drug concentration and exposure time. Four antitumour drugs, in common clinical usage, were selected for study. Tumour-cell survival fo...
journal_title：International journal of cancer
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doi：10.1002/ijc.2910320103
更新日期：1983-07-15 00:00:00
abstract：:We transduced a human gastric carcinoma cell line, HR, with the interleukin 2 (IL-2) gene. Stable HR transfectants secreted nanogram quantities of biologically active IL-2 and had significantly increased expression of IL-2 mRNA relative to that in parental cells. Expression of intracellular IL-2 protein was not quanti...
journal_title：International journal of cancer
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更新日期：1997-07-03 00:00:00
abstract：:Occupational data from 5 case-control studies in the United States involving 2,973 male cases and 3,210 controls were analyzed to estimate the percentage of lung cancer attributable to well-known and suspected lung carcinogens. The studies were conducted in areas heterogeneous in terms of industrial activities. The pe...
journal_title：International journal of cancer
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更新日期：1988-12-15 00:00:00
abstract：:To evaluate the role of chromosome 13 deletions in oral squamous cell carcinoma (SCC) progression and to define the precise localization of putative tumor suppressor genes, we studied tumors from 34 unrelated patients with oral SCC by the polymerase chain reaction (PCR)-loss of heterozygosity (LOH) assay, using 18 dif...
journal_title：International journal of cancer
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更新日期：1998-08-21 00:00:00
abstract：:Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subseq...
journal_title：International journal of cancer
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更新日期：2017-09-01 00:00:00
abstract：:Cancer incidence disparities exist among specific Asian American populations. However, the existing reports exclude data from large metropoles like Chicago, Houston and New York. Moreover, incidence rates by subgroup have been underestimated due to the exclusion of Asians with unknown subgroup. Cancer incidence data f...
journal_title：International journal of cancer
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doi：10.1002/ijc.29958
更新日期：2016-05-01 00:00:00
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更新日期：2020-07-01 00:00:00
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更新日期：2005-11-10 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910520415
更新日期：1992-10-21 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21243
更新日期：2005-12-20 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970529)71:5<810::aid-ijc
更新日期：1997-05-29 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32946
更新日期：2020-06-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25500
更新日期：2011-04-01 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970611)71:6<1049::aid-ij
更新日期：1997-06-11 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21980
更新日期：2006-09-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19990105)80:1<54::aid-ijc1
更新日期：1999-01-05 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910160609
更新日期：1975-12-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：1979-08-01 00:00:00
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journal_title：International journal of cancer
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doi：10.1002/ijc.31202
更新日期：2018-05-01 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910500623
更新日期：1992-04-01 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910360411
更新日期：1985-10-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19990331)81:1<104::aid-ijc
更新日期：1999-03-31 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910250606
更新日期：1980-06-15 00:00:00
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journal_title：International journal of cancer
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doi：10.1002/ijc.26239
更新日期：2012-05-15 00:00:00
abstract：:Several mouse models studying the MLL fusion-induced leukemic transformation showed that a myeloproliferation stage precedes leukemia or occurred as the only phenotype of hematological disorder in mice. We established 6 MLL/AF10(OM-LZ)-immortalized cell lines by retrovirally transducing the fusion gene into bone marro...
journal_title：International journal of cancer
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更新日期：2010-04-01 00:00:00
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journal_title：International journal of cancer
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更新日期：2012-09-01 00:00:00
abstract：:Postmenopausal hormone replacement therapy (HRT) was found to be associated with lower risk of colorectal cancer (CRC). However, little is known regarding associations with molecular subtypes of CRC. The current study includes female participants of a large German population-based case-control study (922 CRC cases and...
journal_title：International journal of cancer
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更新日期：2020-08-15 00:00:00
abstract：:Family history of urogenital cancers has been associated with an increased risk of cancer at the same sites. To evaluate the risks of bladder, prostate and renal cell neoplasms for family history of urogenital cancers in first-degree relatives, we analysed data from a case-control study conducted in northern Italy bet...
journal_title：International journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1002/ijc.23037
更新日期：2007-12-15 00:00:00
