Abstract:
:Permanent cell lines have been established in vitro from lymphoid tumors induced in C57BH/Ka mice by fractionated X-irradiation or by inoculation of the radiation leukemia virus (RadOV). The cultured cells are lymphoblastic, replicate rapidly in vitro, and are tumorigenic in vivo. The cell surface markers Thy 1, Ly 1, Ly 2,3 and GIX are expressed by the lymphoid tumor cells in the mouse and persist in the corresponding cell lines; expression of the H-2 and TL antigens is greatly reduced during in vitro passage, but is restored on in vivo transplantation. The cell lines derived from RadLV-induced tumors (BL/VL lines) produce a virus population (RadLV/LTC) with the thymotropic and leukemogenic attributes of RadLV. Those derived from radiation-induced, virus-negative lymphomas (BL/RL lines) are initially devoid of MuLV expression, but frequently become spontaneous virus producers during in vitro cultivation.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Lieberman M,Declève A,Ricciardi-Castagnoli P,Boniver J,Finn OJ,Kaplan HSdoi
10.1002/ijc.2910240208subject
Has Abstractpub_date
1979-08-01 00:00:00pages
168-77issue
2eissn
0020-7136issn
1097-0215journal_volume
24pub_type
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journal_title:International journal of cancer
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