Syngeneic monoclonal antibodies directed against Rauscher virus-induced myeloid leukemic cells: isolation and characterization.

abstract：:We transduced a human gastric carcinoma cell line, HR, with the interleukin 2 (IL-2) gene. Stable HR transfectants secreted nanogram quantities of biologically active IL-2 and had significantly increased expression of IL-2 mRNA relative to that in parental cells. Expression of intracellular IL-2 protein was not quanti...

journal_title：International journal of cancer

authors： Nagashima S,Kashii Y,Reichert TE,Suminami Y,Suzuki T,Whiteside TL

更新日期：1997-07-03 00:00:00

abstract：:Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare NETs originating from the liver. These tumors are associated with heterogeneous prognosis, and few treatment targets for PHNETs have been identified. Because the major genetic alterations in PHNET are still largely unknown, we performed whole-exome sequ...

journal_title：International journal of cancer

authors： Yang P,Huang X,Lai C,Li L,Li T,Huang P,Ouyang S,Yan J,Cheng S,Lei G,Wang Z,Yu L,Hong Z,Li R,Dong H,Wang C,Yu Y,Wang X,Li X,Wang L,Lv F,Yin Y,Yang H,Song J,Gao Q,Wang X,Zhang S

更新日期：2019-12-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is a complex disease comprising discrete histological and molecular subtypes, for which survival rates remain unacceptably low. Tailored approaches for this deadly heterogeneous disease are urgently needed. Efflux pumps belonging to the ATP-binding cassette (ABC) family of transporters ...

journal_title：International journal of cancer

authors： Jung M,Gao J,Cheung L,Bongers A,Somers K,Clifton M,Ramsay EE,Russell AJ,Valli E,Gifford AJ,George J,Kennedy CJ,Wakefield MJ,Topp M,Ho GY,Australian Ovarian Cancer Study.,Scott CL,Bowtell DD,deFazio A,Norris MD,Hab

更新日期：2020-10-15 00:00:00

abstract：:Protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) is an endogenous inhibitor of STAT3 that negatively regulates STAT3 transcriptional activity and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. In this study...

journal_title：International journal of cancer

authors： Dabir S,Kluge A,McColl K,Liu Y,Lam M,Halmos B,Wildey G,Dowlati A

更新日期：2014-03-01 00:00:00

abstract：:Metastatic tumor formation via vessel route begins with cancer cell extravasation from vessel lumen, migration into the connective tissue surrounding vessels, and invasion into target organ parenchyma. Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) have been recognized to play an i...

journal_title：International journal of cancer

authors： Aokage K,Ishii G,Ohtaki Y,Yamaguchi Y,Hishida T,Yoshida J,Nishimura M,Nagai K,Ochiai A

更新日期：2011-04-01 00:00:00

abstract：:The studies reported here explore the relationship between tumor-specific transplantation antigens (TSTA) and (1) the expression of serologically defined specificities, and (2) the immunogenicity of H-2K- or H-2D-determined alloantigens on methylcholanthrene (MCA)-induced murine fibrosarcomas. Expression of H-2K and H...

journal_title：International journal of cancer

authors： Chauvenet PH,Smith RT

更新日期：1978-07-15 00:00:00

abstract：:The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cas...

journal_title：International journal of cancer

authors： Olsen AO,Gjøen K,Sauer T,Orstavik I,Naess O,Kierulf K,Sponland G,Magnus P

更新日期：1995-05-04 00:00:00

abstract：:Caveolae have been indicated as a center of cytoskeleton regulation for Src kinase/Rho GTPase signaling. In addition, Src recruitment on intact cortical actin cytoskeleton appears to be required for bFGF/FGFR signal activation. Recently, we established a relationship between caveolin-1 (Cav-1) expression and cell migr...

journal_title：International journal of cancer

authors： Fecchi K,Travaglione S,Spadaro F,Quattrini A,Parolini I,Piccaro G,Raggi C,Fabbri A,Felicetti F,Carè A,Fiorentini C,Sargiacomo M

更新日期：2012-03-15 00:00:00

abstract：:Double-label immunofluorescence was used to monitor basement-membrane composition and integrity in 22 human colon polyps, 36 adenocarcinomas and 2 metastases. Cryostat sections were stained with polyclonal anti-laminin anti-serum combined with monoclonal antibodies (MAbs) to all major basement-membrane components (lam...

journal_title：International journal of cancer

authors： Ljubimov AV,Bartek J,Couchman JR,Kapuller LL,Veselov VV,Kovarik J,Perevoshchikov AG,Krutovskikh VA

更新日期：1992-02-20 00:00:00

abstract：:An antigen, protein X (Px), was purified from immune complexes isolated from malignant pleural effusions from patients with adenocarcinoma of the lung by EDTA treatment, PEG 8000 precipitation, protein A affinity chromatography, and Sephadex G-200 separation in the presence of 3 M NaCl. The purified antigen had a M(r)...

journal_title：International journal of cancer

authors： Zeng CQ,Alpert LC,Alpert E

更新日期：1992-10-21 00:00:00

abstract：:Prostate-specific antigen (PSA) is a serine protease secreted by prostatic epithelial cells and is widely used as a marker for prostate cancer. The tissue specificity of PSA makes it a potential target for active specific immunotherapy, especially in prostate cancer patients who have undergone prostatectomy and in who...

journal_title：International journal of cancer

authors： Hodge JW,Schlom J,Donohue SJ,Tomaszewski JE,Wheeler CW,Levine BS,Gritz L,Panicali D,Kantor JA

更新日期：1995-10-09 00:00:00

abstract：:Oxidative stress plays a role in the regulation of cancer cell metastasis which involves cell invasion and adhesion that could be supported by ADAM proteins through the activities of their metalloprotease and disintegrin domains. We hypothesized that oxidative stress could act through the induction of ADAM9 protein in...

journal_title：International journal of cancer

authors： Mongaret C,Alexandre J,Thomas-Schoemann A,Bermudez E,Chéreau C,Nicco C,Goldwasser F,Weill B,Batteux F,Lemare F

更新日期：2011-08-15 00:00:00

abstract：:Regulation of cell differentiation is most often impaired in malignant tumors and may represent a key mechanism for the progression of the disease. CCAAT-enhancer binding protein (C/EBP) is a family of transcription factors involved in the regulation of embryonic gut development in rodents, which has also been detecte...

journal_title：International journal of cancer

authors： Rask K,Thörn M,Pontén F,Kraaz W,Sundfeldt K,Hedin L,Enerbäck S

更新日期：2000-05-01 00:00:00

abstract：:Cells from reticulum-cell sarcomas (RCS), tumors with a probable B-cell origin in the SJL/J mouse strain, induced a high degree of proliferation in O-bearing syngeneic lymph-node and thymus cells obtained from young non-tumours mice. Although of considerably lower magnitude, a proliferation of SJL/J thymus cells to sy...

journal_title：International journal of cancer

authors： Lerman SP,Chapman JM,Carswell EA,Thorbecke GJ

更新日期：1974-12-15 00:00:00

abstract：:Cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (HPV) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (CIN). Additionally, regulatory T (Treg) cells are increasingly understoo...

journal_title：International journal of cancer

authors： Scott ME,Ma Y,Kuzmich L,Moscicki AB

更新日期：2009-03-15 00:00:00

abstract：:Tamoxifen is an important selective estrogen receptor (ER) modulator for treatment of steroid hormone positive breast cancer. In addition to the beneficial effect, tamoxifen is one risk factor for endometrial carcinoma (EnCa) development. We hypothesized that, (1) dysregulation of gene expression and protein phosphory...

journal_title：International journal of cancer

authors： Strissel PL,Ellmann S,Loprich E,Thiel F,Fasching PA,Stiegler E,Hartmann A,Beckmann MW,Strick R

更新日期：2008-12-15 00:00:00

abstract：:MET is a master gene controlling a genetic program driving proliferation, apoptosis protection and invasion. The ROR1 pseudokinase acts as a MET substrate. However, its contribution to MET signaling and MET-dependent biological outcomes remains to be elucidated. By structure-function analysis of ROR1 mutants, we show ...

journal_title：International journal of cancer

authors： Gentile A,Lazzari L,Benvenuti S,Trusolino L,Comoglio PM

更新日期：2014-11-15 00:00:00

abstract：:Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long-term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor-initiating potential, or cancer stem-like cells (CSCs), may particularly contribute to acquired chemoresistance and recurrence. Thus, CS...

journal_title：International journal of cancer

authors： Namekawa T,Ikeda K,Horie-Inoue K,Suzuki T,Okamoto K,Ichikawa T,Yano A,Kawakami S,Inoue S

更新日期：2020-02-15 00:00:00

abstract：:The transcription factor grainyhead-like 2 (GRHL2) plays a crucial role in various developmental processes. Although GRHL2 recently has attracted considerable interest in that it could be identified as a novel suppressor of the epithelial-to-mesenchymal transition, evidence is emerging that GRHL2 also exhibits tumour-...

journal_title：International journal of cancer

authors： Riethdorf S,Frey S,Santjer S,Stoupiec M,Otto B,Riethdorf L,Koop C,Wilczak W,Simon R,Sauter G,Pantel K,Assmann V

更新日期：2016-02-15 00:00:00

abstract：:The annual incidence of non-Hodgkin's lymphomas is increasing by 3 to 4% in different parts of the developed world, while rates for Hodgkin's disease, myelomas and leukemias are more stable. In the case of this group of malignancies, hypothesis generation on risk factors has been limited by the use of the ICD classifi...

journal_title：International journal of cancer

authors： Masala G,Di Lollo S,Picoco C,Crosignani P,Demicheli V,Fontana A,Funtó I,Miligi L,Nanni O,Papucci A,Ramazzotti V,Rodella S,Stagnaro E,Tumino R,Viganó C,Vindigni C,Seniori Costantini A,Vineis P

更新日期：1996-10-09 00:00:00

abstract：:Interest has increased in the potential role of circulating tumour cells in cancer management. Most cell-based studies have been designed to determine the number of circulating tumour cells in a given volume of blood. Ability to understand the biology of the cancer cells would increase the clinical potential. The purp...

journal_title：International journal of cancer

authors： Dent BM,Ogle LF,O'Donnell RL,Hayes N,Malik U,Curtin NJ,Boddy AV,Plummer ER,Edmondson RJ,Reeves HL,May FE,Jamieson D

更新日期：2016-01-01 00:00:00

abstract：:We have obtained a novel multidrug resistant cell line, derived from HT29 G(+) human colon carcinoma cells, by selection with gradually increasing concentrations of the anti-mitotic, microtubule-disrupting agent colchicine. This HT29(col) cell line displayed a 25-fold increase in colchicine resistance and exhibited cr...

journal_title：International journal of cancer

authors： Kok JW,Veldman RJ,Klappe K,Koning H,Filipeanu CM,Müller M

更新日期：2000-07-15 00:00:00

abstract：:Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimi...

journal_title：International journal of cancer

authors： Herbst A,Vdovin N,Gacesa S,Ofner A,Philipp A,Nagel D,Holdt LM,Op den Winkel M,Heinemann V,Stieber P,Graeven U,Reinacher-Schick A,Arnold D,Ricard I,Mansmann U,Hegewisch-Becker S,Kolligs FT

更新日期：2017-05-01 00:00:00

abstract：:Expression of the macrophage antigen CD163 in breast cancer cells is recently shown to be related to early distant recurrence and shortened survival. In this study, 163 patients with rectal cancer, included in the Swedish rectal cancer trial and followed up for a median of 71 months, were examined for the expression o...

journal_title：International journal of cancer

authors： Shabo I,Olsson H,Sun XF,Svanvik J

更新日期：2009-10-15 00:00:00

abstract：:A high molecular weight RNA-reverse transcriptase complex in the culture media of peripheral leukocytes obtained from two Japanese patients with myeloma-leukemia was detected by demonstration of a 3H-uridine peak and a peak of DNA polymerizing activity banding at a density of 1.15-1.19g/ml. The enzyme in the complex w...

journal_title：International journal of cancer

authors： Sawada H,Tashima M,Nakamura T,Uchiyama T,Sagawa K,Takatsuki K,Uchino H,Ito Y

更新日期：1977-07-15 00:00:00

abstract：:Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identif...

journal_title：International journal of cancer

authors： Jones RJ,Seaman WT,Feng WH,Barlow E,Dickerson S,Delecluse HJ,Kenney SC

更新日期：2007-09-15 00:00:00

abstract：:The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other da...

journal_title：International journal of cancer

authors： Iishi H,Tatsuta M,Baba M,Yano H,Iseki K,Uehara H,Nakaizumi A

更新日期：1998-01-30 00:00:00

abstract：:Using a recently developed autochthonous mouse model of squamous cell carcinoma (SCC), a combination therapy targeting polyamine metabolism was evaluated. The therapy combined 2-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), and MQT 1426, a polyamine transport inhibitor. In 1 trial last...

journal_title：International journal of cancer

authors： Chen Y,Weeks RS,Burns MR,Boorman DW,Klein-Szanto A,O'Brien TG

更新日期：2006-05-01 00:00:00

abstract：:A subline of the murine P815 mastocytoma passaged for a long period of time in histoincompatible hosts was found to be deficient in surface MHC class-I antigens by serological and biochemical methods. In agreement with the lack of restriction elements, this variant cell line was no longer susceptible to killing by cyt...

journal_title：International journal of cancer

authors： Bertschmann M,Käsermann D,Keller R

更新日期：1990-10-15 00:00:00

abstract：:Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines. CD59 expression had a low degree of intra- and intertumor heterogeneity. SDS-PA...

journal_title：International journal of cancer

authors： Brasoveanu LI,Altomonte M,Gloghini A,Fonsatti E,Coral S,Gasparollo A,Montagner R,Cattarossi I,Simonelli C,Cattelan A

更新日期：1995-05-16 00:00:00