Abstract：
:An antigen, protein X (Px), was purified from immune complexes isolated from malignant pleural effusions from patients with adenocarcinoma of the lung by EDTA treatment, PEG 8000 precipitation, protein A affinity chromatography, and Sephadex G-200 separation in the presence of 3 M NaCl. The purified antigen had a M(r) 17,000 by SDS-PAGE, and consisted of isoelectric species of pI 6.3 and 6.6. Purified Px recombined with Ig isolated from pleural fluids from patients with lung adenocarcinoma, but not with Ig from patients with breast carcinoma. Using an autologous human and heterologous chicken antibody, Px was found, by immunohistology, in the cytoplasm of some of the well-differentiated lung adenocarcinoma cells, but was not seen in normal lung or a variety of other malignant tissues. A liquid-phase competitive-inhibition RIA was developed. Over 30 ng/ml of Px were found in 9 of 15 pleural fluids from patients with lung carcinoma, none of 20 from patients with breast, ovary, stomach or colon cancer, and in 3 of 15 patients with unknown primary tumor. Our data suggest that Px may be a lung-cancer-associated autoantigen which can elicit a host humoral response in vivo.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Zeng CQ,Alpert LC,Alpert Edoi
10.1002/ijc.2910520404keywords:
subject
Has Abstractpub_date
1992-10-21 00:00:00pages
523-9issue
4eissn
0020-7136issn
1097-0215journal_volume
52pub_type
杂志文章abstract：:TK is a pyrimidine metabolic pathway enzyme involved in salvage DNA synthesis. What roles TK may play in epithelial ovarian cancer and the relationships between TK and the other pyrimidine pathway enzymes remain unclear. We examined TK1 gene expression by RT-PCR and related it to gene expression of TS, TP and DPD in 6...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10319
更新日期：2002-05-20 00:00:00
abstract：:A panel of 7 mouse monoclonal antibodies and the lectin from Ulex europeus, detecting blood-group-related antigens of the ABH and Lewis systems, have been used to define the distribution of these antigenic structures within the human gastrointestinal tract, and to characterize their expression and modulation in colore...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910370505
更新日期：1986-05-15 00:00:00
abstract：:Overuse of antibiotic drugs alters the composition of gut microbiota and has detrimental effects on the host. In our study, we investigated association of gut flora and antibiotics in the prognosis of patients with liver cancer who have undergone chemotherapy by analyzing two independent clinical studies. We retrospec...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32339
更新日期：2019-11-15 00:00:00
abstract：:We found that rhabdomyosarcoma (RMS) subcellular membranes contain sialyltransferase activities for LcOse4Cer and GgOse4Cer acceptors. Chromatographic analyses and neuraminidase lability of the sialyltransferase products indicated that the principal site of sialylation was the non-reducing terminal galactosyl moiety. ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910450531
更新日期：1990-05-15 00:00:00
abstract：:Variability in the expression of enzymes metabolizing carcinogens derived from cigarette smoke may contribute to individual susceptibility to pulmonary carcinogenesis. This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(20000601)86:5<610::aid-ijc
更新日期：2000-06-01 00:00:00
abstract：:High-grade serous epithelial ovarian cancer (HGS-EOC) is a systemic disease, with marked intra and interpatient tumor heterogeneity. The issue of spatial and temporal heterogeneity has long been overlooked, hampering the possibility to identify those genomic alterations that persist, before and after therapy, in the g...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32288
更新日期：2019-11-15 00:00:00
abstract：:DNA repair is a complicated biological process, consisting of several distinct pathways, that plays a fundamental role in the maintenance of genomic integrity. The very important field of DNA repair and cancer risk has developed rapidly in the past decades. In this review of selected published data from our laboratory...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.24126
更新日期：2009-03-01 00:00:00
abstract：:Laser microdissection (LMD) and microarray were used to identify genes associated with colorectal cancer. Stanniocalcin 2 (STC2) expression and clinicopathological significance in 139 clinical colorectal cancer samples were specifically investigated using real-time quantitative reverse transcription-polymerase chain r...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24453
更新日期：2009-08-15 00:00:00
abstract：:Using morphometric and immunohistological techniques, we investigated the distribution of T lymphocytes and subsets, B lymphocytes, macrophages and plasma cells in sections of human breast tissue. In normal lobules and ducts, leukocytes were found in greater density in the epithelium than in the stroma. The intra-epit...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910360404
更新日期：1985-10-15 00:00:00
abstract：:In a hospital-based case-control study of esophageal cancer undertaken in Athens (1989-1991), 43 patients with incident esophageal squamous-cell carcinoma and 56 patients with incident esophageal adenocarcinoma were compared to 200 injury patients. Personal interviews were conducted in the hospital setting, and dietar...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19961104)68:3<300::AID-IJC
更新日期：1996-11-04 00:00:00
abstract：:Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epigenetic mechanisms. Down-regulation of expression of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in the biosynthesis of arginine, has been associated with the development of platinum resistance in ovari...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24546
更新日期：2009-09-15 00:00:00
abstract：:Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whethe...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10209
更新日期：2002-03-10 00:00:00
abstract：:Anticancer drugs docetaxel and vinorelbine suppress cell growth by altering microtubule assembly and activating the proapoptotic signal pathway. Vinorelbine and docetaxel have been approved for treating several advanced cancers. However, their efficacy in the management of advanced hormone-refractory prostate cancer r...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11413
更新日期：2003-11-10 00:00:00
abstract：:The role of the mismatch repair (MMR) system in correcting base-base mismatches is well established; its involvement in the response to DNA double strand breaks, however, is less clear. We investigated the influence of the essential component of MMR, the hMLH1 protein, on the cellular response to DNA-double strand bre...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24893
更新日期：2010-06-15 00:00:00
abstract：:Rapid growth of residual tumor after partial hepatectomy has been observed during the period of liver regeneration in children with malignant embryonal hepatoblastoma. The aim of this study was to elucidate the role of hepatocyte growth-factor-scatter factor (HGF-SF) in this phenomenon. Markedly increased serum levels...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(20000115)85:2<151::AID-IJC
更新日期：2000-01-15 00:00:00
abstract：:In order to identify regulatory genes involved in the development of an apoptosis-resistant phenotype in patients with chemotherapy refractory B-cell chronic lymphocytic leukemia (B-CLL) expression of apoptosis-regulating genes in B-CLL cells was quantified using cDNA arrays and RT-PCR. Data were obtained from and com...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20614
更新日期：2005-02-20 00:00:00
abstract：:By means of a chemical extraction procedure and confocal laser scanning microscopy, we investigated the kinetic patterns of uptake and biolocalization of 5-aminolevulinic acid (ALA)-induced porphyrins in s.c. transplanted tumors, adjacent normal skin and muscle, and liver of mice bearing mammary carcinoma, after i.p. ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910520318
更新日期：1992-09-30 00:00:00
abstract：:Ovarian cancer is the fourth most common cause of cancer deaths among females in the western world after cancer of the breast, colon and lung. The inability to control the disease within the peritoneal cavity is the major cause of treatment failure in patients with ovarian cancer. The majority of ovarian carcinomas ex...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22297
更新日期：2007-02-01 00:00:00
abstract：:We studied dietary risk factors for lung cancer among never-smokers in a population-based case-control study in Stockholm, 1989-1995. Study subjects were older than 30 years of age and had never smoked regularly. A total of 124 cases (35 men, 89 women) and 235 controls (72 men, 163 women) participated. Exposure inform...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19981109)78:4<430::aid-ijc
更新日期：1998-11-09 00:00:00
abstract：:A continuous lymphoma cell line, BJAB, derived from the tumour of an exceptional African case of Burkitt's lymphoma, has previously been described. Unlike 97% of African BL cases studied, neither the original tumour cells nor the cell line contained detectable amounts of EBV (Epstein-Barr virus) DNA, nor did they expr...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910160114
更新日期：1975-07-15 00:00:00
abstract：:Tumor cells interact with endothelial cells during both intra- and extravasation. Understanding how these interactions are modulated could lead to the development of ways to alter the metastatic potential of tumor cells. Three pancreatic cancer cell lines, SW1990, CAPAN-2 and PANC-I, were examined for their ability to...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910570621
更新日期：1994-06-15 00:00:00
abstract：:An experiment in which rats were injected intrapleurally with asbestos, the injection taking place at an age of either 2 or 10 months, is reported. In the former group 19 out of 48 rats developed a mesothelioma compared with 17 out of 90 in the latter group. However, by considering the two groups at equal times after ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910170410
更新日期：1976-04-15 00:00:00
abstract：:The association between the consumption of preserved foods in infancy, childhood and adulthood and the risk of nasopharyngeal carcinoma was investigated in a case-control study among Singapore Chinese: 200 cases (73% male) were compared with 406 hospital controls (71% male). Significantly increased risks were observed...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910590502
更新日期：1994-12-01 00:00:00
abstract：:Factors related to energy metabolism and the metabolic syndrome, such as higher body mass index (BMI), blood glucose, or blood lipids, and blood pressure, are associated with an increased risk of colorectal cancer (CRC). However, CRC is a heterogeneous disease, developing through distinct pathways with differences in ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32104
更新日期：2019-07-15 00:00:00
abstract：:We present an investigation of tumor pH regulation, designed to support a new anticancer therapy concept that we had previously proposed. Our study uses a tumor model of ras-transformed hamster fibroblasts, CCL39, xenografted in the thighs of nude mice. We demonstrate, for the first time, that genetic modifications of...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.26125
更新日期：2012-04-01 00:00:00
abstract：:Esophageal cancer is a leading cause of cancer death, especially in developing countries. In high-risk regions, squamous cell carcinoma is the most common type of esophageal cancer, and its etiology remains poorly understood. The purpose of this study was to evaluate the association between human papillomavirus (HPV) ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21980
更新日期：2006-09-15 00:00:00
abstract：:This large population-based study compared breast-conserving surgery with radiation therapy (BCT) with mastectomy on (long-term) breast cancer-specific (BCSS) and overall survival (OS), and investigated the influence of several prognostic factors. Patients with primary T1-2N0-2M0 breast cancer, diagnosed between 1999 ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31034
更新日期：2018-01-01 00:00:00
abstract：:Eight squirrel monkeys (Saimiri sciureus) challenged with EBV or EBV-transformed SLCL were naturally or experimentally infected with Plasmodium knowlesi or Pl. brasilianum. Most of the animals had been splenectomized and unilaterally nephrectomized. Three of these monkeys received one dose of 6 to 12 X 10(8) autologou...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910170417
更新日期：1976-04-15 00:00:00
abstract：:Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23149
更新日期：2008-03-01 00:00:00
abstract：:The presence of TGF alpha mRNA has been reported previously to occur in primary colon cancers. We report the expression of the normal 4.5 kb TGF alpha transcript in the mucosa of the normal human gastro-intestinal tract from oesophagus through to colon. The highest levels of human TGF alpha mRNA occurred in the duoden...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910430305
更新日期：1989-03-15 00:00:00
