ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells.

Abstract:

:Anticancer drugs docetaxel and vinorelbine suppress cell growth by altering microtubule assembly and activating the proapoptotic signal pathway. Vinorelbine and docetaxel have been approved for treating several advanced cancers. However, their efficacy in the management of advanced hormone-refractory prostate cancer remains to be clarified. Microtubule damage by some anticancer drugs can activate the ERK survival pathway, which conversely compromises chemotherapeutic efficacy. We analyzed the effect of ERK inhibitors PD98059 and U0126 on vinorelbine- and docetaxel-induced cell growth suppression of androgen-independent prostate cancer cells. In androgen-independent C-81 LNCaP cells, inhibition of ERK by PD98059, but not U0126, plus docetaxel resulted in enhanced growth suppression by an additional 20% compared to the sum of each agent alone (p < 0.02). The combination treatment of docetaxel plus PD98059 also increased cellular apoptosis, which was in part due to the inactivation of Bcl-2 by increasing phosphorylated Bcl-2 by more than 6-fold and Bax expression by 3-fold over each agent alone. At these dosages, docetaxel alone caused only marginal phosphorylation of Bcl-2 (10%). Docetaxel plus U0126 had only 20% added effect on Bcl-2 phosphorylation compared to docetaxel alone. Nevertheless, both U0126 and PD98059 exhibited an enhanced effect on docetaxel-induced growth suppression in PC-3 cells. No enhanced effect was observed for vinorelbine plus PD98059 or U0126. Thus, the combination therapy of docetaxel plus PD98059 may represent a new anticancer strategy, requiring lower drug dosages compared to docetaxel monotherapy. This may lower the cytotoxicity and enhance tumor suppression in vivo. This finding of a combination effect could be of potential clinical importance in treating hormone-refractory prostate cancer.

journal_name

Int J Cancer

authors

Zelivianski S,Spellman M,Kellerman M,Kakitelashvilli V,Zhou XW,Lugo E,Lee MS,Taylor R,Davis TL,Hauke R,Lin MF

doi

10.1002/ijc.11413

keywords:

subject

Has Abstract

pub_date

2003-11-10 00:00:00

pages

478-85

issue

3

eissn

0020-7136

issn

1097-0215

journal_volume

107

pub_type

杂志文章
  • Inhibition of in vitro lymphoproliferative responses to tumor-associated antigens by suppressor cells from rats bearing progressively growing Gross leukemia virus-induced tumors.

    abstract::W/Fu rats were injected subcutaneously with low numbers of cells from the Gross leukemia virus-induced lymphoma, (C58NT)D, which induced transient tumor growth and regression (regressors), or with high numbers of tumor cells resulting in progressive tumor growth (progressors). Spleen cells from regressors had a signif...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910160305

    authors: Glaser M,Kirchner H,Herberman RB

    更新日期:1975-09-15 00:00:00

  • Effects of the farnesyltransferase inhibitor UCF-1C/manumycin on growth and p21-ras post-translational processing in NIH3T3 cells.

    abstract::Examination of the effect of the farnesylprotein transferase (FPTase) inhibitor UCF1-C/manumycin on NIH3T3 cells transfected with a normal N-ras gene and expressing high levels of the corresponding p21-ras protein showed that 10 microm UCF1-C immediately and reversibly inhibited growth in these cells, without modifyin...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19980518)76:4<601::aid-ijc

    authors: Servais P,Gulbis B,Fokan D,Galand P

    更新日期:1998-05-18 00:00:00

  • Surface markers on human B and T-lymphocytes. IX. Two-color immunofluorescence studies on the association between ebv receptors and complement receptors on the surface of lymphoid cell lines.

    abstract::Receptors for the third component of complement (C3) were demonstrated on the surface of established human lymphoid cell lines by a membrane fluorescence test with FITC- or TRITC-conjugated antibodies against human C3. Two-color fluorescence staining of EBV receptors and C3 receptors showed complete overlapping of gre...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910170602

    authors: Yefenof E,Klein G,Jondal M,Oldstone MB

    更新日期:1976-06-15 00:00:00

  • New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats.

    abstract::Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting tox...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.32043

    authors: Yamamoto S,Yamashita T,Ito M,Caaveiro JMM,Egashira N,Tozaki-Saitoh H,Tsuda M

    更新日期:2019-10-15 00:00:00

  • The C-terminus of apoptin represents a unique tumor cell-enhanced nuclear targeting module.

    abstract::Chicken anemia virus viral protein 3 (VP3 or apoptin) localizes more efficiently in the nucleus of transformed than nontransformed cells. Although previous studies implicate the C-terminus of apoptin as being responsible, the molecular basis is controversial, and the extent to which altered nuclear transport efficienc...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.23884

    authors: Kuusisto HV,Wagstaff KM,Alvisi G,Jans DA

    更新日期:2008-12-15 00:00:00

  • Retraction.

    abstract::Marfe, G., Pucci, B., De Martino, L., Fiorito, F., Di Stefano, C., Indelicato, M., Aventaggiato, M., Russo, M. A. and Tafani, M. (2009), Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. Int. J. Cancer, 125: 2077-2085. doi: 10.1002/ijc.24572 The above article, published online o...

    journal_title:International journal of cancer

    pub_type: 撤回出版物

    doi:10.1002/ijc.32281

    authors:

    更新日期:2019-08-15 00:00:00

  • A cluster randomized controlled trial of visual, cytology and human papillomavirus screening for cancer of the cervix in rural India.

    abstract::The impact of screening by visual inspection with acetic acid (VIA), cytology or HPV testing on cervical cancer incidence and mortality is investigated in a cluster randomized controlled trial in India. We report findings after the screening phase, when 52 clusters, with a total of 142,701 women aged 30-59 years in Os...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/ijc.21050

    authors: Sankaranarayanan R,Nene BM,Dinshaw KA,Mahe C,Jayant K,Shastri SS,Malvi SG,Chinoy R,Kelkar R,Budukh AM,Keskar V,Rajeshwarker R,Muwonge R,Kane S,Parkin DM,Chauhan MK,Desai S,Fontaniere B,Frappart L,Kothari A,Lucas E

    更新日期:2005-09-10 00:00:00

  • Liver endothelial cells participate in T-cell-dependent host resistance to lymphoma metastasis by production of nitric oxide in vivo.

    abstract::Tumor growth and metastasis of lacZ-transduced murine lymphoma ESbL cells inoculated into syngeneic DBA/2 mice are characterized by a transient plateau phase with a constant tumor diameter and low metastatic load, indicating a host response against the tumor. Here we show that endothelial cells participate in a T-cell...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910630318

    authors: Rocha M,Krüger A,Van Rooijen N,Schirrmacher V,Umansky V

    更新日期:1995-11-03 00:00:00

  • p53 codon 72 ARG/PRO polymorphism is not related to HPV type or lesion grade in low- and high-grade squamous intra-epithelial lesions and invasive squamous carcinoma of the cervix.

    abstract::A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occurring HPV infectio...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19990924)83:1<66::aid-ijc1

    authors: Giannoudis A,Graham DA,Southern SA,Herrington CS

    更新日期:1999-09-24 00:00:00

  • Association study of a functional copy number variation in the WWOX gene with risk of gliomas among Chinese people.

    abstract::Gliomas represents more than 80% of all malignant brain tumors. However, the etiology still remains largely unknown. Human WW domain-containing oxidoreductase (WWOX), which is located at 16q23.1-16q23.2, the common fragile site 16D (FRA16D), an area with a high frequency of gene deletions or chromosomal alterations, h...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ijc.28815

    authors: Yu K,Fan J,Ding X,Li C,Wang J,Xiang Y,Wang QS

    更新日期:2014-10-01 00:00:00

  • Inhibitory effect of linoleic acid on transformation of IEC6 intestinal cells by in vitro azoxymethane treatment.

    abstract::The effect of linoleic acid (LA) on growth and transformation of IEC6 intestinal cells was examined. IEC6 cells expressed mRNAs of 15-lipooxygenase (LOX15) and peroxisome proliferator-activated receptor (PPAR)gamma but not COX-2. Cell growth was suppressed by LA in a dose-dependent manner in IEC6 cells. Three-week tre...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.21393

    authors: Sasaki T,Yoshida K,Shimura H,Ichiba M,Sasahira T,Shimomoto T,Denda A,Kuniyasu H

    更新日期:2006-02-01 00:00:00

  • Nasopharyngeal carcinoma-susceptibility locus is localized to a 132 kb segment containing HLA-A using high-resolution microsatellite mapping.

    abstract::Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.20946

    authors: Lu CC,Chen JC,Tsai ST,Jin YT,Tsai JC,Chan SH,Su IJ

    更新日期:2005-07-10 00:00:00

  • Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors.

    abstract::In vitro, tumor-selective Hsp70 plasma membrane localization correlates with increased sensitivity to lysis mediated by a subpopulation of human natural killer (NK) cells that adhere to plastic following cytokine stimulation. In the present study, we analyzed the capacity of adoptively transferred human NK cells in SC...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0215(20001201)88:5<791::aid-ijc17>3.0

    authors: Multhoff G,Pfister K,Botzler C,Jordan A,Scholz R,Schmetzer H,Burgstahler R,Hiddemann W

    更新日期:2000-12-01 00:00:00

  • Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma.

    abstract::Messenger RNA differential display was used to study liver-gene expression in paired tumor and non-tumor tissues from hepatocellular carcinoma (HCC) patients. mRNA differential display and Northern-blot analyses showed that a 0.8-kb cDNA fragment was diminished or absent from the tumorous tissues of 7 HCC patients. Th...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19980302)75:5<787::aid-ijc

    authors: Chen YM,Shiu JY,Tzeng SJ,Shih LS,Chen YJ,Lui WY,Chen PH

    更新日期:1998-03-02 00:00:00

  • Risk factors for endometrial cancer according to familial susceptibility.

    abstract::Endometrial cancer (EC) shares some environmental or genetic risk factors with colorectal cancer (CRC). It represents a risk factor for CRC. Furthermore, EC is the most frequent extracolonic neoplasm in HNPCC (hereditary nonpolyposis colorectal cancer) and, in this syndrome, it has the same inheritance pattern as CRC....

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19980703)77:1<29::aid-ijc6

    authors: Fornasarig M,Campagnutta E,Talamini R,Franceschi S,Boz G,Scarabelli C,Andreaus CM,Scozzari G,Valentini M

    更新日期:1998-07-03 00:00:00

  • Progenitor and pre-B lymphocytes transformed by Epstein-Barr virus.

    abstract::By rosetting with SRBC coupled to rabbit-anti-human IgM, the surface IgM-negative cells of human fetal bone marrow were enriched, and subsequently infected and transformed by Epstein-Barr virus (EBV). Single clones of the transformed cells were obtained. Ninety percent of the resulting cell clones were surface-immunog...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910390212

    authors: Ernberg I,Falk K,Hansson M

    更新日期:1987-02-15 00:00:00

  • Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells.

    abstract::Ras expression induces increased expression and altered targeting of lysosomal proteases in multiple cell types, but the specific downstream cytoplasmic signaling pathways mediating these changes have not been identified. In this study, we compared the involvement of 3 major Ras effectors, Raf, phosphatidylinositol 3-...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.20398

    authors: Collette J,Ulku AS,Der CJ,Jones A,Erickson AH

    更新日期:2004-11-01 00:00:00

  • Effect of retinoic acid on bovine papillomavirus (BPV) DNA-induced transformation and number of BPV DNA copies.

    abstract::The effect of all-trans-retinoic acid (RA) was examined on (1) transformation induced in C127 cells by transfection with plasmid pdBPV-1 (142-6), which contains DNA of bovine papillomavirus (BPV), (2) the capacity of transformed BPV DNA-containing clones to form colonies with transformed properties (e.g., piling up in...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910420118

    authors: Tsang SS,Li G,Stich HF

    更新日期:1988-07-15 00:00:00

  • Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: AdnaGen AdnaTest BreastCancer Select/Detect™ versus Veridex CellSearch™ system.

    abstract::The detection of CTCs prior to and during therapy is an independent and strong prognostic marker, and it is predictive of poor treatment outcome. A major challenge is that different technologies are available for isolation and characterization of CTCs in peripheral blood (PB). We compare the CellSearch system and Adna...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/ijc.26111

    authors: Andreopoulou E,Yang LY,Rangel KM,Reuben JM,Hsu L,Krishnamurthy S,Valero V,Fritsche HA,Cristofanilli M

    更新日期:2012-04-01 00:00:00

  • Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.

    abstract::A glucuronide doxorubicin prodrug N-[4-doxorubicin-N-carbonyl (oxymethyl) phenyl] O-beta-glucuronyl carbamate (DOX-GA3) has been developed to improve the antitumor effects of doxorubicin (DOX). The prodrug was originally designed to be activated into drug by human beta-glucuronidase (GUS) released from tumor cells in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1075>3

    authors: Houba PH,Boven E,van der Meulen-Muileman IH,Leenders RG,Scheeren JW,Pinedo HM,Haisma HJ

    更新日期:2001-02-15 00:00:00

  • Correlation between the serum level of hepatitis C virus RNA and disease activities in acute and chronic hepatitis C.

    abstract::The influence of viremia on hepatic injury in patients infected with hepatitis C virus was examined by analysis of the relationship between alanine aminotransferase activity and the amount of hepatitis C virus RNA in sequential serum samples from I untreated patient with acute hepatitis C and 3 untreated patients with...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910520510

    authors: Gunji T,Kato N,Mori S,Ootsuyama Y,Hijikata M,Imawari M,Shimotohno K

    更新日期:1992-11-11 00:00:00

  • Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer.

    abstract::The aim of this study was to test the utility of AIMP3, an upstream regulator of DNA damage response following genotoxic stress, as a clinical biomarker in muscle-invasive bladder cancer (MIBC). AIMP3 was identified from a meta-analysis of a global gene-expression dataset. AIMP3 protein expression was determined by im...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ijc.29022

    authors: Gurung PM,Veerakumarasivam A,Williamson M,Counsell N,Douglas J,Tan WS,Feber A,Crabb SJ,Short SC,Freeman A,Powles T,Hoskin PJ,West CM,Kelly JD

    更新日期:2015-02-01 00:00:00

  • Rapid quantification of HTLV-I provirus load: detection of monoclonal proliferation of HTLV-I-infected cells among blood donors.

    abstract::In this report, we quantified HTLV-I provirus load using the AmpliSensor system, which utilizes fluorescence to measure PCR products. With this method, provirus loads could be measured within 6 hr, and the results obtained correlated well with those obtained by other methods. Samples from 256 blood donors, who were po...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19990611)81:6<859::aid-ijc

    authors: Etoh K,Yamaguchi K,Tokudome S,Watanabe T,Okayama A,Stuver S,Mueller N,Takatsuki K,Matsuoka M

    更新日期:1999-06-11 00:00:00

  • Utilization of cytoreductive nephrectomy and patient survival in the targeted therapy era.

    abstract::We sought to analyze utilization and survival outcomes of cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma (RCC) before and after introduction of targeted therapy. We identified patients with metastatic RCC between 1993 and 2010 in the SEER registry and examined temporal trends in utiliz...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.28553

    authors: Conti SL,Thomas IC,Hagedorn JC,Chung BI,Chertow GM,Wagner TH,Brooks JD,Srinivas S,Leppert JT

    更新日期:2014-05-01 00:00:00

  • In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma.

    abstract::A glutamine analogue, L-glutamic acid gamma-monohydroxamate (GAH) demonstrated complete cytotoxicity against L1210 cells in culture and marked anti-tumoral activity in vivo against L1210 leukemia and B16 melanoma. In vitro, GAH caused concentration-dependent inhibition of L1210 cell growth, with complete cell death be...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910450428

    authors: Vila J,Thomasset N,Navarro C,Doré JF

    更新日期:1990-04-15 00:00:00

  • Reactive oxygen species as mediators of the transformed phenotype.

    abstract::Reactive oxygen species (ROS) are known to be involved in different pro- and anticarcinogenic mechanisms. However, their influence on the maintenance of the transformed phenotype has not been studied so far. Here we show that the anchorage-independent growth of transformed murine fibroblasts is inhibited by antioxidan...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19970304)70:5<587::aid-ijc

    authors: Jürgensmeier JM,Panse J,Schäfer R,Bauer G

    更新日期:1997-03-04 00:00:00

  • Allelic loss of chromosome 13q14.3 in human oral cancer: correlation with lymph node metastasis.

    abstract::To evaluate the role of chromosome 13 deletions in oral squamous cell carcinoma (SCC) progression and to define the precise localization of putative tumor suppressor genes, we studied tumors from 34 unrelated patients with oral SCC by the polymerase chain reaction (PCR)-loss of heterozygosity (LOH) assay, using 18 dif...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19980821)79:4<312::aid-ijc

    authors: Ogawara K,Miyakawa A,Shiba M,Uzawa K,Watanabe T,Wang XL,Sato T,Kubosawa H,Kondo Y,Tanzawa H

    更新日期:1998-08-21 00:00:00

  • Modulation of intra-epithelial expansion of human T24 bladder-carcinoma cells in murine urothelium by growth factors and extracellular-matrix components.

    abstract::The high recurrence rate of bladder cancer is probably due to an efficient repopulation of the bladder by residual transformed cells after resection of the tumour. However, the regenerating capacity of the normal urothelial cells is very high. To study the balance between regenerating normal urothelium and out-growth ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910600523

    authors: Rebel JM,Thijssen CD,Vermey M,Zwarthoff EC,Van der Kwast TH

    更新日期:1995-03-03 00:00:00

  • Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde.

    abstract::Chloroethylene oxide and 2-chloroacetaldehyde, two possibly carcinogenic metabolities of vinyl chloride in mammals, caused a dose-dependent induction of 8-azaguanine- and ouabain-resistant mutants in Chinese hamster V79 cells in vitro. Up to one-hundred-fold higher concentrations of 2-chloroethanol or monochloroacetic...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910160414

    authors: Huberman E,Bartsch H,Sachs L

    更新日期:1975-10-15 00:00:00

  • Thyroid cancer after hysterectomy on benign indications: Findings from an observational cohort study in Sweden.

    abstract::To investigate the association between hysterectomy and thyroid cancer subtypes based on histopathology. They did a nationwide, population-based, cohort study from 1973 to 2009 in Sweden. All women above 18 years of age during the period between January 1, 1973 and December 31, 2009 from the Register of Population (n ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.30606

    authors: Falconer H,Yin L,Bellocco R,Altman D

    更新日期:2017-04-15 00:00:00