Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes.


:TK is a pyrimidine metabolic pathway enzyme involved in salvage DNA synthesis. What roles TK may play in epithelial ovarian cancer and the relationships between TK and the other pyrimidine pathway enzymes remain unclear. We examined TK1 gene expression by RT-PCR and related it to gene expression of TS, TP and DPD in 69 samples from epithelial ovarian cancer, 8 low-malignant-potential tumors, 16 benign ovarian tumors and 34 normal ovaries. Additionally, cytosolic and serum TK activities were determined by radioenzymatic assay. TK1 gene expression, the ratio of TK1 to TS gene expression, that of TK1 to TP and that of TK1 to DPD were significantly higher in epithelial ovarian cancer than in normal ovaries. In epithelial ovarian cancer, TK1 gene expression correlated with cytosolic and serum TK activities, TS and TP gene expression and the ratio of TP to DPD gene expression. Patients with high-TK1 gene expression had a significantly poorer survival than those with low TK1 gene expression. Combined analysis demonstrated that the relative risk of cancer death for tumors with high TK1, high TS and high TP gene expression was greater than that for tumors with high TK1 gene expression alone. TK1 gene expression together with TS, TP and DPD gene expression may play important roles in influencing the malignant behavior of epithelial ovarian cancer. Combination therapy including TK inhibitor is a possible therapeutic intervention in patients with epithelial ovarian cancer.


Int J Cancer


Fujiwaki R,Hata K,Nakayama K,Moriyama M,Iwanari O,Katabuchi H,Okamura H,Sakai E,Miyazaki K





Has Abstract


2002-05-20 00:00:00












  • Cause-specific mortality after diagnosis of cancer among HIV-positive patients: A collaborative analysis of cohort studies.

    abstract::People living with HIV (PLHIV) are more likely than the general population to develop AIDS-defining malignancies (ADMs) and several non-ADMs (NADMs). Information is lacking on survival outcomes and cause-specific mortality after cancer diagnosis among PLHIV. We investigated causes of death within 5 years of cancer dia...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Trickey A,May MT,Gill MJ,Grabar S,Vehreschild J,Wit FWNM,Bonnet F,Cavassini M,Abgrall S,Berenguer J,Wyen C,Reiss P,Grabmeier-Pfistershammer K,Guest JL,Shepherd L,Teira R,d'Arminio Monforte A,Del Amo J,Justice A,Cost

    更新日期:2020-06-01 00:00:00

  • Reciprocal activating interaction between 6-sulfo LacNAc+ dendritic cells and NK cells.

    abstract::Dendritic cells (DCs) display an extraordinary capacity to induce T-cell responses providing the opportunity of DC-based cancer vaccination strategies. Additional findings indicate that DCs may also play a crucial role for the activation of natural killer (NK) cells, which are important effectors in innate antitumor i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wehner R,Löbel B,Bornhäuser M,Schäkel K,Cartellieri M,Bachmann M,Rieber EP,Schmitz M

    更新日期:2009-01-15 00:00:00

  • Evidence for tissue factor phosphorylation and its correlation with protease-activated receptor expression and the prognosis of primary breast cancer.

    abstract::Tissue factor (TF)-mediated protease-activated receptor (PAR)-2 signaling is associated with a promigratory, invasive and proangiogenic phenotype in experimental models of breast cancer and has been mechanistically coupled to phosphorylation of the TF cytoplasmic domain (pTF). However, the clinical relevance of these ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rydén L,Grabau D,Schaffner F,Jönsson PE,Ruf W,Belting M

    更新日期:2010-05-15 00:00:00

  • GD2-mediated melanoma cell targeting and cytotoxicity of liposome-entrapped fenretinide.

    abstract::Melanoma is a highly malignant and increasingly common neoplasm. Because metastatic melanoma remains incurable, new treatment approaches are needed. Immunoliposomes have been previously shown to enhance the selective localization of immunoliposome-entrapped drugs to solid tumors with improvements in the therapeutic in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pagnan G,Montaldo PG,Pastorino F,Raffaghello L,Kirchmeier M,Allen TM,Ponzoni M

    更新日期:1999-04-12 00:00:00

  • Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma.

    abstract::Germline mutation of the folliculin gene (BHD) at chromosome 17p11.2 is associated with the development of multiplex hamartomas of the hair follicles, chromophobe renal cell carcinomas (RCC) and renal oncocytomas (RO). We have analyzed the folliculin gene with sequencing for mutations and the chromosome 17p11.2 with m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nagy A,Zoubakov D,Stupar Z,Kovacs G

    更新日期:2004-04-10 00:00:00

  • Determining MDR1/P-glycoprotein expression in breast cancer.

    abstract::The mechanism of chemotherapy resistance in breast cancer is unresolved. MDR1/P-glycoprotein (P-Gp) over-expression confers multidrug resistance in vitro and might play a role in clinical breast cancer. Studies using clinical samples have yielded conflicting results. MDR1/P-Gp mRNA expression was determined relative t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Faneyte IF,Kristel PM,van de Vijver MJ

    更新日期:2001-07-01 00:00:00

  • Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase.

    abstract::Recently, pegylated arginine deiminase (ADI; EC has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. The efficacy of its antitumor activity largely depends on the level of intracellular ASS, whi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yoon CY,Shim YJ,Kim EH,Lee JH,Won NH,Kim JH,Park IS,Yoon DK,Min BH

    更新日期:2007-02-15 00:00:00

  • Socioeconomic factors in cancer in Sweden.

    abstract::It is well known that certain cancers have shown clustering in socioeconomic groups, but limited data are available on recent results and time trends in such clustering. We determined standardized incidence ratios (SIR) for cancer, adjusted for age, period, region, parity and age at first childbirth among men and wome...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hemminki K,Zhang H,Czene K

    更新日期:2003-07-10 00:00:00

  • Proliferating cell nuclear antigen (PCNA) in relation to ras, c-erbB-2,p53, clinico-pathological variables and prognosis in colorectal adenocarcinoma.

    abstract::Proliferating cell nuclear antigen (PCNA) expression was studied by immunohistochemistry on paraffin-embedded sections of 293 primary colorectal adenocarcinomas and 56 corresponding lymph node metastases. PCNA-positive expression was detected in <25% of tumour cells in 172 (59%) cases and in > 25% in 121 (41%) cases. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sun XF,Carstensen JM,Stål O,Zhang H,Nordenskjöld B

    更新日期:1996-02-20 00:00:00

  • Cancer survival in people with AIDS: A population-based study from São Paulo, Brazil.

    abstract::Cancer survival among people with AIDS (PWA) has been described in developed countries, but there is lack of data from developing countries. The aim of this study was to evaluate survival after cancer diagnosis in PWA and compare it with people without AIDS (non-PWA) in São Paulo, Brazil. A probabilistic record linkag...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tanaka LF,Latorre MDRDO,Gutierrez EB,Curado MP,Dal Maso L,Herbinger KH,Froeschl G,Heumann C

    更新日期:2018-02-01 00:00:00

  • The prevalence of antibody to p42 of HTLV-I among ATLL patients in comparison with healthy carriers in Japan.

    abstract::A gene product (p42) of the long open reading frame, now termed tax, of the viral genome of human T-cell leukemia virus type I (HTLV-I) may be related to the transformation of T cells in adult T-cell leukemia-lymphoma (ATLL). To evaluate its association with the disease, we compared the prevalence of antibody to p42 i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yokota T,Cho MJ,Tachibana N,McLane MF,Takatsuki K,Lee TH,Mueller N,Essex M

    更新日期:1989-06-15 00:00:00

  • Lymphangiogenesis in colorectal cancer--prognostic and therapeutic aspects.

    abstract::Colorectal cancer (CRC) represents the second most common cause of cancer mortality in the western world. The tumors frequently show metastatic spread which affects different organs such as lymph nodes, liver and lungs. Although the pattern of spread may vary, the initial step usually involves dissemination to regiona...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Sundlisaeter E,Dicko A,Sakariassen PØ,Sondenaa K,Enger PØ,Bjerkvig R

    更新日期:2007-10-01 00:00:00

  • Germline APOBEC3B deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, PIK3CA mutations, and immune activation.

    abstract::A 30-kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian compared to European descent. This polymorphism creates a chimera with the APOBEC3A (A3A) coding region and A3B 3'UTR, and is associated with an increased risk for breast cancer in Asian women. Here, we explo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pan JW,Zabidi MMA,Chong BK,Meng MY,Ng PS,Hasan SN,Sandey B,Bahnu S,Rajadurai P,Yip CH,Rueda OM,Caldas C,Chin SF,Teo SH

    更新日期:2021-01-07 00:00:00

  • Differential lysis of melanoma clones by autologous recombinant interleukin 2-activated lymphocytes. Relationship with spontaneous resistance to doxorubicin (Dx).

    abstract::To investigate whether human melanoma cells intrinsically resistant to autologous LAKs do exist, and whether a relationship between the level of lysis of LAKs and spontaneous drug resistance can be identified at the clonal level, we studied 44 clones obtained from a metastatic melanoma lesion. The antigenic phenotype ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gambacorti-Passerini C,Rivoltini L,Supino R,Mariani M,Parmiani G

    更新日期:1988-10-15 00:00:00

  • Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients.

    abstract::We investigated the expression pattern of the breast cancer associated gene LIV-1 on mRNA and protein level in 111 human breast cancer patients by in situ hybridization as well as immunohistochemistry and focused on the unknown potential of LIV-1 expression levels as a prognostic marker. To our knowledge, this is the ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kasper G,Weiser AA,Rump A,Sparbier K,Dahl E,Hartmann A,Wild P,Schwidetzky U,Castaños-Vélez E,Lehmann K

    更新日期:2005-12-20 00:00:00

  • Oesophageal mucosa in a population at risk of oesophageal cancer: post-mortem studies.

    abstract::We performed post-mortem studies of oesophageal mucosa from 513 consecutive autopsies of cases who died from unnatural causes or from diseases not related to the oesophagus. Of these, 170 cases were rural blacks from endemic high-risk areas, 98 were urban blacks at high risk, 158 were coloureds at moderate risk and 87...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jaskiewicz K,Banach L,Mafungo V,Knobel GJ

    更新日期:1992-01-02 00:00:00

  • Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis.

    abstract::Desmoids represent the most important cause of death, after colorectal cancer, in patients affected with familial adenomatous polyposis (FAP), an inherited disease due to mutations in the APC gene. The aims of our study were to estimate the risk of developing desmoids in FAP patients and to evaluate the association be...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bertario L,Russo A,Sala P,Eboli M,Giarola M,D'amico F,Gismondi V,Varesco L,Pierotti MA,Radice P,Hereditary Colorectal Tumours Registry.

    更新日期:2001-03-20 00:00:00

  • Tumor lymphangiogenesis and metastatic spread-new players begin to emerge.

    abstract::The metastatic spread of tumor cells is the most lethal aspect of cancer and can occur via various routes, including the lymphatic vasculature. Studies of tumor models in animals and clinicopathological data have indicated that growth of lymphatic vessels (lymphangiogenesis) in the vicinity of solid tumors may contrib...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Achen MG,Stacker SA

    更新日期:2006-10-15 00:00:00

  • Inhibitory effect of 4-methylesculetin on hyaluronan synthesis slows the development of human pancreatic cancer in vitro and in nude mice.

    abstract::We report the inhibitory effect of 4-methylesculetin (ME), a 4-methylumbelliferone derivative, on hyaluronan (HA) synthesis by pancreatic cancer cells, and its resulting anticancer action. First, HA in cell culture was analyzed using competitive inhibition with hyaluronic acid-binding protein (HABP) to study HA synthe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hajime M,Shuichi Y,Makoto N,Masanori Y,Ikuko K,Atsushi K,Mutsuo S,Keiichi T

    更新日期:2007-06-15 00:00:00

  • Diet and risk of esophageal cancer by histologic type in a low-risk population.

    abstract::In a hospital-based case-control study of esophageal cancer undertaken in Athens (1989-1991), 43 patients with incident esophageal squamous-cell carcinoma and 56 patients with incident esophageal adenocarcinoma were compared to 200 injury patients. Personal interviews were conducted in the hospital setting, and dietar...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tzonou A,Lipworth L,Garidou A,Signorello LB,Lagiou P,Hsieh C,Trichopoulos D

    更新日期:1996-11-04 00:00:00

  • Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone.

    abstract::To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter (238)Pu, and the expression profiles were compared with those of normal osteoblasts (OB). The expressions of 72 genes were significan...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Daino K,Ugolin N,Altmeyer-Morel S,Guilly MN,Chevillard S

    更新日期:2009-08-01 00:00:00

  • A prognostic classifier consisting of 17 circulating cytokines is a novel predictor of overall survival for metastatic colorectal cancer patients.

    abstract::We aimed to determine the prognostic values of 39 circulating cytokines in Chinese patients with metastatic colorectal cancer (CRC) and to develop a novel cytokine-based prognostic classifier (CBPC) for prognostic prediction. A total of 176 patients were divided into two cohorts based on the date of first-line chemoth...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen ZY,He WZ,Peng LX,Jia WH,Guo RP,Xia LP,Qian CN

    更新日期:2015-02-01 00:00:00

  • Randomized trial on the effect of radiotherapy in addition to 6 cycles CMF in node-positive breast-cancer patients. The German Breast-Cancer Study Group.

    abstract::In 1984 the GBSG started a multicenter randomized trial to compare the effectiveness of 6 cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) with or without radiotherapy (RT) as adjuvant treatment in node-positive breast-cancer patients treated by mastectomy. During 5 years, 199 patients were randomized. ...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Schmoor C,Bastert G,Dunst J,Bojar H,Christmann D,Unbehaun V,Tümmers G,Bauer W,Sauerbrei W,Schumacher M

    更新日期:2000-05-01 00:00:00

  • Incidence and mortality from stomach cancer in Japan, Slovenia and the USA.

    abstract::The mortality and incidence from stomach cancer were compared in Japan (a country with a high incidence where there was full application of mass screening during this period) and 2 countries with no screening policy: the USA (with a very low incidence) and Slovenia (with an intermediate rate). The registered cases of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lambert R,Guilloux A,Oshima A,Pompe-Kirn V,Bray F,Parkin M,Ajiki W,Tsukuma H

    更新日期:2002-02-20 00:00:00

  • Cytomatrix reorganization in dimethyl sulfoxide-induced "Qi" substate murine hepatic tumor cells.

    abstract::Cultured murine hepatic tumor (HT) cells respond to the polar solvent dimethylsulfoxide (DMSO) with specific alterations in morphology, proliferative kinetics, and biochemical properties. These include entrance into a quiescent "Qi" substate (characterized by accumulation of cells in G1 phase and lowered cellular RNA ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ryan MP,Higgins PJ

    更新日期:1988-08-15 00:00:00

  • KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line.

    abstract::KLF5 is a transcription factor that plays important roles in multiple physical and pathological processes, including cell growth, cell cycle regulation, and angiogenesis. To better characterize KLF5 function in bladder carcinogenesis, we established stable TSU-Pr1 cell clones expressing different levels of KLF5. These...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen C,Benjamin MS,Sun X,Otto KB,Guo P,Dong XY,Bao Y,Zhou Z,Cheng X,Simons JW,Dong JT

    更新日期:2006-03-15 00:00:00

  • Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells.

    abstract::Lysine-specific demethylase 1 (LSD1), a histone lysine demethylase with the main specificity for H3K4me2, has been shown to be overexpressed in rhabdomyosarcoma (RMS) tumor samples. However, its role in RMS biology is not yet well understood. Here, we identified a new role of LSD1 in regulating adhesion of RMS cells. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Haydn T,Kehr S,Willmann D,Metzger E,Schüle R,Fulda S

    更新日期:2020-06-15 00:00:00

  • Early life risk factors in cancer: the relation of birth weight to adult obesity.

    abstract::The intrauterine environment appears to play a role in the development of adult diseases, including several prominent cancers. Our study aims to characterize the relationship between birth weight, a measure of the intrauterine environment, and adult obesity. A population-based sample of women aged 50-79, living in the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Leong NM,Mignone LI,Newcomb PA,Titus-Ernstoff L,Baron JA,Trentham-Dietz A,Stampfer MJ,Willett WC,Egan KM

    更新日期:2003-03-01 00:00:00

  • Correlation between karyotypic pattern and clincopathologic features in 125 breast cancer cases.

    abstract::A correlation analysis was performed on 125 cytogenetically characterized breast cancer cases to assess the relationship between the tumor karyotype and clinicopathologic features. The carcinomas of young women had a higher modal chromosome number than those of older women. The number of chromosomal aberrations and mo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pandis N,Idvall I,Bardi G,Jin Y,Gorunova L,Mertens F,Olsson H,Ingvar C,Beroukas K,Mitelman F,Heim S

    更新日期:1996-04-10 00:00:00

  • Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.

    abstract::In this study the antigenic profile of Hodgkin (H) and Sternberg-Reed (SR) cells from cases of Hodgkin's disease was analysed using a large panel of monoclonal and polyclonal antibodies reactive with cells of lymphoid and haemotopoietic origin. The aim of this investigation was, firstly, to throw light on the origin o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Stein H,Gerdes J,Schwab U,Lemke H,Mason DY,Ziegler A,Schienle W,Diehl V

    更新日期:1982-10-15 00:00:00