Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes.

abstract：:Photodynamic therapy using 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX is a promising tool in bladder-cancer therapy. However, little is known about the cellular mechanisms of phototoxicity. Our aim was to characterize the cellular damage and to optimize differential photodynamic effectiveness between tumo...

journal_title：International journal of cancer

authors： Seidl J,Rauch J,Krieg RC,Appel S,Baumgartner R,Knuechel R

更新日期：2001-06-01 00:00:00

abstract：:T cell responses against malignant cells play a major role in maintaining remission and prolonging overall survival in patients after allogeneic stem cell transplantation and donor lymphocyte infusion (DLI) due to graft-versus-leukemia effect. For better characterization of the T cell responses, we assessed frequency ...

journal_title：International journal of cancer

authors： Hofmann S,Schmitt M,Götz M,Döhner H,Wiesneth M,Bunjes D,Greiner J

更新日期：2019-03-01 00:00:00

abstract：:Studies have shown an increased risk of malignancies in women with endometriosis. Little is known about the impact of endometriosis on cancer survival. We investigated whether the survival after a diagnosis of a malignancy differs in women with a previously diagnosed endometriosis compared to other women. Women with a...

journal_title：International journal of cancer

authors： Melin A,Lundholm C,Malki N,Swahn ML,Sparen P,Bergqvist A

更新日期：2011-08-15 00:00:00

abstract：:Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was reported to be essential ...

journal_title：International journal of cancer

authors： Yoshizaki T,Maruyama Y,Sato H,Furukawa M

更新日期：2001-01-20 00:00:00

abstract：:It is thought that TIL can be activated in vitro by rIL-2 and acquire specific anti-tumor activity. In this study, we investigated this possibility, using lymphocytes isolated from primary lung cancer tissues. In a first series of experiments, TILs and autologous PBLs from 16 patients were cultured in rIL-2 from 7 to ...

journal_title：International journal of cancer

authors： Yano T,Yasumoto K,Togami M,Ishida T,Kimura G,Sugimachi K,Nomoto K

更新日期：1989-04-15 00:00:00

abstract：:Chemokines and chemokine receptors mediate lymphocyte migration and tissue localization. To analyze CCL5 (RANTES) expression by EBV-infected cells, we examined the expression of CCL5 in BL cell lines. Among 4 BL cell lines, those infected with EBV selectively expressed the CCL5 gene and secreted CCL5. Four cell lines ...

journal_title：International journal of cancer

authors： Uchihara JN,Krensky AM,Matsuda T,Kawakami H,Okudaira T,Masuda M,Ohta T,Takasu N,Mori N

更新日期：2005-05-01 00:00:00

abstract：:We have investigated the comparative initial DNA binding properties of 7 platinum-based anticancer drugs: 5 cis-oriented compounds, cisplatin, tetraplatin (Ormaplatin), JM118 [cis ammine dichloro (cyclohexylamine) platinum (II)], JM216 [bisacetato cis ammine dichloro (cyclohexylamine) platinum (IV)] and JM149 [cis amm...

journal_title：International journal of cancer

authors： Mellish KJ,Barnard CF,Murrer BA,Kelland LR

更新日期：1995-09-15 00:00:00

abstract：:Duodenogastric reflux (DGR) causes glandular stomach carcinogenesis in rats without carcinogens. We aimed to investigate how this carcinogenesis might be prevented by a selective COX-2 inhibitor, meloxicam. A series of 188 Fisher 344 rats underwent a surgical DGR procedure and were divided into 2 groups. One group was...

journal_title：International journal of cancer

authors： Oba M,Miwa K,Fujimura T,Harada S,Sasaki S,Hattori T

更新日期：2008-10-01 00:00:00

abstract：:The major goal in cancer immunotherapy is the induction of tumor-specific T lymphocytes capable of killing tumor cells. As both dendritic cells (DCs) and interleukin-12 (IL-12) can play immunostimulatory roles in vivo, the use of a combination of these has become a promising approach. In the present study, we used a m...

journal_title：International journal of cancer

authors： Furumoto K,Arii S,Yamasaki S,Mizumoto M,Mori A,Inoue N,Isobe N,Imamura M

更新日期：2000-09-01 00:00:00

abstract：:Aberrant promoter methylation of normally unmethylated CpG-islands offers a promising tool for the development of molecular biomarkers. We investigated bronchial aspirates of patients admitted for suspected lung cancer with regard to the prevalence of aberrant methylation of potential marker genes. Applying quantitati...

journal_title：International journal of cancer

authors： Grote HJ,Schmiemann V,Geddert H,Rohr UP,Kappes R,Gabbert HE,Böcking A

更新日期：2005-09-20 00:00:00

abstract：:Expression of the macrophage antigen CD163 in breast cancer cells is recently shown to be related to early distant recurrence and shortened survival. In this study, 163 patients with rectal cancer, included in the Swedish rectal cancer trial and followed up for a median of 71 months, were examined for the expression o...

journal_title：International journal of cancer

authors： Shabo I,Olsson H,Sun XF,Svanvik J

更新日期：2009-10-15 00:00:00

abstract：:The metastatic dissemination of cancer cells to remote areas of the body is the most problematic aspect in cancer patients. Among cancers, melanomas are notoriously difficult to treat due to their significantly high metastatic potential even during early stages. Hence, the establishment of advanced therapeutic approac...

journal_title：International journal of cancer

authors： Kinoshita R,Sato H,Yamauchi A,Takahashi Y,Inoue Y,Sumardika IW,Chen Y,Tomonobu N,Araki K,Shien K,Tomida S,Torigoe H,Namba K,Kurihara E,Ogoshi Y,Murata H,Yamamoto KI,Futami J,Putranto EW,Ruma IMW,Yamamoto H,Soh J

更新日期：2019-07-15 00:00:00

abstract：:Recently, several studies have showed that FAS (rs2234767, rs1800682) and FASL (rs763110) functional single nucleotide polymorphisms (SNPs) were associated with the risk of various cancers. However, the association between cervical cancer risk and the three SNPs above remained inconclusive. In this work, we performed ...

journal_title：International journal of cancer

authors： Wu S,Wang S,Fu Y,Tang W,Jin H,Meng Q,Zhang C,Cui M,Cao X,Li X,Zhang Z,Chen R

更新日期：2017-02-15 00:00:00

abstract：:The authors reported in a previous study that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nano-system, exhibited high antitumor activity against human colorectal cancer xenografts. This study was conducted to investigate the advantages of NK012 over irinotecan hydrochloride (CPT-11) administered in comb...

journal_title：International journal of cancer

authors： Nakajima TE,Yasunaga M,Kano Y,Koizumi F,Kato K,Hamaguchi T,Yamada Y,Shirao K,Shimada Y,Matsumura Y

更新日期：2008-05-01 00:00:00

abstract：:Histologically confirmed testicular tumors were diagnosed in 410 dogs from 12 North American veterinary university hospitals and clinics. Three tumor-cell types, Sertoli cell tumor, interstitial cell tumor and seminoma, were about equally represented. Several breeds were identified with high risk for different testicu...

journal_title：International journal of cancer

authors： Hayes HM Jr,Pendergrass TW

更新日期：1976-10-15 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-I) is etiologically associated with adult T-cell leukemia/lymphoma (ATL). We cloned and sequenced host DNA adjacent to the long terminal repeats of HTLV-I from uncultured leukemic cells of 4 ATL patients. The region flanking the provirus was generally A/T-rich (60-64% A/T), and...

journal_title：International journal of cancer

authors： Chou KS,Okayama A,Su IJ,Lee TH,Essex M

更新日期：1996-01-03 00:00:00

abstract：:A deficit in colorectal cancer survival in Denmark and in the UK compared to Sweden, Norway and Finland was found in the EUROCARE studies. We set out to explore if these differences still exist. Patients diagnosed with colorectal cancer as their first invasive cancer at age 15-89 in the period 1994-2000 were identifie...

journal_title：International journal of cancer

authors： Engholm G,Kejs AM,Brewster DH,Gaard M,Holmberg L,Hartley R,Iddenden R,Møller H,Sankila R,Thomson CS,Storm HH

更新日期：2007-09-01 00:00:00

abstract：:Cancer vaccines directed against tumor associate antigen (TAA) have produced encouraging results in preclinical models but not in cancer patients. A major limitation of this strategy is the relative degree of tolerance to these antigens and the low and heterogeneous tumor cell expression of TAA and major histocompatib...

journal_title：International journal of cancer

authors： Correale P,Aquino A,Giuliani A,Pellegrini M,Micheli L,Cusi MG,Nencini C,Petrioli R,Prete SP,De Vecchis L,Turriziani M,Giorgi G,Bonmassar E,Francini G

更新日期：2003-04-20 00:00:00

abstract：:Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incid...

journal_title：International journal of cancer

authors： Kitahara CM,Preston DL,Neta G,Little MP,Doody MM,Simon SL,Sigurdson AJ,Alexander BH,Linet MS

更新日期：2018-11-01 00:00:00

abstract：:Several lines of evidence have demonstrated that IFNs could be relevant in the treatment of certain neoplastic diseases such as carcinomas. In particular, IFN-alpha, in addition to the anti-proliferative and cytostatic effects, was demonstrated to be capable of inducing cell death by apoptosis both in vivo and in vitr...

journal_title：International journal of cancer

authors： Matarrese P,Giandomenico V,Fiorucci G,Rivabene R,Straface E,Romeo G,Affabris E,Malorni W

更新日期：1998-05-18 00:00:00

abstract：:Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14, 15 and 18 are frequently deleted in primary ovarian cancers (OCs). Therefore we used microcell-mediated chromosome transfer (MMCT) to establish the functional effects of transferring normal copies of these chromosomes ...

journal_title：International journal of cancer

authors： Dafou D,Ramus SJ,Choi K,Grun B,Trott DA,Newbold RF,Jacobs IJ,Jones C,Gayther SA

更新日期：2009-03-01 00:00:00

abstract：:Folate is required for biological methylation and nucleotide synthesis, aberrations of which are thought to be the mechanisms that enhance colorectal carcinogenesis produced by folate inadequacy. These functions of folate also depend on the availability of other B-vitamins that participate in "one-carbon metabolism," ...

journal_title：International journal of cancer

authors： Liu Z,Choi SW,Crott JW,Smith DE,Mason JB

更新日期：2008-08-01 00:00:00

abstract：:Proteins can be detected by South-western analyses of human tumour-cell extracts binding to double-stranded oligonucleotide DNA treated in vitro with the chemotherapeutic drug cis-diamminedichloroplatinum (II) (CDDP), but not to untreated DNA. The relative molecular masses of proteins binding to the CDDP-treated doubl...

journal_title：International journal of cancer

authors： McLaughlin K,Coren G,Masters J,Brown R

更新日期：1993-02-20 00:00:00

abstract：:A-kinase anchoring protein 3 (AKAP3) is a sperm protein and its expression appears to be restricted to the testis in normal adult tissues. We investigated AKAP3 mRNA expression in 20 normal ovaries and 54 ovarian cancers of different histological types, grades and stages by reverse transcription-polymerase chain react...

journal_title：International journal of cancer

authors： Hasegawa K,Ono T,Matsushita H,Shimono M,Noguchi Y,Mizutani Y,Kodama J,Kudo T,Nakayama E

更新日期：2004-01-01 00:00:00

abstract：:Kidney cancer often diagnosed at late stages when treatment options are severely limited. Thus, greater understanding of tumor metabolism leading ultimately to novel approaches to diagnosis is needed. Our laboratory has been utilizing metabolomics to evaluate compounds appearing in kidney cancer patients' biofluids at...

journal_title：International journal of cancer

authors： Ganti S,Taylor SL,Kim K,Hoppel CL,Guo L,Yang J,Evans C,Weiss RH

更新日期：2012-06-15 00:00:00

abstract：:By radioimmunoassay (RIA) mammary tumour virus (MTV) antigens were detected in individual milk samples of C3Hf mice, (female BALB/c X male C3Hf)F1 mice and (female C3Hf X male BALB/c)F1 mice; milk samples of BALB/c mice were negative. In the segregating backcross I population, female BALB/c X male (female BALB/c X mal...

journal_title：International journal of cancer

authors： van Nie R,Verstraeten AA

更新日期：1975-12-15 00:00:00

abstract：:The matrix metalloproteinase (MMP) family of proteins mediates various cellular pathways, including apoptosis and angiogenesis. Polymorphisms of MMP genes are associated with increased esophageal adenocarcinoma (EAC) risk. Gastroesophageal reflux disease (GERD) is an established EAC risk factor. We examined whether MM...

journal_title：International journal of cancer

authors： Cheung WY,Zhai R,Bradbury P,Hopkins J,Kulke MH,Heist RS,Asomaning K,Ma C,Xu W,Wang Z,Hooshmand S,Su L,Christiani DC,Liu G

更新日期：2012-12-01 00:00:00

abstract：:The monoclonal antibody (MAb) K1 recognizes an approximate 40 kDa glycoprotein, mesothelin, that is present on the surface of human mesothelial cells, mesotheliomas and ovarian cancers. We have cloned the cDNAs encoding the variable regions of MAb K1 and constructed plasmids for expression of recombinant K1(FAb). Reco...

journal_title：International journal of cancer

authors： Brinkmann U,Webber K,Di Carlo A,Beers R,Chowdhury P,Chang K,Chaudhary V,Gallo M,Pastan I

更新日期：1997-05-16 00:00:00

abstract：:Analysis of the length of circulating DNA in plasma has been reported as a marker for solid tumor detection. We assessed the sensitivity and specificity of increased plasma DNA length to identify patients with head and neck squamous cell carcinoma (HNSCC) and monitor posttreatment disease status. Fifty-eight HNSCC pat...

journal_title：International journal of cancer

authors： Jiang WW,Zahurak M,Goldenberg D,Milman Y,Park HL,Westra WH,Koch W,Sidransky D,Califano J

更新日期：2006-12-01 00:00:00

abstract：:Integrins are extracellular matrix receptors involved in tumour invasion and angiogenesis. Although there is evidence that inhibiting integrins might enhance the efficiency of radiotherapy, little is known about the exact mechanisms involved in the integrin-dependent modulation of tumor radiosensitivity. The purpose o...

journal_title：International journal of cancer

authors： Monferran S,Skuli N,Delmas C,Favre G,Bonnet J,Cohen-Jonathan-Moyal E,Toulas C

更新日期：2008-07-15 00:00:00