Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes.

abstract：:Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease characterized by early-onset colorectal tumors, primarily in the right colon, that are frequently associated with other cancers. In the absence of a reliable biomarker, clinical criteria for diagnosing HNPCC have been proposed by the I...

journal_title：International journal of cancer

authors： Percesepe A,Anti M,Marra G,Roncucci L,Pahor M,Coco C,Armelao F,Gasbarrini G,Ponz de Leon M

更新日期：1994-09-15 00:00:00

abstract：:Seven human ocular melanoma cell lines were established in vitro and 3 of these, GU-4, LLN-40 and its subline C17-11, were characterized. Mice were immunized with these ocular melanoma cell lines, and 2 hybridomas producing monoclonal IgG1 antibodies (MAb) were produced. MAb 2/10SN recognizes a 44-kDa monomeric protei...

journal_title：International journal of cancer

authors： Safi N,Kantor RR,Atkinson B,Moratz C,Wilt AR,Pancake S,Reba R,Mathieson BJ,Desgrez A

更新日期：1992-07-09 00:00:00

abstract：:The insulin like growth factor (IGF) signaling pathway has been shown to contribute to melanoma progression, but little is known about the role of the IGF binding protein 3 (IGFBP-3) in melanoma biology. The aim of the present study was to characterize expression, function and regulation of IGFBP-3 in malignant melano...

journal_title：International journal of cancer

authors： Oy GF,Slipicevic A,Davidson B,Solberg Faye R,Maelandsmo GM,Flørenes VA

更新日期：2010-01-15 00:00:00

abstract：:Thymuses of 14-day-old AKR mouse embryos were infected with Gross murine leukemia virus (MuLV) and then maintained in organ culture for 3 weeks. When they were transplanted to 3-week-old (AKR X C3H)F1 mice, approximately 50% of these developed T lymphomas within 3-4 months. Most (22/23) tumors were of host, F1-hybrid,...

journal_title：International journal of cancer

authors： Riesenfeld I,Tufveson G,Alm GV

更新日期：1980-04-15 00:00:00

abstract：:The EBV-encoded membrane protein (LMP) and the nuclear antigen EBNA-1 were compared for their capacity to induce rejection of transfected murine mammary carcinoma cells in syngeneic hosts. The tumorigenic potential of stable LMP and EBNA-1 expressing sublines of the ACA (H-2f)-derived mammary carcinoma line S6C was te...

journal_title：International journal of cancer

authors： Trivedi P,Masucci MG,Winberg G,Klein G

更新日期：1991-07-09 00:00:00

abstract：:EPLIN is frequently downregulated or lost in various cancers. The purpose of this study was to evaluate the importance of EPLIN in prostate cancer progression, with particular focus on the mechanistic implications to elucidate EPLIN's tumor suppressive function in cancer. EPLIN expression was evaluated in prostate can...

journal_title：International journal of cancer

authors： Collins RJ,Morgan LD,Owen S,Ruge F,Jiang WG,Sanders AJ

更新日期：2018-11-15 00:00:00

abstract：:We quantified the expression of survivin, both as mRNA in real-time PCR and protein in immunohistochemistry, in tumor samples of 112 patients with esophageal cancer (56 squamous cell carcinomas and 56 adenocarcinomas). Overall survival of squamous cell carcinoma patients with high survivin mRNA levels was significantl...

journal_title：International journal of cancer

authors： Rosato A,Pivetta M,Parenti A,Iaderosa GA,Zoso A,Milan G,Mandruzzato S,Del Bianco P,Ruol A,Zaninotto G,Zanovello P

更新日期：2006-10-01 00:00:00

abstract：:The murine B16 melanoma (H-2b) was transfected with a retroviral vector containing the mouse IFN-alpha 1 gene. IFN-alpha 1-transfected cells produced IFN-alpha in vitro and exhibited an altered phenotype characterized by a decreased rate of multiplication, enhanced expression of H-2 antigens, an antiviral state to VSV...

journal_title：International journal of cancer

authors： Kaido T,Bandu MT,Maury C,Ferrantini M,Belardelli F,Gresser I

更新日期：1995-01-17 00:00:00

abstract：:Immunological studies are presented on a patient with a long clinical history suggesting the existence of a tumor-specific immune response. His tumor, first considered benign, progressed to a highly malignant osteosarcoma. Cell-mediated immune reactivity against biopsy cells and against tumor extract was detected in v...

journal_title：International journal of cancer

authors： Vanky F,Klein E,Cornain S,Bakács T,Stjernswärd J,Nilsonne U

更新日期：1976-09-15 00:00:00

abstract：:A 30-kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian compared to European descent. This polymorphism creates a chimera with the APOBEC3A (A3A) coding region and A3B 3'UTR, and is associated with an increased risk for breast cancer in Asian women. Here, we explo...

journal_title：International journal of cancer

authors： Pan JW,Zabidi MMA,Chong BK,Meng MY,Ng PS,Hasan SN,Sandey B,Bahnu S,Rajadurai P,Yip CH,Rueda OM,Caldas C,Chin SF,Teo SH

更新日期：2021-01-07 00:00:00

abstract：:Human papillomavirus (HPV) has been identified as a causative agent of cervical cancer and oropharyngeal cancer (OPC). Intriguingly, estrogen and HPV were shown to play synergistic roles in cervical carcinogenesis. We recently demonstrated that the apolipoprotein B mRNA-editing catalytic polypeptide 3 (APOBEC3, A3) fa...

journal_title：International journal of cancer

authors： Kano M,Kondo S,Wakisaka N,Wakae K,Aga M,Moriyama-Kita M,Ishikawa K,Ueno T,Nakanishi Y,Hatano M,Endo K,Sugimoto H,Kitamura K,Muramatsu M,Yoshizaki T

更新日期：2019-09-15 00:00:00

abstract：:The aim of this study was to assess the diagnostic performance of breast imaging in the diagnosis of breast cancer in a non-screening population. In a consecutive set of patients referred for mammography in one year, the results of palpation and radiological breast imaging were scored on a 5-point grading scale and li...

journal_title：International journal of cancer

authors： Flobbe K,van der Linden ES,Kessels AG,van Engelshoven JM

更新日期：2001-05-15 00:00:00

abstract：:A new antigan has been revealed by means of antisera against Rauscher virus in mice with Rauscher virus-induced leukemia. This antigen appears to be different from both Rauscher type-specific antigen and MULV-gs-1 (p-30), as shown by studies of electrophoretic mobility and immunochemical specificity. Except in leukemi...

journal_title：International journal of cancer

authors： Ievleva ES,Engelhardt NV,Abelev GI

更新日期：1976-06-15 00:00:00

abstract：:Under the aegis of EUROCARE, a European Union project to assemble survival data from population-based cancer registries and analyze them according to standardized procedures, we have investigated and compared colon-cancer survival in 10 European countries. We analyzed 68,283 colon-cancer cases diagnosed between 1978 a...

journal_title：International journal of cancer

authors： Sant M,Capocaccia R,Verdecchia A,Gatta G,Micheli A,Mariotto A,Hakulinen T,Berrino F

更新日期：1995-09-27 00:00:00

abstract：:In advanced cancer patients, the oxidative stress could take place either at the onset of disease or as a function of disease progression. To test this hypothesis, the following parameters were investigated: the erythrocyte activity of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), the serum ...

journal_title：International journal of cancer

authors： Mantovani G,Macciò A,Madeddu C,Mura L,Gramignano G,Lusso MR,Mulas C,Mudu MC,Murgia V,Camboni P,Massa E,Ferreli L,Contu P,Rinaldi A,Sanjust E,Atzei D,Elsener B

更新日期：2002-03-01 00:00:00

abstract：:A subgroup of medulloblastomas shows constitutive activation of the Sonic hedgehog pathway with expression of GLI1. We identified the subset of GLI1 transforming target genes specifically expressed in medulloblastomas by comparing GLI1 targets in RK3E cells transformed by GLI1 with the gene expression profile of Sonic...

journal_title：International journal of cancer

authors： Yoon JW,Gilbertson R,Iannaccone S,Iannaccone P,Walterhouse D

更新日期：2009-01-01 00:00:00

abstract：:Numerous reports suggest that interleukin-6 (IL-6) promotes survival and proliferation of tumor cells through the phosphorylation of a cell-signaling protein, signal-transducer-and-activator-of-transcription-3 (STAT3). Constitutive activation of STAT3 in head and neck squamous cell carcinoma (HNSCC) and its role in pr...

journal_title：International journal of cancer

authors： Chakravarti N,Myers JN,Aggarwal BB

更新日期：2006-09-15 00:00:00

abstract：:Cervical cancer screening test performance has been hampered by either lack of sensitivity of Pap cytology or lack of specificity of Human Papillomavirus (HPV) testing. This uncertainty can lead to unnecessary referral and treatment, which is disturbing for patients and increases costs for health care providers. The i...

journal_title：International journal of cancer

authors： Bergeron C,Ronco G,Reuschenbach M,Wentzensen N,Arbyn M,Stoler M,von Knebel Doeberitz M

更新日期：2015-06-15 00:00:00

abstract：:We have examined, in proliferating neoplastic cells, the effect on DNA of EGTA (a chelator of Ca2+) and W7 (an inhibitor of calmodulin). The treatment results in release of single-stranded DNA fragments (2-10 kb) from pre-labelled HMW DNA. When DNA from synchronized neoplastic cells in S phase is examined, almost all ...

journal_title：International journal of cancer

authors： Lönn U,Lönn S

更新日期：1986-06-15 00:00:00

abstract：:History of diabetes may be associated with decreased prostate cancer (PCa) risk. Published studies have not always accounted for time since diabetes diagnosis or confounding and effect modification by lifestyle factors. The authors investigated the relationship between diabetes and PCa risk in men in the Health Profes...

journal_title：International journal of cancer

authors： Kasper JS,Liu Y,Giovannucci E

更新日期：2009-03-15 00:00:00

abstract：:Using high-throughput analyses and the TRANSFAC database, we characterized TF signatures of head and neck squamous cell carcinoma (HNSCC) subgroups by inferential analysis of target gene expression, correcting for the effects of DNA methylation and copy number. Using this discovery pipeline, we determined that human p...

journal_title：International journal of cancer

authors： Gaykalova DA,Manola JB,Ozawa H,Zizkova V,Morton K,Bishop JA,Sharma R,Zhang C,Michailidi C,Considine M,Tan M,Fertig EJ,Hennessey PT,Ahn J,Koch WM,Westra WH,Khan Z,Chung CH,Ochs MF,Califano JA

更新日期：2015-10-15 00:00:00

abstract：:The variants within the human melanocortin 1 receptor (MC1R) gene are associated with an increased risk of different skin cancers. In this study, we genotyped by direct sequencing, 529 cases of basal cell carcinoma of the skin (BCC) and 533 healthy controls for polymorphisms in the entire MC1R gene. In addition to 10 ...

journal_title：International journal of cancer

authors： Scherer D,Bermejo JL,Rudnai P,Gurzau E,Koppova K,Hemminki K,Kumar R

更新日期：2008-04-15 00:00:00

abstract：:Evidence from epidemiologic studies suggests a possible role of exogenous and endogenous hormones in colorectal carcinogenesis in women. However, with respect to exogenous hormones, in contrast to hormone replacement therapy, few cohort studies have examined oral contraceptive use in relation to colorectal cancer risk...

journal_title：International journal of cancer

authors： Kabat GC,Miller AB,Rohan TE

更新日期：2008-02-01 00:00:00

abstract：:LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...

journal_title：International journal of cancer

authors： To MD,Faseruk SA,Gokgoz N,Pinnaduwage D,Done SJ,Andrulis IL

更新日期：2005-07-01 00:00:00

abstract：:Co-injection of fibroblasts with human epithelial breast-tumor MCF7 cells in the presence of Matrigel enhances tumor growth in nude mice. While most of the matrix metalloproteinases (MMPs) have been shown to be produced by stromal cells, tumor cells such as MCF7 cells are unable to produce MMPs. We therefore, hypothes...

journal_title：International journal of cancer

authors： Noël A,Hajitou A,L'Hoir C,Maquoi E,Baramova E,Lewalle JM,Remacle A,Kebers F,Brown P,Calberg-Bacq CM,Foidart JM

更新日期：1998-04-13 00:00:00

abstract：:Immune cells in tumor microenvironment play a prominent role in tumor progression and metastasis. MicroRNA-155 (miR-155) represents an important player in innate and adaptive immunity by regulating differentiation, maturation and activation of macrophages, dendritic cells, B cells and T cells. However, the role of miR...

journal_title：International journal of cancer

authors： Wang J,Yu F,Jia X,Iwanowycz S,Wang Y,Huang S,Ai W,Fan D

更新日期：2015-03-15 00:00:00

abstract：:3-Nitrobenzanthrone (3-NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3-NBA is likely to occur primarily via the respiratory tract. In our study female Sprague Dawley rats were...

journal_title：International journal of cancer

authors： Bieler CA,Cornelius MG,Klein R,Arlt VM,Wiessler M,Phillips DH,Schmeiser HH

更新日期：2005-10-10 00:00:00

abstract：:In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells into the CNS. A direct comparison of remote metastases found in differen...

journal_title：International journal of cancer

authors： Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

更新日期：1999-09-24 00:00:00

abstract：:Metastasis of colorectal cancer (CRC) is the leading cause of CRC-associated mortality. Angiogenin (ANG), a member of the ribonuclease A superfamily, not only activates endothelial cells to induce tumor angiogenesis, but also targets tumor cells to promote cell survival, proliferation and/or migration. However, its cl...

journal_title：International journal of cancer

authors： Li S,Shi X,Chen M,Xu N,Sun D,Bai R,Chen H,Ding K,Sheng J,Xu Z

更新日期：2019-09-01 00:00:00

abstract：:It is well known that certain cancers have shown clustering in socioeconomic groups, but limited data are available on recent results and time trends in such clustering. We determined standardized incidence ratios (SIR) for cancer, adjusted for age, period, region, parity and age at first childbirth among men and wome...

journal_title：International journal of cancer

authors： Hemminki K,Zhang H,Czene K

更新日期：2003-07-10 00:00:00