Abstract:
:Thymuses of 14-day-old AKR mouse embryos were infected with Gross murine leukemia virus (MuLV) and then maintained in organ culture for 3 weeks. When they were transplanted to 3-week-old (AKR X C3H)F1 mice, approximately 50% of these developed T lymphomas within 3-4 months. Most (22/23) tumors were of host, F1-hybrid, origin while only one was of donor AKR type. No clear evidence for in vitro MuLV-induced lymphoma cells was therefore obtained. Exposure of MuLV-infected embryonic thymuses to interferon during the organ culture period significantly reduced the incidence of lymphomas in mice receiving such thymus transpalnts. Interferon also prevented the appearance of detectable numbers of MuLV antigen-containing lymphocytes in infected organ-cultured thymuses. In contrast, despite the use of very high interferon concentrations, no effects were seen on the number of viable thymic lymphocytes, their proliferation or responsiveness to the polyclonal T-cell mitogens concanavalin A (Con A) and leukoagglutinin (LA). Thus interferon, presumably through an antiviral effect, can limit the MuLV infection in the thymus and its consequence, i.e. development of a lymphoma.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Riesenfeld I,Tufveson G,Alm GVdoi
10.1002/ijc.2910250415subject
Has Abstractpub_date
1980-04-15 00:00:00pages
529-34issue
4eissn
0020-7136issn
1097-0215journal_volume
25pub_type
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journal_title:International journal of cancer
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