Abstract:
:Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4-h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in the control group. NK activity of PBL from alcoholics was still higher than that of similarly treated PBL from control subjects after carbonyl iron and magnet treatment, or after passage through a nylon wool column or after removal of cells rosetting with sheep erythrocytes. Changes in T cell, B cell or macrophage populations, therefore, are not the mechanism for increased NK activity in alcoholics.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Saxena QB,Mezey E,Adler WHdoi
10.1002/ijc.2910260405subject
Has Abstractpub_date
1980-10-15 00:00:00pages
413-7issue
4eissn
0020-7136issn
1097-0215journal_volume
26pub_type
杂志文章abstract::T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580311
更新日期:1994-08-01 00:00:00
abstract::Fine-needle aspiration cytology (FNAC) is currently used in evaluating the nature of breast nodules. In the present study we have examined whether monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) can be employed in FNAC for the diagnosis of breast cancer. For this purpose we have used 2 murine M...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370404
更新日期:1986-04-15 00:00:00
abstract::Interleukin-12 (IL-12) has potent antitumor activities via natural killer cells and cytotoxic T lymphocytes. However, the molecular mechanisms whereby IL-12 induces tumoricidal activities are poorly understood. Here, we report the genome-wide analysis of gene expression in a primary murine mammary carcinoma model that...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20145
更新日期:2004-07-01 00:00:00
abstract::Activated T cells expressing endogenous or transduced TCRs are two cell types currently used in clinical adoptive T-cell therapy. The ability of these cells to recognize their antigen, expand and traffic to the tumor site are the initial steps necessary for successful therapy. In this study, we used in vivo biolumines...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29401
更新日期:2015-07-15 00:00:00
abstract::In a retrospective analysis of 203 patients with small cell lung cancer (SCLC), we examined the prognostic value of c-kit expression on survival. Expression of c-kit was examined immunohistochemically in formalin-fixed, paraffin-embedded tissue sections. c-kit was observed in 87.7% of SCLC tumors. Using the Kaplan-Mei...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20252
更新日期:2004-08-20 00:00:00
abstract::Human 8-oxoguanine DNA glycosylase 1 (hOGG1) plays a major role in the repair of 8-hydroxyguanine, one of the major forms of DNA damage generated by reactive oxygen species in tobacco smoke. If left unrepaired by hOGG1, 8-hydroxyguanine can produce G:C-to-T:A transversions. Recent studies have suggested that the hOGG1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20730
更新日期:2005-04-10 00:00:00
abstract::Although treatment of Hodgkin's lymphoma (HL) with a multi-drug approach has been very successful, its toxicity becomes evident after several years as secondary malignancies and cardiovascular disease. Therefore, the current goal in HL treatment is to find new therapies that specifically target the deregulated signali...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23477
更新日期:2008-07-01 00:00:00
abstract::JNK activity has been implicated in the malignant proliferation, invasion and drug-resistance of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently unknown. Here, we reported that MKK7, not MKK4, directly activates JNK in GCs and exerts oncogenic effects on tumor formation. Notabl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32321
更新日期:2019-11-01 00:00:00
abstract::Studies have shown an increased risk of malignancies in women with endometriosis. Little is known about the impact of endometriosis on cancer survival. We investigated whether the survival after a diagnosis of a malignancy differs in women with a previously diagnosed endometriosis compared to other women. Women with a...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.25718
更新日期:2011-08-15 00:00:00
abstract::Cancer incidence disparities exist among specific Asian American populations. However, the existing reports exclude data from large metropoles like Chicago, Houston and New York. Moreover, incidence rates by subgroup have been underestimated due to the exclusion of Asians with unknown subgroup. Cancer incidence data f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29958
更新日期:2016-05-01 00:00:00
abstract::Desmoids represent the most important cause of death, after colorectal cancer, in patients affected with familial adenomatous polyposis (FAP), an inherited disease due to mutations in the APC gene. The aims of our study were to estimate the risk of developing desmoids in FAP patients and to evaluate the association be...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010320)95:2<102::aid-ijc1018>3
更新日期:2001-03-20 00:00:00
abstract::We have previously reported that the negative signaling regulator Similar Expression to FGF (hSef) is downregulated in prostate cancer and its loss is associated with clinical metastasis. Here, we explored the mechanistic basis of this finding. We first confirmed our clinical observation by testing hSef manipulation i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30604
更新日期:2017-04-15 00:00:00
abstract::Alterations in the gene copy numbers of the proto-oncogenes HER2/neu and c-myc in primary human breast cancer investigated in 73 patients. We detected amplification of HER2/neu in 17 patient samples and amplification of c-myc in 11, while amplification of both was seen in 6 samples. There was no correlation of age, ho...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.2910430218
更新日期:1989-02-15 00:00:00
abstract::Vascular endothelial growth factor-A (VEGF-A) plays an important role in tumour angiogenesis and cancer progression. VEGF gene variation may influence VEGF levels and therefore cancer susceptibility and progression. We studied the role of VEGF single nucleotide polymorphisms and haplotypes in breast cancer susceptibil...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22772
更新日期:2007-09-01 00:00:00
abstract::An orang-utan (Pongo pygmaeus) suspension line, CP81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic N-alkaline phosphatase activity, and to release a B-cell-tropic herpesvirus. This herpesvirus, termed Herpesvirus pongo, had 30--40% DNA homology with EBV an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210614
更新日期:1978-06-15 00:00:00
abstract::The variants within the human melanocortin 1 receptor (MC1R) gene are associated with an increased risk of different skin cancers. In this study, we genotyped by direct sequencing, 529 cases of basal cell carcinoma of the skin (BCC) and 533 healthy controls for polymorphisms in the entire MC1R gene. In addition to 10 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23257
更新日期:2008-04-15 00:00:00
abstract::Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human chromosome 18q21. This chromosomal region maps a gene cluster coding for a family of intracellular serine protease inhibitors (serpins), including SERPINB13. As SERPI...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24507
更新日期:2009-10-01 00:00:00
abstract::We have studied the production and release of cholecystokinin (CCK) forms by rat medullary thyroid cancer (MTC) in vivo. MTC cells were inoculated s.c. into 8 Wag-Rij rats. One month later, after i.v. injection of calcium plasma levels of CCK, calcitonin and tissue contents of gastrin and calcitonin were determined by...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480510
更新日期:1991-07-09 00:00:00
abstract::Therapy-induced senescence (TIS) as a permanent growth arrest can be induced by various stimuli, including anticancer compounds. TIS emerged as a promising strategy to overcome resistance phenomena. However, senescent cancer cells might regain proliferation activity in vivo or even secrete tumor-promoting cytokines. T...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28350
更新日期:2014-01-01 00:00:00
abstract::Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear. Immunohistochemical detection of Gab2 in a large cohort of primary human breast cancers of known outcome revealed that while Gab...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25172
更新日期:2010-09-01 00:00:00
abstract::Mammalian LIM kinase 1 (LIMK1) phosphorylates and inactivates the actin-binding and -depolymerizing factor cofilin and induces actin cytoskeletal changes. LIMK1 is reported to play an important role in cell motility, but the mechanism of induction of cell motility and the role of LIMK1 in tumor growth, angiogenesis an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21650
更新日期:2006-06-01 00:00:00
abstract::To obtain a comprehensive overview of chromosomal alterations that may underlie human papillomavirus (HPV)-mediated immortalization, 4 foreskin keratinocyte cell lines generated by transfection with either HPV 16 (cell lines FK16A and FK16B) or HPV 18 (FK18A and FK18B) were subjected to chromosomal analysis using comp...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980504)76:3<412::aid-ijc
更新日期:1998-05-04 00:00:00
abstract::We previously reported that DX-8951f, a novel water-soluble camptothecin analog, significantly inhibits the growth of various human and murine tumors in vitro and in vivo. The antitumor effects and topoisomerase I inhibitory activity of DX-8951f are stronger than those of other current camptothecin analogs. In this st...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970807)72:4<680::aid-ijc
更新日期:1997-08-07 00:00:00
abstract::The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20754
更新日期:2005-05-20 00:00:00
abstract::To elucidate the relationship, if any, of p53 gene expression according to smoking and drinking habits, 135 subjects with cancer of the upper aero-digestive tract were sampled from a case-control investigation conducted in Pordenone province, Northeast Italy, between 1986 and 1991. Adequate pathological material for i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600625
更新日期:1995-03-16 00:00:00
abstract::Two factors potentially determining the consistent overexpression of sialyl-Le(x) antigen in colon carcinoma and metastases were investigated: (i) the expression of the mucins MUC1 and MUC2, known to carry sialyl-Le(x), by Northern blotting; (ii) the extent of sialic acid O-acetylation, by Western blotting and HPLC. R...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970717)72:2<258::aid-ijc
更新日期:1997-07-17 00:00:00
abstract::Osteosacarcoma (OS) lung metastases are often resistant to chemotherapy. Most anticancer drugs are administered systemically. In many cases this is followed by dose-dependent toxicity, which may not allow the achievement of therapeutic levels in lungs to eradicate metastases. We determined the efficacy of gemcitabine ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21011
更新日期:2005-09-01 00:00:00
abstract::We compared and contrasted intracranial (i.c.) and subcutaneous (s.c.) heterotransplantation of small-cell carcinoma of the lung (SCCL) into athymic nude mice. Fresh human SCCL tumor specimens, tumor colonies grown in soft agarose and continuous cell lines were used. Tumors induced by the three types of specimens were...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280617
更新日期:1981-12-01 00:00:00
abstract::The aim of this register-based follow-up study was to evaluate the long-term cumulative incidence of second primary tumors (SPT) among survivors of hereditary retinoblastoma, with special interest for the incidence of pineoblastoma in retinoblastoma patients born after 1970. The Dutch Retinoblastoma Register was compl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960807)67:4<515::AID-IJC
更新日期:1996-08-07 00:00:00
abstract::We have previously produced a monoclonal antibody (MAb) against TMK-1 cells, a poorly differentiated stomach-cancer cell line, and designated the antigen as 9A3. Immunohistochemical analysis of various tumor tissues revealed that the expression of 9A3 antigen is specific for human adenocarcinoma. In the present study,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480115
更新日期:1991-04-22 00:00:00