The significance of oncogene amplification in primary breast cancer.

abstract：:We evaluated promoter hypermethylation of a panel of tumor suppressor genes as a means to detect epigenetic alterations in oral squamous cell carcinomas (OSCC) of Indian-origin and compare with North-American head and neck squamous cell carcinomas (HNSCC). Quantitative-methylation-specific PCR was used to investigate ...

journal_title：International journal of cancer

authors： Kaur J,Demokan S,Tripathi SC,Macha MA,Begum S,Califano JA,Ralhan R

更新日期：2010-11-15 00:00:00

abstract：:Gene expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyl transferase (OPRT) have been shown to be associated with response to 5-fluorouracil-based therapies. Analyzing these gene expression levels in liver metastases is importan...

journal_title：International journal of cancer

authors： Kuramochi H,Hayashi K,Uchida K,Miyakura S,Shimizu D,Vallbohmer D,Park S,Danenberg KD,Takasaki K,Danenberg PV

更新日期：2006-08-01 00:00:00

abstract：:Epithelial ovarian carcinoma (EOC) is a leading cause of death from gynecologic malignancies, due mainly to the prevalence of undetected metastatic disease. The process of cell invasion during intraperitoneal anchoring of metastatic lesions requires concerted regulation of many processes, including modulation of adhes...

journal_title：International journal of cancer

authors： Barbolina MV,Adley BP,Kelly DL,Shepard J,Fought AJ,Scholtens D,Penzes P,Shea LD,Stack MS

更新日期：2009-08-15 00:00:00

abstract：:Epigenetic alterations play an important role in carcinogenesis. Recent studies suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. Our study was performed to evaluate histone H3 lysine 4 mono-methyl (H3K4me1), -di-methyl (H3K4me2) and -trimethyl (H3K4me3) pattern...

journal_title：International journal of cancer

authors： Ellinger J,Kahl P,Mertens C,Rogenhofer S,Hauser S,Hartmann W,Bastian PJ,Büttner R,Müller SC,von Ruecker A

更新日期：2010-11-15 00:00:00

abstract：:Gliomas are the most common tumors of the central nervous system and have a grave prognosis. Deletion of chromosome 10p15 is one of the most common chromosomal alterations in gliomas. Recently, a candidate tumor suppressor gene, KLF6, which is mapped to chromosome 10p, was found to be frequently mutated in prostate ca...

journal_title：International journal of cancer

authors： Jeng YM,Hsu HC

更新日期：2003-07-10 00:00:00

abstract：:Bone-marrow (BM) hematopoietic precursors are recruited into proliferative activity when colony-stimulating factors (CSF) are sequenced with chemotherapy (CT). Previous studies suggested that further CT can be safely administered only when the increased proliferative activity of these cells has subsided, because most ...

journal_title：International journal of cancer

authors： Danova M,Rosti V,Mazzini G,De Renzis MR,Locatelli F,Cazzola M,Riccardi A,Ascari E

更新日期：1995-11-27 00:00:00

abstract：:Retinoids are a group of vitamin A analogues that have shown promise as chemopreventive and therapeutic agents in many types of malignancy and have been entered in clinical trials with some successful results. To better understand the mechanism that mediates retinoid action and the anti-proliferative effects, we treat...

journal_title：International journal of cancer

authors： Giannini F,Maestro R,Vukosavljevic T,Pomponi F,Boiocchi M

更新日期：1997-01-17 00:00:00

abstract：:The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other da...

journal_title：International journal of cancer

authors： Iishi H,Tatsuta M,Baba M,Yano H,Iseki K,Uehara H,Nakaizumi A

更新日期：1998-01-30 00:00:00

abstract：:Marfe, G., Pucci, B., De Martino, L., Fiorito, F., Di Stefano, C., Indelicato, M., Aventaggiato, M., Russo, M. A. and Tafani, M. (2009), Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. Int. J. Cancer, 125: 2077-2085. doi: 10.1002/ijc.24572 The above article, published online o...

journal_title：International journal of cancer

authors：

更新日期：2019-08-15 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) has profound impacts on cancer progression and also on drug resistance, including epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Nowadays, there is still no predictive biomarker identified for the use of EGFR-TKIs in non-small cell lung cancer (NSCLC...

journal_title：International journal of cancer

authors： Ren S,Su C,Wang Z,Li J,Fan L,Li B,Li X,Zhao C,Wu C,Hou L,He Y,Gao G,Chen X,Ren J,Li A,Xu G,Zhou X,Zhou C,Schmid-Bindert G

更新日期：2014-12-15 00:00:00

abstract：:Matrix metalloproteinases, and notably the gelatinases MMP-2 and MMP-9, have important roles in tumour invasion, metastasis and angiogenesis. Our study investigates the distribution of MMP-2 and MMP-9 in colorectal cancer, the correlation with plasma levels, changes following surgical resection and whether plasma leve...

journal_title：International journal of cancer

authors： Tutton MG,George ML,Eccles SA,Burton S,Swift RI,Abulafi AM

更新日期：2003-11-20 00:00:00

abstract：:A panel of human breast cancer specimens was examined for single base change mutations by DNA sequencing and for larger deletions using a PCR-based assay. In the cancer specimens examined, no sequencing variants were detected other than a previously characterized polymorphism. Although most of the specimens contained ...

journal_title：International journal of cancer

authors： Anandappa SY,Sibson R,Platt-Higgins A,Winstanley JH,Rudland PS,Barraclough R

更新日期：2000-10-15 00:00:00

abstract：:The monoclonal antibody trastuzumab has brought survival benefit to patients with advanced gastric cancer (AGC) that have human epidermal growth factor receptor 2 (HER2) over expression or amplification. This study was designed to compare the clinical outcomes of HER2-negative and HER2-positive AGC patients with or wi...

journal_title：International journal of cancer

authors： Qiu MZ,Li Q,Wang ZQ,Liu TS,Liu Q,Wei XL,Jin Y,Wang DS,Ren C,Bai L,Zhang DS,Wang FH,Li YH,Xu RH

更新日期：2014-05-15 00:00:00

abstract：:The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cas...

journal_title：International journal of cancer

authors： Olsen AO,Gjøen K,Sauer T,Orstavik I,Naess O,Kierulf K,Sponland G,Magnus P

更新日期：1995-05-04 00:00:00

abstract：:The human bowel contains a large and dynamic bacterial population that is not only essential for intestinal health, but also critical for the development of diseases such as cancer. In this respect, the Gram-positive bacterium Streptococcus bovis has been associated with colon cancer for many years. To investigate the...

journal_title：International journal of cancer

authors： Tjalsma H,Schöller-Guinard M,Lasonder E,Ruers TJ,Willems HL,Swinkels DW

更新日期：2006-11-01 00:00:00

abstract：:Neuron-specific src mRNA, which is expressed in human brain tissue by alternative splicing, is associated with neural differentiation. Neuronal c-srcNI expression may be associated with the ability of neuroblastomas to mature; furthermore, c-srcN2 mRNA is induced in chemically differentiated neuroblastoma cells in vit...

journal_title：International journal of cancer

authors： Matsunaga T,Shirasawa H,Tanabe M,Ohnuma N,Kawamura K,Etoh T,Takahashi H,Simizu B

更新日期：1994-09-15 00:00:00

abstract：:We screened 29 human esophageal squamous cell carcinoma (ESC) cell lines for mutations of the p53 gene through all coding exons and exon-intron junctions. Mutations were found in 22 cell lines (76%), consisting of 20 single-base substitutions, 2 small deletions and 1 single-base insertion. Out of 20 single-base substi...

journal_title：International journal of cancer

authors： Tanaka H,Shibagaki I,Shimada Y,Wagata T,Imamura M,Ishizaki K

更新日期：1996-01-26 00:00:00

abstract：:Human papilloma virus is a causative factor in the etiology of cervical cancer with HPV16 being the most prevalent genotype associated with it. Intratype variations in oncogenic E6/E7 and capsid L1 proteins of HPV 16 besides being of phylogenetic importance, are associated with risk of viral persistence and progressio...

journal_title：International journal of cancer

authors： Pillai MR,Hariharan R,Babu JM,Lakshmi S,Chiplunkar SV,Patkar M,Tongaonkar H,Dinshaw K,Jayshree RS,Reddy BK,Siddiqui M,Roychoudury S,Saha B,Abraham P,Gnanamony M,Peedicayil A,Subhashini J,Ram TS,Dey B,Sharma C,Jain

更新日期：2009-07-01 00:00:00

abstract：:We conducted a retrospective cohort study to investigate the colorectal cancer (CRC) incidence and mortality prevention achievable in clinical practice with an optimized colonoscopy protocol targeting near-complete polyp clearance. The protocol consisted of: (i) telephonic reinforcement of bowel preparation instructio...

journal_title：International journal of cancer

authors： Xirasagar S,Li YJ,Hurley TG,Tsai MH,Hardin JW,Hurley DM,Hebert JR,de Groen PC

更新日期：2015-03-15 00:00:00

abstract：:In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells into the CNS. A direct comparison of remote metastases found in differen...

journal_title：International journal of cancer

authors： Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

更新日期：1999-09-24 00:00:00

abstract：:Premature chromosome condensation (PCC) was studied in direct preparations of tissues from patients with haematological diseases and carcinomas of various histological types. PCC was found in 6 out of 166 malignancies (128 haematological cases, 35 carcinomas and 3 malignant effusions) analysed with the GTG-technique. ...

journal_title：International journal of cancer

authors： Kovacs G

更新日期：1985-12-15 00:00:00

abstract：:Melanoma is a highly malignant and increasingly common neoplasm. Because metastatic melanoma remains incurable, new treatment approaches are needed. Immunoliposomes have been previously shown to enhance the selective localization of immunoliposome-entrapped drugs to solid tumors with improvements in the therapeutic in...

journal_title：International journal of cancer

authors： Pagnan G,Montaldo PG,Pastorino F,Raffaghello L,Kirchmeier M,Allen TM,Ponzoni M

更新日期：1999-04-12 00:00:00

abstract：:Marine omega-3 polyunsaturated fatty acids (MO3PUFAs) have anticancer properties and may improve colon cancer survival. However, it remains unknown whether the benefit differs by tumor molecular subtype. We examined data from a phase III randomized trial of FOLFOX or FOLFOX + cetuximab among 1,735 stage III colon canc...

journal_title：International journal of cancer

authors： Song M,Ou FS,Zemla TJ,Hull MA,Shi Q,Limburg PJ,Alberts SR,Sinicrope FA,Giovannucci EL,Van Blarigan EL,Meyerhardt JA,Chan AT

更新日期：2019-07-15 00:00:00

abstract：:The steady-state mRNA level of nucleophosmin/B23 in HeLa cells increased after UV irradiation. Nucleophosmin/B23 antisense transfection potentiated ultraviolet (UV)-induced cell killing. A block in G(2)/M phase, larger peak of apoptotic cells and higher caspase-3 in vitro activity were noted in nucleophosmin/B23 antis...

journal_title：International journal of cancer

authors： Wu MH,Chang JH,Chou CC,Yung BY

更新日期：2002-01-20 00:00:00

abstract：:Second-line ipilimumab has been publicly funded in Ontario for metastatic melanoma (MM) since September 2012. We examined real-world toxicity of second-line ipilimumab compared to standard second-line treatments prior to funding. MM patients who received systemic treatment from April 2005 to March 2015 were included. ...

journal_title：International journal of cancer

authors： Dai WF,Beca J,Croxford R,Isaranuwatchai W,Menjak IB,Petrella TM,Mittmann N,Earle CC,Gavura S,Mercer RE,Hanna TP,Chan KKW

更新日期：2020-10-26 00:00:00

abstract：:We have used immunoprecipitation to test tumor biopsies and normal adult and fetal human tissues for p97, a tumor-associated protein. Five of nine melanoma biopsies contained p97 in low to very high levels. Three of seven non-melanoma tumors contained p97, but in smaller amounts. No p97 was detected in any of the norm...

journal_title：International journal of cancer

authors： Woodbury RG,Brown JP,Loop SM,Hellström KE,Hellström I

更新日期：1981-02-15 00:00:00

abstract：:Data on the incidence of 15 cancers in the Jewish population of Israel from the period 1961-1981 have been studied with emphasis on the risk of disease in relation to birthplace, calendar time, and duration of residence in Israel. The results show wide variations in incidence by birthplace, from less than 2-fold for p...

journal_title：International journal of cancer

authors： Parkin DM,Steinitz R,Khlat M,Kaldor J,Katz L,Young J

更新日期：1990-04-15 00:00:00

abstract：:A case-control study involving interviews with 227 lung-cancer cases and 227 matched hospital controls was conducted in Heilongjiang Province in northeast China to examine the influence of dietary factors on the risk of developing lung cancer. Lung-cancer cases were all incident cases judged to be suitable candidates ...

journal_title：International journal of cancer

authors： Hu J,Johnson KC,Mao Y,Xu T,Lin Q,Wang C,Zhao F,Wang G,Chen Y,Yang Y

更新日期：1997-06-11 00:00:00

abstract：:Increases in the incidence of childhood acute lymphoblastic leukemia (ALL) have been reported in some countries, while other reports from similar geographical regions have indicated stable rates. The reasons for the discrepancies have been debated in the literature, with the focus on whether the observed increases are...

journal_title：International journal of cancer

authors： Milne E,Laurvick CL,de Klerk N,Robertson L,Thompson JR,Bower C

更新日期：2008-03-01 00:00:00

abstract：:Several mouse models studying the MLL fusion-induced leukemic transformation showed that a myeloproliferation stage precedes leukemia or occurred as the only phenotype of hematological disorder in mice. We established 6 MLL/AF10(OM-LZ)-immortalized cell lines by retrovirally transducing the fusion gene into bone marro...

journal_title：International journal of cancer

authors： Fu JF,Hsu CL,Shih LY

更新日期：2010-04-01 00:00:00