Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion.

abstract：:A panel of eight conditionally immortal lines derived by infection of human breast epithelial cells with an amphotropic retrovirus transducing a ts mutant of SV40 large T-antigen was analyzed with respect to individual retroviral integration patterns. Each line contained multiple integration sites which were clonal an...

journal_title：International journal of cancer

authors： Stamps AC,Davies SC,Burman J,O'Hare MJ

更新日期：1994-06-15 00:00:00

abstract：:Estrogen signaling plays an important role in breast carcinogenesis. An increased understanding of estrogen gene targets and their effects will allow for more directed and effective therapies for individuals with breast cancer, particularly those with estrogen receptor positive tumors resistant to tamoxifen therapy. H...

journal_title：International journal of cancer

authors： Tuttle R,Miller KR,Maiorano JN,Termuhlen PM,Gao Y,Berberich SJ

更新日期：2012-05-15 00:00:00

abstract：:The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF, CDC25A, SCOTIN, RASSF1A and CACNA2D2 located in the chromosomal region 3p21.31 associated with the development of early dysplastic lesions of head and neck. In analysis of 72 dysplastic lesions and 116 ...

journal_title：International journal of cancer

authors： Ghosh S,Ghosh A,Maiti GP,Alam N,Roy A,Roy B,Roychoudhury S,Panda CK

更新日期：2008-12-01 00:00:00

abstract：:miRNAs have emerged as post-transcriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Cdc42, one of the best characterized members of the Rho GTPase family, is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and prog...

journal_title：International journal of cancer

authors： Liu M,Lang N,Qiu M,Xu F,Li Q,Tang Q,Chen J,Chen X,Zhang S,Liu Z,Zhou J,Zhu Y,Deng Y,Zheng Y,Bi F

更新日期：2011-03-15 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an angiogenic factor that also functions as an autocrine growth factor for VEGF receptor (VEGFR)-2(+) melanomas. In multiple studies, VEGFR-2 was detected by immunostaining in 78-89% of human melanoma cells, suggesting that most patients with melanoma would benefit from an...

journal_title：International journal of cancer

authors： Molhoek KR,Erdag G,Rasamny JK,Murphy C,Deacon D,Patterson JW,Slingluff CL Jr,Brautigan DL

更新日期：2011-12-15 00:00:00

abstract：:The effects of prolonged administration of genistein, a tyrosine-kinase inhibitor, on sodium-chloride-enhanced induction of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine, and the labeling and apoptotic indices and vessel counts in the gastric mucosa and gastric cancers, were investigated in Wi...

journal_title：International journal of cancer

authors： Tatsuta M,Iishi H,Baba M,Yano H,Uehara H,Nakaizumi A

更新日期：1999-01-29 00:00:00

abstract：:To examine the immunological mechanisms involved in cancer gene therapy using the herpes simplex virus thymidine kinase (HSV-tk) gene and ganciclovir (GCV), murine hepatocellular carcinoma (HCC) cells, BNL1ME A.7R.1, were transduced retrovirally with the HSV-tk gene. HSV-tk-transduced cells exhibited a more than 2,000...

journal_title：International journal of cancer

authors： Kuriyama S,Kikukawa M,Masui K,Okuda H,Nakatani T,Akahane T,Mitoro A,Tominaga K,Tsujinoue H,Yoshiji H,Okamoto S,Fukui H,Ikenaka K

更新日期：1999-10-29 00:00:00

abstract：:Many tumors are impervious to anticancer agents. Resistance due to lack of cytotoxic penetration into the tumor is often overlooked but can play a significant role in undermining therapy. Insufficient and irregular vascularization of tumors is a possible barrier to drug delivery, but there are others, e.g., impaired v...

journal_title：International journal of cancer

authors： Wildiers H,Guetens G,de Boeck G,Landuyt W,Verbeken E,Highley M,de Bruijn EA,van Oosterom AT

更新日期：2002-06-01 00:00:00

abstract：:Dendritic cells (DCs) are antigen presenting cells that play a role in T-cell activation. Liver-associated natural killer T lymphocytes (NKTs) are a unique subset of lymphocytes that may be important in antitumor immunity. Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) expresses hepatitis B virus su...

journal_title：International journal of cancer

authors： Shibolet O,Alper R,Zlotogarov L,Thalenfeld B,Engelhardt D,Rabbani E,Ilan Y

更新日期：2003-08-20 00:00:00

abstract：:Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated wi...

journal_title：International journal of cancer

authors： Pantavos A,Ruiter R,Feskens EF,de Keyser CE,Hofman A,Stricker BH,Franco OH,Kiefte-de Jong JC

更新日期：2015-05-01 00:00:00

abstract：:Three monoclonal antibodies (MAbs) against p53 protein (PAb 24o, DO-I and PAb1801) were used to define the immunophenotype of 13 melanoma cell lines. Immunoreactions could be detected in 12 out of 13 cell lines by using the indirect immunofluorescence technique. In 7 of these the majority of cells displayed cytoplasmi...

journal_title：International journal of cancer

authors： Weiss J,Schwechheimer K,Cavenee WK,Herlyn M,Arden KC

更新日期：1993-06-19 00:00:00

abstract：:A considerable public concern about cancer risk from acrylamide-rich foods followed the announcement that high concentrations of acrylamide are found in fried potatoes and potato chips and, more generally, in starch-containing foods cooked at high temperatures. From a series of hospital-based case-control studies cond...

journal_title：International journal of cancer

authors： Pelucchi C,Franceschi S,Levi F,Trichopoulos D,Bosetti C,Negri E,La Vecchia C

更新日期：2003-07-01 00:00:00

abstract：:Common genetic variations in genes involved in DNA repair or response to genotoxic stress may influence both cancer susceptibility and treatment response individually or interactively. However, in acute myeloid leukemia (AML), the relevance of these genetic variations remains to be fully established. In this study, we...

journal_title：International journal of cancer

authors： Shi JY,Ren ZH,Jiao B,Xiao R,Yun HY,Chen B,Zhao WL,Zhu Q,Chen Z,Chen SJ

更新日期：2011-01-01 00:00:00

abstract：:Diet is the primary source of cadmium-a proven Group 1 human carcinogen-for non-smokers. Observational studies investigating the effect of cadmium from food sources on breast cancer risk have produced inconsistent results. We examined the association between dietary cadmium and risk of breast cancer defined by estroge...

journal_title：International journal of cancer

authors： Grioni S,Agnoli C,Krogh V,Pala V,Rinaldi S,Vinceti M,Contiero P,Vescovi L,Malavolti M,Sieri S

更新日期：2019-05-01 00:00:00

abstract：:The colo-rectum and stomach are the 2 sites for which the role of diet in the etiology of cancer is most heavily implicated. Quantitative estimates as to the proportion of cancer deaths attributable to diet vary considerably. This may be partially due to the application of the concept of population attributable risk w...

journal_title：International journal of cancer

authors： Wahrendorf J

更新日期：1987-11-15 00:00:00

abstract：:Emerging reports now implicate alterations of arachidonic acid (AA) metabolism with prostate carcinogenesis. To test this hypothesis, androgen-primed benign hyperplastic (BHC) and malignant tumorigenic (MTC) cells derived from the Lobund-Wistar rat model of autochthonous prostate adenocarcinoma were incubated with (14...

journal_title：International journal of cancer

authors： Pham H,Banerjee T,Ziboh VA

更新日期：2004-08-20 00:00:00

abstract：:In this study, the anticancer effect of prednisolone was investigated using rats with normal endogen adrenaline levels (intact), reduced adrenaline levels (metyrosine-induced) and adrenaline deficiency (adrenalectomized) via gastric adenocarcinoma model. Gastric adenocarcinoma was induced with N-methyl-N'-nitro-N-nitr...

journal_title：International journal of cancer

authors： Suleyman H,Cadirci E,Albayrak A,Halici Z,Gundogdu C,Hacimuftuoglu A

更新日期：2010-04-01 00:00:00

abstract：:Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...

journal_title：International journal of cancer

authors： Rashidkhani B,Akesson A,Lindblad P,Wolk A

更新日期：2005-12-10 00:00:00

abstract：:We have previously shown that sensory nerve peptides contribute to the pathogenesis of pulmonary hypersensitivity reactions (HSRs) to paclitaxel in rats. Moreover, pemirolast, an antiallergic agent, reverses the HSRs to paclitaxel, although the mechanism is considered to result from the blockade of paclitaxel-induced ...

journal_title：International journal of cancer

authors： Yahata H,Saito M,Sendo T,Itoh Y,Uchida M,Hirakawa T,Nakano H,Oishi R

更新日期：2006-05-15 00:00:00

abstract：:Two genome-wide association studies (GWAS) have identified 5p15.33 (TERT-CLPTM1L) as one of the susceptible regions for glioma in European background. A replication research of our group highlighted the association signals in the TERT gene of this region in a Chinese Han population. To comprehensively explore the regi...

journal_title：International journal of cancer

authors： Zhao Y,Chen G,Zhao Y,Song X,Chen H,Mao Y,Lu D

更新日期：2012-10-01 00:00:00

abstract：:Overuse of antibiotic drugs alters the composition of gut microbiota and has detrimental effects on the host. In our study, we investigated association of gut flora and antibiotics in the prognosis of patients with liver cancer who have undergone chemotherapy by analyzing two independent clinical studies. We retrospec...

journal_title：International journal of cancer

authors： Iida N,Mizukoshi E,Yamashita T,Terashima T,Arai K,Seishima J,Kaneko S

更新日期：2019-11-15 00:00:00

abstract：:Cyclic AMP (cAMP) analogues that selectively bind to either one of the two binding sites of cAMP-dependent protein kinase demonstrate a potent inhibition of the growth stimulated by estrogen in MCF-7 human breast-cancer cells in culture. The site-selective analogues, which are more potent activators of protein kinase ...

journal_title：International journal of cancer

authors： Katsaros D,Ally S,Cho-Chung YS

更新日期：1988-06-15 00:00:00

abstract：:The effects of combined administration of bombesin (40 micrograms/kg body weight) and the ornithine decarboxylase (ODC) inhibitor, 1,3-diaminopropane (DAP), on the development of large and small intestinal tumors and the incidence of their metastasis to the peritoneum induced by azoxymethane (AOM, 7.4 mg/kg body weigh...

journal_title：International journal of cancer

authors： Iishi H,Tatsuta M,Baba M,Uehara H,Nakaizumi A

更新日期：1994-08-15 00:00:00

abstract：:Desmoids represent the most important cause of death, after colorectal cancer, in patients affected with familial adenomatous polyposis (FAP), an inherited disease due to mutations in the APC gene. The aims of our study were to estimate the risk of developing desmoids in FAP patients and to evaluate the association be...

journal_title：International journal of cancer

authors： Bertario L,Russo A,Sala P,Eboli M,Giarola M,D'amico F,Gismondi V,Varesco L,Pierotti MA,Radice P,Hereditary Colorectal Tumours Registry.

更新日期：2001-03-20 00:00:00

abstract：:With the aim of identifying innovative therapeutic strategies for osteosarcoma patients who are refractory to conventional chemotherapy, we analyzed the in vitro effects of the blockage of autocrine circuits. Since the insulin-like growth factor-I receptor (IGF-IR)-mediated loop is relevant to the growth of osteosarco...

journal_title：International journal of cancer

authors： Benini S,Baldini N,Manara MC,Chano T,Serra M,Rizzi S,Lollini PL,Picci P,Scotlandi K

更新日期：1999-02-09 00:00:00

abstract：:A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer [basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma]. We prospecti...

journal_title：International journal of cancer

authors： Park SM,Li T,Wu S,Li WQ,Weinstock M,Qureshi AA,Cho E

更新日期：2017-05-01 00:00:00

abstract：:The aim of this study was to determine whether the skin-sensitizing agent 2,4-dinitrofluorobenzene (DNFB) would elicit the same morphological and biochemical events that are characteristic of 12-O-tetradecanoylphorbol-13-acetate (TPA). While single applications of 0.1% or 0.2% DNFB produced only mild epidermal hyperpl...

journal_title：International journal of cancer

authors： Maldve RE,Fischer SM

更新日期：1995-02-08 00:00:00

abstract：:Anthropometric measures have been related to risk of several cancers. For bladder cancer, however, evidence is sparse. Comparability of existing studies is hampered by use of different obesity-measures, inadequate control for smoking, and few female cases. This study examined associations between height, weight, waist...

journal_title：International journal of cancer

authors： Roswall N,Freisling H,Bueno-de-Mesquita HB,Ros M,Christensen J,Overvad K,Boutron-Ruault MC,Severi G,Fagherazzi G,Chang-Claude J,Kaaks R,Steffen A,Boeing H,Argüelles M,Agudo A,Sánchez MJ,Chirlaque MD,Barricarte Gurrea A

更新日期：2014-12-15 00:00:00

abstract：:Mitotic and meiotic cell cycle regulation is essential for normal development and tumor prevention. The underlying molecular mechanisms are not completely characterized. The aim of our analysis was to derive a global expression map of cell cycle regulators in mitosis and meiosis. First, the expression of cyclins, CDKs...

journal_title：International journal of cancer

authors： Diederichs S,Bäumer N,Schultz N,Hamra FK,Schrader MG,Sandstede ML,Berdel WE,Serve H,Müller-Tidow C

更新日期：2005-08-20 00:00:00

abstract：:Epigenetic inactivation by aberrant DNA methylation has been reported for many microRNA genes in various human malignancies. However, relatively little is known about microRNA gene methylation in hepatocellular carcinoma (HCC). Therefore, a systematic screen for identification of aberrantly hypermethylated microRNA ge...

journal_title：International journal of cancer

authors： Anwar SL,Albat C,Krech T,Hasemeier B,Schipper E,Schweitzer N,Vogel A,Kreipe H,Lehmann U

更新日期：2013-08-01 00:00:00