Abstract:
:The colo-rectum and stomach are the 2 sites for which the role of diet in the etiology of cancer is most heavily implicated. Quantitative estimates as to the proportion of cancer deaths attributable to diet vary considerably. This may be partially due to the application of the concept of population attributable risk which has proved a useful yardstick in estimating the public health impact of completely removing an exposure factor under study. This simple concept may well serve in occupational epidemiology, but with more and more risk factors found on a metric scale, or at least characterized on an ordinal scale, extensions should be considered. In this report, a preventable proportion is defined as the excess risk which would be removed if the population exposure distribution were to change ina favorable direction. A simple way of modelling such changes is proposed. This new measure is illustrated with data from 6 case-control studies on colo-rectal or stomach cancer. The results indicate that the proportion of these cancers which may be prevented assuming arbitrary shifts of a single risk factor towards the next lower risk category if populations were to change their dietary habits is in the order of magnitude of 15% to 20%. This figure is much lower, but not necessarily in contradiction to the figures considered for the proportion of cancers attributable to diet.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Wahrendorf Jdoi
10.1002/ijc.2910400509subject
Has Abstractpub_date
1987-11-15 00:00:00pages
625-8issue
5eissn
0020-7136issn
1097-0215journal_volume
40pub_type
杂志文章abstract::OCT-4 (also known as POU5F1) is a key regulator of self-renewal in embryonic stem cells. Regarding the new cancer stem cell concept, the expression of such genes is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior, such as tumor recurrence or resistance to therapies. Although OCT...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22508
更新日期:2007-04-01 00:00:00
abstract::Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast tumors from 120 pati...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
abstract::Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1996-07-03 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
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abstract::Human T-lymphotropic virus type I (HTLV-I) carriers often have abnormal lymphocytes (Ably) that resemble malignant cells of adult T-cell leukemia (ATL). To identify predictors of the level of Ably in a longitudinal study of asymptomatic HTLV-I carriers, we analyzed data from 215 subjects (67 men and 148 women) with mu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980717)77:2<188::aid-ijc
更新日期:1998-07-17 00:00:00
abstract::Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2018-11-15 00:00:00
abstract::The effects of single-agent therapy with two clinically useful drugs, 5-fluorouracil (5-FU) and 1-3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) against nine human colorectal tumors (rectum T 157 and T 348, lung metastasis T 84, lymph-node metastasis T 245, colon, T 183, T 219, T 347, T 362 and T 380) transplanted and pas...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270103
更新日期:1981-01-15 00:00:00
abstract::Small cell lung cancers (SCLCs) and extrapulmonary small cell cancers (SCCs) are very aggressive tumors arising de novo as primary small cell cancer with characteristic genetic lesions in RB1 and TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated as the cellular ori...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2016-02-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630602
更新日期:1995-12-11 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2009-04-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
abstract::Heat shock protein (HSP) gp96/grp94 contains a signal peptide at the amino terminus and a -KDEL sequence at the carboxy terminus and is a major component of the lumen of the mammalian endoplasmic reticulum (ER). We show, by a number of immunolocalization methods using light and electron microscopy, that a significant ...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1996-08-22 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1998-01-30 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980220)79:1<61::aid-ijc1
更新日期:1998-02-20 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980413)76:2<267::aid-ijc
更新日期:1998-04-13 00:00:00
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journal_title:International journal of cancer
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更新日期:1994-10-15 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章,评审
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480319
更新日期:1991-05-30 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.23839
更新日期:2008-12-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2006-07-15 00:00:00
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journal_title:International journal of cancer
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更新日期:2019-06-01 00:00:00
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journal_title:International journal of cancer
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更新日期:2018-05-01 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.10928
更新日期:2003-04-10 00:00:00
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journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.27955
更新日期:2013-06-15 00:00:00