Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology.

abstract：:Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy with high acquisition costs, and it has raised concerns about affordability and sustainability in many countries. Furthermore, the current centralized production paradigm for the T cells is less than satisfactory. Therefore, several countries ...

journal_title：International journal of cancer

authors： Ran T,Eichmüller SB,Schmidt P,Schlander M

更新日期：2020-12-15 00:00:00

abstract：:Colorectal cancer is among the commonest cancers worldwide. Dietary factors have been linked to colorectal cancer risk, however, few studies have evaluated the relationship between a priori dietary patterns and colorectal cancer risk. We evaluated the effect of adherence to a Mediterranean dietary pattern, as measured...

journal_title：International journal of cancer

authors： Agnoli C,Grioni S,Sieri S,Palli D,Masala G,Sacerdote C,Vineis P,Tumino R,Giurdanella MC,Pala V,Berrino F,Mattiello A,Panico S,Krogh V

更新日期：2013-03-15 00:00:00

abstract：:Despite the steadily increasing number of patients suffering from squamous-cell carcinomas of the oropharyngeal region, little is known about the molecular steps involved in the induction of these neoplasms. We investigated oropharyngeal cancers from 38 patients for mutations in the p53 tumour-suppressor gene. The maj...

journal_title：International journal of cancer

authors： Zariwala M,Schmid S,Pfaltz M,Ohgaki H,Kleihues P,Schäfer R

更新日期：1994-03-15 00:00:00

abstract：:Limited data are available on the carcinogenicity of smokeless tobacco products in organs other than the mouth. Snus is a smokeless tobacco product widely used in Norway. We studied 10,136 Norwegian men enrolled since 1966 in a prospective cohort study, 31.7% of whom were exposed to snus. The relative risk of pancreat...

journal_title：International journal of cancer

authors： Boffetta P,Aagnes B,Weiderpass E,Andersen A

更新日期：2005-05-10 00:00:00

abstract：:ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein enriched in astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore tested PEA15 effects on...

journal_title：International journal of cancer

authors： Gawecka JE,Geerts D,Koster J,Caliva MJ,Sulzmaier FJ,Opoku-Ansah J,Wada RK,Bachmann AS,Ramos JW

更新日期：2012-10-01 00:00:00

abstract：:Colibactin-producing E. coli (CoPEC) are frequently detected in colorectal cancer (CRC) and exhibit procarcinogenic properties. Because increasing evidence show the role of immune environment and especially of antitumor T-cells in CRC development, we investigated the impact of CoPEC on these cells in human CRC and in ...

journal_title：International journal of cancer

authors： Lopès A,Billard E,Casse AH,Villéger R,Veziant J,Roche G,Carrier G,Sauvanet P,Briat A,Pagès F,Naimi S,Pezet D,Barnich N,Dumas B,Bonnet M

更新日期：2020-06-01 00:00:00

abstract：:Cell kinetic studies are of interest for clarifying the concepts of chemotherapeutic strategy in the multimodality therapy of advanced squamous-cell carcinoma of the head and neck. A poorly-differentiated squamous-cell carcinoma of the head and neck heterotransplanted to nude mice was used for analyses of chemotherape...

journal_title：International journal of cancer

authors： Wennerberg J,Alm P,Biörklund A,Killander D,Långström E,Tropé C

更新日期：1984-02-15 00:00:00

abstract：:Using nationwide Danish registries we examined the long-term risk of cervical cancer in women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3) (including adenocarcinoma in situ (AIS)) on the cone compared to women with a normal cytology test. Initially, we identified women born 1918-1990, who were reco...

journal_title：International journal of cancer

authors： Sand FL,Frederiksen K,Munk C,Jensen SM,Kjaer SK

更新日期：2018-05-01 00:00:00

abstract：:Although there are several hypotheses explaining the mechanisms of immune-privileged status of malignant tumor, the exact pathway has yet to be explored. Cyclooxygenase (COX)-2 plays a vital role in prognosis of cancer patients in terms of contribution to neoangiogenesis and apoptosis inhibition; however, the impact o...

journal_title：International journal of cancer

authors： Ohno Y,Ohno S,Suzuki N,Kamei T,Inagawa H,Soma G,Inoue M

更新日期：2005-05-01 00:00:00

abstract：:Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to ampl...

journal_title：International journal of cancer

authors： Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch T

更新日期：1996-07-03 00:00:00

abstract：:Melanoma of unknown primary (MUP) may have a different biology to melanoma of known primary, but clinical trials of novel therapies (e.g., immune checkpoint or BRAF/MEK inhibitors) have not reported the outcomes in this population. We therefore evaluated the overall survival (OS) among patients with MUP in the era of ...

journal_title：International journal of cancer

authors： Verver D,van der Veldt A,van Akkooi A,Verhoef C,Grünhagen DJ,Louwman WJ

更新日期：2020-01-01 00:00:00

abstract：:Adhesion molecules involved in attachment between human pancreatic carcinoma and activated endothelial cells in vitro were investigated. Basal adhesion occurred between 6 pancreatic carcinoma cell lines and unstimulated human umbilical vein endothelial cells (HUVEC), and augmented basal adhesion to activated HUVEC was...

journal_title：International journal of cancer

authors： Iwai K,Ishikura H,Kaji M,Sugiura H,Ishizu A,Takahashi C,Kato H,Tanabe T,Yoshiki T

更新日期：1993-07-30 00:00:00

abstract：:The aim of this study was to determine whether the skin-sensitizing agent 2,4-dinitrofluorobenzene (DNFB) would elicit the same morphological and biochemical events that are characteristic of 12-O-tetradecanoylphorbol-13-acetate (TPA). While single applications of 0.1% or 0.2% DNFB produced only mild epidermal hyperpl...

journal_title：International journal of cancer

authors： Maldve RE,Fischer SM

更新日期：1995-02-08 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is activated in a variety of human cancers, including ovarian cancer. The molecular mechanism by which the STAT3 is activated in cancer cells is poorly understood. We observed that human ovarian xenograft tumors (A2780) in mice were severely hypoxic (pO(2) app...

journal_title：International journal of cancer

authors： Selvendiran K,Bratasz A,Kuppusamy ML,Tazi MF,Rivera BK,Kuppusamy P

更新日期：2009-11-01 00:00:00

abstract：:The clonotypic T-cell receptor (TCR) is a potential target antigen for specific immunotherapy of cutaneous T-cell lymphoma (CTCL). We identified T-cell epitopes from the rearranged TCR beta chain of the malignant T-cell population by the "reverse immunology" approach. Peptide-specific T-cell lines were generated again...

journal_title：International journal of cancer

authors： Zeng J,Müller-Berghaus J,Nguyen XD,Klüter H,Schönhaber H,Song M,Schwinn N,Schadendorf D,Goerdt S,Eichmüller S,Dippel E

更新日期：2006-11-15 00:00:00

abstract：:Cytokines play a crucial role in tumor initiation and progression. Here, we demonstrate that interleukin (IL)-6 is a key factor by driving tumor progression from benign to malignant, invasive tumors in the HaCaT-model of human skin carcinoma. IL-6 activates STAT3 and directly stimulates proliferation and migration of ...

journal_title：International journal of cancer

authors： Lederle W,Depner S,Schnur S,Obermueller E,Catone N,Just A,Fusenig NE,Mueller MM

更新日期：2011-06-15 00:00:00

abstract：:We have shown earlier that extracellular GSH can exert a cell-specific growth-inhibitory effect on human tumor cells. In the present study, 2 human ovarian carcinoma cell lines (A2780 and IGROV-1) were used to investigate the biochemical basis of the GSH growth-inhibitory effect. Whereas cells were resistant, A2780 ce...

journal_title：International journal of cancer

authors： Perego P,Paolicchi A,Tongiani R,Pompella A,Tonarelli P,Carenini N,Romanelli S,Zunino F

更新日期：1997-04-10 00:00:00

abstract：:Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...

journal_title：International journal of cancer

authors： Tomala J,Chmelova H,Strohalm J,Ulbrich K,Sirova M,Rihova B,Kovar M

更新日期：2011-10-15 00:00:00

abstract：:Sexual behavior has been consistently identified as a major risk factor for cervical cancer. Population-based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (HPV) infection. We conducted a case-control study of 199 cases with low-grade squamous intraepithelial lesion...

journal_title：International journal of cancer

authors： Kjaer SK,van den Brule AJ,Bock JE,Poll PA,Engholm G,Sherman ME,Walboomers JM,Meijer CJ

更新日期：1996-03-01 00:00:00

abstract：:Human 8-oxoguanine DNA glycosylase 1 (hOGG1) plays a major role in the repair of 8-hydroxyguanine, one of the major forms of DNA damage generated by reactive oxygen species in tobacco smoke. If left unrepaired by hOGG1, 8-hydroxyguanine can produce G:C-to-T:A transversions. Recent studies have suggested that the hOGG1...

journal_title：International journal of cancer

authors： Hu YC,Ahrendt SA

更新日期：2005-04-10 00:00:00

abstract：:Current evidence suggests poor identification and referral of Lynch syndrome patients. This study evaluated the strategies by which patients with endometrial cancer were referred to genetics services. Data from clinic-based patients with endometrial cancer enrolled through the Australian National Endometrial Cancer po...

journal_title：International journal of cancer

authors： Tan YY,McGaughran J,Ferguson K,Walsh MD,Buchanan DD,Young JP,Webb PM,Obermair A,Spurdle AB,ANECS Group.

更新日期：2013-06-15 00:00:00

abstract：:Melanocortin-1 receptor (MC1R) is a marker of melanoma risk in populations of European ancestry. However, MC1R effects on survival are much less studied. We investigated associations between variation at MC1R and survival in an international, population-based series of single primary melanoma patients enrolled into th...

journal_title：International journal of cancer

authors： Taylor NJ,Reiner AS,Begg CB,Cust AE,Busam KJ,Anton-Culver H,Dwyer T,From L,Gallagher RP,Gruber SB,Rosso S,White KA,Zanetti R,Orlow I,Thomas NE,Rebbeck TR,Berwick M,Kanetsky PA,GEM Study Group.

更新日期：2015-06-01 00:00:00

abstract：:Thiazolidinedione derivatives with potent antiarthritic activity, such as CGP 52608, have been suggested to exert their biological effects through the activation of the orphan nuclear receptor RORalpha. Since response elements for this receptor are present in the promoter region of cell cycle-related genes (i.e., p21(...

journal_title：International journal of cancer

authors： Moretti RM,Montagnani Marelli M,Motta M,Limonta P

更新日期：2001-06-01 00:00:00

abstract：:The antigen-induced leukocyte adherence inhibition (LAI) test is an assay of cellular immune reactivity which was expected to offer a promising adjunct to currently available diagnostic and monitoring procedures in cancer patients. We have applied this assay to (1) 83 inpatients clinically suspected of having breast c...

journal_title：International journal of cancer

authors： Fritze D,Fedra G,Kaufmann M

更新日期：1982-03-15 00:00:00

abstract：:We derived from blood lymphocytes of a melanoma patient a large number of cytolytic T-cell clones directed against a cell line of the autologous tumor. Three distinct groups of antigens were recognized by these CTL on the autologous melanoma cells: group A consisted of stable antigens present on all sublines, whereas ...

journal_title：International journal of cancer

authors： Van den Eynde B,Hainaut P,Hérin M,Knuth A,Lemoine C,Weynants P,van der Bruggen P,Fauchet R,Boon T

更新日期：1989-10-15 00:00:00

abstract：:The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) was found to increase the incidence of phenotypic alterations induced by the direct-acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in human endometrial stromal cells. Following carcinogen treatment, changes in saturation density, gamma-glutam...

journal_title：International journal of cancer

authors： Siegfried JM,Kaufman DG

更新日期：1983-10-15 00:00:00

abstract：:Our aim was to identify plasma microRNA (miRNA)-based signatures to predict 3-year postoperative recurrence risk for patients with stage II and III gastric cancer (GC), so as to provide insights for individualized adjuvant therapy. Plasma miRNA expression was investigated in three phases, involving 407 patients recrui...

journal_title：International journal of cancer

authors： Liu X,Zhang X,Zhang Z,Chang J,Wang Z,Wu Z,Wang C,Sun Z,Ge X,Geng R,Tang W,Dai C,Lin Y,Lin F,Sun M,Jia W,Xue W,Ji J,Hu Y,Qin G,Li J

更新日期：2017-11-15 00:00:00

abstract：:Variability in the expression of enzymes metabolizing carcinogens derived from cigarette smoke may contribute to individual susceptibility to pulmonary carcinogenesis. This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize...

journal_title：International journal of cancer

authors： Piipari R,Savela K,Nurminen T,Hukkanen J,Raunio H,Hakkola J,Mäntylä T,Beaune P,Edwards RJ,Boobis AR,Anttila S

更新日期：2000-06-01 00:00:00

abstract：:Two groups of rabbits were inoculated on the day of birth or at 4 weeks of age with a human T-cell leukemia virus type-I (HTLV-I)-infected and transformed rabbit cell line (Ra-I). Rabbits seroconverted to HTLV-I, as determined by indirect immunofluorescence, by 3 weeks after inoculation and remained persistently serop...

journal_title：International journal of cancer

authors： Cockerell GL,Lairmore M,De B,Rovnak J,Hartley TM,Miyoshi I

更新日期：1990-01-15 00:00:00

abstract：:The annual incidence of non-Hodgkin's lymphomas is increasing by 3 to 4% in different parts of the developed world, while rates for Hodgkin's disease, myelomas and leukemias are more stable. In the case of this group of malignancies, hypothesis generation on risk factors has been limited by the use of the ICD classifi...

journal_title：International journal of cancer

authors： Masala G,Di Lollo S,Picoco C,Crosignani P,Demicheli V,Fontana A,Funtó I,Miligi L,Nanni O,Papucci A,Ramazzotti V,Rodella S,Stagnaro E,Tumino R,Viganó C,Vindigni C,Seniori Costantini A,Vineis P

更新日期：1996-10-09 00:00:00