Italian Mediterranean Index and risk of colorectal cancer in the Italian section of the EPIC cohort.

abstract：:In 2011, a novel form of genome instability was reported by Stephens et al., characterized by tens to hundreds of locally clustered rearrangements affecting one or a few chromosome(s) in cancer cells. This phenomenon, termed chromothripsis, is likely due to a single catastrophic event leading to the simultaneous forma...

journal_title：International journal of cancer

authors： Rode A,Maass KK,Willmund KV,Lichter P,Ernst A

更新日期：2016-05-15 00:00:00

abstract：:CXCR1 and CXCR2 are receptors for CXCL-8 and are differentially expressed on melanoma and endothelial cells. In this study, we determined the functional role of these receptors in melanoma progression. We stably knock-down the expression of CXCR1 and/or CXCR2 in A375-SM (SM; high metastatic) human melanoma cells by sh...

journal_title：International journal of cancer

authors： Singh S,Sadanandam A,Varney ML,Nannuru KC,Singh RK

更新日期：2010-01-15 00:00:00

abstract：:Nitric oxide (NO) generated by either endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS) may be involved in prostate tumorigenesis through the inhibition of reactive oxygen species (ROS)-induced apoptosis. Multicellular DU-145 prostate tumor spheroids endogenously generated NO that para...

journal_title：International journal of cancer

authors： Wartenberg M,Schallenberg M,Hescheler J,Sauer H

更新日期：2003-04-10 00:00:00

abstract：:In mammals, transforming growth factor-beta (TGF-beta) is found in 3 highly homologous isoforms that exert their effects via heteromeric complexes of type-I and type-II receptors (TbetaR-I and TbetaR-II). TGF-beta regulates the growth and metabolism of various cell types, including keratinocytes. We have investigated ...

journal_title：International journal of cancer

authors： Furue M,Kato M,Nakamura K,Nashiro K,Kikuchi K,Okochi H,Miyazono K,Tamaki K

更新日期：1997-05-16 00:00:00

abstract：:Cell cycle regulation is dependent on multiple cellular and molecular events. Cell proliferation requires metabolic sources for the duplication of DNA and cell size. However, nucleotide reservoirs are not sufficient to support cell duplication and, therefore, biosynthetic pathways should be upregulated during cell cyc...

journal_title：International journal of cancer

authors： Vizán P,Alcarraz-Vizán G,Díaz-Moralli S,Solovjeva ON,Frederiks WM,Cascante M

更新日期：2009-06-15 00:00:00

abstract：:A panel of 7 diagnostic cytopathologists, i.e., physicians trained to diagnose the malignant potential of human cells in Papanicolaou-stained smears, was asked to evaluate two sets of microscope slides of stained coverslip preparations of 28 cell culture lines, 15 of which were neoplastic. Slide Set I consisted of 13 ...

journal_title：International journal of cancer

authors： Boone CW,Sanford KK,Frost JK,Mantel N,Gill GW,Jones GM

更新日期：1986-09-15 00:00:00

abstract：:To probe the potential contribution of beta-galactoside-contributing epitopes and receptor proteins (gal-1 and gal-3) to colon malignancy, we first examined the expression of galectins and binding sites in clinical specimens by lectin and immunohistochemistry. Sixty-seven colonic surgical resections were studied, incl...

journal_title：International journal of cancer

authors： Hittelet A,Legendre H,Nagy N,Bronckart Y,Pector JC,Salmon I,Yeaton P,Gabius HJ,Kiss R,Camby I

更新日期：2003-01-20 00:00:00

abstract：:Idiotypic protein (Id) produced by myeloma cells is clone-specific and may be a suitable tumor-specific antigen for immune targeting. Advances in dendritic cell (DC) technology suggest the opportunity for using this potent antigen presentation system to deliver myeloma Id to the autologous host to elicit anti-tumor im...

journal_title：International journal of cancer

authors： Lim SH,Bailey-Wood R

更新日期：1999-10-08 00:00:00

abstract：:An experiment in which rats were injected intrapleurally with asbestos, the injection taking place at an age of either 2 or 10 months, is reported. In the former group 19 out of 48 rats developed a mesothelioma compared with 17 out of 90 in the latter group. However, by considering the two groups at equal times after ...

journal_title：International journal of cancer

authors： Berry G,Wagner JC

更新日期：1976-04-15 00:00:00

abstract：:Cancer blood vessels consist of two interacting types of cells: inner lining endothelial cells (ECs) and surrounding perivascular cells (pericytes, vascular smooth muscle cells or mural cells). PDGFRbeta(CD140b)+ progenitor perivascular cells (PPC) can differentiate into pericytes and regulate vessel stability and vas...

journal_title：International journal of cancer

authors： Mancuso P,Martin-Padura I,Calleri A,Marighetti P,Quarna J,Rabascio C,Braidotti P,Bertolini F

更新日期：2011-09-15 00:00:00

abstract：:This population-based cohort study investigated the occurrence of familial astrocytoma among first-degree relatives of patients with astrocytoma diagnosed between 1985 and 1993 in the northern region of Sweden. The 432 cases received a questionnaire. They were asked to provide names and cancer diagnoses of first-degre...

journal_title：International journal of cancer

authors： Malmer B,Grönberg H,Bergenheim AT,Lenner P,Henriksson R

更新日期：1999-05-05 00:00:00

abstract：:Radiation therapy (RT) continues to be a cornerstone in the treatment for many cancers. Unfortunately, not all individuals respond effectively to RT resulting clinically in two groups consisting of nonresponders (progressive disease) and responders (tumor control/cure). The mechanisms that govern the outcome of radiot...

journal_title：International journal of cancer

authors： Gerber SA,Lim JY,Connolly KA,Sedlacek AL,Barlow ML,Murphy SP,Egilmez NK,Lord EM

更新日期：2014-05-15 00:00:00

abstract：:Studies in Shanghai and in north-east China indicate that cigarette smoking is a major contributor to the high rates of lung cancer in those areas, but doubts persist regarding the influence of cigarette use on lung cancer rates in other areas of China. In addition, the risk of lung cancer associated with other method...

journal_title：International journal of cancer

authors： Lubin JH,Li JY,Xuan XZ,Cai SK,Luo QS,Yang LF,Wang JZ,Yang L,Blot WJ

更新日期：1992-05-28 00:00:00

abstract：:Fibrin deposition in the microenvironment of tumor cells may be critical to tumor growth and metastasis formation. Procoagulant activities of tumor cells themselves, or of infiltrating macrophages, activated by the host's immune system to the tumor, may both contribute to coagulopathies associated with metastases. Lym...

journal_title：International journal of cancer

authors： Geczy CL,Ryan J,Walsh J,Goldstein D

更新日期：1986-05-15 00:00:00

abstract：:BALB/cfC3H female mice which develop mammary tumor virus (MTV)-induced mammary tumors possess not only serun antibodies directed against virus-associated antigens which are expressed on mammary tumor cells but also antibodies directed against antigenic specificities which are unique to each tumor. The possible range o...

journal_title：International journal of cancer

authors： Blair PB,Lane ML

更新日期：1978-04-15 00:00:00

abstract：:The large geographic variations in the incidence of gastric cancer (GC) are likely due to differential environmental exposures, in particular to Helicobacter pylori (H. pylori) infection. We aimed to investigate the impact of H. pylori on the epigenome in normal gastric mucosa and methylation changes associated with c...

journal_title：International journal of cancer

authors： Woo HD,Fernandez-Jimenez N,Ghantous A,Degli Esposti D,Cuenin C,Cahais V,Choi IJ,Kim YI,Kim J,Herceg Z

更新日期：2018-08-01 00:00:00

abstract：:The incidence of testicular cancer was examined in the Nordic and Baltic countries, Poland and Germany by collaboration among 10 cancer registries. Population-based registers were used to analyze a total of 34,309 cases, diagnosed from the start of registration (varying from 1943 in Denmark to 1980 in Latvia and Lithu...

journal_title：International journal of cancer

authors： Adami HO,Bergström R,Möhner M,Zatoński W,Storm H,Ekbom A,Tretli S,Teppo L,Ziegler H,Rahu M

更新日期：1994-10-01 00:00:00

abstract：:We observed previously that two carbohydrate epitopes, extended type 1 chain Le(a)-Le(a) and Le(b)-Le(a), are expressed strongly in human gastric or colorectal cancer and cell lines derived therefrom, but their expression in human normal colorectal cells is highly limited. A monoclonal antibody, termed GNX-8, was esta...

journal_title：International journal of cancer

authors： Yang MC,Hsu FL,Handa K,Hakomori S,Lee MH,Liu LY,Chang SY,Ting J,Wen JY,Ishida I,Chang TH

更新日期：2009-12-21 00:00:00

abstract：:We investigated the marker profile of human ascitic and cultured mesothelial cells, and compared it to that of ovarian carcinoma cells which are related in terms of their histogenesis, unrelated colon carcinomas being used as reference. Mesothelial and ovarian carcinoma cells could not be distinguished by (intermediat...

journal_title：International journal of cancer

authors： van Niekerk CC,Jap PH,Thomas CM,Smeets DF,Ramaekers FC,Poels LG

更新日期：1989-06-15 00:00:00

abstract：:There is limited research on the effect of dietary quality on hepatocellular carcinoma (HCC) risk in populations with relatively high risk of HCC. Using data from Singapore Chinese Health Study, a prospective cohort study, of 63 257 Chinese aged 45 to 74, we assessed four diet-quality index (DQI) scores: the Alternati...

journal_title：International journal of cancer

authors： Luu HN,Neelakantan N,Geng TT,Wang R,Goh GB,Clemente JC,Jin A,van Dam RM,Jia W,Behari J,Koh WP,Yuan JM

更新日期：2020-10-31 00:00:00

abstract：:T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...

journal_title：International journal of cancer

authors： Kudoh S,Stanley J,Edinger MG,Tubbs RR,Klein E,Bukowski RM,Finke JH

更新日期：1994-08-01 00:00:00

abstract：:Cord blood transplantation (CBT) is an effective option for treating hematological malignancies, but graft failure (GF) remains the primary cause of therapy failure. Thus, based on myeloablative conditioning (MAC) of busulfan with cyclophosphamide (Bu/Cy) or total body irradiation with Cy (TBI/Cy), fludarabine (Flu) w...

journal_title：International journal of cancer

authors： Sun Z,Liu H,Luo C,Geng L,Zheng C,Tang B,Zhu X,Tong J,Wang X,Ding K,Wan X,Zhang L,Yao W,Song K,Zhang X,Wu Y,Yang H,Han Y,Liu X,Zhu W,Wu J,Wang Z

更新日期：2018-08-01 00:00:00

abstract：:The incidence of cutaneous melanoma in children aged 0-14 years was examined in Queensland, Australia. Details of notifications were collected from the population-based Australian Paediatric Cancer Registry. Between 1987 and 1994, the age-adjusted incidence rates of invasive cutaneous melanoma occurring in Queensland ...

journal_title：International journal of cancer

authors： Whiteman D,Valery P,McWhirter W,Green A

更新日期：1995-12-11 00:00:00

abstract：:Metastasis is a critical problem in the treatment of human lung cancer. Thus, a suitable animal model of metastasis of human lung cancer is required for in vivo biological and preclinical studies. In this study, we tried to establish a suitable model for this, using SCID mice. Neither human SCLC H69/VP cells (5 x 10(6...

journal_title：International journal of cancer

authors： Yano S,Nishioka Y,Izumi K,Tsuruo T,Tanaka T,Miyasaka M,Sone S

更新日期：1996-07-17 00:00:00

abstract：:Inactivation of the tumor suppressor gene, von Hippel-Lindau (VHL), is known to play an important role in the development of sporadic clear cell renal cell carcinomas (ccRCCs). Even if available targeted therapies for metastatic RCCs (mRCCs) have helped to improve progression-free survival rates, they have no durable ...

journal_title：International journal of cancer

authors： Bouhamdani N,Joy A,Barnett D,Cormier K,Léger D,Chute IC,Lamarre S,Ouellette R,Turcotte S

更新日期：2017-08-15 00:00:00

abstract：:Our study explored the drug interaction of all-trans retinoic acid (ATRA) and RAD001 (everolimus), the inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in acute myelogenous leukemia (AML) NB4 and HL60 cells. RAD001 (10 nM) significantly enhanced the ATRA-induced growth arrest and differentiation of these...

journal_title：International journal of cancer

authors： Nishioka C,Ikezoe T,Yang J,Gery S,Koeffler HP,Yokoyama A

更新日期：2009-10-01 00:00:00

abstract：:Clinical and experimental scintigraphic studies have found that radiolabelled antibodies are not only taken up by tumour(s) but also by normal liver. The accumulation of radionuclides in this organ poses a major problem to the use of radiolabelled antibodies as diagnostic and therapeutic tools. In an attempt to unders...

journal_title：International journal of cancer

authors： Boyle CC,Paine AJ,Mather SJ

更新日期：1992-04-01 00:00:00

abstract：:Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Understanding which human enzymes are involved in AA activation and/or detoxication is important in the assessment of an individual's susceptibility to this plant carcinoge...

journal_title：International journal of cancer

authors： Stiborová M,Frei E,Hodek P,Wiessler M,Schmeiser HH

更新日期：2005-01-10 00:00:00

abstract：:Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blo...

journal_title：International journal of cancer

authors： Tian X,Ge D,Zhang F,Zhang B,Bai W,Xu X,Li Z,Cao Y,Li P,Zou K,Zou L

更新日期：2021-02-15 00:00:00

abstract：:Viruses that replicate selectively in cancer cells hold considerable promise as novel therapeutic agents for the treatment of malignancy. We report an orthotopic model of multi-focal colorectal cancer (CRC) metastases in the livers of syngeneic and immune-competent rats, which permitted rigorous testing of oncolytic v...

journal_title：International journal of cancer

authors： Shinozaki K,Ebert O,Woo SL

更新日期：2005-04-20 00:00:00