Abstract:
:In 2011, a novel form of genome instability was reported by Stephens et al., characterized by tens to hundreds of locally clustered rearrangements affecting one or a few chromosome(s) in cancer cells. This phenomenon, termed chromothripsis, is likely due to a single catastrophic event leading to the simultaneous formation of multiple double-strand breaks, which are repaired by error-prone mechanisms. Since then, the occurrence of chromothripsis was detected in a wide range of tumor entities. In this review, we will discuss potential mechanisms of chromothripsis initiation in cancer and outline the prevalence of chromothripsis across entities. Furthermore, we will examine how chromothriptic events may promote cancer development and how they may affect cancer therapy.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Rode A,Maass KK,Willmund KV,Lichter P,Ernst Adoi
10.1002/ijc.29888subject
Has Abstractpub_date
2016-05-15 00:00:00pages
2322-33issue
10eissn
0020-7136issn
1097-0215journal_volume
138pub_type
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journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:2000-03-20 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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