Donor lymphocyte infusion leads to diversity of specific T cell responses and reduces regulatory T cell frequency in clinical responders.

abstract：:Cholera toxin (which increases intracellular cAMP levels) significantly (p less than 0.05) increased the growth of MCF-7, T47-D and Hs578T human breast carcinoma cells in vitro. The effect of cholera toxin on growth of MCF-7 and T47-D cells was more pronounced in the presence of 17 beta-estradiol (p less than 0.05), i...

journal_title：International journal of cancer

authors： Sheffield LG,Welsch CW

更新日期：1985-10-15 00:00:00

abstract：:A continuous lymphoma cell line, BJAB, derived from the tumour of an exceptional African case of Burkitt's lymphoma, has previously been described. Unlike 97% of African BL cases studied, neither the original tumour cells nor the cell line contained detectable amounts of EBV (Epstein-Barr virus) DNA, nor did they expr...

journal_title：International journal of cancer

authors： Clements GB,Klein G,Povey S

更新日期：1975-07-15 00:00:00

abstract：:A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer [basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma]. We prospecti...

journal_title：International journal of cancer

authors： Park SM,Li T,Wu S,Li WQ,Weinstock M,Qureshi AA,Cho E

更新日期：2017-05-01 00:00:00

abstract：:Two metastatic cell lines, mouse B16-Fl melanoma and human Hs939 melanoma, were examined for their abilities to adhere to confluent vascular endothelial cell monolayers and to the underlying endothelial extracellular matrix. Tumor cells attacked slowly to the endothelial cell monolayers while they adhered rapidly to i...

journal_title：International journal of cancer

authors： Kramer RH,Gonzalez R,Nicolson GL

更新日期：1980-11-15 00:00:00

abstract：:Dendritic cells (DCs) display an extraordinary capacity to induce T-cell responses providing the opportunity of DC-based cancer vaccination strategies. Additional findings indicate that DCs may also play a crucial role for the activation of natural killer (NK) cells, which are important effectors in innate antitumor i...

journal_title：International journal of cancer

authors： Wehner R,Löbel B,Bornhäuser M,Schäkel K,Cartellieri M,Bachmann M,Rieber EP,Schmitz M

更新日期：2009-01-15 00:00:00

abstract：:The intrauterine environment appears to play a role in the development of adult diseases, including several prominent cancers. Our study aims to characterize the relationship between birth weight, a measure of the intrauterine environment, and adult obesity. A population-based sample of women aged 50-79, living in the...

journal_title：International journal of cancer

authors： Leong NM,Mignone LI,Newcomb PA,Titus-Ernstoff L,Baron JA,Trentham-Dietz A,Stampfer MJ,Willett WC,Egan KM

更新日期：2003-03-01 00:00:00

abstract：:We previously produced evidence that the human mammary-carcinoma cell line 8701-BC expresses several metalloproteinases (MMP-1, -2, -9, and -10) and their tissue inhibitors). In order to obtain a better understanding of the environmental control over gelatinolytic activities, we have tested the enzyme production of 87...

journal_title：International journal of cancer

authors： Minafra S,Giambelluca C,Andriolo M,Pucci-Minafra I

更新日期：1995-09-15 00:00:00

abstract：:p27Kip1, one of the cyclin-dependent kinase (CDK) inhibitors (CDKIs), blocks progression from G1 to S phase by binding cyclin D1-CDK4 and/or cyclin E-CDK2 and inhibiting their activities. Reflecting the function of p27 as a CDKI in vitro, a reduced expression of protein p27 has recently been reported to be associated ...

journal_title：International journal of cancer

authors： Anayama T,Furihata M,Ishikawa T,Ohtsuki Y,Ogoshi S

更新日期：1998-08-21 00:00:00

abstract：:Sexual behavior has been consistently identified as a major risk factor for cervical cancer. Population-based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (HPV) infection. We conducted a case-control study of 199 cases with low-grade squamous intraepithelial lesion...

journal_title：International journal of cancer

authors： Kjaer SK,van den Brule AJ,Bock JE,Poll PA,Engholm G,Sherman ME,Walboomers JM,Meijer CJ

更新日期：1996-03-01 00:00:00

abstract：:DNA-dependent protein kinase (DNA-PK) has been intensively investigated for its roles in the nonhomologous end-joining (NHEJ) pathway of DNA double-strand break repair and maintenance of genomic stability. Its catalytic subunit, DNA-PKcs, a serine/threonine protein kinase, has recently been reported to be overexpresse...

journal_title：International journal of cancer

authors： An J,Xu QZ,Sui JL,Bai B,Zhou PK

更新日期：2005-11-20 00:00:00

abstract：:The radiosensitivity of three forms of response to injection of C. parvum in mice has been investigated. The increase in phagocytin index evoked by IP or IV injection of 0.7 mg C. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before C. parv...

journal_title：International journal of cancer

authors： Woodruff MF,Ghaffar A,Whitehead VL

更新日期：1976-05-15 00:00:00

abstract：:Homozygous deletion and loss of heterozygosity (LOH) at chromosome 3p21 have been observed in several types of human cancer including lung cancer and breast cancer. In previous work, we cloned and identified the human RAS association domain family 1A gene (RASSF1A) from the lung tumor suppressor locus 3p21.3. The CpG ...

journal_title：International journal of cancer

authors： Yoon JH,Dammann R,Pfeifer GP

更新日期：2001-10-15 00:00:00

abstract：:Lymphatic leukemia developed in C57BL/6 mice following inoculation of normal thymocytes that and been co-cultured on leukemic thymus epithelial reticulum monolayer cells. Using thymocytes genetically marked in Ly membrane antigens, we showed that the thymomas which developed were produced by the co-cultured thymocytes...

journal_title：International journal of cancer

authors： Haas M

更新日期：1978-01-15 00:00:00

abstract：:The cell-cycle regulator p16 inhibits the complex cdk4-cyclin D1 and controls G1-S transition. In human tumors, p16 inactivation is often accomplished by homozygous deletion (HD) of its encoding gene, CDKN2A. Methylation of the 5' CpG island promoter has been proposed as an alternative mechanism of inactivation. Expre...

journal_title：International journal of cancer

authors： Bortolotto S,Chiadò-Piat L,Cavalla P,Bosone I,Chiò A,Mauro A,Schiffer D

更新日期：2000-11-15 00:00:00

abstract：:The role of gastrin in the control of growth of renal G401 cells isolated from a human nephroblastoma (Wilms' tumour) was investigated. G401 cell growth was enhanced in the presence of exogenous gastrin. Addition of anti-gastrin antibodies to serum-free medium significantly inhibited the growth of G401 cells. G401 cel...

journal_title：International journal of cancer

authors： Blackmore M,Doherty E,Manning JE,Hirst BH

更新日期：1994-05-01 00:00:00

abstract：:Laboratory and epidemiological data have linked vitamin D to breast cancer prevention. Beside dietary intake, endogenous production of vitamin D substantially contributes to a subject's vitamin D status. Most studies, however, have assessed dietary intake only. Although differential effects of vitamin D on premenopaus...

journal_title：International journal of cancer

authors： Abbas S,Chang-Claude J,Linseisen J

更新日期：2009-01-01 00:00:00

abstract：:The enzyme alpha1,3galactosyltransferase synthesizes the alphaGal epitope, a carbohydrate structure (Galalpha1,3Galbeta1,4GlcNAc-R), on glycoconjugates in lower mammals. The enzyme is absent in humans but large amounts of natural antibodies that recognize alphaGal epitopes are present in human serum. It is likely that...

journal_title：International journal of cancer

authors： Aubert M,Crotte C,Bernard JP,Lombardo D,Sadoulet MO,Mas E

更新日期：2003-12-20 00:00:00

abstract：:Lymphocyte blastogenesis induced by autologous tumor biopsy cells, by allogeneic lymphocytes and by PHA, was performed in the presence of autologous or allogeneic serum collected from normal blood donors. In 13 of the 15 cases lymphocyte stimulation by autologous tumor cells was inhibited in the presence of autologous...

journal_title：International journal of cancer

authors： Vánky F,Klein E,Stjernswärd J,Trempe G

更新日期：1975-11-15 00:00:00

abstract：:Metastasis continues to be the leading cause of mortality for patients with cancer. Several years ago, it became clear that chemokines and their receptors could control the tumor progress. CXCR3 has now been identified in many cancers including osteosarcoma and CXCR3 ligands were expressed by lungs that are the primar...

journal_title：International journal of cancer

authors： Pradelli E,Karimdjee-Soilihi B,Michiels JF,Ricci JE,Millet MA,Vandenbos F,Sullivan TJ,Collins TL,Johnson MG,Medina JC,Kleinerman ES,Schmid-Alliana A,Schmid-Antomarchi H

更新日期：2009-12-01 00:00:00

abstract：:Primary breast diffuse large B-cell lymphoma (DLBCL) is an extremely rare presentation of non-Hodgkin's lymphoma that has been associated with poorer clinical outcomes compared with nodal DLBCL in the pre-rituximab era. The aim of this study was to investigate the impact of rituximab on clinical outcomes in patients w...

journal_title：International journal of cancer

authors： Yhim HY,Kim JS,Kang HJ,Kim SJ,Kim WS,Choi CW,Eom HS,Kim JA,Lee JH,Won JH,Shim H,Huh J,Lee DH,Suh C,Kwak JY

更新日期：2012-07-01 00:00:00

abstract：:Allelic loss at the short arm of chromosome 11 is one of the most common and potent events in the progression and metastasis of breast cancer. Here, we present evidence that the Integrin-Linked Kinase (ILK) gene maps to the commonly deleted chromosome 11p15.5 and suppresses malignant growth of human breast cancer cell...

journal_title：International journal of cancer

authors： Chen P,Shen WZ,Karnik P

更新日期：2004-10-10 00:00:00

abstract：:Mouse IFN gamma preparations purified 30-fold were found to have direct cytolytic activity against a number of tumor and normal cells. Cell killing was determined using a sensitive, rapid and accurate assay which employed very low numbers of cells and very small quantities of interferon. The cytolytic activity of IFN ...

journal_title：International journal of cancer

authors： Tyring S,Klimpel GR,Fleischmann WR Jr,Baron S

更新日期：1982-07-15 00:00:00

abstract：:The causative role of human papillomaviruses (HPV) and HPV16 variants has been extensively studied in uterine cervix dysplastic lesions and invasive carcinoma; few such studies, however, have been performed in penile tumors. We have investigated HPV genotype and HPV16 variant distribution on 41 penile cancer biopsies ...

journal_title：International journal of cancer

authors： Tornesello ML,Duraturo ML,Losito S,Botti G,Pilotti S,Stefanon B,De Palo G,Gallo A,Buonaguro L,Buonaguro FM

更新日期：2008-01-01 00:00:00

abstract：:Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1 (AFB1 )-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversial. To clarify thi...

journal_title：International journal of cancer

authors： Shimizu Y,Zhu JJ,Han F,Ishikawa T,Oda H

更新日期：1999-07-19 00:00:00

abstract：:Intracellular thiols have been proposed as mediators of resistance to alkylating agents and cisplatin. As metallothionein is the predominant protein thiol, we examined its relationship to cisplatin resistance in human ovarian cancer cell lines. A human ovarian carcinoma cell line, A2780, derived from an untreated pati...

journal_title：International journal of cancer

authors： Schilder RJ,Hall L,Monks A,Handel LM,Fornace AJ Jr,Ozols RF,Fojo AT,Hamilton TC

更新日期：1990-03-15 00:00:00

abstract：:Screening for cancer has to be carefully organized for maximum effectiveness, and introduced in full understanding of the natural history of the disease. There are major potential harms as well as benefits from screening. The current state of art for breast, cervix and prostate cancer screening is reviewed, only for b...

journal_title：International journal of cancer

authors： Miller AB

更新日期：2010-03-01 00:00:00

abstract：:Recent analyses have suggested decreases over time in colorectal cancer incidence at older ages (≥55 years) but increases at younger ages (20-54 years). Understanding the geographic heterogeneity of incidence facilitates resource allocation for potential interventions and advances our knowledge of differential etiolog...

journal_title：International journal of cancer

authors： Chernyavskiy P,Kennerley VM,Jemal A,Little MP,Rosenberg PS

更新日期：2019-04-15 00:00:00

abstract：:A human tumor clonogenic assay has been used to test the antiproliferative effect of recombinant human leukocyte interferon alpha 2 alone and in combination with each of 8 cytotoxic agents. Cell lines derived from 6 human tumors and primary tumor cells from 13 patients have been used in these clonogenic assay studies....

journal_title：International journal of cancer

authors： Welander CE,Morgan TM,Homesley HD,Trotta PP,Spiegel RJ

更新日期：1985-06-15 00:00:00

abstract：:A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) nega...

journal_title：International journal of cancer

authors： Rudolph A,Milne RL,Truong T,Knight JA,Seibold P,Flesch-Janys D,Behrens S,Eilber U,Bolla MK,Wang Q,Dennis J,Dunning AM,Shah M,Munday HR,Darabi H,Eriksson M,Brand JS,Olson J,Vachon CM,Hallberg E,Castelao JE,Carrac

更新日期：2015-03-15 00:00:00

abstract：:Complement-dependent cytotoxic antibodies to three cervical carcinoma cell lines (Me-180, SW-732 and HeLa) and to Herpes simplex virus type 2 (HSV-2)-infected cells were determined in a long-term study of women with cervical carcinoma. Cytolysis of surface antigens differed significantly between the cervical carcinoma...

journal_title：International journal of cancer

authors： Christenson B

更新日期：1977-11-15 00:00:00