Abstract:
:The radiosensitivity of three forms of response to injection of C. parvum in mice has been investigated. The increase in phagocytin index evoked by IP or IV injection of 0.7 mg C. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before C. parvum injection. Irradiation (500-1,000 rad) 4 days after C. parvum injection had no such effect. The antitumour cytotoxicity in vitro of PE and spleen cells from C. parvum-treated mice was abolished by irradiation of the cell donor (400-800 rad) 4 days before C. parvum injection, but was not reduced by irradiation (800 rad) of the cell donor 4 days after C. parvum injection or of the effector cells in vitro. The antitumour response to systemic (IP) injection of C. parvum was reduced by 350-500 rad whole-body irradiation, irrespective of whether this was given 4 days before or 4 days after C. parvum injection. The response to intratumour injection of C. parvum was even more radiosensitive. It has been suggested in previous papers from this laboratory that the antitumour effect of C. parvum is related to its capacity to stimulate macrophage activity, although in addition T lymphocytes are necessary for local injection to be effective and non-T lymphocytes may be concerned in the response to both local and systemic injection. The present results in no way conflict with this view. They suggest in addition that the effect of C. parvum on the macrophage system is, to a considerable extent, due to stimulation of macrophage precursors to differentiate into actively phagocytic and cytotoxic mature cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Woodruff MF,Ghaffar A,Whitehead VLdoi
10.1002/ijc.2910170515keywords:
subject
Has Abstractpub_date
1976-05-15 00:00:00pages
652-8issue
5eissn
0020-7136issn
1097-0215journal_volume
17pub_type
杂志文章abstract::A panel of conventional and monoclonal antibodies was used to examine the immunohistological characteristics of malignant epithelial cells and infiltrating lymphocytes in frozen sections of nasopharyngeal carcinoma (NPC) biopsies from 10 Tunisian patients. Three main categories of cells were identified. (1) Tumour cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330616
更新日期:1984-06-15 00:00:00
abstract::Carcinoma of the breast is a leading hormone-dependent malignancy, resulting in a high rate of morbidity and mortality. During the complex multi-step process of tumor promotion, this common cancer is initiated as hormone-responsive (HR), non-metastatic cancer, followed by a gradual transition into a highly metastatic ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990505)81:3<443::aid-ijc
更新日期:1999-05-05 00:00:00
abstract::Normal transcription displays a high degree of flexibility over the choice, timing and magnitude of mRNA expression levels that tend to oscillate and cycle. These processes allow for combinatorial actions, feedback control and fine-tuning. A central role has emerged for the transcriptional co-repressor proteins such a...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
abstract::Human kallikrein 11 (hK11/trypsin-like serine protease/TLSP, encoded by the KLK11 gene) is a member of the kallikrein family of secreted serine proteases. Recently, we developed a highly sensitive and specific immunoassay for hK11 and found that this protease is expressed in the prostate, stomach and trachea as well a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11296
更新日期:2003-09-10 00:00:00
abstract::To investigate whether addition of local therapy to EGFR-TKIs could provide survival benefit than EGFR-TKIs alone in EGFR-mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases (LM). Patients with EGFR-mutant NSCLC and oligometastatic or oligoprogressive LM who met inclusion criteria were retr...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2019-05-15 00:00:00
abstract::Osteosarcoma incidence rates in the United States peak in adolescence and in the elderly. The international patterns of osteosarcoma incidence in children have been described, whereas those for young, middle age or elderly adults have not. Using the Cancer Incidence in Five Continents, International Agency for Cancer ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24320
更新日期:2009-07-01 00:00:00
abstract::In order to examine whether or not the expression of the apoptosis-related receptor Fas (CD-95/APO-1) and its ligand (FasL) has relevance for patient survival, immunohistochemistry was used to analyze the proteins of both factors in 164 non-small cell lung carcinomas. Patients with Fas-positive tumors exhibited signif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990621)84:3<239::aid-ijc
更新日期:1999-06-21 00:00:00
abstract::A new permanent cell line (GRU-1) derived from the lymph-node metastasis of a human epithelioid sarcoma was established in tissue culture. Immunohistochemically, the original tumor had exhibited an intriguing potential for multidirectional differentiation with features of mesenchymal, epithelial and neural differentia...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910450126
更新日期:1990-01-15 00:00:00
abstract::Stem cell-like cells have recently been identified in melanoma cell lines, but their relevance for melanoma pathogenesis is controversial. To characterize the stem cell signature of melanoma, expression of stem cell markers BMI-1 and nestin was studied in 64 cutaneous melanomas, 165 melanoma metastases as well as 53 m...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22891
更新日期:2007-10-15 00:00:00
abstract::Several tumour-derived factors have recently been identified which induce tissue factor (TF) expression in endothelial cells in vitro. However, there is only limited evidence that endothelial cells lining tumour blood vessels express elevated procoagulant activity (PCA) in vivo. We have investigated the effects of hum...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960611)66:6<784::AID-IJC
更新日期:1996-06-11 00:00:00
abstract::The potential role of p16(INK4a) methylation in breast cancer is controversial whereas there are no data on fibroadenoma. To assess if inactivation of p16(INK4a) by promoter hypermethylation occurs in this hyperproliferative benign breast lesion or, on the contrary, it is strictly related to the carcinogenic process, ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20771
更新日期:2005-04-10 00:00:00
abstract::Different treatment schedules have been investigated when evaluating the inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 3'-azido-2',3'-dideoxythymidine (AZT) on the replication of human immunodeficiency virus type I (HIV-I) in MT-4 cells, transformation of C3H/3T3 cells by Moloney murine sarcoma v...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460233
更新日期:1990-08-15 00:00:00
abstract::Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical for identifying new therapeutic strategies. Here, we found that the GTPase RAB27A ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32064
更新日期:2019-06-15 00:00:00
abstract::Activated T cells expressing endogenous or transduced TCRs are two cell types currently used in clinical adoptive T-cell therapy. The ability of these cells to recognize their antigen, expand and traffic to the tumor site are the initial steps necessary for successful therapy. In this study, we used in vivo biolumines...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29401
更新日期:2015-07-15 00:00:00
abstract::The intrauterine environment appears to play a role in the development of adult diseases, including several prominent cancers. Our study aims to characterize the relationship between birth weight, a measure of the intrauterine environment, and adult obesity. A population-based sample of women aged 50-79, living in the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10886
更新日期:2003-03-01 00:00:00
abstract::To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter (238)Pu, and the expression profiles were compared with those of normal osteoblasts (OB). The expressions of 72 genes were significan...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24392
更新日期:2009-08-01 00:00:00
abstract::The insulin-like growth factors (IGF-I and IGF-II) play a key role in cellular proliferation and are involved in cellular transformation. The expression of the IGF-I receptor has been demonstrated in a variety of human tumor cell lines including ovarian cancer cells. Phosphorothioate antisense oligodeoxynucleotides (S...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980812)77:4<567::aid-ijc
更新日期:1998-08-12 00:00:00
abstract::Infection with a simian retrovirus (STLV-I) closely related to human T-lymphotropic virus type I (HTLV-I) was investigated in non-human primates living in their native countries in Africa and Asia. Serum antibodies cross-reacting with HTLV-I antigens were detected in 85 of 567 non-human primates of 30 species. Seropos...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910400219
更新日期:1987-08-15 00:00:00
abstract::The Cancer Incidence in Five Continents (CI5) series comprises nine volumes that bring together peer-reviewed results from population-based cancer registries worldwide. The aim of each is to make available comparable data on cancer incidence from as wide a range of geographical locations as possible. In addition, the ...
journal_title:International journal of cancer
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doi:10.1002/ijc.25517
更新日期:2010-12-15 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2013-06-15 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.22872
更新日期:2007-10-15 00:00:00
abstract::Interest has increased in the potential role of circulating tumour cells in cancer management. Most cell-based studies have been designed to determine the number of circulating tumour cells in a given volume of blood. Ability to understand the biology of the cancer cells would increase the clinical potential. The purp...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29680
更新日期:2016-01-01 00:00:00
abstract::Using a direct binding liquid competition radioimmunoassay, the amount of the ras oncogene protein product, p21, was quantitated in a variety of human tumors and adjacent apparently normal tissues. In 48 of 50 matched tumor and normal tissue biopsy specimens from 50 patients, more ras p21 was detected in the tumor tha...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430315
更新日期:1989-03-15 00:00:00
abstract::Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase inhibitor 2 (CDKN2...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970822)74:4<407::aid-ijc
更新日期:1997-08-22 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2004-06-20 00:00:00
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journal_title:International journal of cancer
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abstract::Inbred rats were treated with extranuclear tumour membrane fractions or 3 M KCl-solubilized extracts of two antigenically distinct 3-methylcholanthrene-induced sarcomas, Mc7 and Mc57. The rats developed tumour-specific humoral antibody responses, but were not immune to tumour challenge. Moreover, they were unresponsiv...
journal_title:International journal of cancer
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journal_title:International journal of cancer
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abstract::A hospital-based case-control study of renal-cell carcinoma was conducted in France from 1987 to 1991. A total of 196 histologically confirmed cases (138 males and 58 females) and 347 controls (235 males and 112 females), matched for sex, age at interview, hospital and interviewer, were included. The risk of renal-cel...
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更新日期:1993-08-19 00:00:00