Tumor production of angiostatin is enhanced after exposure to TNF-alpha.

abstract：:The genetic events underlying the development of prostate cancer are poorly defined. c-Myc is often activated in tumors that have progressed to metastatic status, so events that promote this process may be important. Bin1 is a nucleocytoplasmic adaptor protein with features of a tumor suppressor that was identified th...

journal_title：International journal of cancer

authors： Ge K,Minhas F,Duhadaway J,Mao NC,Wilson D,Buccafusca R,Sakamuro D,Nelson P,Malkowicz SB,Tomaszewski J,Prendergast GC

更新日期：2000-04-15 00:00:00

abstract：:The amplification of the q21 band of chromosome 8 (8q21) occurs in a large percentage of breast cancers. WWP1, an HECT domain-containing ubiquitin E3 ligase located in the 8q21 region, negatively regulates the TGF-beta tumor suppressor pathway. To characterize the role of WWP1 in breast cancer, we analyzed WWP1 gene d...

journal_title：International journal of cancer

authors： Chen C,Zhou Z,Ross JS,Zhou W,Dong JT

更新日期：2007-07-01 00:00:00

abstract：:RB1 gene expression has been reported to be upregulated in colorectal carcinomas (CRC) at both the mRNA and protein levels when compared to normal colonic mucosa. However, allelic loss at the genomic level has been detected in CRC with widely differing frequencies ranging from 11.5% to 50%. To determine whether there ...

journal_title：International journal of cancer

authors： Lai PS,Cheah PY,Kadam P,Chua CL,Lie DK,Li HH,Eu KW,Seow-Choen F,Lee AS

更新日期：2006-09-01 00:00:00

abstract：:Androgen deprivation therapy (ADT) remains a key approach in the treatment of prostate cancer (PCa). However, PCa inevitably relapses and becomes ADT resistant. Besides androgens, there is evidence that thyroid hormone thyroxine (T4) and its active form 3,5,3'-triiodo-L-thyronine (T3) are involved in the progression o...

journal_title：International journal of cancer

authors： Aksoy O,Pencik J,Hartenbach M,Moazzami AA,Schlederer M,Balber T,Varady A,Philippe C,Baltzer PA,Mazumder B,Whitchurch JB,Roberts CJ,Haitel A,Herac M,Susani M,Mitterhauser M,Marculescu R,Stangl-Kremser J,Hassler MR,Kr

更新日期：2021-02-01 00:00:00

abstract：:We examined pp60c-src protein kinase activity in human gastric carcinoma cell lines and gastric carcinoma tissues as well as normal mucosa. pp60c-src kinase activity was detected in all 5 carcinoma cell lines at various levels. Of 16 gastric carcinoma tissues, 8 showed higher pp60c-src kinase activity in tumor tissues...

journal_title：International journal of cancer

authors： Takekura N,Yasui W,Yoshida K,Tsujino T,Nakayama H,Kameda T,Yokozaki H,Nishimura Y,Ito H,Tahara E

更新日期：1990-05-15 00:00:00

abstract：:Since advanced melanoma remains practically incurable, early detection is an important step toward a reduction in mortality. High expectations are entertained for a technique known as dermoscopy or epiluminescence light microscopy; however, evaluation of pigmented skin lesions by this method is often extremely complex...

journal_title：International journal of cancer

authors： Rubegni P,Cevenini G,Burroni M,Perotti R,Dell'Eva G,Sbano P,Miracco C,Luzi P,Tosi P,Barbini P,Andreassi L

更新日期：2002-10-20 00:00:00

abstract：:As many patients with mammary carcinoma are now treated by conservative forms of surgery, there is a need for prognostic information obtainable from the primary tumour alone. One possible source is the antigenic profile of tumour cells. Using an indirect immunoperoxidase technique, we stained histological sections of ...

journal_title：International journal of cancer

authors： Wilkinson MJ,Howell A,Harris M,Taylor-Papadimitriou J,Swindell R,Sellwood RA

更新日期：1984-03-15 00:00:00

abstract：:We have studied the relationship between tumor necrosis factor (TNF)-sensitivity and doxorubicin-resistance in our doxorubicin-resistant cell line panel consisting of the parental cell line GLC4 plus GLC4-Adr2x and GLC4-Adr350x with respective resistance factors of 2 and 350 compared with GLC4. At the highest dose of ...

journal_title：International journal of cancer

authors： Sleijfer S,Asschert JG,Timmer-Bosscha H,Mulder NH

更新日期：1998-07-03 00:00:00

abstract：:We report that the Rhesus (Rh)-negative phenotype is more prevalent in patients with small-cell lung cancer (SCLC) than in the normal Caucasian population (SCLC: 25% Rh-negative vs. 15% expected, p less than 0.0001). This finding has been validated for a Central and a Northern European population (Switzerland and UK)....

journal_title：International journal of cancer

authors： Cerny T,Fey MF,Oppliger R,Castiglione M,Nachbur B,Gertsch M,Gasser A,Joss RA,Thatcher N,Lind M

更新日期：1992-09-30 00:00:00

abstract：:Previous studies have reported that poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum (Por & Muc) show a low incidence and poor prognosis. However, genetic alterations and tumourigenesis of Por & Muc remain unclear. In our study, we analyzed the genetic and epigenetic alterations of P...

journal_title：International journal of cancer

authors： Kanazawa T,Watanabe T,Kazama S,Tada T,Koketsu S,Nagawa H

更新日期：2002-11-20 00:00:00

abstract：:It has been established that disturbances in intracellular signaling pathways play a considerable part in the oncologic process. Phosphatidylinositol-3-kinase (PI3K) has become of key interest in cancer therapy because of its high mutation frequency and/or gain in function of its catalytic subunits in cancer cells. We...

journal_title：International journal of cancer

authors： Gobin B,Huin MB,Lamoureux F,Ory B,Charrier C,Lanel R,Battaglia S,Redini F,Lezot F,Blanchard F,Heymann D

更新日期：2015-02-15 00:00:00

abstract：:The recently described PGM-2 leukemia displays a hierarchical structure with bipotential stem cells, B-lymphocyte and macrophage progenitor cells, and post-mitotic end cells. Because the different cell types can easily be identified in vitro by clonal culture assays and simple staining procedures, this leukemia is a u...

journal_title：International journal of cancer

authors： Dührsen U,Knieling G,Hossfeld DK

更新日期：1995-03-03 00:00:00

abstract：:Multiple myeloma (MM) is a B lymphocyte malignancy that remains incurable despite extensive research efforts. This is due, in part, to frequent disease recurrences associated with the persistence of myeloma cancer stem cells (mCSCs). Bone marrow mesenchymal stromal cells (BMSCs) play critical roles in supporting mCSCs...

journal_title：International journal of cancer

authors： Choi DS,Stark DJ,Raphael RM,Wen J,Su J,Zhou X,Chang CC,Zu Y

更新日期：2015-03-01 00:00:00

abstract：:The major obstacle for the treatment of gastric cancer is recurrence and metastasis; yet, its molecular mechanism is largely unknown. 2-methoxyestradiol (2-ME), a metabolite of the estradiol-17beta, has recently been demonstrated to have multifactorial effects against tumor proliferation and angiogenesis; how these ef...

journal_title：International journal of cancer

authors： Lin HL,Yang MH,Wu CW,Chen PM,Yang YP,Chu YR,Kao CL,Ku HH,Lo JF,Liou JP,Chi CW,Chiou SH

更新日期：2007-12-01 00:00:00

abstract：:The purpose of this study was to assess the relationship between progression-free survival (PFS) in patients treated with DFMO + PCV (procarbazine, CCNU, vincristine) chemotherapy for malignant gliomas with tumor cell ornithine decarboxylase (ODC) activity. Formalin-fixed slides were obtained for study patients with a...

journal_title：International journal of cancer

authors： Levin VA,Jochec JL,Shantz LM,Aldape KD

更新日期：2007-11-15 00:00:00

abstract：:The clinical diagnosis of cervical neoplasia by spectroscopic methods is potentially a reliable, fast and cost-effective alternative to the conventional smear test. However, it is currently limited by significant inter-patient variation in the spectroscopic properties of the cervix. Characterisation of suitable in vit...

journal_title：International journal of cancer

authors： Martin SF,Wood AD,McRobbie MM,Mazilu M,McDonald MP,Samuel ID,Herrington CS

更新日期：2007-05-01 00:00:00

abstract：:Cancer vaccines directed against tumor associate antigen (TAA) have produced encouraging results in preclinical models but not in cancer patients. A major limitation of this strategy is the relative degree of tolerance to these antigens and the low and heterogeneous tumor cell expression of TAA and major histocompatib...

journal_title：International journal of cancer

authors： Correale P,Aquino A,Giuliani A,Pellegrini M,Micheli L,Cusi MG,Nencini C,Petrioli R,Prete SP,De Vecchis L,Turriziani M,Giorgi G,Bonmassar E,Francini G

更新日期：2003-04-20 00:00:00

abstract：:We have reported the establishment of a mitomycin-C (MMC)-resistant non-small-cell lung-cancer cell line, PC-9/MC4. As determined by an MTT assay, this resistant cell line was found to be 4 times more sensitive to adriamycin (ADM) than was the parental PC-9. There were no significant differences in sensitivity to etop...

journal_title：International journal of cancer

authors： Kasahara K,Shibata K,Bando T,Numata Y,Fujimura M,Matsuda T

更新日期：1994-10-15 00:00:00

abstract：:Malignant gliomas recur even after extensive surgery and chemo-radiotherapy. Although a relatively novel chemotherapeutic agent, temozolomide (TMZ), has demonstrated promising activity against gliomas, the effects last only a few months and drug resistance develops thereafter in many cases. It has been acknowledged th...

journal_title：International journal of cancer

authors： Zhuang D,Liu Y,Mao Y,Gao L,Zhang H,Luan S,Huang F,Li Q

更新日期：2012-01-15 00:00:00

abstract：:Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of ...

journal_title：International journal of cancer

authors： Jiang S,Li T,Yang Z,Hu W,Yang Y

更新日期：2018-10-01 00:00:00

abstract：:The presence, concentration and selected molecular characteristics of the human mammary carcinoma glycoprotein molecule set MTGP, a trace and apparently tumor-specific molecule, were examined in fifteen cell cultures established from mammary carcinomas, tissue from seven mammary carcinomas and control cultures. Both c...

journal_title：International journal of cancer

authors： Leung JP,Nelson-Rees WA,Moore GE,Cailleau R,Edgington TS

更新日期：1981-07-15 00:00:00

abstract：:This paper deals with a spontaneous malignant transformation in one of our XP fibroblast lines. This cell line, designated XP29MA, was derived from a 14-year-old boy who did not show skin tumors or precancerous alterations either at the time of clinical examination or when the biopsy was taken. We have compared the fo...

journal_title：International journal of cancer

authors： Thielmann HW,Fischer E,Dzarlieva RT,Komitowski D,Popanda O,Edler L

更新日期：1983-06-15 00:00:00

abstract：:Malignant cells possess a high degree of proteolytic activity in which the plasminogen activator system plays an important role. An increased expression of urokinase type plasminogen activator (uPA) is of significance for degradation of the extracellular tumor matrix, facilitating invasiveness and growth. Inhibition o...

journal_title：International journal of cancer

authors： Billström A,Hartley-Asp B,Lecander I,Batra S,Astedt B

更新日期：1995-05-16 00:00:00

abstract：:Tamoxifen is an important selective estrogen receptor (ER) modulator for treatment of steroid hormone positive breast cancer. In addition to the beneficial effect, tamoxifen is one risk factor for endometrial carcinoma (EnCa) development. We hypothesized that, (1) dysregulation of gene expression and protein phosphory...

journal_title：International journal of cancer

authors： Strissel PL,Ellmann S,Loprich E,Thiel F,Fasching PA,Stiegler E,Hartmann A,Beckmann MW,Strick R

更新日期：2008-12-15 00:00:00

abstract：:Familial atypical multiple mole melanoma (FAMMM) is an autosomal dominant disease characterized by the familial occurrence of malignant melanoma of the skin and multiple atypical precursor lesions. Germline mutations in the p16 (CDKN2A) gene have been reported in at least a quarter of such families. An association has...

journal_title：International journal of cancer

authors： Vasen HF,Gruis NA,Frants RR,van Der Velden PA,Hille ET,Bergman W

更新日期：2000-09-15 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is rare in most parts of the world, but prevalent in Southern China. Although this disease poses a serious health problem in our population, the genetic alterations that lead to the development of NPC have yet to be defined. In a comparative genomic hybridization (CGH) study on NPC by ou...

journal_title：International journal of cancer

authors： Tsang YS,Lo KW,Leung SF,Choi PH,Fong Y,Lee JC,Huang DP

更新日期：1999-10-29 00:00:00

abstract：:This nested case-control study based on 1.7 million live births in Sweden explores the associations between maternal and perinatal factors and the occurrence of childhood non-Hodgkin's lymphoma (NHL). The National Swedish Cancer Registry ascertained 168 cases in successive birth cohorts from 1973 through 1989 recorded...

journal_title：International journal of cancer

authors： Adami J,Glimelius B,Cnattingius S,Ekbom A,Zahm SH,Linet M,Zack M

更新日期：1996-03-15 00:00:00

abstract：:The steady-state level of nucleophosmin/B23 mRNA decreased during berberine-induced (25 microg/ml, 24 to 96 hr) apoptosis of human leukemia HL-60 cells. A decline in telomerase activity was also observed in HL-60 cells treated with berberine. A stable clone of nucleophosmin/B23 overexpressed in HL-60 cells was selecte...

journal_title：International journal of cancer

authors： Wu HL,Hsu CY,Liu WH,Yung BY

更新日期：1999-06-11 00:00:00

abstract：:Expression of intermediate filaments (IFs) has been suggested to be a reliable marker for differentiating epithelial and non-epithelial tumors. Moreover, the c-erbB-2 and p53 genes are considered to be involved relatively early in the process of human carcinogenesis. In order to elucidate the origin of uterine carcino...

journal_title：International journal of cancer

authors： Gorai I,Yanagibashi T,Taki A,Udagawa K,Miyagi E,Nakazawa T,Hirahara F,Nagashima Y,Minaguchi H

更新日期：1997-09-04 00:00:00

abstract：:A new non peptidic farnesyltransferase inhibitor, RPR-115135, in combination with 5-FU was studied in 10 human colon cancer cell lines (HCT-116, RKO, DLD-1, Colo-320, LoVo, SW-620, HT-29, HCT-15, Colo-205 and KM-12) carrying several mutations but well characterized for p53 and Ras status. We found that there was a sli...

journal_title：International journal of cancer

authors： Russo P,Malacarne D,Falugi C,Trombino S,O'Connor PM

更新日期：2002-07-20 00:00:00