Tumor production of angiostatin is enhanced after exposure to TNF-alpha.


:Infection of tumors with an adenoviral vector expressing a chimeric gene composed of the CArG elements of the Egr-1 promoter and a cDNA encoding TNF-alpha (Ad.Egr-TNF) has previously been shown to result in the production of high intratumoral levels of TNF-alpha and thereby tumor regression. The antitumor effects of TNF-alpha were ascribed to vascular thrombosis. We and others, have reported that inhibition of tumor vessel thrombosis using anticoagulation therapy does not abrogate the antitumor effects after TNF-alpha treatment. To investigate the potential antiangiogenic effects of TNF-alpha, we studied the generation of angiostatin after intratumoral injection of Ad.Egr-TNF. We report an increase in plasma angiostatin levels both during and after treatment with Ad.Egr-TNF that parallel tumor regression. We also report that TNF-alpha enhances angiostatin production by inducing the activity of plasminogen activator and the release of MMP-9 by tumor cells. These studies support a model in which the antiangiogenic effects of TNF-alpha on the tumor microvasculature are mediated by generation of angiostatin.


Int J Cancer


Mauceri HJ,Seetharam S,Beckett MA,Lee JY,Gupta VK,Gately S,Stack MS,Brown CK,Swedberg K,Kufe DW,Weichselbaum RR





Has Abstract


2002-02-01 00:00:00














  • Cell death induced by N-(4-hydroxyphenyl)retinamide in human epidermal keratinocytes is modulated by TGF-beta and diminishes during the progression of squamous cell carcinoma.

    abstract::It has been demonstrated that the chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) induces apoptotic cell death, but recent data has suggested that late stage/recurrent tumours lose their response to 4-HPR-induced cell death by mechanisms that are unknown. Our study investigated the ability of 4-HPR to indu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Davies M,Paterson IC,Ganapathy A,Prime SS

    更新日期:2006-12-15 00:00:00

  • Differential effects of polyunsaturated fatty acids on chemosensitivity of NIH3T3 cells and its transformants.

    abstract::Polyunsaturated fatty acids (PUFAs) have been suggested, on the basis of animal-model studies, to be related not only to cancer development but also to chemotherapeutic effects. Controversy persists, however, as to which types of PUFAs are beneficial in terms of chemosensitivity. In this study, we used the NIH3T3 cell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tsai WS,Nagawa H,Muto T

    更新日期:1997-01-27 00:00:00

  • Roles of lytic viral infection and IL-6 in early versus late passage lymphoblastoid cell lines and EBV-associated lymphoproliferative disease.

    abstract::Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identif...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jones RJ,Seaman WT,Feng WH,Barlow E,Dickerson S,Delecluse HJ,Kenney SC

    更新日期:2007-09-15 00:00:00

  • Cell-mediated immune reactivity of Sinclair melanoma-bearing swine to 3 M KCl extracts of swine and human melanoma.

    abstract::Leukocyte migration inhibition (LMI) assays were performed using 3 M KCI extracts to detect cell-mediated immune reactions against tumor-associated antigens (TAA) of swine melanoma. Positive LMI reactivity was 70% or greater in melanoma-bearing swine compared to 10% reactivity or less in normal swine tested with extra...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hook RR Jr,Hamby CV,Millikan LE,Berkelhammer J,Stills HF Jr,Oxenhandler RW

    更新日期:1983-05-15 00:00:00

  • Comparative biological responses of rabbits infected with human T-lymphotropic virus type I isolates from patients with lymphoproliferative and neurodegenerative disease.

    abstract::An experimental rabbit model was used to determine host responses to infection by various human T-lymphotropic virus type-I (HTLV-I) strains. Seven groups of 4 to 5 rabbits each were inoculated with lethally-irradiated HTLV-I-infected cell lines derived from patients with adult T-cell leukemia/lymphoma or from patient...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lairmore MD,Roberts B,Frank D,Rovnak J,Weiser MG,Cockerell GL

    更新日期:1992-01-02 00:00:00

  • Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol.

    abstract::Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras e...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Unver N,Delgado O,Zeleke K,Cumpian A,Tang X,Caetano MS,Wang H,Katayama H,Yu H,Szabo E,Wistuba II,Moghaddam SJ,Hanash SM,Ostrin EJ

    更新日期:2018-04-01 00:00:00

  • Overexpression of the met/HGF receptor in renal cell carcinomas.

    abstract::The c-met oncogene encodes the receptor for hepatocyte growth factor/scatter factor (HGF/SF), a multifunctional cytokine able to mediate morphogenesis as well as mitogenesis, motogenesis and invasiveness of epithelial cells. HGF/SF has been implicated in branching tubulogenesis of the developing kidney and in regenera...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Natali PG,Prat M,Nicotra MR,Bigotti A,Olivero M,Comoglio PM,Di Renzo MF

    更新日期:1996-06-21 00:00:00

  • Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma.

    abstract::The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kang S,Kim JW,Kang GH,Lee S,Park NH,Song YS,Park SY,Kang SB,Lee HP

    更新日期:2006-05-01 00:00:00

  • Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling.

    abstract::The aim of our study was to further explore the use of anti-angiogenic therapy targeting the vascular endothelial growth factor receptor (VEGFR) on endothelial cells while simultaneously targeting platelet-derived growth factor receptors (PDGFRs) on adjacent pericytes. B16 mouse melanoma tumors exogenously expressing ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hasumi Y,Kłosowska-Wardega A,Furuhashi M,Ostman A,Heldin CH,Hellberg C

    更新日期:2007-12-15 00:00:00

  • Angiogenic potential of malignant and non-malignant human breast tissues in an in vivo angiogenesis model.

    abstract::Tumors need to acquire an angiogenic phenotype for outgrowth and metastasis formation. Limited information on the angiogenic potential of specific tissues, especially human breast tissues is available. Here we describe an in vivo model, using the dorsal skin fold chamber in immunodeficient nude mice, where various tis...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lichtenbeld HC,Barendsz-Janson AF,van Essen H,Struijker Boudier H,Griffioen AW,Hillen HF

    更新日期:1998-07-29 00:00:00

  • Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral-host interaction with implications for disease intervention.

    abstract::HPV35 has been found in only ∼2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub-Saharan Africa, warranting further investigation and consideration of impact on preventive strategies. We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using multiple large epide...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pinheiro M,Gage JC,Clifford GM,Demarco M,Cheung LC,Chen Z,Yeager M,Cullen M,Boland JF,Chen X,Raine-Bennett T,Steinberg M,Bass S,Befano B,Xiao Y,Tenet V,Walker J,Zuna R,Poitras NE,Gold MA,Dunn T,Yu K,Zhu B,Bu

    更新日期:2020-11-15 00:00:00

  • Incidence of cancer in Nairobi, Kenya (2004-2008).

    abstract::Cancer incidence rates are presented for the Nairobi Cancer Registry, a population-based cancer registry (PBCR) covering the population of the capital city of Kenya (3.2 million inhabitants in 2009). Case finding was by active methods, with standard and checks for accuracy and validity. During the period 2004-2008 a t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Korir A,Okerosi N,Ronoh V,Mutuma G,Parkin M

    更新日期:2015-11-01 00:00:00

  • Expression of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in benign, borderline, malignant primary and metastatic ovarian tumors.

    abstract::Elevated levels of expression of the urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 have shown to be related to poor prognosis in a variety of cancer types. In the present study, cytosolic levels of uPA and PAI-1 were determined with enzyme-linked immunosorbent assays in cytosols prepared from 244 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van der Burg ME,Henzen-Logmans SC,Berns EM,van Putten WL,Klijn JG,Foekens JA

    更新日期:1996-12-20 00:00:00

  • Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation.

    abstract::We have examined several types of tumor cell lines and shown that they invariably expressed little or no Egr-1, in contrast to their normal counterparts. We have previously shown that the expression of exogenous Egr-1 in human breast and other tumor cells markedly reduces transformed growth and tumorigenicity. We ther...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Huang RP,Fan Y,de Belle I,Niemeyer C,Gottardis MM,Mercola D,Adamson ED

    更新日期:1997-07-03 00:00:00

  • Radiation-induced expression of functional Fas ligand in EBV-positive human nasopharyngeal carcinoma cells.

    abstract::Ionizing radiation remains a major therapeutic tool against human cancers, especially epithelial tumors, which account for the majority of human malignancies. Although Fas and Fas-L are essential determinants of apoptosis, few data support their role in the cytotoxic effect of ionizing radiation. Epstein-Barr-virus (E...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Abdulkarim B,Sabri S,Deutsch E,Vaganay S,Marangoni E,Vainchenker W,Bongrand P,Busson P,Bourhis J

    更新日期:2000-04-15 00:00:00

  • Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer.

    abstract::Gene silencing by DNA hypermethylation of CpG islands is a well-characterized phenomenon in cancer. The effect of hypomethylation in particular of non-CpG island genes is much less well described. By genome-wide screening, we identified 105 genes in microsatellite stable (MSS) colorectal adenocarcinomas with an invers...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Øster B,Linnet L,Christensen LL,Thorsen K,Ongen H,Dermitzakis ET,Sandoval J,Moran S,Esteller M,Hansen TF,Lamy P,COLOFOL steering group.,Laurberg S,Ørntoft TF,Andersen CL

    更新日期:2013-05-15 00:00:00

  • Inhibition by galanin of experimental carcinogenesis induced by azaserine in rat pancreas.

    abstract::The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other da...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Iishi H,Tatsuta M,Baba M,Yano H,Iseki K,Uehara H,Nakaizumi A

    更新日期:1998-01-30 00:00:00

  • Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma.

    abstract::Stem cell-like cells have recently been identified in melanoma cell lines, but their relevance for melanoma pathogenesis is controversial. To characterize the stem cell signature of melanoma, expression of stem cell markers BMI-1 and nestin was studied in 64 cutaneous melanomas, 165 melanoma metastases as well as 53 m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mihic-Probst D,Kuster A,Kilgus S,Bode-Lesniewska B,Ingold-Heppner B,Leung C,Storz M,Seifert B,Marino S,Schraml P,Dummer R,Moch H

    更新日期:2007-10-15 00:00:00

  • Circulating adipokine concentrations and risk of five obesity-related cancers: A Mendelian randomization study.

    abstract::Obesity is considered a chronic inflammatory state characterized by continued secretion of adipokines and cytokines. Experimental and epidemiological evidence indicates that circulating adipokines may be associated with the development of obesity-related cancers, but it is unclear if these associations are causal or c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dimou NL,Papadimitriou N,Mariosa D,Johansson M,Brennan P,Peters U,Chanock SJ,Purdue M,Bishop DT,Gago-Dominquez M,Giles GG,Moreno V,Platz EA,Tangen CM,Wolk A,Zheng W,Wu X,Campbell PT,Giovannucci E,Lin Y,CCFR, Endom

    更新日期:2020-10-10 00:00:00

  • A new experimental metastasis model in athymic nude mice, the human malignant melanoma LOX.

    abstract::The human tumor line LOX was established as an s.c. xenograft in nude mice from a lymph-node metastasis of a patient with malignant melanoma. I.v. injection into adult nude mice of single-cell suspensions prepared from xenografts resulted in progressively growing lung tumor colonies that killed the animals. No differe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fodstad O,Aamdal S,McMenamin M,Nesland JM,Pihl A

    更新日期:1988-03-15 00:00:00

  • Risk of second malignant neoplasms among lymphoma patients with a family history of cancer.

    abstract::Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL)...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Landgren O,Pfeiffer RM,Stewart L,Gridley G,Mellemkjaer L,Hemminki K,Goldin LR,Travis LB

    更新日期:2007-03-01 00:00:00

  • Are energy and energy-providing nutrients related to exocrine carcinoma of the pancreas?

    abstract::During 1984-88 a population-based case-control study was carried out in The Netherlands in collaboration with the International Agency for Research on Cancer in order to further explore the possible relationship between diet and exocrine pancreatic carcinoma. Past habitual dietary intake was assessed in 164 cases and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bueno de Mesquita HB,Moerman CJ,Runia S,Maisonneuve P

    更新日期:1990-09-15 00:00:00

  • ABCC4/MRP4 contributes to the aggressiveness of Myc-associated epithelial ovarian cancer.

    abstract::Epithelial ovarian cancer (EOC) is a complex disease comprising discrete histological and molecular subtypes, for which survival rates remain unacceptably low. Tailored approaches for this deadly heterogeneous disease are urgently needed. Efflux pumps belonging to the ATP-binding cassette (ABC) family of transporters ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jung M,Gao J,Cheung L,Bongers A,Somers K,Clifton M,Ramsay EE,Russell AJ,Valli E,Gifford AJ,George J,Kennedy CJ,Wakefield MJ,Topp M,Ho GY,Australian Ovarian Cancer Study.,Scott CL,Bowtell DD,deFazio A,Norris MD,Hab

    更新日期:2020-10-15 00:00:00

  • Transplanted cultured cells from pregnancy-dependent mammary tumors have a heterogenous developmental potential.

    abstract::Cultured cells derived from pregnancy-dependent mouse mammary tumors (plaques) when transplanted into the gland-free mammary fat pad display a heterogeneous developmental potential. They not only gave rise to plaques but also produced normal mammary gland, hyperplastic alvoelar nodules (HAN), and autonomous mammary tu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Aidells BD,Lee AE

    更新日期:1979-05-15 00:00:00

  • Microsatellite instability in medullary breast carcinomas.

    abstract::Microsatellite instability (MSI) has been reported to occur in a wide variety of sporadic tumours, such as colorectal and gastric cancers. MSI positivity has been associated with a particular clinico-pathologic profile, including the presence of abundant lymphoid infiltration, poor differentiation and a relatively goo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schmitt FC,Soares R,Gobbi H,Milanezzi F,Santos-Silva F,Cirnes L,Costa C,Seruca R

    更新日期:1999-08-27 00:00:00

  • Maternal and perinatal risk factors for Wilms' tumor: a nationwide nested case-control study in Sweden.

    abstract::This report describes maternal and perinatal risk factors for Wilms' tumor analyzed in a case-control study nested in a nationwide cohort in Sweden. The Swedish National Cancer Registry ascertained 110 cases from among successive birth cohorts from 1973 through 1984, identified by the Swedish Medical Birth Registry, t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lindblad P,Zack M,Adami HO,Ericson A

    更新日期:1992-04-22 00:00:00

  • Influence of VEGF-A gene variation and protein levels in breast cancer susceptibility and severity.

    abstract::Vascular endothelial growth factor-A (VEGF-A) plays an important role in tumour angiogenesis and cancer progression. VEGF gene variation may influence VEGF levels and therefore cancer susceptibility and progression. We studied the role of VEGF single nucleotide polymorphisms and haplotypes in breast cancer susceptibil...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Balasubramanian SP,Cox A,Cross SS,Higham SE,Brown NJ,Reed MW

    更新日期:2007-09-01 00:00:00

  • The molecular rationale of Src inhibition in colorectal carcinomas.

    abstract::Src has been one of the most studied proto-oncogenes. The cellular Src (c-Src) holds a critical role in several human malignancies and has emerged as a key factor that promotes tumor progression during the multistep process of colorectal cancer (CRC) pathogenesis. The robust activation of Src in CRC of aggressive phen...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Gargalionis AN,Karamouzis MV,Papavassiliou AG

    更新日期:2014-05-01 00:00:00

  • Parity and hepatocellular carcinoma. A population-based study in Sweden.

    abstract::The association between parity and hepatocellular carcinoma (HCC) was studied using a data-base generated by linking 2 Swedish nation-wide registries; the Cancer Registry and the Fertility Registry. Among women born between 1925 and 1960, 133 patients with HCC recorded in the Cancer Registry between 1958 and 1984 were...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lambe M,Trichopoulos D,Hsieh CC,Ekbom A,Pavia M

    更新日期:1993-11-11 00:00:00

  • Analgesics and cancers of the renal pelvis and ureter.

    abstract::To evaluate renal pelvis and ureter (RPU) cancer risk in relation to lifetime use of analgesics, a population-based case-control study was carried out in 3 areas of the United States. Among 502 cases and 496 controls diagnosed and interviewed during 1983-1986, no significant increases in risk were found for any of the...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Linet MS,Chow WH,McLaughlin JK,Wacholder S,Yu MC,Schoenberg JB,Lynch C,Fraumeni JF Jr

    更新日期:1995-07-04 00:00:00