Overexpression of RB1 transcript is significantly correlated with 13q14 allelic imbalance in colorectal carcinomas.

abstract：:A functional promoter polymorphism in the progesterone receptor (PR) gene previously has been associated with an increased risk of postmenopausal breast cancer. Whether the relationship between genetic variation in PR and risk of breast cancer is modified by postmenopausal hormone (PMH) use is unknown. Thus, we conduc...

journal_title：International journal of cancer

authors： Kotsopoulos J,Tworoger SS,De Vivo I,Hankinson SE,Hunter DJ,Willett WC,Chen WY

更新日期：2009-10-01 00:00:00

abstract：:Oesophageal squamous cell carcinoma (ESCC) has markedly high incidence rates in Kenya and much of East Africa, with a dire prognosis and poorly understood aetiology. Consumption of hot beverages-a probable carcinogen to humans-is associated with increased ESCC risk in other settings and is habitually practiced in Keny...

journal_title：International journal of cancer

authors： Middleton DR,Menya D,Kigen N,Oduor M,Maina SK,Some F,Chumba D,Ayuo P,Osano O,Schüz J,McCormack V

更新日期：2019-06-01 00:00:00

abstract：:3-Nitrobenzanthrone (3-NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3-NBA is likely to occur primarily via the respiratory tract. In our study female Sprague Dawley rats were...

journal_title：International journal of cancer

authors： Bieler CA,Cornelius MG,Klein R,Arlt VM,Wiessler M,Phillips DH,Schmeiser HH

更新日期：2005-10-10 00:00:00

abstract：:Esophageal cancer is ranked as the eighth most common cancer and the sixth leading cause of cancer deaths worldwide. To identify candidate tumor suppressor genes related to esophageal squamous cell carcinoma (ESCC) development, a cDNA microarray analysis was performed using paired tumor and nontumor tissue samples fro...

journal_title：International journal of cancer

authors： Ng HY,Ko JM,Yu VZ,Ip JC,Dai W,Cal S,Lung ML

更新日期：2016-06-15 00:00:00

abstract：:More than 90% of oral cancers are histopathologically squamous cell carcinomas (SCCs). According to clinical behavior and histopathological features, we hypothesize that oral SCC can originate from either oral squamous epithelium or minor salivary glands. Here, we examined whether some oral SCCs originate from minor s...

journal_title：International journal of cancer

authors： Kinouchi M,Izumi S,Nakashiro KI,Haruyama Y,Kobashi G,Uchida D,Hasegawa T,Kawamata H

更新日期：2018-11-15 00:00:00

abstract：:While dietary antioxidants are emerging as potentially modifiable risk factors for esophageal adenocarcinoma (EAC), studies on dietary antioxidants and its precursor Barrett's esophagus (BE) are limited. The present study extends previous work on BE by investigating risks of nondysplastic BE, dysplastic BE and EAC ass...

journal_title：International journal of cancer

authors： Ibiebele TI,Hughes MC,Nagle CM,Bain CJ,Whiteman DC,Webb PM,Study of Digestive Health and Australian Cancer Study.

更新日期：2013-07-01 00:00:00

abstract：:Retinoic acid (RA) and its natural and synthetic analogs, the retinoids, regulate many biological processes, including development, differentiation, cell growth, morphogenesis, metabolism and homeostasis. Retinoid effects are mediated by specific nuclear receptors, the RARs and RXRs. Because of their ability to contro...

journal_title：International journal of cancer

authors： Lu XP,Fanjul A,Picard N,Shroot B,Pfahl M

更新日期：1999-01-18 00:00:00

abstract：:The effect of blockade of NF-kappaB activity on human pancreatic cancer angiogenesis was determined in an orthotopic xenograft model. Highly metastatic L3.3 human pancreatic cancer cells, which expressed an elevated level of constitutive NF-kappaB activity, were transfected with a mutated IkappaBalpha (IkappaBalphaM)....

journal_title：International journal of cancer

authors： Xiong HQ,Abbruzzese JL,Lin E,Wang L,Zheng L,Xie K

更新日期：2004-01-10 00:00:00

abstract：:Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting tox...

journal_title：International journal of cancer

authors： Yamamoto S,Yamashita T,Ito M,Caaveiro JMM,Egashira N,Tozaki-Saitoh H,Tsuda M

更新日期：2019-10-15 00:00:00

abstract：:Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most human breast cance...

journal_title：International journal of cancer

authors： Domann FE,Rice JC,Hendrix MJ,Futscher BW

更新日期：2000-03-15 00:00:00

abstract：:Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epigenetic mechanisms. Down-regulation of expression of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in the biosynthesis of arginine, has been associated with the development of platinum resistance in ovari...

journal_title：International journal of cancer

authors： Nicholson LJ,Smith PR,Hiller L,Szlosarek PW,Kimberley C,Sehouli J,Koensgen D,Mustea A,Schmid P,Crook T

更新日期：2009-09-15 00:00:00

abstract：:Caveolae have been indicated as a center of cytoskeleton regulation for Src kinase/Rho GTPase signaling. In addition, Src recruitment on intact cortical actin cytoskeleton appears to be required for bFGF/FGFR signal activation. Recently, we established a relationship between caveolin-1 (Cav-1) expression and cell migr...

journal_title：International journal of cancer

authors： Fecchi K,Travaglione S,Spadaro F,Quattrini A,Parolini I,Piccaro G,Raggi C,Fabbri A,Felicetti F,Carè A,Fiorentini C,Sargiacomo M

更新日期：2012-03-15 00:00:00

abstract：:Cancer awareness public campaigns aim to shorten the interval between symptom onset and presentation to a doctor (the 'patient interval'). Appreciating variation in promptness of presentation can help to better target awareness campaigns. We explored variation in patient intervals recorded in consultations with genera...

journal_title：International journal of cancer

authors： Keeble S,Abel GA,Saunders CL,McPhail S,Walter FM,Neal RD,Rubin GP,Lyratzopoulos G

更新日期：2014-09-01 00:00:00

abstract：:The present experiments were performed to investigate the possibility of inhibiting tumor growth in vivo with syngeneic lymphocytes sensitized in vitro on monolayers of the tumor under test, and to study the effect of a thymic humoral factor (THF) in this sensitization process. Monolayers of fibrosarcoma cells were us...

journal_title：International journal of cancer

authors： Small M,Trainin N

更新日期：1975-06-15 00:00:00

abstract：:The topic of this review is the role of stromal-epithelial interactions in normal and malignant prostatic growth. Because cell-cell interactions and androgens play such key roles in the prostate, the goal of this review will be to apply endocrinologic and developmental concepts to the understanding of normal and malig...

journal_title：International journal of cancer

authors： Cunha GR,Hayward SW,Wang YZ,Ricke WA

更新日期：2003-10-20 00:00:00

abstract：:Normal transcription displays a high degree of flexibility over the choice, timing and magnitude of mRNA expression levels that tend to oscillate and cycle. These processes allow for combinatorial actions, feedback control and fine-tuning. A central role has emerged for the transcriptional co-repressor proteins such a...

journal_title：International journal of cancer

authors： Battaglia S,Maguire O,Campbell MJ

更新日期：2010-06-01 00:00:00

abstract：:The high burden of cervical cancer and inadequate/suboptimal cytology screening in developing countries led to the evaluation of visual screening tests, like visual inspection with acetic acid (VIA) and Lugol's iodine (VILI). We describe the performance of VIA, VILI and cytology, carried out in a multinational project...

journal_title：International journal of cancer

authors： Deodhar K,Sankaranarayanan R,Jayant K,Jeronimo J,Thorat R,Hingmire S,Muwonge R,Chiwate A,Deshpande R,Ajit D,Kelkar R,Rekhi B,Ruben I,Malvi SG,Chinoy R,Jambhekar N,Nene BM

更新日期：2012-09-15 00:00:00

abstract：:The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt...

journal_title：International journal of cancer

authors： Monsonego J,Hudgens MG,Zerat L,Zerat JC,Syrjänen K,Halfon P,Ruiz F,Smith JS

更新日期：2011-08-01 00:00:00

abstract：:A major objective of peptide vaccination is the induction of tumor-reactive CD8+ T-cells. We have shown that HLA-A2 positive cancer patients frequently develop an antigen-specific CD8+ T-cell response after vaccination with NY-ESO-1 peptides p157-165/p157-167. These T-cells are highly reactive with the peptides used f...

journal_title：International journal of cancer

authors： Karbach J,Gnjatic S,Pauligk C,Bender A,Maeurer M,Schultze JL,Nadler K,Wahle C,Knuth A,Old LJ,Jäger E

更新日期：2007-11-01 00:00:00

abstract：:Our study directly compares the performance of liquid-based (LBC) and conventional cytology for detecting high-grade cervical intraepithelial neoplasia and cancer (CIN 2+) in high-risk, previously unscreened women. As part of a larger randomized clinical trial assessing the efficacy and safety of a "screen and treat" ...

journal_title：International journal of cancer

authors： Taylor S,Kuhn L,Dupree W,Denny L,De Souza M,Wright TC Jr

更新日期：2006-02-15 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is a causative factor of humoral hypercalcemia in malignancy. However, it is difficult to explain the mechanism of anorexia/cachexia with PTHrP secretion in detail. Previously, we demonstrated that the expressions of orexigenic peptides increased and anorexigenic peptides de...

journal_title：International journal of cancer

authors： Suzuki H,Hashimoto H,Kawasaki M,Watanabe M,Otsubo H,Ishikura T,Fujihara H,Ohnishi H,Onuma E,Yamada-Okabe H,Takuwa Y,Ogata E,Nakamura T,Ueta Y

更新日期：2011-05-01 00:00:00

abstract：:Chen, B., Liu, X., Savell, V.H., Dilday, B.R., Johnson, M.W., Jenkins, J.J., and Parham, D.M., Increased DNA methyltransferase expression in rhabdomyosarcomas. Int. J. Cancer, 83, 10-14 (1999). Due to a printer's error, the bottom of Figure 3 was cut off after the proofs had been approved by the author. The correct fi...

journal_title：International journal of cancer

authors： Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

更新日期：1999-12-10 00:00:00

abstract：:Several lines of evidence have demonstrated that IFNs could be relevant in the treatment of certain neoplastic diseases such as carcinomas. In particular, IFN-alpha, in addition to the anti-proliferative and cytostatic effects, was demonstrated to be capable of inducing cell death by apoptosis both in vivo and in vitr...

journal_title：International journal of cancer

authors： Matarrese P,Giandomenico V,Fiorucci G,Rivabene R,Straface E,Romeo G,Affabris E,Malorni W

更新日期：1998-05-18 00:00:00

abstract：:Etiological risk factors for proximal (right-sided) colon cancers may be different to those of distal colon and rectal (left-sided) cancers if these tumors develop along distinct pathways. The CpG Island Methylator Phenotype (CIMP+) occurs in approximately 15% of colorectal cancers (CRC) and predominantly in the proxi...

journal_title：International journal of cancer

authors： Iacopetta B,Heyworth J,Girschik J,Grieu F,Clayforth C,Fritschi L

更新日期：2009-07-01 00:00:00

abstract：:Spleen cells from mice infected with Friend leukemia virus (FLV) inoculated by the intravenous route give rise to macroscopically visible colonies in the spleens of normal F1 histocompatible hybrid hosts. A study of H-2 antigens as generic markers for identification of strains of origin of cells constituting the splee...

journal_title：International journal of cancer

authors： Wendling F,Tambourin PE

更新日期：1978-10-15 00:00:00

abstract：:Examination of the effect of the farnesylprotein transferase (FPTase) inhibitor UCF1-C/manumycin on NIH3T3 cells transfected with a normal N-ras gene and expressing high levels of the corresponding p21-ras protein showed that 10 microm UCF1-C immediately and reversibly inhibited growth in these cells, without modifyin...

journal_title：International journal of cancer

authors： Servais P,Gulbis B,Fokan D,Galand P

更新日期：1998-05-18 00:00:00

abstract：:Increasing evidence indicates that breast cancer pathogenesis is linked with DNA double-strand break (DSB) repair dysfunction. This conclusion is based on advances in the study of functions of breast cancer susceptibility genes such as BRCA1 and BRCA2, on the identification of breast cancer-associated changes regardin...

journal_title：International journal of cancer

authors： Keimling M,Kaur J,Bagadi SA,Kreienberg R,Wiesmüller L,Ralhan R

更新日期：2008-08-01 00:00:00

abstract：:Premature chromosome condensation (PCC) was studied in direct preparations of tissues from patients with haematological diseases and carcinomas of various histological types. PCC was found in 6 out of 166 malignancies (128 haematological cases, 35 carcinomas and 3 malignant effusions) analysed with the GTG-technique. ...

journal_title：International journal of cancer

authors： Kovacs G

更新日期：1985-12-15 00:00:00

abstract：:Studies of colon cancer risk in males have reported strong positive associations with obesity, particularly with central adiposity. The association has been weaker and less consistent for women. In a prospective cohort study of women, body measurements were taken directly; fat mass and fat-free mass being estimated by...

journal_title：International journal of cancer

authors： MacInnis RJ,English DR,Hopper JL,Gertig DM,Haydon AM,Giles GG

更新日期：2006-03-15 00:00:00

abstract：:To identify characteristics of gastric cancer associated with hereditary non-polyposis colorectal cancer (HNPCC), we gathered clinical data and tumor samples relating to patients recorded in the Finnish HNPCC registry. Our series included 51 families with a characterized mutation and/or that met the Amsterdam criteria...

journal_title：International journal of cancer

authors： Aarnio M,Salovaara R,Aaltonen LA,Mecklin JP,Järvinen HJ

更新日期：1997-10-21 00:00:00