NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells.

abstract：:In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall survival rate. Cisplatin exposure of sensitive cells has been previously associated with a down-regulation of Bcl-X(L) expression and apoptosis, whereas recurrence...

journal_title：International journal of cancer

authors： Brotin E,Meryet-Figuière M,Simonin K,Duval RE,Villedieu M,Leroy-Dudal J,Saison-Behmoaras E,Gauduchon P,Denoyelle C,Poulain L

更新日期：2010-02-15 00:00:00

abstract：:NK cell recognition of tumor cells is mediated by a delicate balance of signals received by MHC class I-binding inhibitory NK cell receptors and activating NK cell receptors, which mainly bind to virus-, stress- or tumor-induced ligands. In addition, adhesion molecules such as the intercellular adhesion molecule-1 (IC...

journal_title：International journal of cancer

authors： Textor S,Accardi R,Havlova T,Hussain I,Sylla BS,Gissmann L,Cerwenka A

更新日期：2011-03-01 00:00:00

abstract：:In a previous study, human ZNF312b was identified as a cell proliferation-associated oncogene via the K-ras/extracellular signal-regulated kinase cascade in gastric cancer. However, the mechanism concerning its transcriptional activation remains unknown. Here, we show that DNA methylation and histone acetylation of th...

journal_title：International journal of cancer

authors： Song IS,Ha GH,Kim JM,Jeong SY,Lee HC,Kim YS,Kim YJ,Kwon TK,Kim NS

更新日期：2011-11-01 00:00:00

abstract：:Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To explore whether phenotypic differences among PPGLs reflect a MAX-mediated mechanism and opposing influence...

journal_title：International journal of cancer

authors： Qin N,de Cubas AA,Garcia-Martin R,Richter S,Peitzsch M,Menschikowski M,Lenders JW,Timmers HJ,Mannelli M,Opocher G,Economopoulou M,Siegert G,Chavakis T,Pacak K,Robledo M,Eisenhofer G

更新日期：2014-11-01 00:00:00

abstract：:This is a prospective study of lymphoid tissue showing benign reactive hyperplasia (18 lymph nodes and 2 tonsils), using cytogenetic analysis of cells stimulated with T- or B-cell mitogens. The reason for this study was the detection of an abnormal chromosomal population in cells from an enlarged lymph node excised fr...

journal_title：International journal of cancer

authors： Grace J,Hall BE,Lew M,Singh S,Pittman S,Palmer AA,Zbroja R,Wass J,Vincent PC

更新日期：1989-12-15 00:00:00

abstract：:The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...

journal_title：International journal of cancer

authors： Luckenbach GA,Layton D

更新日期：1981-06-15 00:00:00

abstract：:Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines. CD59 expression had a low degree of intra- and intertumor heterogeneity. SDS-PA...

journal_title：International journal of cancer

authors： Brasoveanu LI,Altomonte M,Gloghini A,Fonsatti E,Coral S,Gasparollo A,Montagner R,Cattarossi I,Simonelli C,Cattelan A

更新日期：1995-05-16 00:00:00

abstract：:The monoclonal antibody trastuzumab has brought survival benefit to patients with advanced gastric cancer (AGC) that have human epidermal growth factor receptor 2 (HER2) over expression or amplification. This study was designed to compare the clinical outcomes of HER2-negative and HER2-positive AGC patients with or wi...

journal_title：International journal of cancer

authors： Qiu MZ,Li Q,Wang ZQ,Liu TS,Liu Q,Wei XL,Jin Y,Wang DS,Ren C,Bai L,Zhang DS,Wang FH,Li YH,Xu RH

更新日期：2014-05-15 00:00:00

abstract：:MAGE genes encoding tumor-rejection antigens recognized by cytotoxic T lymphocytes are expressed at the mRNA level in various malignant tumors. We have investigated the expression of genes MAGE-1, -2, -3/-6 and -4a/-4b at the mRNA level in malignant and non-malignant ovarian tumors as well as in normal ovaries by reve...

journal_title：International journal of cancer

authors： Yamada A,Kataoka A,Shichijo S,Kamura T,Imai Y,Nishida T,Itoh K

更新日期：1995-12-20 00:00:00

abstract：:The combination of cis-diamminedichloroplatinum(II) (CDDP) and 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), a topoisomerase-I inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To elucidate the mechanism of...

journal_title：International journal of cancer

authors： Masumoto N,Nakano S,Esaki T,Fujishima H,Tatsumoto T,Niho Y

更新日期：1995-07-04 00:00:00

abstract：:Human papillomavirus (HPV) vaccines protect against infections with the most oncogenic HPV types, cervical intraepithelial neoplasia (CIN) and cervical cancer. We investigated whether development of cervical intraepithelial neoplasia (CIN) lesions in HPV-vaccinated women is associated with vaccine-targeted HPV types o...

journal_title：International journal of cancer

authors： Kann H,Hortlund M,Eklund C,Dillner J,Faust H

更新日期：2020-05-01 00:00:00

abstract：:To generate broad eating patterns, which could explain more adequately the breast cancer etiology, we conducted an exploratory factor analysis in Montevideo, Uruguay. The study included 442 newly diagnosed and microscopically confirmed cases with breast cancer and 442 hospitalized controls, with non-neoplastic disease...

journal_title：International journal of cancer

authors： Ronco AL,De Stefani E,Boffetta P,Deneo-Pellegrini H,Acosta G,Mendilaharsu M

更新日期：2006-10-01 00:00:00

abstract：:The U.S. Preventive Services Task Force (USPSTF) recently updated their national lung screening guidelines and recommended low-dose computed tomography (LDCT) for lung cancer (LC) screening through age 80. However, the risk of overdiagnosis among older populations is a concern. Using four comparative models from the C...

journal_title：International journal of cancer

authors： Han SS,Ten Haaf K,Hazelton WD,Munshi VN,Jeon J,Erdogan SA,Johanson C,McMahon PM,Meza R,Kong CY,Feuer EJ,de Koning HJ,Plevritis SK

更新日期：2017-06-01 00:00:00

abstract：:The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of ...

journal_title：International journal of cancer

authors： Kang S,Kim JW,Kang GH,Lee S,Park NH,Song YS,Park SY,Kang SB,Lee HP

更新日期：2006-05-01 00:00:00

abstract：:Survivin protein is an attractive candidate for cancer immunotherapy since it is abundantly expressed in most common human cancers and mostly absent in normal adult tissues. Malignant mesothelioma (MM) is a deadly cancer associated with asbestos or erionite exposure for which no successful therapies are currently avai...

journal_title：International journal of cancer

authors： Bertino P,Panigada M,Soprana E,Bianchi V,Bertilaccio S,Sanvito F,Rose AH,Yang H,Gaudino G,Hoffmann PR,Siccardi A,Carbone M

更新日期：2013-08-01 00:00:00

abstract：:Ten patients with bulky brain glioblastoma, recurring after surgery, radiotherapy or chemotherapy, underwent direct intralesional radioimmunotherapy (RIT) using a monoclonal antibody (MAb), BC-2, raised against tenascin and labelled with 131I. Tenascin, the BC-2-recognized glycoprotein, is an antigen expressed by the ...

journal_title：International journal of cancer

authors： Riva P,Arista A,Sturiale C,Moscatelli G,Tison V,Mariani M,Seccamani E,Lazzari S,Fagioli L,Franceschi G

更新日期：1992-04-22 00:00:00

abstract：:To better inform the next clinical trials of vascular disrupting agent combretastatin-A4-phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at evaluating CA4P therapeutic efficacy in rats with primary hepatocellular carcinomas (HCCs) of a full spectrum of differentiation and vasculari...

journal_title：International journal of cancer

authors： Liu Y,De Keyzer F,Wang Y,Wang F,Feng Y,Chen F,Yu J,Liu J,Song S,Swinnen J,Bormans G,Oyen R,Huang G,Ni Y

更新日期：2018-10-01 00:00:00

abstract：:Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human ...

journal_title：International journal of cancer

authors： Vajdic CM,van Leeuwen MT,Turner JJ,McDonald AM,Webster AC,McDonald SP,Chapman JR,Kaldor JM,Grulich AE

更新日期：2010-12-01 00:00:00

abstract：:Murine hepatocellular carcinoma cells were retrovirally transduced with the bacterial cytosine deaminase (CD) gene. CD-transduced cells exhibited more than 120-fold higher sensitivity to 5-fluorocytosine (5-FC) compared with parental cells. When syngeneic immunocompetent mice were inoculated s.c. with parental hepatoc...

journal_title：International journal of cancer

authors： Kuriyama S,Kikukawa M,Masui K,Okuda H,Nakatani T,Sakamoto T,Yoshiji H,Fukui H,Ikenaka K,Mullen CA,Tsujii T

更新日期：1999-05-17 00:00:00

abstract：:The incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases have increased in the last decades. In parallel, treatment for tonsillar cancer has been intensified e.g., by accelerated radiotherapy, and chemotherapy, resulting in more side effects. Patients with HPV-...

journal_title：International journal of cancer

authors： Attner P,Näsman A,Du J,Hammarstedt L,Ramqvist T,Lindholm J,Munck-Wikland E,Dalianis T,Marklund L

更新日期：2012-09-01 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta1) enhances human MDA-MB-231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit proliferation of this cell line. In contrast to basal invasion, which is plasmin-, urokinase (uPA)-, tissue-type plasminogen activator (t-PA)-, matrix metall...

journal_title：International journal of cancer

authors： Farina AR,Coppa A,Tiberio A,Tacconelli A,Turco A,Colletta G,Gulino A,Mackay AR

更新日期：1998-03-02 00:00:00

abstract：:Retinoic acid (RA) and its natural and synthetic analogs, the retinoids, regulate many biological processes, including development, differentiation, cell growth, morphogenesis, metabolism and homeostasis. Retinoid effects are mediated by specific nuclear receptors, the RARs and RXRs. Because of their ability to contro...

journal_title：International journal of cancer

authors： Lu XP,Fanjul A,Picard N,Shroot B,Pfahl M

更新日期：1999-01-18 00:00:00

abstract：:Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase inhibitor 2 (CDKN2...

journal_title：International journal of cancer

authors： Dong Y,Walsh MD,McGuckin MA,Cummings MC,Gabrielli BG,Wright GR,Hurst T,Khoo SK,Parsons PG

更新日期：1997-08-22 00:00:00

abstract：:Testicular germ cell tumors (TGCTs) are a clinically and pathologically heterogeneous disease, and little is known of its genetic basis. Only low susceptibility risk loci have been identified for both sporadic and familial cases. Therefore, we tried to identify new susceptibility genes responsible for familial testicu...

journal_title：International journal of cancer

authors： Paumard-Hernández B,Calvete O,Inglada Pérez L,Tejero H,Al-Shahrour F,Pita G,Barroso A,Carlos Triviño J,Urioste M,Valverde C,González Billalabeitia E,Quiroga V,Francisco Rodríguez Moreno J,Fernández Aramburo A,López C,Maroto

更新日期：2018-10-15 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90% of all forms of oral cancer worldwide. Although great efforts have been made in the past decades, the 5-year survival rate of OSCC patients is no more than 60% due to tumor metastasis and subsequent recurrence. The metastasis from the p...

journal_title：International journal of cancer

authors： Ling Z,Cheng B,Tao X

更新日期：2020-10-22 00:00:00

abstract：:This report describes maternal and perinatal risk factors for Wilms' tumor analyzed in a case-control study nested in a nationwide cohort in Sweden. The Swedish National Cancer Registry ascertained 110 cases from among successive birth cohorts from 1973 through 1984, identified by the Swedish Medical Birth Registry, t...

journal_title：International journal of cancer

authors： Lindblad P,Zack M,Adami HO,Ericson A

更新日期：1992-04-22 00:00:00

abstract：:Dendritic cells (DCs) display an extraordinary capacity to induce T-cell responses providing the opportunity of DC-based cancer vaccination strategies. Additional findings indicate that DCs may also play a crucial role for the activation of natural killer (NK) cells, which are important effectors in innate antitumor i...

journal_title：International journal of cancer

authors： Wehner R,Löbel B,Bornhäuser M,Schäkel K,Cartellieri M,Bachmann M,Rieber EP,Schmitz M

更新日期：2009-01-15 00:00:00

abstract：:Seminomas and control tissues were analyzed for several tumor markers. Very high levels of placental alkaline phosphatase (PLAP)-like enzyme levels were found in all 18 seminomas studied. The majority of the seminomas were of phenotype I, thus differing from palcental PLAP. The mean amount of enzyme protein as measure...

journal_title：International journal of cancer

authors： Yamamoto H,Rudén U,Ljungdahl-Ståhle E,Brehmer-Andersson E,Hirano K,Hisazumi H,Stigbrand T,Wahren B

更新日期：1987-11-15 00:00:00

abstract：:Although surgical resection is considered the adequate treatment in early stages of nonsmall cell lung cancer, long-term survival is not satisfactory and recurrence rate is high. We previously showed that postoperative chemotherapy at stage IB reduces recurrences and prolongs overall survival. We extended size and obs...

journal_title：International journal of cancer

authors： Roselli M,Mariotti S,Ferroni P,Laudisi A,Mineo D,Pompeo E,Ambrogi V,Mineo TC

更新日期：2006-08-15 00:00:00

abstract：:A panel of 7 mouse monoclonal antibodies and the lectin from Ulex europeus, detecting blood-group-related antigens of the ABH and Lewis systems, have been used to define the distribution of these antigenic structures within the human gastrointestinal tract, and to characterize their expression and modulation in colore...

journal_title：International journal of cancer

authors： Cordon-Cardo C,Lloyd KO,Sakamoto J,McGroarty ME,Old LJ,Melamed MR

更新日期：1986-05-15 00:00:00