No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency.


:Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human immunodeficiency virus (HIV) infection 1982-2004 (n = 17,175). National, population-based registries were linked and standardized incidence ratios (SIRs) were computed for each cohort and lymphoma subtype. Risk of diffuse large B-cell lymphoma was significantly increased after transplantation (SIR 17.83, 95% CI: 13.61-22.95) and after HIV infection (SIR 58.81, 95% CI: 52.59-65.56). Rates of follicular lymphoma (FL) were neither significantly increased nor decreased in transplant recipients (SIR 0.82, 95% CI: 0.10-2.96) and in people with HIV (SIR 1.25, 95% CI: 0.41-2.91). The findings argue against an infectious or other immunodeficiency-related etiology for FL and clearly differentiate it from diffuse large B-cell lymphoma.


Int J Cancer


Vajdic CM,van Leeuwen MT,Turner JJ,McDonald AM,Webster AC,McDonald SP,Chapman JR,Kaldor JM,Grulich AE




Has Abstract


2010-12-01 00:00:00












  • MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutations.

    abstract::We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta Neuropathol 2011). To investigate the patterns and incidence of MGMT methylation in astrocytic and oligodendroglial tumors, we quantitatively assessed methylatio...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mulholland S,Pearson DM,Hamoudi RA,Malley DS,Smith CM,Weaver JM,Jones DT,Kocialkowski S,Bäcklund LM,Collins VP,Ichimura K

    更新日期:2012-09-01 00:00:00

  • A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6- and E7-specific T-cell responses.

    abstract::This study investigates the clinical course of low grade squamous intraepithelial lesions (LSIL), HPV status and HPV16-specific immune response in a large prospective study of 125 women with LSIL followed cytologically, virologically and histologically. Women with low-grade abnormal smears were recruited and followed-...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Woo YL,van den Hende M,Sterling JC,Coleman N,Crawford RA,Kwappenberg KM,Stanley MA,van der Burg SH

    更新日期:2010-01-01 00:00:00

  • Current status of the molecular genetics of human prostatic adenocarcinomas.

    abstract::Molecular genetic mechanisms involved in the progression of prostate cancer are not well understood due to extensive tumor heterogeneity and lack of suitable models. New methods such as fluorescence in-situ hybridization (FISH), comparative genomic hybridization (CGH) and microsatellite analysis have documented losses...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Karan D,Lin MF,Johansson SL,Batra SK

    更新日期:2003-01-20 00:00:00

  • In vitro and in vivo modulation of multi-drug resistance with amiodarone.

    abstract::The modulating effect on drug resistance of amiodarone (AM) and its metabolite desethylamiodarone (DEA) was studied in a P-glycoprotein-positive human colon carcinoma cell line COLO 320, and a human small-cell lung carcinoma cell line GLC4 and its adriamycin (Adr)-resistant subline GLC4-Adr (both P-glycoprotein-negati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van der Graaf WT,de Vries EG,Uges DR,Nanninga AG,Meijer C,Vellenga E,Mulder PO,Mulder NH

    更新日期:1991-06-19 00:00:00

  • Automated diagnosis of pigmented skin lesions.

    abstract::Since advanced melanoma remains practically incurable, early detection is an important step toward a reduction in mortality. High expectations are entertained for a technique known as dermoscopy or epiluminescence light microscopy; however, evaluation of pigmented skin lesions by this method is often extremely complex...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rubegni P,Cevenini G,Burroni M,Perotti R,Dell'Eva G,Sbano P,Miracco C,Luzi P,Tosi P,Barbini P,Andreassi L

    更新日期:2002-10-20 00:00:00

  • Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin.

    abstract::CD30 is selectively expressed on the tumor cells of a variety of malignant disorders of the immune system and can therefore be used as a target for an anti-CD30 antibody-based immunotherapy. However, CD30 is cleaved at the cell surface by tumor necrosis factor-alpha converting enzyme (TACE). This metalloproteinase rel...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hansen HP,Matthey B,Barth S,Kisseleva T,Mokros T,Davies SJ,Beckett RP,Foelster-Holst R,Lange HH,Engert A,Lemke H

    更新日期:2002-03-10 00:00:00

  • CARD9 prevents lung cancer development by suppressing the expansion of myeloid-derived suppressor cells and IDO production.

    abstract::Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor protein and highly expressed in myeloid cells. Our previous study demonstrates a critical protective effect of CARD9 in the development of colitis-associated colon cancer. Nevertheless, the effect of CARD9 in lung cancer remains unclear. Here, using...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Qu J,Liu L,Xu Q,Ren J,Xu Z,Dou H,Shen S,Hou Y,Mou Y,Wang T

    更新日期:2019-10-15 00:00:00

  • Comparison of the metastasis-inducing protein S100A4 (p9ka) with other prognostic markers in human breast cancer.

    abstract::Our aim was to compare the occurrence and prognostic significance over 14-20 years of immunocytochemically detected S100A4 and other tumour variables in primary tumours from 349 patients with operable breast cancer. For a cut-off of 1% staining of the malignant cells, the antibody to S100A4 stains positively 56% of th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Platt-Higgins AM,Renshaw CA,West CR,Winstanley JH,De Silva Rudland S,Barraclough R,Rudland PS

    更新日期:2000-03-20 00:00:00

  • Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-Virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma.

    abstract::Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained point mutations relative to the prototype LMP1 gene, leading to amino...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mehl AM,Fischer N,Rowe M,Hartmann F,Daus H,Trümper L,Pfreundschuh M,Müller-Lantzsch N,Grässer FA

    更新日期:1998-04-13 00:00:00

  • ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model.

    abstract::Angiogenesis inhibitors have been used to treat some cancers, but the therapeutic potential of these agents for gastric cancer has remained unclear. To investigate their therapeutic potential, we examined the effect of ZD6474, an agent that selectively targets vascular endothelial growth factor receptor-2 (VEGFR-2; KD...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Arao T,Yanagihara K,Takigahira M,Takeda M,Koizumi F,Shiratori Y,Nishio K

    更新日期:2006-01-15 00:00:00

  • PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status.

    abstract::Protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) is an endogenous inhibitor of STAT3 that negatively regulates STAT3 transcriptional activity and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. In this study...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dabir S,Kluge A,McColl K,Liu Y,Lam M,Halmos B,Wildey G,Dowlati A

    更新日期:2014-03-01 00:00:00

  • In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma.

    abstract::A glutamine analogue, L-glutamic acid gamma-monohydroxamate (GAH) demonstrated complete cytotoxicity against L1210 cells in culture and marked anti-tumoral activity in vivo against L1210 leukemia and B16 melanoma. In vitro, GAH caused concentration-dependent inhibition of L1210 cell growth, with complete cell death be...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vila J,Thomasset N,Navarro C,Doré JF

    更新日期:1990-04-15 00:00:00

  • The spectrum of malignancies in HIV-infected patients in 2006 in France: the ONCOVIH study.

    abstract::Since no large descriptive studies of incident cancers in HIV-infected patients are available in France, the nationwide cross-sectional ONCOVIH study aimed to prospectively report new malignancies diagnosed in HIV-infected patients in cancer centers and HIV/AIDS centers. We estimated the number of cancers in France fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lanoy E,Spano JP,Bonnet F,Guiguet M,Boué F,Cadranel J,Carcelain G,Couderc LJ,Frange P,Girard PM,Oksenhendler E,Poizot-Martin I,Semaille C,Agut H,Katlama C,Costagliola D,ONCOVIH study group.

    更新日期:2011-07-15 00:00:00

  • Up-regulation of alpha 2 beta 1 integrin cell-surface expression protects A431 cells from epidermal growth factor-induced apoptosis.

    abstract::High epidermal growth factor (EGF) concentration (10(-8) M) induces inhibition of A431 cell proliferation, resulting in part from an apoptotic process. For some cells escaping this process, proliferation was associated with a decrease in apoptosis. Moreover, these surviving cells displayed marked morphological changes...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Smida Rezgui S,Honore S,Rognoni JB,Martin PM,Penel C

    更新日期:2000-08-01 00:00:00

  • Familial prostate cancer and possible associated malignancies: nation-wide register cohort study in Sweden.

    abstract::There is a familial aggregation of prostate cancer, and 5 to 10% of all prostate cancers are estimated to be inherited in an autosomal-dominant mode. A population-based cohort study was performed in order to study familial prostate cancer and associated malignancies. A nation-wide register cohort study was conducted u...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Damber L,Grönberg H,Damber JE

    更新日期:1998-10-29 00:00:00

  • Dickkopf1: a tumor suppressor or metastasis promoter?

    abstract::Dickkopf1 (DKK1), a secreted inhibitor of the Wnt/β-catenin pathway, is a negative regulator of bone formation. DKK1 acts as a switch that transitions prostate cancer bone metastases from osteolytic to osteoblastic and also is an active indicator of poor outcome for multiple myeloma. However, in other tumor types, DKK...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Menezes ME,Devine DJ,Shevde LA,Samant RS

    更新日期:2012-04-01 00:00:00

  • Cytolytic activity of circulating human monocytes on transformed and untransformed human fibroblasts.

    abstract::Monocytes from the peripheral blood of 10 normal adult human donors were tested for their cytolytic activity on untransformed or SV40-transformed, early passage, human fibroblasts. Two pairs of human fibroblast lines (2303 and SV40-2303, 2931 and SV40-2931) were used and lysis was assessed in terms of release of [3H]t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mantovani A,Tagliabue A,Dean JH,Jerrells TR,Herberman RB

    更新日期:1979-01-15 00:00:00

  • Expression of cholecystokinin forms by medullary thyroid cancer.

    abstract::We have studied the production and release of cholecystokinin (CCK) forms by rat medullary thyroid cancer (MTC) in vivo. MTC cells were inoculated s.c. into 8 Wag-Rij rats. One month later, after i.v. injection of calcium plasma levels of CCK, calcitonin and tissue contents of gastrin and calcitonin were determined by...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Poston GJ,Draviam EJ,Seitz PK,Rajaraman S,Alexander RW,Cooper CW,Townsend CM Jr,Thompson JC

    更新日期:1991-07-09 00:00:00

  • Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China.

    abstract::Isothiocyanates (ITC) in cruciferous vegetables may be chemopreventive against gastric cancer development. Glutathione S-transferases (GSTs) may modify the chemopreventive effect of ITC. The relationship between urinary total ITC and risk of gastric cancer was prospectively examined. Between 1986 and 1989, 18,244 midd...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Moy KA,Yuan JM,Chung FL,Wang XL,Van Den Berg D,Wang R,Gao YT,Yu MC

    更新日期:2009-12-01 00:00:00

  • Recovery of leukocyte function after super-high-dose chemotherapy with peripheral blood stem cell transplantation in testicular cancer patients.

    abstract::Leukocyte functions (superoxide production and phagocytosis) were evaluated in patients with testicular cancer who had undergone super-high-dose chemotherapy (SHDT) with peripheral blood stem cell transplantation (PBSCT). In 5 patients with advanced or relapsed testicular cancer who received 8 cycles of SHDT with PBSC...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yamada Y,Hara I,Gohji K,Okada H,Arakawa S,Kamidono S

    更新日期:1997-07-03 00:00:00

  • Receptors for hormones and growth factors and (onco)-gene amplification in human ovarian cancer.

    abstract::Receptor status and gene amplification were studied in advanced human ovarian adenocarcinoma tissues, borderline and benign ovarian tumours and normal ovarian tissues. Sixty-five percent (53/82) of ovarian adenocarcinomas, 57% (8/14) of benign/borderline tumours and only 31% (5/16) of normal ovarian tissues studied sh...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Berns EM,Klijn JG,Henzen-Logmans SC,Rodenburg CJ,van der Burg ME,Foekens JA

    更新日期:1992-09-09 00:00:00

  • Application of differential display to identify genes for lung cancer detection in peripheral blood.

    abstract::A blood assay for detection of lung cancer biomarkers could significantly improve cancer patient prognosis and survival rates. Amplified fragment length polymorphism-differential display (AFLP-DD) was used to identify gene transcripts found in lung cancer tissue and the peripheral blood of lung cancer patients. The cl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Matsunaga H,Hangai N,Aso Y,Okano K,Kawamura M,Kobayashi K,Kambara H,Hoger JH,Mitsuhashi M

    更新日期:2002-08-10 00:00:00

  • A case-control study of diet and lung cancer in northeast China.

    abstract::A case-control study involving interviews with 227 lung-cancer cases and 227 matched hospital controls was conducted in Heilongjiang Province in northeast China to examine the influence of dietary factors on the risk of developing lung cancer. Lung-cancer cases were all incident cases judged to be suitable candidates ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hu J,Johnson KC,Mao Y,Xu T,Lin Q,Wang C,Zhao F,Wang G,Chen Y,Yang Y

    更新日期:1997-06-11 00:00:00

  • Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3.

    abstract::The calcium-sensing receptor (CaSR) is suggested to mediate the antiproliferative effects of calcium in colon. However, in colorectal cancer (CRC) the expression of the CaSR is silenced and the underlying mechanisms leading to its loss are poorly understood. We investigated whether loss of the CaSR expression in color...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fetahu IS,Höbaus J,Aggarwal A,Hummel DM,Tennakoon S,Mesteri I,Baumgartner-Parzer S,Kállay E

    更新日期:2014-11-01 00:00:00

  • Genome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes.

    abstract::The large geographic variations in the incidence of gastric cancer (GC) are likely due to differential environmental exposures, in particular to Helicobacter pylori (H. pylori) infection. We aimed to investigate the impact of H. pylori on the epigenome in normal gastric mucosa and methylation changes associated with c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Woo HD,Fernandez-Jimenez N,Ghantous A,Degli Esposti D,Cuenin C,Cahais V,Choi IJ,Kim YI,Kim J,Herceg Z

    更新日期:2018-08-01 00:00:00

  • The effect of schedule, protein binding and growth factors on the activity of suramin.

    abstract::Suramin has been shown to have antiproliferative activity, either by blocking the binding of growth factors to their receptors or by inhibiting critical cellular enzymes. In 6 different cell lines from 5 tumour types (MCF-7, MCF-7/ADRR, PC3, HT-29, UM-SCC-11B and SW-1573/IR500), we studied the effect of scheduling of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lopez Lopez R,Peters GJ,van Loenen AC,Pizao PE,van Rijswijk RE,Wagstaff J,Pinedo HM

    更新日期:1992-07-30 00:00:00

  • Optimization of differential photodynamic effectiveness between normal and tumor urothelial cells using 5-aminolevulinic acid-induced protoporphyrin IX as sensitizer.

    abstract::Photodynamic therapy using 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX is a promising tool in bladder-cancer therapy. However, little is known about the cellular mechanisms of phototoxicity. Our aim was to characterize the cellular damage and to optimize differential photodynamic effectiveness between tumo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Seidl J,Rauch J,Krieg RC,Appel S,Baumgartner R,Knuechel R

    更新日期:2001-06-01 00:00:00

  • Effect on breast cancer mortality of biennial mammographic screening of women under age 50.

    abstract::The effects on breast cancer mortality seen after 16 years of biennial screening of younger women are assessed in this prospective cohort study. Since 1975 some 13,500 women, aged 35-49 in 1975, were invited to participate in the Nijmegen screening programme comprising a mammographic examination every 2 years. By the ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Peer PG,Werre JM,Mravunac M,Hendriks JH,Holland R,Verbeek AL

    更新日期:1995-03-16 00:00:00

  • Substrate-dependent effect of epidermal growth factor on intercellular adhesion and synthesis of triton-insoluble proteins in human carcinoma A431 cells.

    abstract::Human epidermoid carcinoma A431 cells attach more rapidly to collagen type-I and -IV substrates than to surfaces coated with laminin or fibronectin. The diminished intercellular interaction and rounding up manifested when these cells are exposed to epidermal growth factor (EGF) in tissue culture plastic or collagen fi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rieber M,Gil F,Rieber MS,Urbina C

    更新日期:1986-03-15 00:00:00

  • In vitro and in vivo antitumor activity of liposomal Fenretinide targeted to human neuroblastoma.

    abstract::Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In advanced disease stages, prognosis is poor and treatments have limited efficacy, thus novel strategies are warranted. The synthetic retinoid Fenretinide (HPR) induces apoptosis in NB and melanoma cell lines. We reported an in vitro potenti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Raffaghello L,Pagnan G,Pastorino F,Cosimo E,Brignole C,Marimpietri D,Montaldo PG,Gambini C,Allen TM,Bogenmann E,Ponzoni M

    更新日期:2003-05-01 00:00:00