Autocrine/paracrine erythropoietin signalling promotes JAK/STAT-dependent proliferation of human cervical cancer cells.

abstract：:Although tumor heterogeneity is widely accepted, the existence of cancer stem cells (CSCs) and their proposed role in tumor maintenance has always been challenged and remains a matter of debate. Recently, a path-breaking chapter was added to this saga when three independent groups reported the in vivo existence of CSC...

journal_title：International journal of cancer

authors： Singh AK,Arya RK,Maheshwari S,Singh A,Meena S,Pandey P,Dormond O,Datta D

更新日期：2015-05-01 00:00:00

abstract：:Pancreatic adenocarcinoma (PDAC) is known to have a poor prognosis partly because of lack of effective biomarkers. In the test set, we investigated dysbindin (DTNBP1) as a potential biomarker for PDAC by comparing preoperative and postoperative serum mass spectrometry (MS) proteomic profilings. Of the included 50 PDAC...

journal_title：International journal of cancer

authors： Guo X,Lv X,Fang C,Lv X,Wang F,Wang D,Zhao J,Ma Y,Xue Y,Bai Q,Yao X,Chen Y

更新日期：2016-10-15 00:00:00

abstract：:The morphology of rat liver cells containing alpha-feto-protein (AFP) during early stages of carcinogenesis induced by 3'methyl-4-dimethylaminoazobenzene and 2-acetylaminofluorene was investigated. Indirect immunofluorescence was used to detect AFP. AFP was not found in the cells of hyperplastic nodules but was presen...

journal_title：International journal of cancer

authors： Tchipysheva TA,Guelstein VI,Bannikov GA

更新日期：1977-09-15 00:00:00

abstract：:Creatinine-adjusted levels of estrone, estradiol and estriol were determined in overnight urine specimens from 220 post-menopausal women, aged 54 to 66 years, from Boston (121 women) and Athens (99 women). The associations of individual and total estrogens with various characteristics of the women (age at menopause, y...

journal_title：International journal of cancer

authors： Trichopoulos D,Brown J,MacMahon B

更新日期：1987-12-15 00:00:00

abstract：:Melanoma of unknown primary (MUP) may have a different biology to melanoma of known primary, but clinical trials of novel therapies (e.g., immune checkpoint or BRAF/MEK inhibitors) have not reported the outcomes in this population. We therefore evaluated the overall survival (OS) among patients with MUP in the era of ...

journal_title：International journal of cancer

authors： Verver D,van der Veldt A,van Akkooi A,Verhoef C,Grünhagen DJ,Louwman WJ

更新日期：2020-01-01 00:00:00

abstract：:Epidemiologic evidence on the association of antioxidant intake and prostate cancer incidence is inconsistent. Total antioxidant intake and prostate cancer incidence have not previously been examined. Using the ferric-reducing antioxidant potential (FRAP) assay, the total antioxidant content (TAC) of diet and suppleme...

journal_title：International journal of cancer

authors： Russnes KM,Wilson KM,Epstein MM,Kasperzyk JL,Stampfer MJ,Kenfield SA,Smeland S,Blomhoff R,Giovannucci EL,Willett WC,Mucci LA

更新日期：2014-03-01 00:00:00

abstract：:Ether-linked glycerophospholipids (ether lipids, EL) are selectively toxic and anti-proliferative agents against cancer cells in vitro. The reason for such selectivity is not completely clear. Their mechanism of action is mediated through an interaction with the plasma membrane and the membrane lipid composition may m...

journal_title：International journal of cancer

authors： Diomede L,Piovani B,Modest EJ,Noseda A,Salmona M

更新日期：1991-09-30 00:00:00

abstract：:The roles of fibroblast growth factor-2 (FGF-2) in the hepatocellular carcinoma (HCC) development are still controversial. In this study, we investigated the expression of FGF-2 in chronic hepatitis (CH) type C patients with or without HCC and the immunoregulation of FGF-2 in NK sensitivity of HCC cells. The FGF-2 exp...

journal_title：International journal of cancer

authors： Tsunematsu H,Tatsumi T,Kohga K,Yamamoto M,Aketa H,Miyagi T,Hosui A,Hiramatsu N,Kanto T,Hayashi N,Takehara T

更新日期：2012-01-15 00:00:00

abstract：:Eight squirrel monkeys (Saimiri sciureus) challenged with EBV or EBV-transformed SLCL were naturally or experimentally infected with Plasmodium knowlesi or Pl. brasilianum. Most of the animals had been splenectomized and unilaterally nephrectomized. Three of these monkeys received one dose of 6 to 12 X 10(8) autologou...

journal_title：International journal of cancer

authors： Leibold W,Huldt G,Flanagan TD,Andersson M,Dalens M,Wright DH,Voller A,Klein G

更新日期：1976-04-15 00:00:00

abstract：:Retinoids are a group of vitamin A analogues that have shown promise as chemopreventive and therapeutic agents in many types of malignancy and have been entered in clinical trials with some successful results. To better understand the mechanism that mediates retinoid action and the anti-proliferative effects, we treat...

journal_title：International journal of cancer

authors： Giannini F,Maestro R,Vukosavljevic T,Pomponi F,Boiocchi M

更新日期：1997-01-17 00:00:00

abstract：:In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis characterized by cell shrinkage and cell membrane scrambling. Eryptotic erythrocytes are rapidly cleared from circulating blood and may adhere to the vascular wall. Stimulation of eryptosis thus impairs microcirculation and leads to anemia as...

journal_title：International journal of cancer

authors： Lang E,Bissinger R,Qadri SM,Lang F

更新日期：2017-10-15 00:00:00

abstract：:The most recent data available demonstrate a 120-fold difference between the lowest and highest incidence rates of prostatic cancer, the disease being very common in North America, particularly among Blacks, and in Scandinavia, while it is rare in Japan and other oriental countries. The highest mortality for prostatic...

journal_title：International journal of cancer

authors： Zaridze DG,Boyle P,Smans M

更新日期：1984-02-15 00:00:00

abstract：:We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of stromelysin-1 and redu...

journal_title：International journal of cancer

authors： Engel G,Popowicz P,Marshall H,Norling G,Svensson C,Auer G,Akusjärvi G,Linder S

更新日期：1992-07-09 00:00:00

abstract：:A cDNA library specific for mRNA over-expressed in prostate cancer was generated by subtractive hybridization of transcripts originating from prostatic hyperplasia and cancer tissues. cDNA encoding ribosomal proteins L4, L5, L7a, L23a, L30, L37, S14 and S18 was found to be present among 100 analyzed clones. Levels of ...

journal_title：International journal of cancer

authors： Vaarala MH,Porvari KS,Kyllönen AP,Mustonen MV,Lukkarinen O,Vihko PT

更新日期：1998-09-25 00:00:00

abstract：:To evaluate the relation between the degree of lymph node metastasis and the growth potential of tumour cells and the local immune function in gastric cancer, we analyzed data on 444 patients with advanced serosally invasive gastric cancer who underwent curative gastrectomy. Tumour growth potential was evaluated based...

journal_title：International journal of cancer

authors： Maehara Y,Tomisaki S,Oda S,Kakeji Y,Tsujitani S,Ichiyoshi Y,Akazawa K,Sugimachi K

更新日期：1997-04-22 00:00:00

abstract：:The presence of carcinogen-DNA adducts in human tissues is evidence of exposure to carcinogens and may be an indicator of cancer risk. DNA was isolated from non-tumorous bronchial tissue of 37 cigarette smokers, 8 former smokers and 8 non-smokers and analyzed for the presence of aromatic and/or hydrophobic DNA adducts...

journal_title：International journal of cancer

authors： Phillips DH,Schoket B,Hewer A,Bailey E,Kostic S,Vincze I

更新日期：1990-10-15 00:00:00

abstract：:Annamycin (Ann) is a non-cross-resistant lipophilic anthracycline antiobiotic optimally suited for liposome delivery. We studied how vesicle size and presence of phospholipids with a high phase transition temperature and monosialoganglioside (GM I) in the liposome bilayers affect the pharmacokinetics, tumor selectivit...

journal_title：International journal of cancer

authors： Zou Y,Ling YH,Reddy S,Priebe W,Perez-Soler R

更新日期：1995-05-29 00:00:00

abstract：:Targeting of T lymphocytes against epidermal growth-factor-receptor (EGF-R)+ tumor cells was achieved by constructing a hybrid hybridoma which secretes an anti-EGF-R/anti-CD3 bispecific monoclonal antibody (biMAb) of hybrid isotype (IgG1/IgG2a). Purification of biMAb molecules from parental anti-EGF-R and anti-CD3 MAb...

journal_title：International journal of cancer

authors： Ferrini S,Cambiaggi A,Sforzini S,Marciano S,Canevari S,Mezzanzanica D,Colnaghi MI,Grossi CE,Moretta L

更新日期：1993-12-02 00:00:00

abstract：:Adenoviral oncolysis is a promising new modality for treatment of cancer based on selective viral replication in tumor cells. However, tumor cell killing by adenoviral oncolysis needs to be improved to achieve therapeutic benefit in the clinic. Towards this end, the activation of anti-tumor immunity by adenoviral onco...

journal_title：International journal of cancer

authors： Schierer S,Hesse A,Müller I,Kämpgen E,Curiel DT,Schuler G,Steinkasserer A,Nettelbeck DM

更新日期：2008-01-01 00:00:00

abstract：:We have surveyed the incidence of adult T-cell leukemia/lymphoma (ATLL) in an endemic area of 290,464 inhabitants for 7 years. We now revise our previous results on the basis of additional findings and estimate the age- and sex-specific cumulative rate for HTLV-I carriers, the adoption of which is recommended by curre...

journal_title：International journal of cancer

authors： Kondo T,Kono H,Miyamoto N,Yoshida R,Toki H,Matsumoto I,Hara M,Inoue H,Inatsuki A,Funatsu T

更新日期：1989-06-15 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) plays an important role in essential cellular processes such as proliferation, survival and migration. Aberrant activation of EGFR is frequently found in human cancers of various origins and has been implicated in cancer pathogenesis. The therapeutic antibody cetuximab (Erbitux)...

journal_title：International journal of cancer

authors： Müller N,Hartmann C,Genssler S,Koch J,Kinner A,Grez M,Wels WS

更新日期：2014-06-01 00:00:00

abstract：:Cancer is well established as an age-associated disease, and there is substantial overlap in the molecular, cellular and physiological changes observed with both ageing and the progression of cancer. Age-specific declines in resilience mechanisms such as DNA repair or epigenetic maintenance may contribute to the devel...

journal_title：International journal of cancer

authors： Lau CE,Robinson O

更新日期：2021-01-04 00:00:00

abstract：:MM is a B-cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, presence of paraprotein in serum and occurrence of osteolytic bone lesions. MMPs are a family of proteolytic enzymes that can contribute to cancer growth, invasion, angiogenesis, bone degradation and other processes impor...

journal_title：International journal of cancer

authors： Van Valckenborgh E,Bakkus M,Munaut C,Noël A,St Pierre Y,Asosingh K,Van Riet I,Van Camp B,Vanderkerken K

更新日期：2002-10-20 00:00:00

abstract：:Oral tongue squamous cell carcinoma (OTSCC) is associated with poor prognosis. To improve prognostication, we analyzed four gene probes (TERC, CCND1, EGFR and TP53) and the centromere probe CEP4 as a marker of chromosomal instability, using fluorescence in situ hybridization (FISH) in single cells from the tumors of s...

journal_title：International journal of cancer

authors： Wangsa D,Chowdhury SA,Ryott M,Gertz EM,Elmberger G,Auer G,Åvall Lundqvist E,Küffer S,Ströbel P,Schäffer AA,Schwartz R,Munck-Wikland E,Ried T,Heselmeyer-Haddad K

更新日期：2016-01-01 00:00:00

abstract：:We have obtained a novel multidrug resistant cell line, derived from HT29 G(+) human colon carcinoma cells, by selection with gradually increasing concentrations of the anti-mitotic, microtubule-disrupting agent colchicine. This HT29(col) cell line displayed a 25-fold increase in colchicine resistance and exhibited cr...

journal_title：International journal of cancer

authors： Kok JW,Veldman RJ,Klappe K,Koning H,Filipeanu CM,Müller M

更新日期：2000-07-15 00:00:00

abstract：:Integrins are extracellular matrix receptors involved in tumour invasion and angiogenesis. Although there is evidence that inhibiting integrins might enhance the efficiency of radiotherapy, little is known about the exact mechanisms involved in the integrin-dependent modulation of tumor radiosensitivity. The purpose o...

journal_title：International journal of cancer

authors： Monferran S,Skuli N,Delmas C,Favre G,Bonnet J,Cohen-Jonathan-Moyal E,Toulas C

更新日期：2008-07-15 00:00:00

abstract：:Dimethylarsinic acid (DMA) is a major metabolite of inorganic arsenicals, which are epidemiologically significant chemicals in relation to liver cancer in mammals. The present study was conducted to determine the promoting effects of organic arsenicals related to DMA [monomethylarsonic acid (MMA) and trimethylarsine o...

journal_title：International journal of cancer

authors： Nishikawa T,Wanibuchi H,Ogawa M,Kinoshita A,Morimura K,Hiroi T,Funae Y,Kishida H,Nakae D,Fukushima S

更新日期：2002-07-10 00:00:00

abstract：:Antioxidants, primarily from fruits and vegetables, have been hypothesized to protect against non-Hodgkin lymphoma (NHL). The oxygen radical absorbance capacity (ORAC) assay, which measures total antioxidant capacity of individual foods and accounts for synergism, can be estimated using a food-frequency questionnaire ...

journal_title：International journal of cancer

authors： Holtan SG,O'Connor HM,Fredericksen ZS,Liebow M,Thompson CA,Macon WR,Micallef IN,Wang AH,Slager SL,Habermann TM,Call TG,Cerhan JR

更新日期：2012-09-01 00:00:00

abstract：:Classical midgut carcinoids are rare intestinal neuroendocrine tumors that often present with metastases at diagnosis. In contrast to foregut carcinoids, midgut carcinoids are not related to the multiple endocrine neoplasia type 1 syndrome, and the mechanisms involved in their tumorigenesis are unknown. Eight classica...

journal_title：International journal of cancer

authors： Löllgen RM,Hessman O,Szabo E,Westin G,Akerström G

更新日期：2001-06-15 00:00:00

abstract：:Trifluorothymidine (TFT) is part of the oral drug formulation TAS-102. Both 5-fluorouracil (5-FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross-resistance to 5-FU. Therefore, we examined whether mechanistic differences in cell death could underlie their different ...

journal_title：International journal of cancer

authors： Bijnsdorp IV,Peters GJ,Temmink OH,Fukushima M,Kruyt FA

更新日期：2010-05-15 00:00:00