Abstract:
:To evaluate the relation between the degree of lymph node metastasis and the growth potential of tumour cells and the local immune function in gastric cancer, we analyzed data on 444 patients with advanced serosally invasive gastric cancer who underwent curative gastrectomy. Tumour growth potential was evaluated based on the value proliferating cell nuclear antigen (PCNA) in the primary tumour, and dendritic cell infiltration into the tumour was determined as an indicator of local immune function. The values of PCNA labeling in the primary tumour increased and the infiltration of dendritic cells into the tumour decreased in relation to the extent of lymph node metastasis. High growth potential and low immune function were seen in cases with n3 lymph node metastasis. There was a reverse relation between the PCNA labeling index and dendritic cell infiltration. A variety of forms of recurrence was noted in patients with lymph node metastasis while the prognosis was less favorable, in relation to the degree of lymph node metastasis. Thus, the potential for nodal spread appears to be associated with the growth potential of tumour cells and with the local immune status of the tumour.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Maehara Y,Tomisaki S,Oda S,Kakeji Y,Tsujitani S,Ichiyoshi Y,Akazawa K,Sugimachi Kdoi
10.1002/(sici)1097-0215(19970422)74:2<224::aid-ijcsubject
Has Abstractpub_date
1997-04-22 00:00:00pages
224-8issue
2eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19970422)74:2<224::AID-IJCjournal_volume
74pub_type
杂志文章abstract::In the last decade, mitochondrial DNA (mtDNA) haplogroups have been associated with the occurrence of breast cancer. However, the underlying mechanism is not known. Combining a case-control study with a large cohort of women from Southern China with breast cancer and functional analyses with trans-mitochondrial techno...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31207
更新日期:2018-05-01 00:00:00
abstract::Despite the steadily increasing number of patients suffering from squamous-cell carcinomas of the oropharyngeal region, little is known about the molecular steps involved in the induction of these neoplasms. We investigated oropharyngeal cancers from 38 patients for mutations in the p53 tumour-suppressor gene. The maj...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560608
更新日期:1994-03-15 00:00:00
abstract::A syngeneic tumor system in DBA/2 mice consisting of a methyl-cholanthrene-induced, weakly metastatic lymphoma, L5178YE (= Eb), its spontaneous strongly metastatic variant, L5178YES (= ESb), and an unrelated, methylcholanthrene-induced, metastasizing tumor, MDAY-D2, were used to study the relationship between metastat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360514
更新日期:1985-11-15 00:00:00
abstract::Cell kinetics is a predictive parameter of breast-cancer aggressiveness, and mutations occurring in mammary tumorigenesis may favor uncontrolled cell proliferation. In this study, cell kinetics, clinico-pathological characteristics and genetic alterations at the int-2, bcl-1, c-myc, c-erbB-2, and DF3 loci were analyze...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610102
更新日期:1995-03-29 00:00:00
abstract::While dietary antioxidants are emerging as potentially modifiable risk factors for esophageal adenocarcinoma (EAC), studies on dietary antioxidants and its precursor Barrett's esophagus (BE) are limited. The present study extends previous work on BE by investigating risks of nondysplastic BE, dysplastic BE and EAC ass...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28016
更新日期:2013-07-01 00:00:00
abstract::The macrophage electrophoretic mobility (MEM) test was performed on guinea-pig macrophages treated with the interaction products of encephalitogenic protein and peripheral lymphocytes from 44 patients with colorectal cancer and 33 "healthy" controls. In 54/60 tests involving patients, statistically significant reducti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910190407
更新日期:1977-04-15 00:00:00
abstract::We have examined the effect of various cell monolayers on the ability of mouse spleen cells to lyse tumor cell targets (natural cytotoxicity reaction). Natural killer (NK) cell activity was reduced by as much as 75% depending on the cell substrate, with the greatest protection afforded by endothelial cells. Cell adhes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410612
更新日期:1988-06-15 00:00:00
abstract::Renal-cell carcinomas (RCC) are clinically, histologically and cytogenetically very heterogeneous. The present histological WHO classification shows no clear correlation between histologic subtypes and specific chromosomal abnormalities. In 1986, a new classification was proposed by Thoenes and Störkel based on the ce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550210
更新日期:1993-09-09 00:00:00
abstract::RAGE is a central driver of tumorigenesis by sustaining an inflammatory tumor microenvironment. This study links the soluble forms of RAGE (sRAGE and esRAGE) with clinical outcome of melanoma patients. Moreover, tissue expression of RAGE was analyzed using immunohistochemistry on two independent tissue microarrays (TM...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29619
更新日期:2015-12-01 00:00:00
abstract::Inbred rats were treated with extranuclear tumour membrane fractions or 3 M KCl-solubilized extracts of two antigenically distinct 3-methylcholanthrene-induced sarcomas, Mc7 and Mc57. The rats developed tumour-specific humoral antibody responses, but were not immune to tumour challenge. Moreover, they were unresponsiv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180511
更新日期:1976-11-15 00:00:00
abstract::2-methoxyestradiol (2ME(2)) is an endogenous metabolite of estradiol with estrogen-receptor-independent antitumor and antiangiogenic activity. We examined the effects of 2ME(2) on the cellular proliferation of 8 human melanoma cell lines. We show that 2ME(2) inhibited cell proliferation by inducing apoptosis and an ar...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20473
更新日期:2004-12-10 00:00:00
abstract::Use of hormone replacement therapy (HRT) has been hypothesized to affect survival of epithelial ovarian cancer (EOC). We studied 5-year survival in patients with invasive EOC and borderline ovarian tumors (BOT) according to HRT use before and after diagnosis in a prospective nation-wide cohort study of 799 women diagn...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22218
更新日期:2006-12-15 00:00:00
abstract::BPV-1 induces focus formation in murine C127 cells and fibropapillomas in bovine fetal skin xenografts. In this study, we compared the specificity of neutralization of BPV-1 in both assay systems, using sera and monoclonal antibodies (MAbs) selected to define neutralizing epitopes. Sera from rabbits and cattle, inocul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490224
更新日期:1991-09-09 00:00:00
abstract::Germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ was previously suggested to have an impact on drug response in vitro. Here, we investigated the effect on breast cancer survival of germline variation in these genes in 925 Finnish breast cancer patients and further analyzed five sing...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27884
更新日期:2013-05-01 00:00:00
abstract::Cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (HPV) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (CIN). Additionally, regulatory T (Treg) cells are increasingly understoo...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.24117
更新日期:2009-03-15 00:00:00
abstract::There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32091
更新日期:2019-07-01 00:00:00
abstract::Childhood cancers (age at diagnosis: 0-14 years) comprise a variety of malignancies, with incidence varying worldwide by age, sex, ethnicity and geography, that provide insights into cancer etiology. A total of 1,334 childhood cancers registered in population-based cancer registry, Chennai, India, during 1990-2001 and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23428
更新日期:2008-06-01 00:00:00
abstract::Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human chromosome 18q21. This chromosomal region maps a gene cluster coding for a family of intracellular serine protease inhibitors (serpins), including SERPINB13. As SERPI...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24507
更新日期:2009-10-01 00:00:00
abstract::We examined the biologic properties of a small-cell-lung-carcinoma (SCLC) cell line (designated MN-1112) established from a patient with SCLC who showed paraneoplastic retinopathy syndrome. Morphologic and immunocytochemical analyses showed that MN-1112 cells possess features of the classic type of SCLC. MN-1112 cells...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960301)65:5<671::AID-IJC
更新日期:1996-03-01 00:00:00
abstract::Many recent data indicate that some alleles encoded in the central major histocompatibility complex (MHC) region (Class III) of short arm of chromosome 6 may modify the risk of cancer development. Therefore we determined 4 single nucleotide polymorphisms (SNPs) of this region (TNF-alpha -308 G > A, RAGE -429 T > C, HS...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22922
更新日期:2007-10-15 00:00:00
abstract::The antineoplastic effect of paclitaxel is mainly related to its ability to bind the beta subunit of tubulin, thus preventing tubulin chain depolarization and inducing apoptosis. The relevance of the Class I beta-tubulin characteristics have also been confirmed in the clinical setting where mutations of paclitaxel-bin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22557
更新日期:2007-05-15 00:00:00
abstract::Licensed human papillomavirus (HPV) vaccines are expected to prevent high-risk (hr) HPV-infections (most notably types 16 and 18). Whether HPV vaccination will change the distribution of hrHPVs at the population level is open, since competition between HPV types is not well understood. Two stratified random subcohorts...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24539
更新日期:2009-11-01 00:00:00
abstract::It is generally assumed that inflammation influences carcinogenesis. We previously reported that dextran sodium sulfate (DSS) strongly enhances colon carcinogenesis in the Apc(Min/+) mice and the over-expression of inducible nitric oxide synthase (iNOS) contributes to this enhancement. In the current study, we investi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22736
更新日期:2007-08-01 00:00:00
abstract::In previous studies we showed that human sarcoma and melanoma cell lines synthesize and secrete into culture medium a glycoprotein, migrating in urea sodium dodecyl sulfate-polyacrylamide gel electrophoresis at Mr 140,000. It is not detected in cultures of the corresponding normal cells. Conditioned medium of the mela...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370114
更新日期:1986-01-15 00:00:00
abstract::Prostate cancer incidence has increased during recent years, possibly linked to environmental exposures. Exposure to environmental carcinogens is unlikely to be evenly distributed geographically, which may give rise to variations in disease occurrence that is detectable in a spatial analysis. The aim of our study was ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10113
更新日期:2002-02-10 00:00:00
abstract::The distance of nerve invasion is an important prognostic factor in pancreatic cancer. The extracellular matrix (ECM) of nerve, mainly composed of laminin, collagen IV and anchoring fibrils, might affect nerve invasion. However, this relationship has not been demonstrated. Our study aimed at discovering the promoting ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25104
更新日期:2010-08-15 00:00:00
abstract::The correlation between tumorigenicity and cell-surface adhesiveness was investigated in eight mouse fibroblastoid cell lines. Four of the lines (Mc 11-Mc 15) were derived from mouse MC-induced fibrosarcomas, two were derivatives of L cells (A9, A9HT), and two (clone 3 and clone 7 H7F4) were obtained by fusion of A9HT...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230318
更新日期:1979-03-15 00:00:00
abstract::Comparisons of patients receiving different cancer treatments reflect the effects of both treatment and patient selection. In breast cancer, however, if radiotherapy decisions are unrelated to laterality, comparisons of left-sided and right-sided cancers can demonstrate the causal effects of higher-versus-lower cardia...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32908
更新日期:2020-09-01 00:00:00
abstract::A substantial proportion of women with cervical cancer that have participated in cervical screening have a history of an abnormal cytology result. Our objective was to assess the impact of histological investigation and treatment of women with abnormal cytology on the subsequent risk of invasive cervical cancer. All i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25749
更新日期:2011-09-15 00:00:00
abstract::HNPCC is an autosomal dominantly inherited cancer-susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract cancers. The underlying pathoge...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10240
更新日期:2002-04-10 00:00:00