Characterization of a small-cell-lung-carcinoma cell line from a patient with cancer-associated retinopathy.


:We examined the biologic properties of a small-cell-lung-carcinoma (SCLC) cell line (designated MN-1112) established from a patient with SCLC who showed paraneoplastic retinopathy syndrome. Morphologic and immunocytochemical analyses showed that MN-1112 cells possess features of the classic type of SCLC. MN-1112 cells grew in suspension forming relatively large clumps of cells with a doubling time of 72 hr. By light-microscope examination, the cells were relatively small and had scanty cytoplasm. The cells produced NSE, ACTH and CK (BB isozyme); they also expressed recoverin, a novel photoreceptor protein, detected by Northern-blot and Western-immunoblot analysis using human-recoverin-specific DNA probe and anti-bovine-recoverin polyclonal antibody. This report shows that human recoverin is expressed in cultured SCLC cells. Our results support the hypothesis that, in cancer-associated retinopathy (CAR) patients, auto-immune antibody targeting for ectopic recoverin in SCLC is initially produced and cross-reacts with the retinal protein, resulting in the retinal degeneration that occurs in CAR patients.


Int J Cancer


Yamaji Y,Matsubara S,Yamadori I,Sato M,Fujita T,Fujita J,Takahara J




Has Abstract


1996-03-01 00:00:00














  • Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients.

    abstract::Targeting the GA733 antigen (also known as CO17-1A, EGP, KS1-4, KSA, Ep-CAM) by monoclonal antibody CO17-1A or anti-idiotypic antibodies mimicking the CO17-1A or GA733 epitope has induced prolonged survival and specific immune responses to the antigen, respectively, in colorectal cancer (CRC) patients. In pre-clinical...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Staib L,Birebent B,Somasundaram R,Purev E,Braumüller H,Leeser C,Küttner N,Li W,Zhu D,Diao J,Wunner W,Speicher D,Beger HG,Song H,Herlyn D

    更新日期:2001-04-01 00:00:00

  • Effects of tumor promoters on growth and on cellular redistribution of phospholipid/Ca2+-dependent protein kinase in human breast cancer cells.

    abstract::Active, structurally unrelated tumor promoters (12-0-tetradecanoyl-phorbol-13-acetate (TPA), teleocidin and aplysiatoxin) inhibit growth of mammary carcinoma cells (MCF7- greater than BT-20 greater than MDA-MB-231 greater than = ZR-75-1 greater than HBL-100). This efficiency in inhibiting cell growth correlates with t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Regazzi R,Fabbro D,Costa SD,Borner C,Eppenberger U

    更新日期:1986-05-15 00:00:00

  • Evidence of heterogeneity within colorectal liver metastases for allelic losses, mRNA level expression and in vitro response to chemotherapeutic agents.

    abstract::A goal of oncology is to predict chemosensitivity of tumors. This approach assumes that in a patient all tumor deposits are homogeneous. We have tested the heterogeneity between several samples of the same liver metastasis (LM; intrametastatic heterogeneity) or between multiple LM (intermetastatic heterogeneity) from ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Goasguen N,de Chaisemartin C,Brouquet A,Julié C,Prevost GP,Laurent-Puig P,Penna C

    更新日期:2010-09-01 00:00:00

  • Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein.

    abstract::Activity of Janus kinase 2 (JAK2) in the JAK2/STAT5 signaling pathway is critically controlled by suppressor of cytokine signaling-1 (SOCS-1). We have previously shown that SOCS-1 is biallelically mutated in the primary mediastinal B-cell lymphoma (PMBL) cell line MedB-1, resulting in impaired JAK2 degradation and sus...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Melzner I,Weniger MA,Bucur AJ,Brüderlein S,Dorsch K,Hasel C,Leithäuser F,Ritz O,Dyer MJ,Barth TF,Möller P

    更新日期:2006-04-15 00:00:00

  • Residential ambient benzene exposure in the United States and subsequent risk of hematologic malignancies.

    abstract::Benzene is considered a carcinogen, mostly based on evidence of causality for myeloid leukemia from high levels of exposure in occupational studies. We used United States Environmental Protection Agency National Ambient Toxics Assessment (NATA) estimates of low-level ambient benzene to examine potential associations f...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Teras LR,Diver WR,Deubler EL,Krewski D,Flowers CR,Switchenko JM,Gapstur SM

    更新日期:2019-11-15 00:00:00

  • Increased endothelial uptake of paclitaxel as a potential mechanism for its antiangiogenic effects: potentiation by Cox-2 inhibition.

    abstract::Paclitaxel has antiangiogenic properties, but the mechanisms for the enhanced sensitivity of endothelial cells (ECs) to this drug are not established. The aims of our study were to compare the distribution of paclitaxel into ECs with other cell types, to assess the effects of low doses of paclitaxel on Cox-2 expressio...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Merchan JR,Jayaram DR,Supko JG,He X,Bubley GJ,Sukhatme VP

    更新日期:2005-01-20 00:00:00

  • Tamoxifen and toremifene treatment of breast cancer and risk of subsequent endometrial cancer: a population-based case-control study.

    abstract::A population-based case-control study was performed to evaluate the risk of endometrial cancer related to tamoxifen or toremifene treatment. All patients with breast cancer diagnosis since 1980 in Finland who subsequently developed an endometrial cancer by the end of 1995 and 3 matched controls were identified among t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pukkala E,Kyyrönen P,Sankila R,Holli K

    更新日期:2002-07-20 00:00:00

  • Epidemiology and the causes of breast cancer.

    abstract::This article describes the characteristics of 3 dominant features of breast cancer epidemiology. These characteristics include the association of disease risk with childbearing, its relationship to ovarian activity and its international variation (particularly as the latter differs in the years before and after menopa...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: MacMahon B

    更新日期:2006-05-15 00:00:00

  • Production of T-cell lines with inhibitory or stimulatory activity against syngeneic tumors in vivo. A preliminary report.

    abstract::We obtained Thy-I-positive cells directly from growing methylcholanthrene-induced (MCA-1510) sarcomas using fluorescence-activated cell sorting, then cultured these lymphocytes in medium containing Interleukin-2 and tested their activity in vivo against various MCA-sarcoma lines with the Winn assay. We found that cult...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mulé JJ,Forstrom JW,George E,Hellström I,Hellström KE

    更新日期:1981-11-15 00:00:00

  • Embryo-derived teratocarcinoma: I. The role of strain and gender in the control of teratocarcinogenesis.

    abstract::The role of gender and genetic (strain-specific) factors in the regulation of teratocarcinogenesis was studied by monitoring the outgrowth of benign and malignant embryo-derived teratoid tumors, i.e., teratomas and teratocarconomas in several mouse strains. Teratocarcinomas were produced in all mouse strains tested, b...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Solter D,Dominis M,Damjanov I

    更新日期:1979-12-15 00:00:00

  • Nerve invasion distance is dependent on laminin gamma2 in tumors of pancreatic cancer.

    abstract::The distance of nerve invasion is an important prognostic factor in pancreatic cancer. The extracellular matrix (ECM) of nerve, mainly composed of laminin, collagen IV and anchoring fibrils, might affect nerve invasion. However, this relationship has not been demonstrated. Our study aimed at discovering the promoting ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mitsunaga S,Fujii S,Ishii G,Kinoshita T,Hasebe T,Aoyagi K,Sasaki H,Ochiai A

    更新日期:2010-08-15 00:00:00

  • Distinct clinical features associated with microsatellite instability in colorectal cancers of young patients.

    abstract::The Hong Kong Chinese population has an unusually high incidence of colorectal cancer in the young, suggestive of hereditary susceptibility. To search for a genetic basis for this predisposition, we studied the incidence of microsatellite instability (MSI) in paraffin-embedded colectomy specimens of 124 young (<50 yea...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ho JW,Yuen ST,Chung LP,Kwan KY,Chan TL,Leung SY,Chan AS,Tse Cw,Lam PW,Luk IS

    更新日期:2000-07-20 00:00:00

  • Extracellular matrix and HIF-1 signaling: the role of prolidase.

    abstract::Hypoxia-inducible factor-1 (HIF-1) plays an important role in stress-responsive gene expression. Although primarily sensitive to hypoxia, HIF-1 signaling can be regulated by a number of stress factors including metabolic stress, growth factors and molecules present in the extracellular matrix (ECM). Degradation of ECM...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Surazynski A,Donald SP,Cooper SK,Whiteside MA,Salnikow K,Liu Y,Phang JM

    更新日期:2008-03-15 00:00:00

  • Infectious DNA recovered from avian tumor-virus-producing cells.

    abstract::A single treatment of chick embryo fibroblasts with DNA recovered from chick embryo fibroblasts productively infected and transformed with four different strains of RSV, or productively infected with two different strains of RAV, resulted in virus production and cell transformation (in the case of RSV) two or three p...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vigier P,Montagnier L

    更新日期:1975-01-15 00:00:00

  • VEGFR-2 expression in human melanoma: revised assessment.

    abstract::Vascular endothelial growth factor (VEGF) is an angiogenic factor that also functions as an autocrine growth factor for VEGF receptor (VEGFR)-2(+) melanomas. In multiple studies, VEGFR-2 was detected by immunostaining in 78-89% of human melanoma cells, suggesting that most patients with melanoma would benefit from an...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Molhoek KR,Erdag G,Rasamny JK,Murphy C,Deacon D,Patterson JW,Slingluff CL Jr,Brautigan DL

    更新日期:2011-12-15 00:00:00

  • Fractional allelic imbalance in human breast cancer increases with tetraploidization and chromosome loss.

    abstract::We have previously reported a complete allelotype study of 86 primary breast carcinomas, in which each non-acrocentric chromosome arm was studied with at least one polymorphic DNA-marker for the presence of allelic imbalance (AI, allelic loss or allelic gain) in the tumor. Here we report the statistical analysis of th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cornelisse CJ,Kuipers-Dijkshoorn N,van Vliet M,Hermans J,Devilee P

    更新日期:1992-02-20 00:00:00

  • Distribution and characterization of alpha hCG in the serum and tumor cytosol of patients with breast cancer.

    abstract::Serum and tumor tissue from breast cancer patients were evaluated for the presence of alpha subunit of hCG, by means of the specific radioimmunoassay. Elevated serum levels occurred in 0/50 (0%) of normal female controls, 1/17 (6%) of patients with benign breast disease, 3/53 (6%) of patients with primary breast cance...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shindelman JE,Ortmeyer AE,Wada HG,Stockdale F,Sussman HH

    更新日期:1980-05-15 00:00:00

  • Microsatellite alterations and p53, TGFbetaRII, IGFIIR and BAX mutations in sporadic non-small-cell lung cancer.

    abstract::Fifty-two sporadic primary non-small-cell lung carcinomas (NSCLC) were examined for microsatellite instability. Six different microsatellite markers localized on chromosomes 2, 5, 8, 10, 11 and 17 were used. Genomic instability was observed in 35% (18/52) of NSCLC at single or multiple loci. The tumors were also analy...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Caligo MA,Ghimenti C,Marchetti A,Lonobile A,Buttitta F,Pellegrini S,Bevilacqua G

    更新日期:1998-11-23 00:00:00

  • Assessment of highly angiogenic and disseminated in the peripheral blood disease in breast cancer patients predicts for resistance to adjuvant chemotherapy and early relapse.

    abstract::The assessment of tumor molecular features in combination with the detection of occult malignant cells may provide important clinical information, beyond the standard staging of breast cancer. Using a nested RT-PCR technique, we assessed prospectively the presence of cytokeratin-19 (CK19) mRNA positive cells in the bl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Giatromanolaki A,Koukourakis MI,Kakolyris S,Mavroudis D,Kouroussis C,Mavroudi C,Perraki M,Sivridis E,Georgoulias V

    更新日期:2004-02-10 00:00:00

  • Human papillomavirus and cervical intraepithelial neoplasia grade II-III: a population-based case-control study.

    abstract::The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cas...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Olsen AO,Gjøen K,Sauer T,Orstavik I,Naess O,Kierulf K,Sponland G,Magnus P

    更新日期:1995-05-04 00:00:00

  • Molecular analysis of the polymorphisms of thymidylate synthase on cell-free circulating DNA in blood of patients with advanced colorectal carcinoma.

    abstract::As a key enzyme in folate metabolism, the thymidylate synthase (TS) is important for the synthesis of nucleotides. Its polymorphisms may affect the TS gene expression and the susceptibility for Fluoropyrimidine (FU)-based chemotherapies. In this study, we assessed the relationship between the TS genotypes and clinical...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schwarzenbach H,Goekkurt E,Pantel K,Aust DE,Stoehlmacher J

    更新日期:2010-08-15 00:00:00

  • Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors.

    abstract::In vitro, tumor-selective Hsp70 plasma membrane localization correlates with increased sensitivity to lysis mediated by a subpopulation of human natural killer (NK) cells that adhere to plastic following cytokine stimulation. In the present study, we analyzed the capacity of adoptively transferred human NK cells in SC...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Multhoff G,Pfister K,Botzler C,Jordan A,Scholz R,Schmetzer H,Burgstahler R,Hiddemann W

    更新日期:2000-12-01 00:00:00

  • Accuracy of concurrent visual and cytology screening in detecting cervical cancer precursors in rural India.

    abstract::The high burden of cervical cancer and inadequate/suboptimal cytology screening in developing countries led to the evaluation of visual screening tests, like visual inspection with acetic acid (VIA) and Lugol's iodine (VILI). We describe the performance of VIA, VILI and cytology, carried out in a multinational project...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Deodhar K,Sankaranarayanan R,Jayant K,Jeronimo J,Thorat R,Hingmire S,Muwonge R,Chiwate A,Deshpande R,Ajit D,Kelkar R,Rekhi B,Ruben I,Malvi SG,Chinoy R,Jambhekar N,Nene BM

    更新日期:2012-09-15 00:00:00

  • Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development.

    abstract::Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear. Immunohistochemical detection of Gab2 in a large cohort of primary human breast cancers of known outcome revealed that while Gab...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fleuren ED,O'Toole S,Millar EK,McNeil C,Lopez-Knowles E,Boulghourjian A,Croucher DR,Schramek D,Brummer T,Penninger JM,Sutherland RL,Daly RJ

    更新日期:2010-09-01 00:00:00

  • Whole exome sequencing identifies PLEC, EXO5 and DNAH7 as novel susceptibility genes in testicular cancer.

    abstract::Testicular germ cell tumors (TGCTs) are a clinically and pathologically heterogeneous disease, and little is known of its genetic basis. Only low susceptibility risk loci have been identified for both sporadic and familial cases. Therefore, we tried to identify new susceptibility genes responsible for familial testicu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Paumard-Hernández B,Calvete O,Inglada Pérez L,Tejero H,Al-Shahrour F,Pita G,Barroso A,Carlos Triviño J,Urioste M,Valverde C,González Billalabeitia E,Quiroga V,Francisco Rodríguez Moreno J,Fernández Aramburo A,López C,Maroto

    更新日期:2018-10-15 00:00:00

  • Smokeless tobacco use and risk of cancer of the pancreas and other organs.

    abstract::Limited data are available on the carcinogenicity of smokeless tobacco products in organs other than the mouth. Snus is a smokeless tobacco product widely used in Norway. We studied 10,136 Norwegian men enrolled since 1966 in a prospective cohort study, 31.7% of whom were exposed to snus. The relative risk of pancreat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Boffetta P,Aagnes B,Weiderpass E,Andersen A

    更新日期:2005-05-10 00:00:00

  • Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3.

    abstract::Signal transducer and activator of transcription 3 (STAT3) is activated in a variety of human cancers, including ovarian cancer. The molecular mechanism by which the STAT3 is activated in cancer cells is poorly understood. We observed that human ovarian xenograft tumors (A2780) in mice were severely hypoxic (pO(2) app...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Selvendiran K,Bratasz A,Kuppusamy ML,Tazi MF,Rivera BK,Kuppusamy P

    更新日期:2009-11-01 00:00:00

  • Alcohol consumption and colon cancer prognosis among participants in north central cancer treatment group phase III trial N0147.

    abstract::Alcohol consumption is associated with a modest increased risk of colon cancer, but its relationship with colon cancer survival has not been elucidated. Using data from a phase III randomized adjuvant trial, we assessed the association of alcohol consumption with colon cancer outcomes. Patients completed a risk factor...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Phipps AI,Shi Q,Limburg PJ,Nelson GD,Sargent DJ,Sinicrope FA,Chan E,Gill S,Goldberg RM,Kahlenberg M,Nair S,Shields AF,Newcomb PA,Alberts SR,Alliance for Clinical Trials in Oncology.

    更新日期:2016-09-01 00:00:00

  • Cell surface changes observed in MC-29 virus-infected chicken-embryo fibroblast (CEC) cultures.

    abstract::By transmission and scanning electron microscopic studies of MC-29 virus-infected CEC cultures, C-type virus particles were detected in the medium of infected cultures, in infected cells and in intracellular vacuoles. Virus budding was also observed. In the scanning electron microscope (SEM) so-called blebs appeared o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Podmaniczky E,Szende B,Lapis K,Ferenc G

    更新日期:1976-10-15 00:00:00

  • SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL.

    abstract::Suppressor of cytokine signaling 3 (SOCS3), as a key regulator of cytokine signaling, has the potential to modulate numerous cellular processes. Its involvement in inflammatory disease is well established, and there is increasing evidence for a role in breast cancer as a regulator of signal transducers and activators ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Barclay JL,Anderson ST,Waters MJ,Curlewis JD

    更新日期:2009-04-15 00:00:00