Characterization of a small-cell-lung-carcinoma cell line from a patient with cancer-associated retinopathy.

Abstract:

:We examined the biologic properties of a small-cell-lung-carcinoma (SCLC) cell line (designated MN-1112) established from a patient with SCLC who showed paraneoplastic retinopathy syndrome. Morphologic and immunocytochemical analyses showed that MN-1112 cells possess features of the classic type of SCLC. MN-1112 cells grew in suspension forming relatively large clumps of cells with a doubling time of 72 hr. By light-microscope examination, the cells were relatively small and had scanty cytoplasm. The cells produced NSE, ACTH and CK (BB isozyme); they also expressed recoverin, a novel photoreceptor protein, detected by Northern-blot and Western-immunoblot analysis using human-recoverin-specific DNA probe and anti-bovine-recoverin polyclonal antibody. This report shows that human recoverin is expressed in cultured SCLC cells. Our results support the hypothesis that, in cancer-associated retinopathy (CAR) patients, auto-immune antibody targeting for ectopic recoverin in SCLC is initially produced and cross-reacts with the retinal protein, resulting in the retinal degeneration that occurs in CAR patients.

journal_name

Int J Cancer

authors

Yamaji Y,Matsubara S,Yamadori I,Sato M,Fujita T,Fujita J,Takahara J

doi

10.1002/(SICI)1097-0215(19960301)65:5<671::AID-IJC

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

671-6

issue

5

eissn

0020-7136

issn

1097-0215

pii

10.1002/(SICI)1097-0215(19960301)65:5<671::AID-IJC

journal_volume

65

pub_type

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