The 8.1 ancestral MHC haplotype is strongly associated with colorectal cancer risk.

abstract：:The current paradigm stipulates that inhibition of histone deacetylase (HDAC) 6 is essential for the combinatorial effect of proteasome and HDAC inhibitors for the treatment of cancers. Our study aims to investigate the effect of combining different class I HDAC inhibitors (without HDAC6 action) with a proteasome inhi...

journal_title：International journal of cancer

authors： Hui KF,Chiang AK

更新日期：2014-12-15 00:00:00

abstract：:Resistance to cisplatin is a major obstacle to successful treatment of head and neck squamous cell carcinoma (HNSCC). To investigate the molecular mechanism of this resistance, we compared the gene expression profiles between the cisplatin-sensitive SCC cell lines (Sa-3, H-1 and KB) and the cisplatin-resistant cell li...

journal_title：International journal of cancer

authors： Yamano Y,Uzawa K,Saito K,Nakashima D,Kasamatsu A,Koike H,Kouzu Y,Shinozuka K,Nakatani K,Negoro K,Fujita S,Tanzawa H

更新日期：2010-01-15 00:00:00

abstract：:Incidence rates of Wilms' tumor (WT) markedly differ in East Asian and Caucasian children. In the present study, we examined WT1 deletions/mutations and loss of heterozygosity (LOH) on 11p and 11q in a large number of WTs and compared our findings with those from 4 series of Caucasian WTs. Incidence rates of the subtl...

journal_title：International journal of cancer

authors： Nakadate H,Yokomori K,Watanabe N,Tsuchiya T,Namiki T,Kobayshi H,Suita S,Tsunematsu Y,Horikoshi Y,Hatae Y,Endo M,Komada Y,Eguchi H,Toyoda Y,Kikuta A,Kobayashi R,Kaneko Y

更新日期：2001-11-01 00:00:00

abstract：:The growth of 7/9 Burkitt's lymphoma (BL) cell lines and 5/6 human melanoma cell lines was inhibited by certain human fibroblast-like cell lines, especially human myofibroblast cell lines. In contrast to BL lines, 3/5 lymphoblastoid cell lines were less susceptible and 3/4 human leukaemic lines were resistant. The eff...

journal_title：International journal of cancer

authors： Wu KF,Pope JH,Ellem KA

更新日期：1985-04-15 00:00:00

abstract：:Chemotherapy with taxanes such as paclitaxel (PTX) is a key component of triple negative breast cancer (TNBC) treatment. PTX is used in combination with other drugs in both the adjuvant setting and in advanced breast cancer. Because a proportion of patients respond poorly to PTX or relapse after its use, a greater und...

journal_title：International journal of cancer

authors： Lasham A,Mehta SY,Fitzgerald SJ,Woolley AG,Hearn JI,Hurley DG,Ruza I,Algie M,Shelling AN,Braithwaite AW,Print CG

更新日期：2016-09-01 00:00:00

abstract：:Since it is difficult to predict the probability of persistent teratoma or of a viable tumor in patients with normalized tumor markers and a normal CT scan following chemotherapy for advanced stage testis cancer, recommendations regarding adjunctive surgery have ranged from observation to surgical exploration for all ...

journal_title：International journal of cancer

authors： Kuczyk M,Machtens S,Stief C,Jonas U

更新日期：1999-12-10 00:00:00

abstract：:We have previously developed 3 monoclonal anti-idiotypic antibodies (Ab2) of LOU rat origin directed against the binding site of the murine monoclonal IgM LAM8, which recognizes the small-cell lung carcinoma (SCLC)-associated sialoglycoprotein antigen sGP 90-135. The aim of this study was to compare the efficiencies o...

journal_title：International journal of cancer

authors： Lehmann HP,Zwicky C,Waibel R,Stahel RA

更新日期：1992-01-02 00:00:00

abstract：:Paclitaxel exerts its cytotoxic effect by kinetic suppression of microtubules that block cells in the G2/M phase of the cell cycle and trigger apoptosis. To investigate apoptosis induced by paclitaxel in nasopharyngeal carcinoma (NPC), and its possible molecular mechanism of action, the human NPC cell lines HNE-1 (bea...

journal_title：International journal of cancer

authors： Tan G,Heqing L,Jiangbo C,Ming J,Yanhong M,Xianghe L,Hong S,Li G

更新日期：2002-01-10 00:00:00

abstract：:In a previous study, human ZNF312b was identified as a cell proliferation-associated oncogene via the K-ras/extracellular signal-regulated kinase cascade in gastric cancer. However, the mechanism concerning its transcriptional activation remains unknown. Here, we show that DNA methylation and histone acetylation of th...

journal_title：International journal of cancer

authors： Song IS,Ha GH,Kim JM,Jeong SY,Lee HC,Kim YS,Kim YJ,Kwon TK,Kim NS

更新日期：2011-11-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...

journal_title：International journal of cancer

authors： Biran A,Brownstein M,Haklai R,Kloog Y

更新日期：2011-02-01 00:00:00

abstract：:Lethally X-irradiated LEW rats reconstituted with syngeneic bone marrow and given low-dose Cyclosporine A (CyA) for 5 weeks develop, after withdrawal of CyA, symptoms of disease resembling graft-vs.-host disease (GVHD) as seen after allogeneic bone-marrow transplantation. Symptoms of disease may include acute dermatit...

journal_title：International journal of cancer

authors： Wodzig KW,Beijleveld LJ,Damoiseaux JG,Arends JW,van Breda Vriesman PJ

更新日期：1997-07-29 00:00:00

abstract：:The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese populat...

journal_title：International journal of cancer

authors： Matsumoto K,Yasugi T,Nakagawa S,Okubo M,Hirata R,Maeda H,Yoshikawa H,Taketani Y

更新日期：2003-10-10 00:00:00

abstract：:Human papillomavirus (HPV) infection is the pathogenesis of anogenital cancers and genital warts in both men and women, whereas there is a scarcity of large studies focused on HPV prevalence in different anogenital sites of both sexes in the same population. From May to July 2014, 2,309 men and 2,378 women aged 18-55 ...

journal_title：International journal of cancer

authors： Wei F,Li M,Wu X,Yin K,Lan J,Sheng W,Guo M,Huang S,Wang Y,Li Y,Li R,Su Y,Wu T,Zhang J,Xia N

更新日期：2018-03-15 00:00:00

abstract：:Breast cancer screening is known to reduce breast cancer mortality. A high breast density may affect this reduction. We assessed the effect of screening on breast cancer mortality in women with dense and fatty breasts separately. Analyses were performed within the Nijmegen (Dutch) screening programme (1975-2008), whic...

journal_title：International journal of cancer

authors： van der Waal D,Ripping TM,Verbeek AL,Broeders MJ

更新日期：2017-01-01 00:00:00

abstract：:This phase I study tested the safety, feasibility, pharmacokinetics and pharmacodynamics of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion (HIPEC) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC) undergoing secondary cytoreductive surgery followed by p...

journal_title：International journal of cancer

authors： Zivanovic O,Abramian A,Kullmann M,Fuhrmann C,Coch C,Hoeller T,Ruehs H,Keyver-Paik MD,Rudlowski C,Weber S,Kiefer N,Poelcher ML,Thiesler T,Rostamzadeh B,Mallmann M,Schaefer N,Permantier M,Latten S,Kalff J,Thomale J,

更新日期：2015-02-01 00:00:00

abstract：:The independent effects of parity and age at first birth on breast cancer incidence are investigated in a 1% sample of women aged 16 to 59 from the 1971 Census of England and Wales. Over the period 1971-81, 1,003 breast cancer cases occurred in the cohort of 113,263 women who were either married, widowed or divorced a...

journal_title：International journal of cancer

authors： Leon DA

更新日期：1989-06-15 00:00:00

abstract：:Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in 5-year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is...

journal_title：International journal of cancer

authors： Garwicz S,Anderson H,Olsen JH,Winther JF,Sankila R,Langmark F,Tryggvadóttir L,Möller TR,Association of the Nordic Cancer Registries.,Nordic Society for Pediatric Hematology Oncology.

更新日期：2012-10-01 00:00:00

abstract：:Kaposi sarcoma (KS) is among the most common childhood malignancies in central, eastern, and southern Africa. Although its unique clinical features have been established, biological mechanisms related to the causative agent, KS-associated herpes-virus (KSHV), have yet to be explored in children. We performed a prospec...

journal_title：International journal of cancer

authors： El-Mallawany NK,Mehta PS,Kamiyango W,Villiera J,Peckham-Gregory EC,Kampani C,Krysiak R,Sanders MK,Caro-Vegas C,Eason AB,Ahmed S,Schutze GE,Martin SC,Kazembe PN,Scheurer ME,Dittmer DP

更新日期：2019-01-01 00:00:00

abstract：:Adult T-cell leukemia (ATL) is a retrovirus-associated leukemia with poor prognosis and often has deletions of the p16INK4a and p15INK4b genes on chromosome 9p21. The gene for methylthioadenosine phosphorylase (MTAP), a purine and methionine metabolic enzyme, resides approximately 100 Kb telomeric to the p16INK4a gene...

journal_title：International journal of cancer

authors： Hori Y,Hori H,Yamada Y,Carrera CJ,Tomonaga M,Kamihira S,Carson DA,Nobori T

更新日期：1998-01-05 00:00:00

abstract：:Analysis of the length of circulating DNA in plasma has been reported as a marker for solid tumor detection. We assessed the sensitivity and specificity of increased plasma DNA length to identify patients with head and neck squamous cell carcinoma (HNSCC) and monitor posttreatment disease status. Fifty-eight HNSCC pat...

journal_title：International journal of cancer

authors： Jiang WW,Zahurak M,Goldenberg D,Milman Y,Park HL,Westra WH,Koch W,Sidransky D,Califano J

更新日期：2006-12-01 00:00:00

abstract：:Quality of life outcomes provide essential information for patients and physicians in oncology care. However, the validity of progression-free survival (PFS) as a surrogate for quality of life, and the inclusion and reporting of quality of life endpoints in clinical trials, is unclear. We performed a retrospective stu...

journal_title：International journal of cancer

authors： Hwang TJ,Gyawali B

更新日期：2019-04-01 00:00:00

abstract：:Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those t...

journal_title：International journal of cancer

authors： Llauradó M,Abal M,Castellví J,Cabrera S,Gil-Moreno A,Pérez-Benavente A,Colás E,Doll A,Dolcet X,Matias-Guiu X,Vazquez-Levin M,Reventós J,Ruiz A

更新日期：2012-04-01 00:00:00

abstract：:Peripheral blood leukocytes from patients with confirmed pulmonary neoplasia were tested for cytotoxicity against cultured cells derived from lung tumours of various histological types, foetal and normal adult lung tissue and tumours arising in organs other than the lung. Leukocytes from 73 percent of patients were cy...

journal_title：International journal of cancer

authors： Vose BM,Moore M,Jack GD

更新日期：1975-02-15 00:00:00

abstract：:A general concern exists that cervical cancer screening using human papillomavirus (HPV) testing may lead to considerable overtreatment. We evaluated the trade-off between benefits and overtreatment among different screening strategies differing by primary tests (cytology, p16/Ki-67, HPV alone or in combinations), int...

journal_title：International journal of cancer

authors： Sroczynski G,Esteban E,Widschwendter A,Oberaigner W,Borena W,von Laer D,Hackl M,Endel G,Siebert U

更新日期：2020-08-15 00:00:00

abstract：:In colorectal cancer (CRC), hepatic arterial infusion (HAI) chemotherapy may convert primarily unresectable CRC liver metastases (CLM) into resectability, although the risk of metastatic recurrence remains high after CLM ablation. We investigated the role of antitumour immunity invoked by first-line oxaliplatin-HAI fo...

journal_title：International journal of cancer

authors： Abrahamsson H,Jensen BV,Berven LL,Nielsen DL,Šaltytė Benth J,Johansen JS,Larsen FO,Johansen JS,Ree AH

更新日期：2020-04-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have identified several loci contributing to lung cancer and COPD risk independently; however, inflammation-related pathways likely harbor additional lung cancer risk-associated variants in biologically relevant immune genes that differ dependent on COPD. We selected single nucle...

journal_title：International journal of cancer

authors： Watza D,Lusk CM,Dyson G,Purrington KS,Wenzlaff AS,Neslund-Dudas C,Soubani AO,Gadgeel SM,Schwartz AG

更新日期：2020-08-01 00:00:00

abstract：:The identification of specific tumor mRNA markers by reverse transcription-polymerase chain reaction might be a valuable diagnostic adjunct for the detection of breast cancer metastases in axillary sentinel lymph nodes (SLNs). In this study we have compared the diagnostic accuracy of an extensive histopathologic exami...

journal_title：International journal of cancer

authors： Manzotti M,Dell'Orto P,Maisonneuve P,Zurrida S,Mazzarol G,Viale G

更新日期：2001-09-20 00:00:00

abstract：:CD4(+) Th cells that are restricted by MHC class II molecules play an important role in the induction of antitumor immune responses. We have established a stable CD4(+) Th cell clone (Th35-1A) from the PBMCs of a patient with primary cutaneous melanoma. The Th cell clone is noncytolytic and proliferates specifically i...

journal_title：International journal of cancer

authors： Somasundaram R,Swoboda R,Caputo L,Lee A,Jackson N,Marincola FM,Guerry D,Herlyn D

更新日期：2003-04-10 00:00:00

abstract：:The utility of EBV load as a tumor marker in nasopharyngeal carcinoma (NPC) patients suggests that it might also serve as a screening test for individuals who are at high risk for developing NPC. We previously demonstrated that unaffected individuals from high-risk families had elevated anti-EBV antibody levels compar...

journal_title：International journal of cancer

authors： Yang X,Goldstein AM,Chen CJ,Rabkin CS,Chen JY,Cheng YJ,Hsu WL,Sun B,Diehl SR,Liu MY,Walters M,Shao W,Ortiz-Conde BA,Whitby D,Elmore SH,Gulley ML,Hildesheim A

更新日期：2006-02-01 00:00:00

abstract：:2-methoxyestradiol (2ME(2)) is an endogenous metabolite of estradiol with estrogen-receptor-independent antitumor and antiangiogenic activity. We examined the effects of 2ME(2) on the cellular proliferation of 8 human melanoma cell lines. We show that 2ME(2) inhibited cell proliferation by inducing apoptosis and an ar...

journal_title：International journal of cancer

authors： Dobos J,Tímár J,Bocsi J,Burián Z,Nagy K,Barna G,Peták I,Ladányi A

更新日期：2004-12-10 00:00:00