Abstract：
:Peripheral blood leukocytes from patients with confirmed pulmonary neoplasia were tested for cytotoxicity against cultured cells derived from lung tumours of various histological types, foetal and normal adult lung tissue and tumours arising in organs other than the lung. Leukocytes from 73 percent of patients were cytotoxic for lung-tumour derived cells compared with age- and sex-matched normal donors, while the frequencies of reactivity against normal adult lung-derived cells and cells from unrelated tumours (e.g. bladder, colon, breast) were 42 percent and 18 percent respectively. Leukocytes from lung cancer patients were also cytotoxic for cells derived from foetal lung but susceptibility to cytolysis was variable, cells from 13- and 14-week embryos revealing greatest reactivity (88 percent). Leukocytes from patients with a variety of tumours of non-pulmonary origin or with non-malignant conditions (including respiratory disorders) were also reactive with lung-tumour-derived target cells but with a lower overall frequency (35 percent) than those from lung-cancer patients. The significance of these cytotoxicity data for the existence of tumour-specific host immunoreactivity in lung neoplasia is discussed.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Vose BM,Moore M,Jack GDdoi
10.1002/ijc.2910150216keywords:
subject
Has Abstractpub_date
1975-02-15 00:00:00pages
308-20issue
2eissn
0020-7136issn
1097-0215journal_volume
15pub_type
杂志文章abstract：:KLF5 is a transcription factor that plays important roles in multiple physical and pathological processes, including cell growth, cell cycle regulation, and angiogenesis. To better characterize KLF5 function in bladder carcinogenesis, we established stable TSU-Pr1 cell clones expressing different levels of KLF5. These...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21533
更新日期：2006-03-15 00:00:00
abstract：:The sialosyl Lewis a antigen was identified in a ganglioside extract from a malignant human urothelial cell line (Hu 1703He) by fast atom bombardment mass spectrometry. The presence of this antigen in urothelial cell lines with varying tumorigenic properties was further studied using the 19-9 monoclonal antibody (MAb)...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910450635
更新日期：1990-06-15 00:00:00
abstract：:Understanding the role of signal transduction in regulating pathways responsible for cell growth, survival and apoptosis is critical for cancer therapy. We developed and characterized a HER2/neu and Fas overexpressing cell line (BNT.888 ACA2) from a salivary gland adenocarcinoma that arose in a HER2/neu transgenic mou...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21837
更新日期：2006-07-15 00:00:00
abstract：:Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. The efficacy of its antitumor activity largely depends on the level of intracellular ASS, whi...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22322
更新日期：2007-02-15 00:00:00
abstract：:Hybridomas producing syngeneic monoclonal antibodies (MAbs) were prepared by fusion of spleen cells of BALB/c mice, which were immunized with sublethal doses of RMB-I cells. This cell line originates from a Rauscher virus (R-MuLV)-induced myeloid leukemia and forms tumors when re-inoculated into mice. MAbs were charac...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910420121
更新日期：1988-07-15 00:00:00
abstract：:Melanocortin-1 receptor (MC1R) is a marker of melanoma risk in populations of European ancestry. However, MC1R effects on survival are much less studied. We investigated associations between variation at MC1R and survival in an international, population-based series of single primary melanoma patients enrolled into th...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29317
更新日期：2015-06-01 00:00:00
abstract：:We established gastric cancer-specific CD8+ T-cell (T(CD8+)) lines derived from different lymphocyte sources in the same patients by repeated stimulation with mitomycin-C-treated autologous tumor cells with low-dose interleukin-2, and we compared recognition patterns among the T(CD8+) derived from solid tumor, lymph n...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970611)71:6<978::aid-ijc
更新日期：1997-06-11 00:00:00
abstract：:The topic of this review is the role of stromal-epithelial interactions in normal and malignant prostatic growth. Because cell-cell interactions and androgens play such key roles in the prostate, the goal of this review will be to apply endocrinologic and developmental concepts to the understanding of normal and malig...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.11335
更新日期：2003-10-20 00:00:00
abstract：:A case of epidermodysplasia verruciformis in a patient from Upper-Volta is described. Slightly elevated, flat warts were observed on hands, feet, arms and legs, and pityriasis versicolor-like lesions were found mainly on the trunk. The patient showed no malignant tumors. Histological examination revealed hyperkeratosi...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910270511
更新日期：1981-05-15 00:00:00
abstract：:Estrogen signaling plays an important role in breast carcinogenesis. An increased understanding of estrogen gene targets and their effects will allow for more directed and effective therapies for individuals with breast cancer, particularly those with estrogen receptor positive tumors resistant to tamoxifen therapy. H...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.26239
更新日期：2012-05-15 00:00:00
abstract：:The interactions of MCF-7 tumor cells with human vascular endothelial cells (EC) and subendothelial extracellular matrices (ECM) were morphologically observed by electron microscopy and quantitatively evaluated by labelling tumor cells with 111Indium-oxine. MCF-7 tumor cells adhered more rapidly to ECM than to the api...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910400416
更新日期：1987-10-15 00:00:00
abstract：:The aim of this study was to determine whether the skin-sensitizing agent 2,4-dinitrofluorobenzene (DNFB) would elicit the same morphological and biochemical events that are characteristic of 12-O-tetradecanoylphorbol-13-acetate (TPA). While single applications of 0.1% or 0.2% DNFB produced only mild epidermal hyperpl...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910600420
更新日期：1995-02-08 00:00:00
abstract：:Previous studies have shown that the in vitro-selected adriamycin-resistant human small-cell lung-carcinoma cell line GLC4-ADR150 displays multidrug resistance as the result of 3-fold decreased DNA-topoisomerase II (topo II) activity and a 6-fold reduction in adriamycin accumulation. Not the MDR1 gene, but the MRP gen...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910610317
更新日期：1995-05-04 00:00:00
abstract：:The inhibitory effects of novel prodrugs, inclusion complexes of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid (GOFA) and auraptene (AUR) with beta-cyclodextrin (CD), on colon carcinogenesis were investigated using an azoxymethane (AOM)/dextran sodium sulfate (DSS) model. Male CD-1 (ICR) mice initiated wit...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24833
更新日期：2010-02-15 00:00:00
abstract：:Vaccination against oncogenic human papillomavirus (HPV) types is one key intervention for cervical cancer prevention. This follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the HPV-16/18 AS04-adjuvanted vaccine administered to young women aged 10...
journal_title：International journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1002/ijc.25887
更新日期：2011-11-01 00:00:00
abstract：:Although reproductive factors have been shown to be related to the composition of bile and functioning of the biliary system, their relationship with biliary tract cancer has not been studied in detail. Between 1984 and 1987 we conducted a case-control study of 75 women with cancer of the biliary tract and 252 control...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910570203
更新日期：1994-04-15 00:00:00
abstract：:Chromosome 17 is a frequent target during breast-cancer formation and progression. It has been shown to be affected by allele losses at multiple sites, as well as by DNA amplification. Our aim was to delineate a map of the genetic alterations on chromosome 17 in a given set of breast tumors. To this end we analyzed 15...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910560208
更新日期：1994-01-15 00:00:00
abstract：:Indoor air pollution (IAP) caused by cooking has been associated with lung cancer risk in retrospective case-control studies in developing and rural countries. We report the association of cooking conditions, fuel use, oil use, and risk of lung cancer in a developed urban population in a prospective cohort of women in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29020
更新日期：2015-02-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the treatment of HCC. In this study, two sorafenib-resistant HCC cell lines and a nude mouse subcutaneously tumor model were used to explore the possible mechanisms lead...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31022
更新日期：2017-12-15 00:00:00
abstract：:Epigenetic silencing of MLH1 is the most common cause of defective DNA mismatch repair in endometrial and colorectal cancers. We hypothesized that variation in the MLH1 gene might contribute to the risk for MLH1 methylation and epigenetic silencing. We undertook a case-control study to test for the association between...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22406
更新日期：2007-04-15 00:00:00
abstract：:Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tu...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33230
更新日期：2021-02-01 00:00:00
abstract：:In a case-control study on lung cancer, risk was analysed in relation to smoking habits and frequency of vegetable and fruit consumption. Lung cancer cases in West Sweden and population controls were interviewed using a questionnaire where the frequency of consumption of dietary items and smoking habits were assessed....
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21384
更新日期：2006-02-01 00:00:00
abstract：:As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. The present study was designed to investigate the combined effects of COX-1 and COX-2 selective inhibitors on spontaneous p...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20012
更新日期：2004-04-20 00:00:00
abstract：:A population-based case-control study was performed to evaluate the risk of endometrial cancer related to tamoxifen or toremifene treatment. All patients with breast cancer diagnosis since 1980 in Finland who subsequently developed an endometrial cancer by the end of 1995 and 3 matched controls were identified among t...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10454
更新日期：2002-07-20 00:00:00
abstract：:Artemisia asiatica Nakai has been used in traditional Asian medicine for the treatment of inflammatory and other disorders. Previous studies have revealed that the formulated ethanol extract (DA-9601) of A. asiatica has pronounced antioxidative and antiinflammatory activities and exhibits cytoprotective effects agains...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10489
更新日期：2002-08-01 00:00:00
abstract：:IL-21 is a member of the IL-2 cytokine family, produced by CD4+ T cells. We previously showed that immunotherapy (IT) with IL-21-transduced neuroblastoma cells (Neuro2a/IL-21) cured 33% of syngeneic mice bearing systemic NB. Here, we studied whether the removal of Treg cells could potentiate the therapeutic efficacy o...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25140
更新日期：2010-09-01 00:00:00
abstract：:Folate is required for biological methylation and nucleotide synthesis, aberrations of which are thought to be the mechanisms that enhance colorectal carcinogenesis produced by folate inadequacy. These functions of folate also depend on the availability of other B-vitamins that participate in "one-carbon metabolism," ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23599
更新日期：2008-08-01 00:00:00
abstract：:We investigated the expression pattern of the breast cancer associated gene LIV-1 on mRNA and protein level in 111 human breast cancer patients by in situ hybridization as well as immunohistochemistry and focused on the unknown potential of LIV-1 expression levels as a prognostic marker. To our knowledge, this is the ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21235
更新日期：2005-12-20 00:00:00
abstract：:Novel classes of drug that interfere with the signalling of the small G-protein Ras, the so-called Ras antagonists, are showing much promise as novel anti-cancer agents. In this study, we demonstrate that the novel Ras antagonist farnesylthiosalicylic acid (FTS) inhibits the growth of Colo 853 melanoma cells through a...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10213
更新日期：2002-04-01 00:00:00
abstract：:The present studies investigated the expression of the platelet-derived growth factor (PDGF) and PDGF-receptor genes in human meningiomas. Northern blot analysis demonstrated that all meningiomas examined expressed both the c-sis/PDGF-2 proto-oncogene and the PDGF-receptor gene. In situ hybridization localized the c-s...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910460106
更新日期：1990-07-15 00:00:00
