Lung cancer risks in relation to vegetable and fruit consumption and smoking.

abstract：:In order to update the findings of relative risk associated with cigarette smoking for lung cancer by histologic type in Japan, the data from a population-based cohort study of 91,738 men and women were analyzed. During 1990-1999, 422 lung cancer incident cases were identified. The relative risk for all incident cases...

journal_title：International journal of cancer

authors： Sobue T,Yamamoto S,Hara M,Sasazuki S,Sasaki S,Tsugane S,JPHC Study Group. Japanese Public Health Center.

更新日期：2002-05-10 00:00:00

abstract：:Oxidative stress plays a role in the regulation of cancer cell metastasis which involves cell invasion and adhesion that could be supported by ADAM proteins through the activities of their metalloprotease and disintegrin domains. We hypothesized that oxidative stress could act through the induction of ADAM9 protein in...

journal_title：International journal of cancer

authors： Mongaret C,Alexandre J,Thomas-Schoemann A,Bermudez E,Chéreau C,Nicco C,Goldwasser F,Weill B,Batteux F,Lemare F

更新日期：2011-08-15 00:00:00

abstract：:Human papillomavirus (HPV) genomes usually persist as episomal molecules in HPV associated preneoplastic lesions whereas they are frequently integrated into the host cell genome in HPV-related cancers cells. This suggests that malignant conversion of HPV-infected epithelia is linked to recombination of cellular and vi...

journal_title：International journal of cancer

authors： Luft F,Klaes R,Nees M,Dürst M,Heilmann V,Melsheimer P,von Knebel Doeberitz M

更新日期：2001-04-01 00:00:00

abstract：:Meibomian gland carcinoma (MGC) and basal cell carcinoma (BCC) are common eyelid carcinomas that exhibit highly dissimilar degrees of proliferation and prognoses. We address here the question of the differential mechanisms between these two eyelid cancers that explain their different outcome. A total of 102 confirmed ...

journal_title：International journal of cancer

authors： Zhang L,Huang X,Zhu X,Ge S,Gilson E,Jia R,Ye J,Fan X

更新日期：2016-03-15 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a cell plasticity process required for metastasis and chemoresistance of carcinoma cells. We report a crucial role of the signal adaptor proteins CRK and CRKL in promoting EMT and tumor aggressiveness, as well as resistance against chemotherapy in colorectal and pancreatic ca...

journal_title：International journal of cancer

authors： Franke FC,Slusarenko BO,Engleitner T,Johannes W,Laschinger M,Rad R,Nitsche U,Janssen KP

更新日期：2020-09-15 00:00:00

abstract：:Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...

journal_title：International journal of cancer

authors： Rashidkhani B,Akesson A,Lindblad P,Wolk A

更新日期：2005-12-10 00:00:00

abstract：:Family history of urogenital cancers has been associated with an increased risk of cancer at the same sites. To evaluate the risks of bladder, prostate and renal cell neoplasms for family history of urogenital cancers in first-degree relatives, we analysed data from a case-control study conducted in northern Italy bet...

journal_title：International journal of cancer

authors： Randi G,Pelucchi C,Negri E,Talamini R,Galeone C,Franceschi S,La Vecchia C

更新日期：2007-12-15 00:00:00

abstract：:We previously reported that exosomal nanoparticles secreted by human pancreatic tumoral cell lines decrease tumoral cell proliferation through the mitochondria-dependent apoptotic pathway, because of activation of pro-apoptotic phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and of glucose synthase kina...

journal_title：International journal of cancer

authors： Ristorcelli E,Beraud E,Mathieu S,Lombardo D,Verine A

更新日期：2009-09-01 00:00:00

abstract：:Studies in human, animal and cellular systems suggest that phenols from virgin olive oil are capable of inhibiting several stages in carcinogenesis, including metastasis. The invasion cascade comprises cell attachment to extracellular matrix components or basement membrane, degradation of basement membrane by proteoly...

journal_title：International journal of cancer

authors： Hashim YZ,Rowland IR,McGlynn H,Servili M,Selvaggini R,Taticchi A,Esposto S,Montedoro G,Kaisalo L,Wähälä K,Gill CI

更新日期：2008-02-01 00:00:00

abstract：:In this study the antigenic profile of Hodgkin (H) and Sternberg-Reed (SR) cells from cases of Hodgkin's disease was analysed using a large panel of monoclonal and polyclonal antibodies reactive with cells of lymphoid and haemotopoietic origin. The aim of this investigation was, firstly, to throw light on the origin o...

journal_title：International journal of cancer

authors： Stein H,Gerdes J,Schwab U,Lemke H,Mason DY,Ziegler A,Schienle W,Diehl V

更新日期：1982-10-15 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an important role in stress-responsive gene expression. Although primarily sensitive to hypoxia, HIF-1 signaling can be regulated by a number of stress factors including metabolic stress, growth factors and molecules present in the extracellular matrix (ECM). Degradation of ECM...

journal_title：International journal of cancer

authors： Surazynski A,Donald SP,Cooper SK,Whiteside MA,Salnikow K,Liu Y,Phang JM

更新日期：2008-03-15 00:00:00

abstract：:Invasiveness is one of the key features of aggressive prostate cancer; however, our understanding of the precise mechanisms effecting invasion remains limited. The ceramide hydrolyzing enzyme acid ceramidase (AC), overexpressed in most prostate tumors, causes an aggressive and invasive phenotype through downstream eff...

journal_title：International journal of cancer

authors： Beckham TH,Lu P,Cheng JC,Zhao D,Turner LS,Zhang X,Hoffman S,Armeson KE,Liu A,Marrison T,Hannun YA,Liu X

更新日期：2012-11-01 00:00:00

abstract：:Rat yolk-sac tumors were induced by intraperitoneal (i.p.) displacement of the visceral yolk sac in fetectomized W/Fu rats. Serum was obtained from each female rat prior to the pregnancy preceding the tumor-inducing procedure and then once a month during the induction period. The sera were analyzed for the presence of...

journal_title：International journal of cancer

authors： Lindvall ML,Alumets J,Sjögren HO

更新日期：1987-07-15 00:00:00

abstract：:Clinical trials utilizing strategies to manipulate tumor oxygenation, blood flow and angiogenesis are under way, although limited quantitative information exists regarding basic tumor pathophysiology. The current study utilized murine KHT fibrosarcomas, spontaneous mammary carcinomas and first-generation spontaneous t...

journal_title：International journal of cancer

authors： Fenton BM,Lord EM,Paoni SF

更新日期：2001-09-01 00:00:00

abstract：:We have previously described an inverse relationship between Cu-Zn superoxide dismutase (SOD) activity and invasiveness of a clone of human tongue cancer cells. In these cells, suppression of Cu-Zn SOD activity by transfection with anti-sense cDNA enhanced motility in vitro. The present studies were undertaken to dete...

journal_title：International journal of cancer

authors： Tanaka M,Kogawa K,Nishihori Y,Kuribayashi K,Nakamura K,Muramatsu H,Koike K,Sakamaki S,Niitsu Y

更新日期：1997-10-09 00:00:00

abstract：:The prognostic impact of distinct KRAS mutations in colorectal carcinomas is not fully characterized. We hypothesized that the prognostic impact of KRAS mutations is modulated by KRAS mutant allele-specific imbalance (MASI). KRAS MASI was assessed by sequencing electropherograms in KRAS-mutated colorectal carcinomas (...

journal_title：International journal of cancer

authors： Hartman DJ,Davison JM,Foxwell TJ,Nikiforova MN,Chiosea SI

更新日期：2012-10-15 00:00:00

abstract：:Trifluorothymidine (TFT) is part of the oral drug formulation TAS-102. Both 5-fluorouracil (5-FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross-resistance to 5-FU. Therefore, we examined whether mechanistic differences in cell death could underlie their different ...

journal_title：International journal of cancer

authors： Bijnsdorp IV,Peters GJ,Temmink OH,Fukushima M,Kruyt FA

更新日期：2010-05-15 00:00:00

abstract：:The protein C4.4A, a structural homologue of the urokinase-type plasminogen activator receptor, is a potential new biomarker in non-small cell lung cancer, with high levels of expression recently shown to correlate to poor survival of adenocarcinoma patients. In this study, C4.4A immunoreactivity in precursor lesions ...

journal_title：International journal of cancer

authors： Jacobsen B,Santoni-Rugiu E,Illemann M,Kriegbaum MC,Laerum OD,Ploug M

更新日期：2012-06-01 00:00:00

abstract：:There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer...

journal_title：International journal of cancer

authors： Solans M,Benavente Y,Saez M,Agudo A,Naudin S,Hosnijeh FS,Noh H,Freisling H,Ferrari P,Besson C,Mahamat-Saleh Y,Boutron-Ruault MC,Kühn T,Kaaks R,Boeing H,Lasheras C,Rodríguez-Barranco M,Amiano P,Huerta JM,Barricarte A

更新日期：2019-07-01 00:00:00

abstract：:Interleukin-10 (IL-10) is an inhibitory cytokine produced by various cell types. It exhibits strong sequence homology to BCRF-1 (viral IL-10, vIL-10), an open reading frame in the Epstein-Barr-virus (EBV) genome. Using in situ hybridization (ISH), polymerase chain reaction (PCR) and immunohistochemistry, we checked 41...

journal_title：International journal of cancer

authors： Yao M,Ohshima K,Suzumiya J,Kume T,Shiroshita T,Kikuchi M

更新日期：1997-07-29 00:00:00

abstract：:Esophageal cancer is a leading cause of cancer death, especially in developing countries. In high-risk regions, squamous cell carcinoma is the most common type of esophageal cancer, and its etiology remains poorly understood. The purpose of this study was to evaluate the association between human papillomavirus (HPV) ...

journal_title：International journal of cancer

authors： Gao GF,Roth MJ,Wei WQ,Abnet CC,Chen F,Lu N,Zhao FH,Li XQ,Wang GQ,Taylor PR,Pan QJ,Chen W,Dawsey SM,Qiao YL

更新日期：2006-09-15 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins, many of which play critical roles in tumor cell growth and survival. The ansamycin-based Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in Phase III clinical tes...

journal_title：International journal of cancer

authors： Yin X,Zhang H,Lundgren K,Wilson L,Burrows F,Shores CG

更新日期：2010-03-01 00:00:00

abstract：:Sperm protein 17 (Sp17) is an antigenic protein highly expressed in spermatozoa. Sp17 expression was demonstrated recently in multiple myeloma, suggesting that it may be a novel cancer-testis antigen. Expression of Sp17 mRNA and protein was examined in human ovarian tumors. Sp17 mRNA was evaluated by reverse transcrip...

journal_title：International journal of cancer

authors： Straughn JM Jr,Shaw DR,Guerrero A,Bhoola SM,Racelis A,Wang Z,Chiriva-Internati M,Grizzle WE,Alvarez RD,Lim SH,Strong TV

更新日期：2004-03-01 00:00:00

abstract：:A challenging task of the immune system is to fight cancer cells. However, a variety of human cancers educate immune cells to become tumor supportive. This is exemplified for tumor-associated macrophages (TAMs), which are polarized towards an anti-inflammatory and cancer promoting phenotype. Mechanistic explanations, ...

journal_title：International journal of cancer

authors： Weigert A,Schiffmann S,Sekar D,Ley S,Menrad H,Werno C,Grosch S,Geisslinger G,Brüne B

更新日期：2009-11-01 00:00:00

abstract：:Use of dietary supplements is rising in countries where colorectal cancer is prevalent. We conducted a systematic literature review and meta-analyses of prospective cohort studies on dietary supplement use and colorectal cancer risk. We identified relevant studies in Medline, Embase and Cochrane up to January 2013. Or...

journal_title：International journal of cancer

authors： Heine-Bröring RC,Winkels RM,Renkema JM,Kragt L,van Orten-Luiten AC,Tigchelaar EF,Chan DS,Norat T,Kampman E

更新日期：2015-05-15 00:00:00

abstract：:Actin, a highly conserved protein comprising cell stress fibers and other cellular structures, is found in both the cytoplasm and nucleus of cells and responds to both epigenetic signals and altered gene expression occurring during tumorigenesis. We have previously shown that changes in the cytoplasmic F- and G-actin ...

journal_title：International journal of cancer

authors： Rao JY,Bonner RB,Hurst RE,Liang YY,Reznikoff CA,Hemstreet GP 3rd

更新日期：1997-02-07 00:00:00

abstract：:The interactions which occur between antigenic tumor cells and normal or immune lymphoid cells in a 3-day in vitro culture, have been studied with a murine sarcoma virus (MSV)-induced tumor. The 3H-thymidine incorporation of lymphoma cells growing in suspension, and the radioactive-chromium release of freshly sampled ...

journal_title：International journal of cancer

authors： Senik A,Hebrero FP,Levy JP

更新日期：1975-12-15 00:00:00

abstract：:Androgen deprivation therapy (ADT) remains a key approach in the treatment of prostate cancer (PCa). However, PCa inevitably relapses and becomes ADT resistant. Besides androgens, there is evidence that thyroid hormone thyroxine (T4) and its active form 3,5,3'-triiodo-L-thyronine (T3) are involved in the progression o...

journal_title：International journal of cancer

authors： Aksoy O,Pencik J,Hartenbach M,Moazzami AA,Schlederer M,Balber T,Varady A,Philippe C,Baltzer PA,Mazumder B,Whitchurch JB,Roberts CJ,Haitel A,Herac M,Susani M,Mitterhauser M,Marculescu R,Stangl-Kremser J,Hassler MR,Kr

更新日期：2021-02-01 00:00:00

abstract：:The tumor-suppressor genes p14(ARF), p16(INK4a) and Tp53 are commonly inactivated in many tumors. We investigated their role in the pathogenesis of 9 bile tract cancer cell lines and 21 primary sporadic extrahepatic bile duct carcinomas. p53 and p16 protein expression was examined by Western blot analysis and immunohi...

journal_title：International journal of cancer

authors： Caca K,Feisthammel J,Klee K,Tannapfel A,Witzigmann H,Wittekind C,Mössner J,Berr F

更新日期：2002-02-01 00:00:00

abstract：:A new human cell line, designated Ty-82, was established from the pleural effusion of a 22-year-old woman with undifferentiated thymic carcinoma. This cell line consisted of primitive cells that were positive for alpha-naphthyl butyrate esterase and acid phosphatase. The cells were shown to express epithelial membrane...

journal_title：International journal of cancer

authors： Kuzume T,Kubonishi I,Takeuchi S,Takeuchi T,Iwata J,Sonobe H,Ohtsuki Y,Miyoshi I

更新日期：1992-01-21 00:00:00