Abstract:
:Meibomian gland carcinoma (MGC) and basal cell carcinoma (BCC) are common eyelid carcinomas that exhibit highly dissimilar degrees of proliferation and prognoses. We address here the question of the differential mechanisms between these two eyelid cancers that explain their different outcome. A total of 102 confirmed MGC and 175 diagnosed BCC cases were analyzed. Twenty confirmed MGC and twenty diagnosed BCC cases were collected to determine the telomere length, the presence of senescent cells, and the expression levels of the telomere capping shelterin complex, P53, and the E3 ubiquitin ligase Siah1. Decreased protein levels of the shelterin subunits, shortened telomere length, over-expressed Ki-67, and Bcl2 as well as mutations in P53 were detected both in MGC and BCC. It suggests that the decreased protein levels of the shelterin complex and the shortened telomere length contribute to the tumorigenesis of MGC and BCC. However, several parameters distinguish MGC from BCC samples: (i) the mRNA level of the shelterin subunits decreased in MGC but it increased in BCC; (ii) P53 was more highly mutated in MGC; (iii) Siah1 mRNA was over-expressed in BCC; (iv) BCC samples contain a higher level of senescent cells; (v) Ki-67 and Bcl2 expression were lower in BCC. These results support a model where a preserved P53 checkpoint in BCC leads to cellular senescence and reduced tumor proliferation as compared to MGC.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Zhang L,Huang X,Zhu X,Ge S,Gilson E,Jia R,Ye J,Fan Xdoi
10.1002/ijc.29882subject
Has Abstractpub_date
2016-03-15 00:00:00pages
1442-52issue
6eissn
0020-7136issn
1097-0215journal_volume
138pub_type
杂志文章abstract::Paraffin sections from 190 epithelial ovarian tumours, including 159 malignant and 31 benign epithelial tumours, were analysed immunohistochemically for expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16INK4A (p16). Most benign tumours showed no p16 expression in the tumour cells, whereas only...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1997-02-20 00:00:00
abstract::Ras expression induces increased expression and altered targeting of lysosomal proteases in multiple cell types, but the specific downstream cytoplasmic signaling pathways mediating these changes have not been identified. In this study, we compared the involvement of 3 major Ras effectors, Raf, phosphatidylinositol 3-...
journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21982
更新日期:2006-09-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1997-03-17 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-10-15 00:00:00
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pub_type: 杂志文章
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更新日期:1981-10-15 00:00:00
abstract::Although multiple myeloma (MM) is predominantly a disease of the elderly, few studies have focused on the identification of prognostic factors in this group of patients. Four hundred twenty five MM patients >65 years were uniformly treated with chemotherapy (MP or VCMP/VBAD). Multivariate analysis identified 4 factors...
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pub_type: 杂志文章
doi:10.1002/ijc.20491
更新日期:2004-12-10 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.23262
更新日期:2008-04-15 00:00:00
abstract::Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was ...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.20648
更新日期:2005-02-20 00:00:00
abstract::Resveratrol, which may occur in wine, was suggested to act as a chemopreventive agent against the carcinogenic effects of ethanol. The assumption was based on data from experimental animals, which have shown that resveratrol above certain thresholds may reduce the incidence of tumours in several of the alcohol-related...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28336
更新日期:2014-01-01 00:00:00
abstract::Chronic gastritis caused by Helicobacter pylori (H. pylori) infection could lead to the development of gastric cancer. The finding that multiple gastric cancers can develop synchronously and/or metachronously suggests the development of field cancerization in chronically inflamed, H. pylori-infected gastric mucosa. Th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31578
更新日期:2018-10-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20206
更新日期:2004-07-20 00:00:00
abstract::ECOG 1696 was a Phase II multi-center trial testing vaccination with melanoma peptides, gp100, MART-1 and tyrosinase delivered alone, with GM-CSF, IFN-α2b or both cytokines to HLA-A2(+) patients with metastatic melanoma. Here, the frequency of circulating CD8(+) tetramer(+) (tet(+) ) T cells and maturation stages of...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.26481
更新日期:2012-08-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24630
更新日期:2009-12-01 00:00:00
abstract::Due to the generally poor prognosis of head and neck squamous cell carcinoma (HNSCC), treatment has been intensified, these last decades, leading to an increase of serious side effects. High-risk human papillomavirus (HR-HPV) infection has been recently etiologically linked to a subset of oropharyngeal squamous cell c...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28847
更新日期:2015-04-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960126)65:3<314::AID-IJC
更新日期:1996-01-26 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960822)69:4<340::AID-IJC
更新日期:1996-08-22 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960422)69:2<125::AID-IJC
更新日期:1996-04-22 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980703)77:1<101::aid-ijc
更新日期:1998-07-03 00:00:00
abstract::Kaposi's sarcoma is currently the most common tumor in Zimbabwe. The purpose of our study is to compare the effectiveness of supportive care vs. 3 intervention approaches, namely oral Etoposide, a 3-drug combination, and radiotherapy using quality of life (QOL) as the primary measure of success. In addition, our study...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::Freshly isolated human peripheral blood monocytes from healthy volunteers are not cytotoxic to allogeneic A375 melanoma cells, but they were rendered tumoricidal by incubation in vitro with either liposomes containing 5 micrograms/mumol phospholipid of muramyl tripeptide phosphatidylethanolamine (liposome-MTP-PE; opti...
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更新日期:2021-01-27 00:00:00
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journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1989-02-15 00:00:00
abstract::PAX3 encodes a transcription factor, which with Zic1 is necessary for induction of the neural crest during early embryonic development. There are 7 human PAX3 isoforms (a-h). PAX3e is the full length isoform comprising 10 exons. PAX3c comprises 8 exons plus 5 codons of intron 8, while PAX3g has a truncated transactiva...
journal_title:International journal of cancer
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更新日期:2007-03-15 00:00:00
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journal_title:International journal of cancer
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abstract::A series of 111 human bladder tumors were screened using oligonucleotide mutant specific probes, restriction enzyme analysis and single-stranded confirmation polymorphism (SSCP) for the presence of H-ras activation events. Thirty-three tumors were found to harbor H-ras mutations where a glycine to valine (G-->T) chang...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1993-11-11 00:00:00
abstract::The protein C4.4A, a structural homologue of the urokinase-type plasminogen activator receptor, is a potential new biomarker in non-small cell lung cancer, with high levels of expression recently shown to correlate to poor survival of adenocarcinoma patients. In this study, C4.4A immunoreactivity in precursor lesions ...
journal_title:International journal of cancer
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更新日期:2012-06-01 00:00:00