Sister chromatid exchange in lymphoma line and lymphoblastoid cell lines before and after heterotransplantation into nude mice.

abstract：:We have reported the establishment of a mitomycin-C (MMC)-resistant non-small-cell lung-cancer cell line, PC-9/MC4. As determined by an MTT assay, this resistant cell line was found to be 4 times more sensitive to adriamycin (ADM) than was the parental PC-9. There were no significant differences in sensitivity to etop...

journal_title：International journal of cancer

authors： Kasahara K,Shibata K,Bando T,Numata Y,Fujimura M,Matsuda T

更新日期：1994-10-15 00:00:00

abstract：:Multiple myeloma, a neoplasm of plasma cells, accounts for approximately approximately 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates increase with age, particularly after age 40, and are higher in men, particularly African American men. The etiology is unknown with no esta...

journal_title：International journal of cancer

authors： Alexander DD,Mink PJ,Adami HO,Cole P,Mandel JS,Oken MM,Trichopoulos D

更新日期：2007-01-01 00:00:00

abstract：:The U.S. Preventive Services Task Force (USPSTF) recently updated their national lung screening guidelines and recommended low-dose computed tomography (LDCT) for lung cancer (LC) screening through age 80. However, the risk of overdiagnosis among older populations is a concern. Using four comparative models from the C...

journal_title：International journal of cancer

authors： Han SS,Ten Haaf K,Hazelton WD,Munshi VN,Jeon J,Erdogan SA,Johanson C,McMahon PM,Meza R,Kong CY,Feuer EJ,de Koning HJ,Plevritis SK

更新日期：2017-06-01 00:00:00

abstract：:To study the drug delivery to tumor by utilization of an oligopeptide transport activity, we examined the accumulation of dipeptides and the peptide-mimetic anti-cancer drug, bestatin, a substrate of oligopeptide transporter PepT1. Firstly, we established HeLa cells stably expressing human peptide transporter (hPepT1)...

journal_title：International journal of cancer

authors： Nakanishi T,Tamai I,Takaki A,Tsuji A

更新日期：2000-10-15 00:00:00

abstract：:Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to ampl...

journal_title：International journal of cancer

authors： Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch T

更新日期：1996-07-03 00:00:00

abstract：:Oligodeoxynucleotides containing CpG motifs (CpG-ODN) display broad immunostimulating activity and are currently under clinical trial in various malignancies, including recurrent glioblastomas. Combining CpG-ODN with another therapy that could induce antigen release might enhance tumor-specific immune response. We inv...

journal_title：International journal of cancer

authors： Meng Y,Carpentier AF,Chen L,Boisserie G,Simon JM,Mazeron JJ,Delattre JY

更新日期：2005-10-10 00:00:00

abstract：:Two putative genes (termed pro 1 and pro 2) specifying sensitivity to induction of neoplastic transformation by TPA in mouse epidermal JB6 cells were cloned by sib selection from a size-selected genomic library of clonal cells sensitive to promotion of transformation. By restriction analysis, heteroduplex analysis, di...

journal_title：International journal of cancer

authors： Lerman MI,Hegamyer GA,Colburn NH

更新日期：1986-02-15 00:00:00

abstract：:We have previously shown that anti-Ly-6C monoclonal antibody (MAb) 2B6-F2 identifies a subset of (CBA +/- C57BL/6)F1 splenic NK-1.1+ natural T (NT) cells which kill the NK-sensitive YAC-1 target in vitro. Furthermore, these Ly-6C+ cells are responsible for 40-50% of in vitro YAC-1 killing in all mouse strains tested. ...

journal_title：International journal of cancer

authors： Martiniello R,Burton RC,Smart YC

更新日期：1996-05-16 00:00:00

abstract：:The cytokines that regulate angiogenesis in normal and malignant prostate tissue are not well studied. Using an RT-PCR-based screen, we observed that cultured, low-passage normal human prostate epithelial cells (PrECs) express a variety of cytokines which have been shown to have angiogenic and/or endothelial cell-acti...

journal_title：International journal of cancer

authors： Campbell CL,Savarese DM,Quesenberry PJ,Savarese TM

更新日期：1999-03-15 00:00:00

abstract：:Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40,000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox reg...

journal_title：International journal of cancer

authors： Nielsen K,Måsbäck A,Olsson H,Ingvar C

更新日期：2012-08-01 00:00:00

abstract：:Expression of the MDR1 (P-glycoprotein) gene confers resistance to several classes of chemotherapeutic drugs (multi-drug resistance). Colon carcinomas frequently express high levels of MDR1 mRNA and P-glycoprotein, presumably reflecting the origin of these tumors from MDR1-expressing normal colonic cells. In 4 colon c...

journal_title：International journal of cancer

authors： Frommel TO,Coon JS,Tsuruo T,Roninson IB

更新日期：1993-09-09 00:00:00

abstract：:Nitric oxide may serve as one cofactor for human papillomavirus (HPV)-induced development of cervical cancer. Therefore, we first assessed the levels of cervical fluid nitric oxide metabolite (NOx) in 283 women with and without high-risk (hr) HPV. The NOx level in women with hr HPV (48.4 μmol/L [95% CI: 39.4-56.6], n ...

journal_title：International journal of cancer

authors： Rahkola P,Väisänen-Tommiska M,Tuomikoski P,Ylikorkala O,Mikkola TS

更新日期：2011-06-15 00:00:00

abstract：:Breast cancer (BC) and diabetes mellitus (DM) are major health problems. We examined the association between DM and BC stage at diagnosis and subsequent survival in a Finnish cohort of female BC patients. All BC cases (N = 73,170) diagnosed in 1995-2013 with dates and causes of death were identified from the Finnish C...

journal_title：International journal of cancer

authors： Murto MO,Artama M,Pukkala E,Visvanathan K,Murtola TJ

更新日期：2018-06-01 00:00:00

abstract：:To evaluate the role of chromosome 13 deletions in oral squamous cell carcinoma (SCC) progression and to define the precise localization of putative tumor suppressor genes, we studied tumors from 34 unrelated patients with oral SCC by the polymerase chain reaction (PCR)-loss of heterozygosity (LOH) assay, using 18 dif...

journal_title：International journal of cancer

authors： Ogawara K,Miyakawa A,Shiba M,Uzawa K,Watanabe T,Wang XL,Sato T,Kubosawa H,Kondo Y,Tanzawa H

更新日期：1998-08-21 00:00:00

abstract：:Epidemiologic studies indicate that human T-cell lymphotropic virus type I (HTLV-I), the causative agent of most cases of adult T-cell leukemia/lymphoma (ATLL) in Southeast Japan and the Caribbean islands and the probable cause of a progressive neurological disorder often referred to as tropical spastic paraparesis, o...

journal_title：International journal of cancer

authors： Levine PH,Blattner WA,Clark J,Tarone R,Maloney EM,Murphy EM,Gallo RC,Robert-Guroff M,Saxinger WC

更新日期：1988-07-15 00:00:00

abstract：:Morphologic and metabolic studies have been carried out on Friend leukemia cell (FLC) tumors (grown in DBA/2 mice) or fibrosarcomas (grown in C3H/HeN or C3H/HeJ mice) shortly after peritumoral injection of recombinant mouse tumor necrosis factor (TNF) alpha. Marked vascular congestion and focal extravasation of erythr...

journal_title：International journal of cancer

authors： Proietti E,Belardelli F,Carpinelli G,Di Vito M,Woodrow D,Moss J,Sestili P,Fiers W,Gresser I,Podo F

更新日期：1988-10-15 00:00:00

abstract：:We present an investigation of tumor pH regulation, designed to support a new anticancer therapy concept that we had previously proposed. Our study uses a tumor model of ras-transformed hamster fibroblasts, CCL39, xenografted in the thighs of nude mice. We demonstrate, for the first time, that genetic modifications of...

journal_title：International journal of cancer

authors： Chiche J,Le Fur Y,Vilmen C,Frassineti F,Daniel L,Halestrap AP,Cozzone PJ,Pouysségur J,Lutz NW

更新日期：2012-04-01 00:00:00

abstract：:The presented results show the effect of targeting of collagen receptor, alpha1beta1 integrin expressed on the endothelial cells on the development of experimental melanoma and pathological angiogenesis. Obtustatin, a snake venom KTS-disintegrin, was applied as a specific inhibitor of this integrin. This low molecular...

journal_title：International journal of cancer

authors： Brown MC,Staniszewska I,Del Valle L,Tuszynski GP,Marcinkiewicz C

更新日期：2008-11-01 00:00:00

abstract：:Normal human fibroblasts obtained from a whole embryo were malignantly transformed with only 60Co gamma rays, but after extensive passage. The fibroblasts were exposed intermittently to 60Co gamma rays, 13 times, 2,800 rads in total, from the primary culture to the 40th passage level. At the 50th passage level the cel...

journal_title：International journal of cancer

authors： Mihara K,Bai L,Kano Y,Miyazaki M,Namba M

更新日期：1992-02-20 00:00:00

abstract：:Limited penetration of anticancer drugs through tumour tissue is an important factor that may limit therapeutic effects against solid tumours. Here we report studies of the penetration of radiolabelled methotrexate through multicellular layers (MCL) of murine EMT-6 and human MCF-7 cells grown on semiporous teflon memb...

journal_title：International journal of cancer

authors： Cowan DS,Tannock IF

更新日期：2001-01-01 00:00:00

abstract：:Premature chromosome condensation (PCC) was studied in direct preparations of tissues from patients with haematological diseases and carcinomas of various histological types. PCC was found in 6 out of 166 malignancies (128 haematological cases, 35 carcinomas and 3 malignant effusions) analysed with the GTG-technique. ...

journal_title：International journal of cancer

authors： Kovacs G

更新日期：1985-12-15 00:00:00

abstract：:Tumor cells express the glycolytic regulator pyruvate kinase subtype M2 (M2-PK), which can occur in a tetrameric form with high affinity to its substrate phosphoenolpyruvate (PEP) and a dimeric form with a low PEP affinity. The transition between both conformations contributes to the control of glycolysis and is impor...

journal_title：International journal of cancer

authors： Spoden GA,Mazurek S,Morandell D,Bacher N,Ausserlechner MJ,Jansen-Dürr P,Eigenbrodt E,Zwerschke W

更新日期：2008-07-15 00:00:00

abstract：:JNK activity has been implicated in the malignant proliferation, invasion and drug-resistance of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently unknown. Here, we reported that MKK7, not MKK4, directly activates JNK in GCs and exerts oncogenic effects on tumor formation. Notabl...

journal_title：International journal of cancer

authors： Wang Y,Xia Y,Hu K,Zeng M,Zhi C,Lai M,Wu L,Liu S,Zeng S,Huang Z,Ma S,Yuan Z

更新日期：2019-11-01 00:00:00

abstract：:We previously reported that DX-8951f, a novel water-soluble camptothecin analog, significantly inhibits the growth of various human and murine tumors in vitro and in vivo. The antitumor effects and topoisomerase I inhibitory activity of DX-8951f are stronger than those of other current camptothecin analogs. In this st...

journal_title：International journal of cancer

authors： Joto N,Ishii M,Minami M,Kuga H,Mitsui I,Tohgo A

更新日期：1997-08-07 00:00:00

abstract：:A subline of the murine P815 mastocytoma passaged for a long period of time in histoincompatible hosts was found to be deficient in surface MHC class-I antigens by serological and biochemical methods. In agreement with the lack of restriction elements, this variant cell line was no longer susceptible to killing by cyt...

journal_title：International journal of cancer

authors： Bertschmann M,Käsermann D,Keller R

更新日期：1990-10-15 00:00:00

abstract：:The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cas...

journal_title：International journal of cancer

authors： Olsen AO,Gjøen K,Sauer T,Orstavik I,Naess O,Kierulf K,Sponland G,Magnus P

更新日期：1995-05-04 00:00:00

abstract：:Lung cancer is the leading cause of cancer mortality in the world. Although exposure to carcinogens is considered to be the main cause, genetic variation may contribute to lung cancer risk. Murine double minute 2, MDM2, is a key regulator of p53 activity and recently a polymorphism in the promoter region of the MDM2 g...

journal_title：International journal of cancer

authors： Lind H,Zienolddiny S,Ekstrøm PO,Skaug V,Haugen A

更新日期：2006-08-01 00:00:00

abstract：:We have employed the DNA-mediated gene transfer method to introduce the allogenic major-histocompatibility-complex(MHC)-class-I gene H-2Kb into the K36.16 tumor cells, H-2k, in order to generate tumor-specific immunity. The acquisition of immunogenicity by the H-2Kb-transformed clones following gene transfer is associ...

journal_title：International journal of cancer

authors： Chia KY,Lim SP,Oei AA,Sabapathy TK,Hui KM

更新日期：1994-04-15 00:00:00

abstract：:Regional lymph-node (LN) lymphocytes may constitute an important defence against the spread of human melanoma beyond regional LNs. The present study was directed to clonal analysis of lymphocytes cultured either directly from the LNs or after stimulation in cultures with autologous melanoma (MLTC). T-cell clones deriv...

journal_title：International journal of cancer

authors： Chen Q,Hersey P

更新日期：1992-05-08 00:00:00

abstract：:The association between subtypes of hepatitis C virus (HCV) and risk of hepatocellular carcinoma (HCC) remained inconclusive and evaluated in both case-control and cohort studies. In the case-control study, 397 HCC cases from medical centers were compared with 410 community-based non-HCC controls. All of them were ant...

journal_title：International journal of cancer

authors： Lee MH,Yang HI,Lu SN,Jen CL,You SL,Wang LY,L'Italien G,Chen CJ,Yuan Y,REVEAL-HCV Study Group.

更新日期：2014-09-01 00:00:00