Ly-6C+ natural T (NT) cells mediate immune surveillance against NK-sensitive and NK-resistant transplantable tumours in certain strains of mice.

abstract：:DCs hold promise for cancer immunotherapy due to their functional ambivalence: iDCs internalize antigens, then mDCs trigger naive T-cell activation. However, no consensus has been reached concerning the optimal mode of antigen acquisition for efficient cross-priming of TAA-specific CTLs, and this remains a field of in...

journal_title：International journal of cancer

authors： Labarrière N,Bretaudeau L,Gervois N,Bodinier M,Bougras G,Diez E,Lang F,Gregoire M,Jotereau F

更新日期：2002-09-20 00:00:00

abstract：:A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension ...

journal_title：International journal of cancer

authors： Stone KR,Mickey DD,Wunderli H,Mickey GH,Paulson DF

更新日期：1978-03-15 00:00:00

abstract：:Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. The mechanisms of enhanced bone resorption in patients with myeloma are not fully defined. We have previously identified the role of brain-derived neurotrophic factor (BDNF) in pr...

journal_title：International journal of cancer

authors： Sun CY,Chu ZB,She XM,Zhang L,Chen L,Ai LS,Hu Y

更新日期：2012-02-15 00:00:00

abstract：:The aim of this study was to examine the cellular distribution of osteopontin (OPN) protein [by immunohistochemical (IHC) analysis] and mRNA [by in situ hybridization (ISH)] in the primary tumors of lymph node negative (LNN) breast cancer patients and to determine whether the level of immunodetectable OPN may be assoc...

journal_title：International journal of cancer

authors： Tuck AB,O'Malley FP,Singhal H,Harris JF,Tonkin KS,Kerkvliet N,Saad Z,Doig GS,Chambers AF

更新日期：1998-10-23 00:00:00

abstract：:Membrane-type metalloproteinase-1 (MT1-MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro-MMP-2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP-2 activation that yields to the mature form is less understoo...

journal_title：International journal of cancer

authors： Sounni NE,Baramova EN,Munaut C,Maquoi E,Frankenne F,Foidart JM,Noël A

更新日期：2002-03-01 00:00:00

abstract：:In order to examine the role of cell surface laminin in tumor metastasis we have utilized four well-characterized murine fibrosarcoma cell lines. Two of these lines were highly metastatic when injected into syngeneic mice while the remaining two lines were significantly less metastatic. Using indirect immunofluorescen...

journal_title：International journal of cancer

authors： Malinoff HL,McCoy JP Jr,Varani J,Wicha MS

更新日期：1984-05-15 00:00:00

abstract：:Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women re...

journal_title：International journal of cancer

authors： Foerster M,McKenzie F,Zietsman A,Galukande M,Anele A,Adisa C,Parham G,Pinder L,Schüz J,McCormack V,Dos-Santos-Silva I

更新日期：2021-01-15 00:00:00

abstract：:We compared and contrasted intracranial (i.c.) and subcutaneous (s.c.) heterotransplantation of small-cell carcinoma of the lung (SCCL) into athymic nude mice. Fresh human SCCL tumor specimens, tumor colonies grown in soft agarose and continuous cell lines were used. Tumors induced by the three types of specimens were...

journal_title：International journal of cancer

authors： Gazdar AF,Carney DN,Sims HL,Simmons A

更新日期：1981-12-01 00:00:00

abstract：:The purpose of this analysis was to correlate isotope selection with the urinary symptoms of patients who received a combination of external beam radiotherapy (EBRT) and a transperineal interstitial permanent prostate brachytherapy (TIPPB) boost with either a (103)palladium ((103)Pd) or a (125)iodine ((125)I) radioiso...

journal_title：International journal of cancer

authors： Chen CT,Waterman FM,Valicenti RK,Gomella LG,Strup SE,Dicker AP

更新日期：2001-01-01 00:00:00

abstract：:Recent clinical trials have indicated that addition of tamoxifen (TAM) to a combination of cisplatin (DDP), carmustine and dacarbazine markedly increases the overall objective response rate of patients with metastatic malignant melanoma. Previous studies have determined that there is remarkable synergy between TAM and...

journal_title：International journal of cancer

authors： McClay EF,Albright KD,Jones JA,Christen RD,Howell SB

更新日期：1993-12-02 00:00:00

abstract：:We have previously reported that losses of genomic material from the long arm of chromosome 18 are frequent in atypical and anaplastic meningiomas but rare in benign meningiomas. In the present study, we have investigated a series of 37 meningiomas for mutation and expression of 4 tumor suppressor genes (MADH2, MADH4,...

journal_title：International journal of cancer

authors： Büschges R,Boström J,Wolter M,Blaschke B,Weber RG,Lichter P,Collins VP,Reifenberger G

更新日期：2001-05-15 00:00:00

abstract：:Hyaluronan (HA) has been shown to play crucial roles in the tumorigenicity of malignant tumors. Previous studies demonstrated that inhibition of HA suppressed the tumorigenicity of various malignant tumors including breast cancer. 4-methylumbelliferone (MU) has been reported to inhibit HA synthesis in several cell typ...

journal_title：International journal of cancer

authors： Urakawa H,Nishida Y,Wasa J,Arai E,Zhuo L,Kimata K,Kozawa E,Futamura N,Ishiguro N

更新日期：2012-01-15 00:00:00

abstract：:140.240, an IgG2a mouse monoclonal antibody raised against a cultured human melanoma cell line, was highly specific for melanoma cells as determined by direct and absorption analyses in a mixed hemadsorption assay. Supernatants of doubly cloned hybridomas producing antibody 140.240 reacted with all cultured and fresh ...

journal_title：International journal of cancer

authors： Liao SK,Clarke BJ,Khosravi M,Kwong PC,Brickenden A,Dent PB

更新日期：1982-11-15 00:00:00

abstract：:Paclitaxel is widely used to treat cancer patients through the blocking of mitosis and result in formation of polyploidy giant cancer cells (PGCCs), which are generally believed to be nondividing cells or in mitotic catastrophe. Here, we showed that PGCCs following the treatment of paclitaxel of MCF-7 breast cancer ce...

journal_title：International journal of cancer

authors： Zhang S,Mercado-Uribe I,Liu J

更新日期：2014-02-01 00:00:00

abstract：:The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...

journal_title：International journal of cancer

authors： Luckenbach GA,Layton D

更新日期：1981-06-15 00:00:00

abstract：:The p16INK4 gene is a candidate tumour-suppressor gene which maps to the genomic locus 9p21, and mutations of this gene are associated with melanoma and other cancers. Biochemical studies suggest that p16INK4 mediates its effects by specifically inhibiting the G1 cyclin-dependent kinases CDK4 and CDK6, thereby regulat...

journal_title：International journal of cancer

authors： Lilischkis R,Sarcevic B,Kennedy C,Warlters A,Sutherland RL

更新日期：1996-04-10 00:00:00

abstract：:The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food...

journal_title：International journal of cancer

authors： Linseisen J,Rohrmann S,Miller AB,Bueno-de-Mesquita HB,Büchner FL,Vineis P,Agudo A,Gram IT,Janson L,Krogh V,Overvad K,Rasmuson T,Schulz M,Pischon T,Kaaks R,Nieters A,Allen NE,Key TJ,Bingham S,Khaw KT,Amiano P,Bar

更新日期：2007-09-01 00:00:00

abstract：:In Japan, cervical cancer incidence has increased since the late 1990s especially among young women, despite a decreasing trend in most developed countries. Here, we examined age, period and birth cohort trends in cervical cancer incidence rates from 1985 to 2012. Incidence rates were ascertained using three populatio...

journal_title：International journal of cancer

authors： Utada M,Chernyavskiy P,Lee WJ,Franceschi S,Sauvaget C,de Gonzalez AB,Withrow DR

更新日期：2019-05-01 00:00:00

abstract：:Vaccination against oncogenic human papillomavirus (HPV) types is one key intervention for cervical cancer prevention. This follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the HPV-16/18 AS04-adjuvanted vaccine administered to young women aged 10...

journal_title：International journal of cancer

authors： Petäjä T,Pedersen C,Poder A,Strauss G,Catteau G,Thomas F,Lehtinen M,Descamps D

更新日期：2011-11-01 00:00:00

abstract：:This paper reports the results of 8 years of HLA typing of newly diagnosed nasopharyngeal carcinoma (NPC) patients among Chinese in Singapore, and compares the HLA profile of NPC cases with that of the normal Chinese population. Earlier results had indicated an association with A2 and BW46, but the heterogeneity of th...

journal_title：International journal of cancer

authors： Chan SH,Day NE,Kunaratnam N,Chia KB,Simons MJ

更新日期：1983-08-15 00:00:00

abstract：:This report describes maternal and perinatal risk factors for Wilms' tumor analyzed in a case-control study nested in a nationwide cohort in Sweden. The Swedish National Cancer Registry ascertained 110 cases from among successive birth cohorts from 1973 through 1984, identified by the Swedish Medical Birth Registry, t...

journal_title：International journal of cancer

authors： Lindblad P,Zack M,Adami HO,Ericson A

更新日期：1992-04-22 00:00:00

abstract：:Epidemiologic evidence on the association of antioxidant intake and prostate cancer incidence is inconsistent. Total antioxidant intake and prostate cancer incidence have not previously been examined. Using the ferric-reducing antioxidant potential (FRAP) assay, the total antioxidant content (TAC) of diet and suppleme...

journal_title：International journal of cancer

authors： Russnes KM,Wilson KM,Epstein MM,Kasperzyk JL,Stampfer MJ,Kenfield SA,Smeland S,Blomhoff R,Giovannucci EL,Willett WC,Mucci LA

更新日期：2014-03-01 00:00:00

abstract：:Although 45% of men and 39% of women will be diagnosed with cancer in their lifetime, it is difficult to predict which individuals will be affected. For some cancers, substantial progress in individual risk estimation has already been made. However, relatively few models have been developed to predict lung cancer risk...

journal_title：International journal of cancer

authors： Cassidy A,Duffy SW,Myles JP,Liloglou T,Field JK

更新日期：2007-01-01 00:00:00

abstract：:While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...

journal_title：International journal of cancer

authors： Jochems SHJ,Reulen RC,van Osch FHM,Witlox WJA,Goossens ME,Brinkman M,Giles GG,Milne RL,van den Brandt PA,White E,Weiderpass E,Huybrechts I,Hémon B,Agudo A,Bueno-de-Mesquita B,Cheng KK,van Schooten FJ,Bryan RT,Wesseliu

更新日期：2020-10-15 00:00:00

abstract：:Abnormal expression of homeobox genes may lead to the development of leukemias, lymphomas, and solid tumors. Expression of homeobox genes in mammary glands, however, has not been studied actively until recently. We have examined the expression of POU homeobox genes in human breast cancer cell lines and human breast ti...

journal_title：International journal of cancer

authors： Jin T,Branch DR,Zhang X,Qi S,Youngson B,Goss PE

更新日期：1999-03-31 00:00:00

abstract：:Using radioiodinated Staphylococcus aureus protein A [125I]SPA to measure syngeneic, allogeneic and heterogeneic IgG bound to murine tumor cells, we performed a serological analysis of surface antigens of 8 solid tumors and 2 leukemias of BALB/c mice (3 chemically-induced colon carcinomas, 3 chemically-induced sarcoma...

journal_title：International journal of cancer

authors： Cleveland PH,Belnap LP,Knotts FB,Nayak SK,Baird SM,Pilch YH

更新日期：1979-03-15 00:00:00

abstract：:We have used differential-display PCR (DD-PCR) to compare renal-cell carcinoma (RCC) and normal kidney gene expression with the aim of identifying genes specifically associated with RCC. Using a modified DD-PCR approach, which was non-radioactive, quicker and simpler than the conventional method, 24 cDNA samples were ...

journal_title：International journal of cancer

authors： Rae FK,Stephenson SA,Nicol DL,Clements JA

更新日期：2000-12-01 00:00:00

abstract：:In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...

journal_title：International journal of cancer

authors： Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

更新日期：1999-09-24 00:00:00

abstract：:Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...

journal_title：International journal of cancer

authors： Srour B,Plancoulaine S,Andreeva VA,Fassier P,Julia C,Galan P,Hercberg S,Deschasaux M,Latino-Martel P,Touvier M

更新日期：2018-11-15 00:00:00

abstract：:The modulation of DNA topology by topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and has thus become a highly attractive target for chemotherapeutic drugs. However, these drugs are highly toxic, and so new approaches are required. One such strategy is to target topoisom...

journal_title：International journal of cancer

authors： Barker CR,Hamlett J,Pennington SR,Burrows F,Lundgren K,Lough R,Watson AJ,Jenkins JR

更新日期：2006-06-01 00:00:00