Abstract:
:The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Axelson H,Panda CK,Klein Gdoi
10.1002/ijc.2910560322subject
Has Abstractpub_date
1994-02-01 00:00:00pages
418-21issue
3eissn
0020-7136issn
1097-0215journal_volume
56pub_type
杂志文章abstract::Human papillomavirus (HPV) is detected in nearly all cervical cancers and approximately half of vaginal cancers. However, vaginal cancer is an order of magnitude less common than cervical cancer, not only in the general population but also among women with HIV/AIDS. It is interesting therefore that recent studies foun...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27363
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abstract::Experimental and epidemiological data support a role for sex steroid hormones in the pathogenesis of endometrial cancer. The associations of pre-diagnostic blood concentrations of estradiol, estrone, testosterone, androstenedione, DHEAS and SHBG with endometrial cancer risk were investigated. A case-control study was ...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.11529
更新日期:2004-01-20 00:00:00
abstract::Use of herbal preparations containing Aristolochia species has led to progressive nephropathy and urothelial cancer in humans. Analysis of DNA adducts formed in human target tissues and studies in animal models have pointed out a major role of the secondary plant metabolites, aristolochic acids, in these effects. Only...
journal_title:International journal of cancer
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更新日期:2006-03-01 00:00:00
abstract::DNA-dependent protein kinase (DNA-PK) has been intensively investigated for its roles in the nonhomologous end-joining (NHEJ) pathway of DNA double-strand break repair and maintenance of genomic stability. Its catalytic subunit, DNA-PKcs, a serine/threonine protein kinase, has recently been reported to be overexpresse...
journal_title:International journal of cancer
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doi:10.1002/ijc.21093
更新日期:2005-11-20 00:00:00
abstract::To determine the relationship between p16MTS1/CDK4I expression, gene inactivation and 9p21 loss of heterozygosity (LOH) in the development of laryngeal carcinomas, we have examined p16MTS1/CDK4I protein and mRNA expression in a series of 7 normal and 36 tumoral tissues, and the presence of gene alterations and 9p21 LO...
journal_title:International journal of cancer
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更新日期:1999-05-31 00:00:00
abstract::To generate broad eating patterns, which could explain more adequately the breast cancer etiology, we conducted an exploratory factor analysis in Montevideo, Uruguay. The study included 442 newly diagnosed and microscopically confirmed cases with breast cancer and 442 hospitalized controls, with non-neoplastic disease...
journal_title:International journal of cancer
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更新日期:2006-10-01 00:00:00
abstract::ARID1A has been identified as a novel tumor suppressor gene in ovarian cancer and subsequently in various other tumor types. ARID1A belongs to the ARID domain containing gene family, which comprises of 15 genes involved, for example, in transcriptional regulation, proliferation and chromatin remodeling. In this study,...
journal_title:International journal of cancer
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abstract::There is a familial aggregation of prostate cancer, and 5 to 10% of all prostate cancers are estimated to be inherited in an autosomal-dominant mode. A population-based cohort study was performed in order to study familial prostate cancer and associated malignancies. A nation-wide register cohort study was conducted u...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1998-10-29 00:00:00
abstract::Expression of the monocyte chemoattractant protein-1 (MCP-1) was examined in human central nervous system tumours (glioblastomas and astrocytomas) and normal human brain. Northern blot analysis demonstrated constitutive expression of MCP-1 mRNA in 6 of 12 glioblastoma cell lines. Expression could be stimulated by inte...
journal_title:International journal of cancer
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更新日期:1994-07-15 00:00:00
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journal_title:International journal of cancer
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更新日期:2012-10-01 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:2012-06-15 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
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更新日期:2004-11-10 00:00:00
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journal_title:International journal of cancer
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更新日期:1992-05-28 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.27682
更新日期:2013-01-15 00:00:00
abstract::Occupational data from 5 case-control studies in the United States involving 2,973 male cases and 3,210 controls were analyzed to estimate the percentage of lung cancer attributable to well-known and suspected lung carcinogens. The studies were conducted in areas heterogeneous in terms of industrial activities. The pe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420610
更新日期:1988-12-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540609
更新日期:1993-07-30 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1997-04-22 00:00:00
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journal_title:International journal of cancer
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更新日期:1988-09-15 00:00:00
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journal_title:International journal of cancer
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abstract::Liver cancers are strongly linked to hepatitis B virus (HBV) and hepatitis C virus (HCV). Egypt has the highest prevalence of HCV worldwide and has rising rates of hepatocellular carcinoma (HCC). Egypt's unique nature of liver disease presents questions regarding the distribution of HBV and HCV in the etiology of HCC....
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of cancer
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更新日期:1999-07-02 00:00:00
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