Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB.

abstract：:Small-cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often correlated with poor pro...

journal_title：International journal of cancer

authors： Van Waardenburg RC,Meijer C,Burger H,Nooter K,De Vries EG,Mulder NH,De Jong S

更新日期：1997-11-14 00:00:00

abstract：:Preparations of stress protein gp96 from tumor cells are active as tumor vaccines by eliciting immune responses against mixtures of individual tumor peptide antigens which are complexed to gp96. Due to the individual antigenicity of tumors, a vaccine consisting of tumor-derived gp96 has to be prepared individually for...

journal_title：International journal of cancer

authors： Heike M,Frenzel C,Meier D,Galle PR

更新日期：2000-05-15 00:00:00

abstract：:Spreading is a critical process involved in motility and growth of tumor cells during the metastatic cascade. Focal adhesion kinase, src-proteins and PKC have been reported to participate in the regulation of cytoskeleton organization in both normal and transformed cells during spreading. The role of other signaling e...

journal_title：International journal of cancer

authors： Aguirre Ghiso JA,Farías EF,Alonso DF,Arregui C,Bal de Kier Joffé E

更新日期：1997-05-29 00:00:00

abstract：:In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...

journal_title：International journal of cancer

authors： Bellini A,Bessoltane-Bentahar N,Bhalshankar J,Clement N,Raynal V,Baulande S,Bernard V,Danzon A,Chicard M,Colmet-Daage L,Pierron G,Le Roux L,Planchon JM,Combaret V,Lapouble E,Corradini N,Thebaud E,Gambart M,Valteau-Cou

更新日期：2019-11-15 00:00:00

abstract：:To generate non-small cell lung cancer (NSCLC)-reactive lymphocytes, we transfected an HLA-A2-expressing human NSCLC line (1355) with the cDNA encoding the lymphocyte co-stimulatory molecule CD80. Following selection in G418, 1355.7 demonstrated stable cell-surface expression of CD80. Allogeneic mixed lymphocyte tumor...

journal_title：International journal of cancer

authors： Bixby DL,Yannelli JR

更新日期：1998-12-09 00:00:00

abstract：:The DNA of 22 fibrosarcomas, newly induced in BALB/c mice by subcutaneous doses of 3-methylcholanthrene (3-MCA), was tested in NIH 3T3 transformation assay. Activation of K-ras and N-ras was found in 7 and 3 cases respectively. No H-ras activation was detected. Polymerase chain reaction and oligonucleotide hybridizati...

journal_title：International journal of cancer

authors： Carbone G,Borrello MG,Molla A,Rizzetti MG,Pierotti MA,Della Porta G,Parmiani G

更新日期：1991-02-20 00:00:00

abstract：:Bcl-2 expression is up-regulated in prostate cancer cells after androgen ablation and associated with development of androgen independence and chemoresistance. We recently reported that antisense Bcl-2 oligodeoxynucleotides (ODNs) delay progression to androgen independence in the androgen-dependent (AD) human LNCaP pr...

journal_title：International journal of cancer

authors： Leung S,Miyake H,Zellweger T,Tolcher A,Gleave ME

更新日期：2001-03-15 00:00:00

abstract：:It is thought that TIL can be activated in vitro by rIL-2 and acquire specific anti-tumor activity. In this study, we investigated this possibility, using lymphocytes isolated from primary lung cancer tissues. In a first series of experiments, TILs and autologous PBLs from 16 patients were cultured in rIL-2 from 7 to ...

journal_title：International journal of cancer

authors： Yano T,Yasumoto K,Togami M,Ishida T,Kimura G,Sugimachi K,Nomoto K

更新日期：1989-04-15 00:00:00

abstract：:Residential proximity to electrical power lines of different voltage in relation to childhood leukemia was investigated through a case-control study undertaken in Greece during 1993-1994. The study comprised 117 incident cases of childhood leukemia and 202 age-, gender- and place-of-residence-matched controls. Four me...

journal_title：International journal of cancer

authors： Petridou E,Trichopoulos D,Kravaritis A,Pourtsidis A,Dessypris N,Skalkidis Y,Kogevinas M,Kalmanti M,Koliouskas D,Kosmidis H,Panagiotou JP,Piperopoulou F,Tzortzatou F,Kalapothaki V

更新日期：1997-11-04 00:00:00

abstract：:Cervical cancer and many other anogenital and oropharyngeal carcinomas are strongly associated with high-risk human papillomavirus (HPV) persistent infections. HPV E7 oncoprotein is the major viral transforming factor, emerging as a natural candidate for immunotherapy, since it is constitutively expressed in HPV-induc...

journal_title：International journal of cancer

authors： Cerutti ML,Alonso LG,Tatti S,de Prat-Gay G

更新日期：2012-04-15 00:00:00

abstract：:The effect that polymorphonuclear leukocytes (PMN) may have on the metastatic colonization of tumor cells is controversial: some laboratories have reported that PMN can inhibit metastasis whereas others have shown an augmentation effect. We have exploited our finding that a particular fibrosarcoma (BMT-11) transplante...

journal_title：International journal of cancer

authors： Ishikawa M,Koga Y,Hosokawa M,Kobayashi H

更新日期：1986-06-15 00:00:00

abstract：:Serum biomarkers are urgently needed for patient stratification and efficient treatment monitoring in pancreatic cancer (PC). Within a prospective diagnostic observation study, blood samples were obtained from 78 patients with advanced PC before and weekly during the course of palliative chemotherapy. Circulating nucl...

journal_title：International journal of cancer

authors： Wittwer C,Boeck S,Heinemann V,Haas M,Stieber P,Nagel D,Holdenrieder S

更新日期：2013-12-01 00:00:00

abstract：:In ovarian cancer cells, the macrophage colony-stimulating factor-1 (CSF-1) induces the release of plasminogen activator inhibitor-2 (PAI-2), and high levels of PAI-2 as well as of CSF-1 in ovarian cancer ascites are independently correlated with poor outcome. We now study the effect of CSF-1 on PAI-2 expression in vi...

journal_title：International journal of cancer

authors： Chambers SK,Ivins CM,Carcangiu ML

更新日期：1997-12-19 00:00:00

abstract：:We have examined, in proliferating neoplastic cells, the effect on DNA of EGTA (a chelator of Ca2+) and W7 (an inhibitor of calmodulin). The treatment results in release of single-stranded DNA fragments (2-10 kb) from pre-labelled HMW DNA. When DNA from synchronized neoplastic cells in S phase is examined, almost all ...

journal_title：International journal of cancer

authors： Lönn U,Lönn S

更新日期：1986-06-15 00:00:00

abstract：:Telomerase appears to be an important factor for the control of cellular proliferation capacity and for tumorigenesis. Enzyme activity is highly increased in almost all human tumors and distinguishes them from benign lesions. Besides its diagnostic value, telomerase activity appears to be associated with tumor progres...

journal_title：International journal of cancer

authors： Hoos A,Hepp HH,Kaul S,Ahlert T,Bastert G,Wallwiener D

更新日期：1998-02-20 00:00:00

abstract：:The effects on cell survival in tissue culture of Adriamycin, of various Adriamycin derivatives and of the parent compound, daunomycin, have been studied. Adriamycin and three of its C-14 derivatives show similar toxicities towards cells chronically exposed in culture. Acute (30 min) exposures are significantly less t...

journal_title：International journal of cancer

authors： Byfield JE,Lynch M,Kulhanian F,Chan PY

更新日期：1977-02-15 00:00:00

abstract：:We have previously shown that sensory nerve peptides contribute to the pathogenesis of pulmonary hypersensitivity reactions (HSRs) to paclitaxel in rats. Moreover, pemirolast, an antiallergic agent, reverses the HSRs to paclitaxel, although the mechanism is considered to result from the blockade of paclitaxel-induced ...

journal_title：International journal of cancer

authors： Yahata H,Saito M,Sendo T,Itoh Y,Uchida M,Hirakawa T,Nakano H,Oishi R

更新日期：2006-05-15 00:00:00

abstract：:In a series of consecutive 51chromium (51Cr) assays, 21 melanoma and 14 colo-rectal carcinoma patients were tested for their in vitro cell-mediated immune reactions to melanoma, rectal adenocarcinoma, and normal fibroblast target cells. Blood lymphocytes (BL) from four individuals were included in each experiment. In ...

journal_title：International journal of cancer

authors： Steele G Jr,Sjögren HO,Stadenberg I

更新日期：1976-01-15 00:00:00

abstract：:Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capaci...

journal_title：International journal of cancer

authors： Thomson DM

更新日期：1975-06-15 00:00:00

abstract：:Numbers of B, T and total lymphocytes, monocytes, heterophils, eosinophils and basophils have been examined in the peripheral blood of chickens between 2 and 42 days after infection with Marek's disease virus. During the stage of the acute restrictively productive virus infection of lymphoid tissues at 2-9 days after ...

journal_title：International journal of cancer

authors： Payne LN,Rennie M

更新日期：1976-10-15 00:00:00

abstract：:To identify genes associated with radioresistant oral squamous cell carcinoma (OSCC), we compared gene expression signatures between OSCC cell lines exhibiting radioresistance and cells with radiosensitivity after X-ray irradiation in a dose-dependent manner using Affymetrix GeneChip analysis with Human Genome-U133 pl...

journal_title：International journal of cancer

authors： Ishigami T,Uzawa K,Higo M,Nomura H,Saito K,Kato Y,Nakashima D,Shiiba M,Bukawa H,Yokoe H,Kawata T,Ito H,Tanzawa H

更新日期：2007-05-15 00:00:00

abstract：:Seven human ocular melanoma cell lines were established in vitro and 3 of these, GU-4, LLN-40 and its subline C17-11, were characterized. Mice were immunized with these ocular melanoma cell lines, and 2 hybridomas producing monoclonal IgG1 antibodies (MAb) were produced. MAb 2/10SN recognizes a 44-kDa monomeric protei...

journal_title：International journal of cancer

authors： Safi N,Kantor RR,Atkinson B,Moratz C,Wilt AR,Pancake S,Reba R,Mathieson BJ,Desgrez A

更新日期：1992-07-09 00:00:00

abstract：:Smoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops this disease. Although previously tobacco-derived carcinogens and enzyme polymorphisms have been identified to increase the risk for smokers, recent epidemiological data suggest even sex-specificity as a new and additional fac...

journal_title：International journal of cancer

authors： Stapelfeld C,Dammann C,Maser E

更新日期：2020-05-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is a morbid cancer with poor outcomes. Statins possess anticancer properties such as immunomodulatory and anti-inflammatory effects. The objective of our study is to identify the association between statin use among untreated HNSCC patients and overall death, disease-speci...

journal_title：International journal of cancer

authors： Getz KR,Bellile E,Zarins KR,Rullman C,Chinn SB,Taylor JMG,Rozek LS,Wolf GT,Mondul AM

更新日期：2020-12-15 00:00:00

abstract：:In a series of 87 primary breast tumors, somatostatin receptor (SSR) expression was detected by in vitro autoradiography in 58 tumors. In 41 tumors the SSR expression was homogeneous and in 17 it was heterogeneous. Although the tumors were not selected by the investigators upon entry in the study, examination of the t...

journal_title：International journal of cancer

authors： Bootsma AH,van Eijck C,Schouten KK,Reubi JC,Waser B,Foekens JA,van Pel R,Zwarthoff EC,Lamberts SW,de Klein A

更新日期：1993-05-28 00:00:00

abstract：:Colorectal cancer is the third most common form of malignancy, behind prostate and lung cancers. Despite recent advances in medicine, mortality from colorectal cancer remains high, highlighting the need for improved therapies. Numerous studies have demonstrated increased activation of EGFR and its family members (EGFR...

journal_title：International journal of cancer

authors： Nautiyal J,Banerjee S,Kanwar SS,Yu Y,Patel BB,Sarkar FH,Majumdar AP

更新日期：2011-02-15 00:00:00

abstract：:The role of plasma oxidant-antioxidant status in survival after breast cancer surgery was investigated in a cohort of patients (n = 363) hospitalized in Southern France between 1989 and 1992. The median follow-up was 8 years after surgery for histologically confirmed breast cancer. Plasma analyses were performed after...

journal_title：International journal of cancer

authors： Saintot M,Mathieu-Daude H,Astre C,Grenier J,Simony-Lafontaine J,Gerber M

更新日期：2002-02-10 00:00:00

abstract：:We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A). L1210-bearing DBA-2 mice were treated with increasing CGP 48664A doses from 1 day after i.p. L1210 cell inoculation. Treatment was continued for 4 days, after w...

journal_title：International journal of cancer

authors： Dorhout B,Te Velde RJ,Ferwerda H,Kingma AW,De Hoog E,Muskiet FA

更新日期：1995-04-10 00:00:00

abstract：:We have analyzed the BRAF locus on chromosome 7q34 with microsatellites for allelic changes and exons 11 and 15 of the BRAF with sequencing for mutations in 50 kidney cancers including 20 papillary, 15 conventional and 15 chromophobe renal cell carcinomas (RCC). Allelic changes at the BRAF locus were seen in 16 of the...

journal_title：International journal of cancer

authors： Nagy A,Balint I,Kovacs G

更新日期：2003-10-10 00:00:00

abstract：:The secretion of antibody by hybridoma cells allows the growth of individual cells to be measured by a hemolytic plaque assay. Similarly, plaque reduction assays were sensitive indicators of tumor immunity. A series of strains of hybridoma have been isolated from an original isolate which is sensitive to cytotoxic T c...

journal_title：International journal of cancer

authors： Ezaki T,Marbrook J

更新日期：1985-01-15 00:00:00