Abstract:
:The secretion of antibody by hybridoma cells allows the growth of individual cells to be measured by a hemolytic plaque assay. Similarly, plaque reduction assays were sensitive indicators of tumor immunity. A series of strains of hybridoma have been isolated from an original isolate which is sensitive to cytotoxic T cells and NK cells. In the derivation of a spleen-seeking variant, the cells appear to have lost immunogenic but not antigenic characteristics. This model lends itself to the quantitative study of immune constraints on tumor growth in vivo. Combined with the selection of tumor variants, the model is of wide application to many fields of tumor biology, particularly where sensitive measurement of tumor cell number and viability is crucial.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ezaki T,Marbrook Jdoi
10.1002/ijc.2910350117subject
Has Abstractpub_date
1985-01-15 00:00:00pages
107-11issue
1eissn
0020-7136issn
1097-0215journal_volume
35pub_type
杂志文章abstract::Epigenetic inactivation by aberrant DNA methylation has been reported for many microRNA genes in various human malignancies. However, relatively little is known about microRNA gene methylation in hepatocellular carcinoma (HCC). Therefore, a systematic screen for identification of aberrantly hypermethylated microRNA ge...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28068
更新日期:2013-08-01 00:00:00
abstract::Exfoliated nasopharyngeal (NP) cells from 62 normal Cantonese Chinese having IgA/VCA antibodies for more than a year and from 39 similar persons without IgA/VCA antibodies, were tested for the presence of EBV/DNA sequences by spot followed by blot hybridization tests, using the cloned internal repeat of B95-8 viral DN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910320504
更新日期:1983-11-15 00:00:00
abstract::To investigate the genetic changes that occur during establishment of gastric cancer cell lines, 4 gastric cancer cell lines and their original tumor tissues were examined for microsatellite instability (MSI), loss of heterozygosity (LOH), and p53 mutation. MSI status did not change during the establishment, though th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000815)87:4<512::aid-ijc8>3.0.
更新日期:2000-08-15 00:00:00
abstract::In Japan, cervical cancer incidence has increased since the late 1990s especially among young women, despite a decreasing trend in most developed countries. Here, we examined age, period and birth cohort trends in cervical cancer incidence rates from 1985 to 2012. Incidence rates were ascertained using three populatio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32014
更新日期:2019-05-01 00:00:00
abstract::Target-specific acute myeloid leukemia (AML) immunotherapy requires selective cell-surface antigens on AML blast cells. CD64 is a promising candidate antigen because it is abundantly expressed on monocytoid differentiated AML subtypes. In previous studies, a chemically linked full-length anti-CD64 immunotoxin based on...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25766
更新日期:2011-09-01 00:00:00
abstract::A study was conducted in northern Iran in areas of very high, high and moderately low incidence of oesophageal cancer. Morphine metabolites in urine as an indicator of opium use, and a variety of nutritional and biochemical measures, including salivary antipyrine half-life, were determined in households with a case of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350505
更新日期:1985-05-15 00:00:00
abstract::Adult T-cell leukemia (ATL) is a retrovirus-associated leukemia with poor prognosis and often has deletions of the p16INK4a and p15INK4b genes on chromosome 9p21. The gene for methylthioadenosine phosphorylase (MTAP), a purine and methionine metabolic enzyme, resides approximately 100 Kb telomeric to the p16INK4a gene...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980105)75:1<51::aid-ijc9
更新日期:1998-01-05 00:00:00
abstract::Limited data are available on the carcinogenicity of smokeless tobacco products in organs other than the mouth. Snus is a smokeless tobacco product widely used in Norway. We studied 10,136 Norwegian men enrolled since 1966 in a prospective cohort study, 31.7% of whom were exposed to snus. The relative risk of pancreat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20811
更新日期:2005-05-10 00:00:00
abstract::Fibronectin in human solid tumors was studied by indirect immunofluorescence staining of biopsy material. Altogether 73 tumors were examined, comprising 12 sarcomas, 3 melanomas 1 reticulum cell sarcoma, 39 carcinomas, 6 benign soft-tissue tumors and 12 benign epithelial tumors. In all sarcomas the individual tumor ce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270403
更新日期:1981-01-01 00:00:00
abstract::The role of the mismatch repair (MMR) system in correcting base-base mismatches is well established; its involvement in the response to DNA double strand breaks, however, is less clear. We investigated the influence of the essential component of MMR, the hMLH1 protein, on the cellular response to DNA-double strand bre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24893
更新日期:2010-06-15 00:00:00
abstract::A new cell line from a sporadic Wilms' tumor was established and extensively characterized. In nude mice, the tumor cells rapidly formed tumors which, in histological characteristics and extracellular-matrix (ECM) composition resembled sarcomatoid Wilms' tumor. The tumor cells produced B chains of laminin, but no A ch...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540524
更新日期:1993-07-09 00:00:00
abstract::In order to target NK cells against the Hodgkin's-derived cell line L540, we developed bispecific monoclonal antibodies (Bi-MAbs) by somatic hybridization of the 2 mouse hybridoma cell line HRS-3 and A9 which produce monoclonal antibodies (MAbs) with reactivity against the Hodgkin and Reed-Sternberg cell-associated CD...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550523
更新日期:1993-11-11 00:00:00
abstract::DT-diaphorase (DTD) is a flavoprotein which catalyzes obligate two-electron reduction of a diverse group of substrates. We have reported previously that non-tumorigenic mouse lung alveolar type-II pneumocytes have high DTD activity, while cell lines derived from lung tumors do not. In contrast, other investigators, us...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490126
更新日期:1991-08-19 00:00:00
abstract::Cytoskeleton and extracellular matrix-related proteins (CECMPs) represent the most common class of cancer mutants, owing to the large size of their coding regions and the randomness of mutagenesis. We used a bioinformatics approach to assess the impact of amino acid (AA) substitutions on the sensitivity of CECMPs to p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31111
更新日期:2018-03-01 00:00:00
abstract::Chile's gallbladder cancer rates are among the highest in the world, being the leading cause of cancer deaths among Chilean women. To provide insights into the etiology of gallbladder cancer, we conducted an ecologic study examining the geographical variation of gallbladder cancer and several putative risk factors. Th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23662
更新日期:2008-09-15 00:00:00
abstract::Dendritic cells (DCs) are antigen presenting cells that play a role in T-cell activation. Liver-associated natural killer T lymphocytes (NKTs) are a unique subset of lymphocytes that may be important in antitumor immunity. Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) expresses hepatitis B virus su...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11201
更新日期:2003-08-20 00:00:00
abstract::Over-expression of the HER2/neu (HER2) proto-oncogene in breast carcinoma imparts an enhanced metastatic potential. Metastasis requires escape of the tumor cell from the vasculature into subjacent tissue, a transmigration event across an endothelial cell (EC) monolayer. EC retraction has been reported to precede trans...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1061>3
更新日期:2001-02-01 00:00:00
abstract::We investigated the expression pattern of the breast cancer associated gene LIV-1 on mRNA and protein level in 111 human breast cancer patients by in situ hybridization as well as immunohistochemistry and focused on the unknown potential of LIV-1 expression levels as a prognostic marker. To our knowledge, this is the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21235
更新日期:2005-12-20 00:00:00
abstract::Limited penetration of anticancer drugs through tumour tissue is an important factor that may limit therapeutic effects against solid tumours. Here we report studies of the penetration of radiolabelled methotrexate through multicellular layers (MCL) of murine EMT-6 and human MCF-7 cells grown on semiporous teflon memb...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010101)91:1<120::aid-ijc1021>3
更新日期:2001-01-01 00:00:00
abstract::Cytological screening for cervical cancer is hampered by high false negative rates. Inter-observer reproducibility needs optimizing. The potential of p16(INK4a) as a biomarker for cervical lesions was examined in a study of liquid-based cytology (LBC), HPV DNA testing by MY09/MY11 consensus PCR and type-specific PCRs ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11589
更新日期:2004-03-01 00:00:00
abstract::Cancer incidence rates are presented for the Nairobi Cancer Registry, a population-based cancer registry (PBCR) covering the population of the capital city of Kenya (3.2 million inhabitants in 2009). Case finding was by active methods, with standard and checks for accuracy and validity. During the period 2004-2008 a t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29674
更新日期:2015-11-01 00:00:00
abstract::A subline of the murine P815 mastocytoma passaged for a long period of time in histoincompatible hosts was found to be deficient in surface MHC class-I antigens by serological and biochemical methods. In agreement with the lack of restriction elements, this variant cell line was no longer susceptible to killing by cyt...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460431
更新日期:1990-10-15 00:00:00
abstract::The evolution of precancerous cervical lesions is poorly understood. A widely held model of cervical intraepithelial neoplasia grade 3 (CIN3) development is sequential progression from normal through CIN1 and CIN2 to CIN3. Another hypothesis, the "molecular switch" model, postulates that CIN3 can evolve directly from ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31549
更新日期:2018-10-01 00:00:00
abstract::The influence of viremia on hepatic injury in patients infected with hepatitis C virus was examined by analysis of the relationship between alanine aminotransferase activity and the amount of hepatitis C virus RNA in sequential serum samples from I untreated patient with acute hepatitis C and 3 untreated patients with...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520510
更新日期:1992-11-11 00:00:00
abstract::This article describes the characteristics of 3 dominant features of breast cancer epidemiology. These characteristics include the association of disease risk with childbearing, its relationship to ovarian activity and its international variation (particularly as the latter differs in the years before and after menopa...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.21404
更新日期:2006-05-15 00:00:00
abstract::The presence of androgen receptor variant 7 (AR-V7) variants becomes a significant hallmark of castration-resistant prostate cancer (CRPC) relapsed from hormonal therapy and is associated with poor survival of CRPC patients because of lacking a ligand-binding domain. Currently, it still lacks an effective agent to tar...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30893
更新日期:2017-11-15 00:00:00
abstract::The most recent data available demonstrate a 120-fold difference between the lowest and highest incidence rates of prostatic cancer, the disease being very common in North America, particularly among Blacks, and in Scandinavia, while it is rare in Japan and other oriental countries. The highest mortality for prostatic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330210
更新日期:1984-02-15 00:00:00
abstract::Cervical cancer screening will rely, increasingly, on HPV testing as a primary screen. The requirement for triage tests which can delineate clinically significant infection is thus prescient. In this EUROGIN 2017 roadmap, justification behind the most evidenced triages is outlined, as are challenges for implementation...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.31261
更新日期:2018-08-15 00:00:00
abstract::Data from an international case-control study of breast cancer that was conducted in the 1960s were used to examine whether multiple births affect the risk of breast cancer in the mother. Among 2821 parous breast-cancer patients, 88 had had one or more multiple births, whereas among 8882 controls 247 had had one or mo...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910540114
更新日期:1993-04-22 00:00:00
abstract::Ocular adnexal MALT lymphoma (OAML) is linked to Chlamydophila psittaci (Cp) infection. Viability and infectivity of Cp, demonstrated by growth in culture, has not been yet investigated in these patients. We conducted a single-center prospective case-control study to assess the prevalence, viability and infectivity of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23596
更新日期:2008-09-01 00:00:00