Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer.

abstract：:The hepatitis B virus (HBV) is a major causative agent of chronic liver disease and subsequent liver cirrhosis worldwide. The reduced sensitivity of virus-infected liver cells to apoptosis may play a role in the failure to remove virus-infected cells and eventually promote viral chronicity. The purpose of our study wa...

journal_title：International journal of cancer

authors： Barreiros AP,Sprinzl M,Rosset S,Höhler T,Otto G,Theobald M,Galle PR,Strand D,Strand S

更新日期：2009-01-01 00:00:00

abstract：:Activating Ras mutations are involved in a significant fraction of human tumors. A suppressor screen using a retroviral mouse fibroblast cDNA library was performed to identify novel factors in Ras-mediated transformation. We identified a novel potent inhibitor of Ras-mediated morphological transformation encoded by a ...

journal_title：International journal of cancer

authors： Bjørndal B,Myklebust LM,Rosendal KR,Myromslien FD,Lorens JB,Nolan G,Bruland O,Lillehaug JR

更新日期：2007-03-01 00:00:00

abstract：:Gastric cancer is the second most common cause of cancer deaths worldwide. The identification of molecular genetic parameters that are associated with response to chemotherapy and prognosis is of utmost interest. We examined methylation of the apoptosis-related genes, TMS1 and DAPK, in 81 primary gastric cancers using...

journal_title：International journal of cancer

authors： Kato K,Iida S,Uetake H,Takagi Y,Yamashita T,Inokuchi M,Yamada H,Kojima K,Sugihara K

更新日期：2008-02-01 00:00:00

abstract：:Loss of cell polarity is one of the hallmarks of malignant carcinomas. Most of the understanding about the link between cell polarity and proliferation control comes from studies on the Drosophila tumor suppressors discs large (Dlg), scribble (Scrib) and lethal giant larvae (lgl). Mammalian homologues of these protein...

journal_title：International journal of cancer

authors： Gardiol D,Zacchi A,Petrera F,Stanta G,Banks L

更新日期：2006-09-15 00:00:00

abstract：:Somatic cell hybrids have been made between a transformed mouse bladder carcinoma cell line and normal mouse bladder epithelium and mesenchyme. In the epithelial tumour/mesenchyme hybrids the malignant phenotype was expressed dominantly whereas in the carcinoma/normal epithelium hybrids the malignant potential was gre...

journal_title：International journal of cancer

authors： Cowell JK,Franks LM

更新日期：1984-05-15 00:00:00

abstract：:Membrane-type metalloproteinase-1 (MT1-MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro-MMP-2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP-2 activation that yields to the mature form is less understoo...

journal_title：International journal of cancer

authors： Sounni NE,Baramova EN,Munaut C,Maquoi E,Frankenne F,Foidart JM,Noël A

更新日期：2002-03-01 00:00:00

abstract：:Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly...

journal_title：International journal of cancer

authors： Hou X,Tao Y,Pang Y,Li X,Jiang G,Liu Y

更新日期：2018-12-15 00:00:00

abstract：:The objective of this study was to assess the utility of a second generation human papillomavirus (HPV) virus-like particle (VLP)-based ELISA as an adjunct to HPV DNA testing to identify women at risk for high-grade cervical intraepithelial neoplasia (CIN). Participants provided blood, cervical samples and interviewer...

journal_title：International journal of cancer

authors： Einstein MH,Studentsov YY,Ho GY,Fazzari M,Marks M,Kadish AS,Goldberg GL,Runowicz CD,Burk RD

更新日期：2007-01-01 00:00:00

abstract：:Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital-based case-control study, we tested the hypothesis that a C to T variant (Thr241Met) of DNA...

journal_title：International journal of cancer

authors： Shen H,Sturgis EM,Dahlstrom KR,Zheng Y,Spitz MR,Wei Q

更新日期：2002-06-20 00:00:00

abstract：:Conversion of solid sarcomas and carcinomas into ascites tumors depends on the in vivo selection of phenotypically altered tumor cell variants that can grow in the dissociated form. Once selected, they retain this property even after prolonged s.c. growth as solid tumors. From an s.c.-passaged subline of an ascites-co...

journal_title：International journal of cancer

authors： Minarovits J,Steinitz M,Boldog F,Imreh S,Wirschubsky Z,Ingvarsson S,Hedenskog M,Minarovits-Kormuta S,Klein G

更新日期：1990-03-15 00:00:00

abstract：:To evaluate the incidence of second malignant tumors in a cohort of subjects previously treated for childhood cancer, we analyzed data from the Off-Therapy Registry (OTR) of the Italian Association of Pediatric Hematology/Oncology, which collects information on children treated for Hodgkin's disease, non-Hodgkin's lym...

journal_title：International journal of cancer

authors： Rosso P,Terracini B,Fears TR,Jankovic M,Fossati Bellani F,Arrighini A,Carli M,Cordero di Montezemolo L,Garrè ML,Guazzelli C

更新日期：1994-11-15 00:00:00

abstract：:Representational difference analysis was used to identify genes that are expressed in a human melanoma cell line and not in normal skin. A cDNA clone that appeared to be specific for tumors was obtained and the corresponding gene was sequenced. This new gene was named LAGE-I. Using a LAGE-I probe to screen a cDNA libr...

journal_title：International journal of cancer

authors： Lethé B,Lucas S,Michaux L,De Smet C,Godelaine D,Serrano A,De Plaen E,Boon T

更新日期：1998-06-10 00:00:00

abstract：:While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...

journal_title：International journal of cancer

authors： Jochems SHJ,Reulen RC,van Osch FHM,Witlox WJA,Goossens ME,Brinkman M,Giles GG,Milne RL,van den Brandt PA,White E,Weiderpass E,Huybrechts I,Hémon B,Agudo A,Bueno-de-Mesquita B,Cheng KK,van Schooten FJ,Bryan RT,Wesseliu

更新日期：2020-10-15 00:00:00

abstract：:The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food...

journal_title：International journal of cancer

authors： Linseisen J,Rohrmann S,Miller AB,Bueno-de-Mesquita HB,Büchner FL,Vineis P,Agudo A,Gram IT,Janson L,Krogh V,Overvad K,Rasmuson T,Schulz M,Pischon T,Kaaks R,Nieters A,Allen NE,Key TJ,Bingham S,Khaw KT,Amiano P,Bar

更新日期：2007-09-01 00:00:00

abstract：:The activity of ecto-nucleotidases has been determined on intact cells from Burkitt lymphoma (BL) and lymphoblastoid cell lines established in vitro (LCLs). BL cells never express ecto-5'-nucleotidase (5'-N) and exhibit only low levels of ecto-ATPase activity, whereas LCL-cells usually express both enzymes to varying ...

journal_title：International journal of cancer

authors： Gutensohn W,Jahn H

更新日期：1988-03-15 00:00:00

abstract：:Our objective was to examine whether parental exposure to atomic bomb radiation has led to increased cancer and/or noncancer mortality rates among the offspring. We studied 41,010 subjects born from May 1946 through December 1984 (i.e., conceived between 1 month and 38 years after the bombings) and surviving for at le...

journal_title：International journal of cancer

authors： Izumi S,Suyama A,Koyama K

更新日期：2003-11-01 00:00:00

abstract：:Acrylamide, a probable human carcinogen, is formed during the cooking of many commonly consumed foods. Data are scant on whether dietary acrylamide represents an important cancer risk in humans. We studied the association between acrylamide and prostate cancer risk using 2 measures of acrylamide exposure: intake from ...

journal_title：International journal of cancer

authors： Wilson KM,Bälter K,Adami HO,Grönberg H,Vikström AC,Paulsson B,Törnqvist M,Mucci LA

更新日期：2009-05-15 00:00:00

abstract：:Suramin has been shown to have antiproliferative activity, either by blocking the binding of growth factors to their receptors or by inhibiting critical cellular enzymes. In 6 different cell lines from 5 tumour types (MCF-7, MCF-7/ADRR, PC3, HT-29, UM-SCC-11B and SW-1573/IR500), we studied the effect of scheduling of ...

journal_title：International journal of cancer

authors： Lopez Lopez R,Peters GJ,van Loenen AC,Pizao PE,van Rijswijk RE,Wagstaff J,Pinedo HM

更新日期：1992-07-30 00:00:00

abstract：:There are no reliable serologic tumor markers for transitional cell carcinoma (TCC) of the urinary bladder and noninvasive urine investigations are inadequate. We used fluorescent microsatellite analysis (MSA) to detect serum DNA and urine-sediment DNA alterations in patients with bladder cancer and prospectively coll...

journal_title：International journal of cancer

authors： von Knobloch R,Hegele A,Brandt H,Olbert P,Heidenreich A,Hofmann R

更新日期：2001-10-01 00:00:00

abstract：:Renewed interest in the use of therapeutic enzymes combined with an improved knowledge of cancer cell metabolism, has led to the translation of several arginine depletion strategies into early phase clinical trials. Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginos...

journal_title：International journal of cancer

authors： Fultang L,Vardon A,De Santo C,Mussai F

更新日期：2016-08-01 00:00:00

abstract：:The prognostic impact of distinct KRAS mutations in colorectal carcinomas is not fully characterized. We hypothesized that the prognostic impact of KRAS mutations is modulated by KRAS mutant allele-specific imbalance (MASI). KRAS MASI was assessed by sequencing electropherograms in KRAS-mutated colorectal carcinomas (...

journal_title：International journal of cancer

authors： Hartman DJ,Davison JM,Foxwell TJ,Nikiforova MN,Chiosea SI

更新日期：2012-10-15 00:00:00

abstract：:Low ionic strength (50 to 100 mM NaCl) and pH 6.0 were found to be optimal conditions for in vitro conversion of Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA)-negative nuclei to EBNA-positive nuclei by addition of the complement-fixing (CF) antigen extracted from Raji cells. In vitro conversion of nuclei ...

journal_title：International journal of cancer

authors： Hirsch I,Suchánková A,Závadová H,Vonka V

更新日期：1978-11-15 00:00:00

abstract：:Dendritic cells (DCs) and natural killer (NK) cells are key players at the interface between innate resistance and acquired immunity. NK cells can induce DC maturation, a differentiation process whereby DCs respond to a environmental stimulus and acquire the ability of eliciting adaptive immunity. Conversely, maturing...

journal_title：International journal of cancer

authors： Capobianco A,Rovere-Querini P,Rugarli C,Manfredi AA

更新日期：2006-12-15 00:00:00

abstract：:Cancer incidence disparities exist among specific Asian American populations. However, the existing reports exclude data from large metropoles like Chicago, Houston and New York. Moreover, incidence rates by subgroup have been underestimated due to the exclusion of Asians with unknown subgroup. Cancer incidence data f...

journal_title：International journal of cancer

authors： Jin H,Pinheiro PS,Xu J,Amei A

更新日期：2016-05-01 00:00:00

abstract：:Retinoids are a group of vitamin A analogues that have shown promise as chemopreventive and therapeutic agents in many types of malignancy and have been entered in clinical trials with some successful results. To better understand the mechanism that mediates retinoid action and the anti-proliferative effects, we treat...

journal_title：International journal of cancer

authors： Giannini F,Maestro R,Vukosavljevic T,Pomponi F,Boiocchi M

更新日期：1997-01-17 00:00:00

abstract：:Although reproductive factors have been shown to be related to the composition of bile and functioning of the biliary system, their relationship with biliary tract cancer has not been studied in detail. Between 1984 and 1987 we conducted a case-control study of 75 women with cancer of the biliary tract and 252 control...

journal_title：International journal of cancer

authors： Moerman CJ,Berns MP,Bueno de Mesquita HB,Runia S

更新日期：1994-04-15 00:00:00

abstract：:The insulin like growth factor (IGF) signaling pathway has been shown to contribute to melanoma progression, but little is known about the role of the IGF binding protein 3 (IGFBP-3) in melanoma biology. The aim of the present study was to characterize expression, function and regulation of IGFBP-3 in malignant melano...

journal_title：International journal of cancer

authors： Oy GF,Slipicevic A,Davidson B,Solberg Faye R,Maelandsmo GM,Flørenes VA

更新日期：2010-01-15 00:00:00

abstract：:MAGE-1 and MAGE-3 or -6 are genes encoding melanoma-rejection antigens recognized by cytotoxic T lymphocytes in an HLA-A1 restriction manner. MAGE-1 and MAGE-3 or -6 were expressed in 5/14 (36%) and 6/14 (43%) neuroblastoma (NB) cell lines, and in 20/41 (49%) and 24/41 (59%) clinical NB-related tumors, respectively. A...

journal_title：International journal of cancer

authors： Ishida H,Matsumura T,Salgaller ML,Ohmizono Y,Kadono Y,Sawada T

更新日期：1996-10-21 00:00:00

abstract：:In an ongoing case-control study in Athens on the etiology of hepatocellular carcinoma (HCC), an analysis was made in order to assess whether HCV genotype 1b is associated with hepatocellular carcinoma (HCC). The HCV genotype was determined in 17 HCC patients, 87 patients with chronic hepatitis C (CHC) without cirrhos...

journal_title：International journal of cancer

authors： Hatzakis A,Katsoulidou A,Kaklamani E,Touloumi G,Koumantaki Y,Tassopoulos NC,Karvountzis G,Gioustozi A,Hadziyannis S,Trichopoulos D

更新日期：1996-09-27 00:00:00

abstract：:A randomized screening trial was started in Europe to show the effect of early detection and treatment of prostate cancer on mortality (European Study on Screening of Prostate Cancer). In one centre (Rotterdam), the screening protocol initially consisted of 3 screening tests for all men: prostate-specific antigen (PSA...

journal_title：International journal of cancer

authors： Beemsterboer PM,Kranse R,de Koning HJ,Habbema JD,Schröder FH

更新日期：1999-08-20 00:00:00