Properties of recombinant interleukin 2-cultured tumor-infiltrating lymphocytes in human lung cancer.

abstract：:It has become axiomatic that critical windows of susceptibility to genotoxins exist and that genetic damage in utero may be a trigger for later life cancers. Data supporting this critical window hypothesis are remarkably few. This study provides a quantitative bridge between DNA damage by the liver carcinogen aflatoxi...

journal_title：International journal of cancer

authors： Chawanthayatham S,Thiantanawat A,Egner PA,Groopman JD,Wogan GN,Croy RG,Essigmann JM

更新日期：2015-03-15 00:00:00

abstract：:The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...

journal_title：International journal of cancer

authors： Menendez JA,Vellon L,Colomer R,Lupu R

更新日期：2005-05-20 00:00:00

abstract：:It was suggested that the brain microenvironment plays a role in glioma progression. Here we investigate the mechanism by which astrocytes which are abundant in glioma tumors, promote cancer cell invasion. In this study, we evaluated the effects of astrocytes on glioma biology both in vitro and in vivo and determined ...

journal_title：International journal of cancer

authors： Shabtay-Orbach A,Amit M,Binenbaum Y,Na'ara S,Gil Z

更新日期：2015-09-01 00:00:00

abstract：:The aim of our study was to estimate uptake of prostate-specific antigen (PSA) testing in an entire country, including time trends and geographical differences. Data from the Swedish Cancer Register on prostate cancer incidence between 1980 and 2007 and published data from the Gothenburg branch of the European randomi...

journal_title：International journal of cancer

authors： Jonsson H,Holmström B,Duffy SW,Stattin P

更新日期：2011-10-15 00:00:00

abstract：:A challenging task of the immune system is to fight cancer cells. However, a variety of human cancers educate immune cells to become tumor supportive. This is exemplified for tumor-associated macrophages (TAMs), which are polarized towards an anti-inflammatory and cancer promoting phenotype. Mechanistic explanations, ...

journal_title：International journal of cancer

authors： Weigert A,Schiffmann S,Sekar D,Ley S,Menrad H,Werno C,Grosch S,Geisslinger G,Brüne B

更新日期：2009-11-01 00:00:00

abstract：:Inhibitors of matrix metalloproteinases (MMPs) were developed as anticancer agents based on the observation that MMPs facilitate local tumor spread and metastasis by promoting matrix degradation and cell migration. Unfortunately, these inhibitors were unsuccessful in the clinical treatment of several cancers, includin...

journal_title：International journal of cancer

authors： Chen X,Su Y,Fingleton B,Acuff H,Matrisian LM,Zent R,Pozzi A

更新日期：2005-08-10 00:00:00

abstract：:Family history (FH) of lung cancer is an established risk factor for lung cancer, but the modifying effect of smoking in relatives has been rarely examined. Also, the role of FH of nonmalignant lung diseases on lung cancer risk is not well known. We examined the role of FH of cancer and nonmalignant lung diseases in l...

journal_title：International journal of cancer

authors： Gao Y,Goldstein AM,Consonni D,Pesatori AC,Wacholder S,Tucker MA,Caporaso NE,Goldin L,Landi MT

更新日期：2009-07-01 00:00:00

abstract：:The metastatic dissemination of cancer cells to remote areas of the body is the most problematic aspect in cancer patients. Among cancers, melanomas are notoriously difficult to treat due to their significantly high metastatic potential even during early stages. Hence, the establishment of advanced therapeutic approac...

journal_title：International journal of cancer

authors： Kinoshita R,Sato H,Yamauchi A,Takahashi Y,Inoue Y,Sumardika IW,Chen Y,Tomonobu N,Araki K,Shien K,Tomida S,Torigoe H,Namba K,Kurihara E,Ogoshi Y,Murata H,Yamamoto KI,Futami J,Putranto EW,Ruma IMW,Yamamoto H,Soh J

更新日期：2019-07-15 00:00:00

abstract：:A new cell line from a sporadic Wilms' tumor was established and extensively characterized. In nude mice, the tumor cells rapidly formed tumors which, in histological characteristics and extracellular-matrix (ECM) composition resembled sarcomatoid Wilms' tumor. The tumor cells produced B chains of laminin, but no A ch...

journal_title：International journal of cancer

authors： Talts JF,Aufderheide E,Sorokin L,Ocklind G,Mattsson R,Ekblom P

更新日期：1993-07-09 00:00:00

abstract：:Cancer Procoagulant (CP), a cysteine proteinase which triggers blood coagulation by directly activating Factor X (FX) in the absence of Factor VII (F VII), has recently been isolated from rabbit V2 carcinoma and biochemically characterized. We have studied the procoagulant activity of tissue extracts from 4 murine exp...

journal_title：International journal of cancer

authors： Falanga A,Bolognese Dalessandro AP,Casali B,Roncaglioni MC,Donati MB

更新日期：1987-06-15 00:00:00

abstract：:As many patients with mammary carcinoma are now treated by conservative forms of surgery, there is a need for prognostic information obtainable from the primary tumour alone. One possible source is the antigenic profile of tumour cells. Using an indirect immunoperoxidase technique, we stained histological sections of ...

journal_title：International journal of cancer

authors： Wilkinson MJ,Howell A,Harris M,Taylor-Papadimitriou J,Swindell R,Sellwood RA

更新日期：1984-03-15 00:00:00

abstract：:To identify CTL-directed antigens in gastrointestinal cancer, we have investigated antigens recognized by the HLA-A2-restricted CTL line established from T cells infiltrating into colon cancer and report herein cleavage and polyadenylation specificity factor (CPSF) as a potent antigen holding peptides capable of induc...

journal_title：International journal of cancer

authors： Maeda Y,Ito M,Harashima N,Nakatsura T,Hida N,Imai N,Sato Y,Shichijo S,Todo S,Itoh K

更新日期：2002-05-20 00:00:00

abstract：:Ciclopirox olamine (CPX) is a synthetic antifungal agent clinically used to treat mycoses of the skin and nails. Here, we show that CPX inhibited tumor growth in human breast cancer MDA-MB-231 xenografts. To unveil the underlying mechanism, we further studied the antitumor activity of CPX in cell culture. The results ...

journal_title：International journal of cancer

authors： Zhou H,Shen T,Luo Y,Liu L,Chen W,Xu B,Han X,Pang J,Rivera CA,Huang S

更新日期：2010-11-15 00:00:00

abstract：:The insulin-like growth factor I (IGF-I) signaling pathway has been shown to play an important role in several aspects of cancer biology, including metastasis. The aim of this study was to define the contribution of serum (endocrine) and local (tumour microenvironment) IGF-I on osteosarcoma tumour growth and metastasi...

journal_title：International journal of cancer

authors： Hong SH,Briggs J,Newman R,Hoffman K,Mendoza A,LeRoith D,Helman L,Yakar S,Khanna C

更新日期：2009-05-01 00:00:00

abstract：:We evaluated whether regular mammographic screening of women aged 65 years or older affected breast cancer mortality. In Nijmegen, a population-based screening program for breast cancer was started in 1975, with biennial mammography for women aged 35-64 years. Since 1977, elderly women have also been participating. Fo...

journal_title：International journal of cancer

authors： Van Dijck JA,Verbeek AL,Beex LV,Hendriks JH,Holland R,Mravunac M,Straatman H,Werre JM

更新日期：1996-06-11 00:00:00

abstract：:Erythropoietin (Epo) regulates erythropoiesis by binding to its receptor (EpoR) and promoting cell proliferation, differentiation and inhibition of apoptosis. Epo is widely used to treat cervical cancer-related anaemia. However, there are data suggesting that administration of Epo is associated with an increment in re...

journal_title：International journal of cancer

authors： Lopez TV,Lappin TR,Maxwell P,Shi Z,Lopez-Marure R,Aguilar C,Rocha-Zavaleta L

更新日期：2011-12-01 00:00:00

abstract：:Liver cancers are strongly linked to hepatitis B virus (HBV) and hepatitis C virus (HCV). Egypt has the highest prevalence of HCV worldwide and has rising rates of hepatocellular carcinoma (HCC). Egypt's unique nature of liver disease presents questions regarding the distribution of HBV and HCV in the etiology of HCC....

journal_title：International journal of cancer

authors： Lehman EM,Wilson ML

更新日期：2009-02-01 00:00:00

abstract：:EBV-specific cytotoxic T cells (Tc) induced in vitro have continuously proliferated in vitro for over 9 months. The long-term maintenance of the Tc growth was dependent on periodic supplementation of both irrediated EBV-transformed autologous lymphoblastoid cell line (LCL) cels and conditioned medium. The latter was d...

journal_title：International journal of cancer

authors： Sugamura K,Tanaka Y,Hinuma Y

更新日期：1981-08-15 00:00:00

abstract：:A "divergent pathway" model for the development of cutaneous melanoma has been proposed. The model hypothesizes that melanomas occurring in people with a low tendency to develop nevi will, on average, arise more commonly on habitually sun-exposed body sites such as the head and neck. In contrast, people with an inhere...

journal_title：International journal of cancer

authors： Olsen CM,Zens MS,Stukel TA,Sacerdote C,Chang YM,Armstrong BK,Bataille V,Berwick M,Elwood JM,Holly EA,Kirkpatrick C,Mack T,Bishop JN,Østerlind A,Swerdlow AJ,Zanetti R,Green AC,Karagas MR,Whiteman DC

更新日期：2009-02-15 00:00:00

abstract：:We have obtained a novel multidrug resistant cell line, derived from HT29 G(+) human colon carcinoma cells, by selection with gradually increasing concentrations of the anti-mitotic, microtubule-disrupting agent colchicine. This HT29(col) cell line displayed a 25-fold increase in colchicine resistance and exhibited cr...

journal_title：International journal of cancer

authors： Kok JW,Veldman RJ,Klappe K,Koning H,Filipeanu CM,Müller M

更新日期：2000-07-15 00:00:00

abstract：:Pathological deregulation of the transforming growth factor, beta 1 (TGFB1) pathway has been implicated in the development of several major diseases, including cancers. Regulatory variation in the TGFB1 gene may lead to altered TGFB1 expression and activity, and thus, modulate an individual's susceptibility to disease...

journal_title：International journal of cancer

authors： Healy J,Dionne J,Bélanger H,Larivière M,Beaulieu P,Labuda D,Sinnett D

更新日期：2009-09-15 00:00:00

abstract：:The survival experience of 284 patients with cancer of the cervix uteri registered by the population-based Zimbabwe National Cancer Registry in 1995-1997 is described. The vital status of these subjects was established by linkage with death registration and by retrieval of patient files from medical records department...

journal_title：International journal of cancer

authors： Chokunonga E,Ramanakumar AV,Nyakabau AM,Borok MZ,Chirenje ZM,Sankila R,Parkin DM

更新日期：2004-03-20 00:00:00

abstract：:In children, renal cell carcinoma (RCC) is rare. This study is the first report of pediatric patients with RCC registered by the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG). Pediatric patients with histologically confirmed RCC, registered in SIOP 93-01, 2001 and UK-IMPORT databases,...

journal_title：International journal of cancer

authors： van der Beek JN,Hol JA,Coulomb-l'Hermine A,Graf N,van Tinteren H,Pritchard-Jones K,Houwing ME,de Krijger RR,Vujanic GM,Dzhuma K,Schenk JP,Littooij AS,Ramírez-Villar GL,Murphy D,Ray S,Al-Saadi R,Gessler M,Godzinski J,R

更新日期：2021-01-18 00:00:00

abstract：:The relationship between the strength of the estrogenic and progestational components of combined oral contraceptives and risk of endometrial carcinoma was examined in a multinational hospital-based case-control study comparing 220 cases from 7 countries with 1,537 age- and hospital-matched controls. Oral contraceptiv...

journal_title：International journal of cancer

authors： Rosenblatt KA,Thomas DB

更新日期：1991-12-02 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a cell plasticity process required for metastasis and chemoresistance of carcinoma cells. We report a crucial role of the signal adaptor proteins CRK and CRKL in promoting EMT and tumor aggressiveness, as well as resistance against chemotherapy in colorectal and pancreatic ca...

journal_title：International journal of cancer

authors： Franke FC,Slusarenko BO,Engleitner T,Johannes W,Laschinger M,Rad R,Nitsche U,Janssen KP

更新日期：2020-09-15 00:00:00

abstract：:Recombinant human interferon beta (rIFN-beta) inhibited in a time- and dose-dependent manner the proliferation of 18/18 human colon carcinoma cell lines in monolayer culture and 8/9 lines in a soft agar assay but had no effect on 4 human fibroblast cell lines. Maximal inhibition of cell proliferation by rIFN-beta requ...

journal_title：International journal of cancer

authors： Wong VL,Rieman DJ,Aronson L,Dalton BJ,Greig R,Anzano MA

更新日期：1989-03-15 00:00:00

abstract：:Over 10% of children with Wilms tumor (WT) have an underlying cancer predisposition syndrome (CPS). Cognizant of increasing demand for genetic evaluation and limited resources across health care settings, there is an urgent need to rationalize genetic referrals for this population. The McGill Interactive Pediatric Onc...

journal_title：International journal of cancer

authors： Cullinan N,Villani A,Mourad S,Somers GR,Reichman L,van Engelen K,Stephens D,Weksberg R,Foulkes WD,Malkin D,Grant R,Goudie C

更新日期：2020-02-15 00:00:00

abstract：:Phosphorylation/activation of c-jun NH2-terminal kinase (JNK) has an ambivalent role, pro-proliferation or antiproliferation, in human cancers, which is determined by different cell types and by its crosstalk with other kinases. So far, the role of phosphorylated JNK (p-JNK) in breast cancer is mostly undefined. In th...

journal_title：International journal of cancer

authors： Yeh YT,Hou MF,Chung YF,Chen YJ,Yang SF,Chen DC,Su JH,Yuan SS

更新日期：2006-06-01 00:00:00

abstract：:To determine the relationship between p16MTS1/CDK4I expression, gene inactivation and 9p21 loss of heterozygosity (LOH) in the development of laryngeal carcinomas, we have examined p16MTS1/CDK4I protein and mRNA expression in a series of 7 normal and 36 tumoral tissues, and the presence of gene alterations and 9p21 LO...

journal_title：International journal of cancer

authors： Jares P,Nadal A,Fernández PL,Pinyol M,Hernández L,Cazorla M,Hernández S,Beà S,Cardesa A,Campo E

更新日期：1999-05-31 00:00:00

abstract：:Deletion of chromosome 5q is common in prostate cancer and is linked to aggressive disease. Most previous studies focused on 5q21 where CHD1 is located, but deletion of mapping studies has identified a second deletion hotspot at 5q13. To clarify the prevalence and clinical relevance of 5q13 deletions and to determine ...

journal_title：International journal of cancer

authors： Möller K,Kluth M,Ahmed M,Burkhardt L,Möller-Koop C,Büscheck F,Weidemann S,Tsourlakis MC,Minner S,Heinzer H,Huland H,Graefen M,Sauter G,Schlomm T,Dum D,Simon R

更新日期：2021-02-01 00:00:00